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2021 Vol. 18, No. 17 Published: 2021-06-15

	4	Effects of reinforcing-reducing method by twirling of acupuncture on contents of malondialdehyde and glutathione peroxidase in hippocampus of spontaneously hypertensive rats
		XUE Yanjun WU Jiaojuan ZHANG Xudong YU Pengcheng WU Xiaoli LIU Qingguo
		Objective To explore the effects of reinforcing-reducing method by twirling of acupuncture on contents of malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) in hippocampus of spontaneously hypertensive rats. Methods A total of 18 spontaneously hypertensive rats were divided into three groups by random number table method: reducing method group, reinforcing method group, and model group, with six rats in each group. Six WKY rats were served as blank group. All rats were SPF grade, nine-week-old male rats. After one week of acclimatization, reducing method group and reinforcing method group were intervened with corresponding manipulation of reducing and reinforcing on bilateral tàichōng once a day for 14 days. Model group and blank control group received the same grasping and fixation stimulation at the same points of reinducing method group and reinforcing method group. Hippocampus samples were collected on the 15th day, and the morphology of hippocampus was observed by HE staining, MDA content was detected by thiobarbituric acid method and GSH-Px content was detected by colorimetry. Results HE staining results showed that the cells in the blank group had complete structure, regular morphology, normal intercellular space, most nuclei were deeply stained, nucleoli were clear, and no denatured necrosis was observed. Compared with the blank group, the staining in the model group was significantly lighter, and nuclear pyknosis, cell lysis and fragmentation, vacuolar degeneration and apoptotic cells were observed. Compared with the model group, the cell contour was clear, the cell staining was deep, the nucleoli were clear, and the cell structure was basically normal in both the reducing method group and reinforcing method group. MDA content in model group was higher than that in blank group, while GSH-Px content in model group was lower than that in blank group, and the differences were highly statistically significant (P ＜ 0.01). MDA contents in reducing method group and reinforcing method group were lower than those in model group, the contents of GSH-Px in the reducing method group and reinforcing method group were higher than those in the model group, and the differences were statistically significant (P < 0.05 or P ＜ 0.01). Conclusion Reinforcing-reducing method by twirling of acupuncture can regulate the expression level of MDA and GSH-Px in the hippocampus of spontaneously hypertensive rats, inhibit the oxidative reaction, and reduce the damage of oxygen radicals to the hippocampus of spontaneously hypertensive rats, which may be one of the protective mechanisms of reinforcing-reducing method by twirling of acupuncture on hypertensive hippocampal injury.
		2021 Vol. 18 (17): 4-7,17 [Abstract] ( 151 ) HTML (1 KB) PDF (794 KB) ( 63 )

	8	Screening of gastric cancer related molecules based on weighted gene co-expression network analysis
		XIAO Youde1 ZHENG Yongfa2 GE Wei1
		Objective To screen out molecules related to the occurrence and prognosis of gastric cancer through weighted gene co-expression network analysis (WGCNA), so as to provide a reference for the treatment and prognosis of gastric cancer. Methods The gene expression profile and clinical data of gastric cancer patients were downloaded from the TCGA database, retrieval time was from the establishment to November 14, 2020. WGCNA was used to analyze gene expression in gastric cancer patients. The core target genes were screened and their functions were analyzed, and validation was performed using ONCOMINE and GEO databases. Results A total of 359 patients with gastric cancer were included. The BLUE module was associated with the occurrence and prognosis, CDC5L was acted as the core gene, and CDC5L was correlated with the occurrence and prognosis of gastric cancer. ONCOMINE database validation results showed that the expression of CDC5L in cancer tissues was higher than that in adjacent tissues (P < 0.01). GEO database validation results showed that patients with low expression of CDC5L had better prognosis. Conclusion CDC5L is associated with the occurrence and prognosis in gastric cancer patients, and it can provide reference for the study of the occurrence, metastasis and treatment of gastric cancer.
		2021 Vol. 18 (17): 8-12，24 [Abstract] ( 111 ) HTML (1 KB) PDF (1613 KB) ( 80 )

	13	Expression and clinopathological significance of UBD in Kazakh, Uyghur and Han esophageal squamous cell carcinoma
		LUO Xiaolei1,2 KAWULI Jumai1,2 SUN Qingchao1,2 LI Desheng1,2 MADINIYAT Niyaz2,3 ZHANG Liwei1,2 YILIYAER Xiaheding1,2
		Objective To investigate the expression of protein and mRNA levels of Ubiquitin D (UBD) with cancer tissues and adjacent tissues in esophageal squamous cell carcinoma patients in Kazakh, Uygur, and Han nationalities, and to explore its clinicopathological significance. Methods A total of 173 cases of esophageal squamous cell carcinoma patients with cancer tissue and adjacent tissue specimens were collected (normal esophageal mucosa tissue> 5 cm from cancer tissue) from 2011 to 2014, including Uyghur, Kazakh and Han nationalities. Immunohistochemical staining method, real-time fluorescent quantitative PCR and HE staining method were used to detect the expression level of UBD, and the clinicalpathological characteristics of patients were combined for analysis. Results The protein and mRNA levels of UBD in esophageal squamous cell carcinoma tissues of the three ethnic groups were higher than those of adjacent tissues, and the differences were statistically significant (P ＜ 0.05). In the esophageal squamous cell carcinoma tissues of different ethnic groups, there was no significant difference in the expression of UBD at the protein and mRNA levels (P ＞ 0.05). UBD expression in esophageal squamous cell carcinoma tissues was related to tumor neuro vascular invasion, TNM stage, N stage and differentiation degree (P ＜ 0.05), and it wasn’t related to gender, age, T stage, tumor location, tumor size, etc.(P ＞ 0.05). Conclusion UBD may have an important influence on the malignant development of esophageal squamous cell carcinoma, and it is expected to become a reference indicator for predicting the potential of metastasis.
		2021 Vol. 18 (17): 13-17 [Abstract] ( 86 ) HTML (1 KB) PDF (868 KB) ( 55 )

	18	Analysis of research trends and hotspots of Tripterygium wilfordii multiglucoside in recent 20 years based on knowledge graph
		WANG Hongyun1 TU Sijie1 WANG Xiaoqin2,3 ZOU Xinrong2,3
		Objective To explor the research trend and progress around the theme of “Tripterygium wilfordii multiglucoside (TWM)” in China in the past 20 years by bibliometric visualization analysis. Methods All literatures directly related to TWM included in CNKI database from January 2000 to August 2020 were as the research object, combined with software such as CiteSpace and Vosviewer, the publication trends, journals, institutions, authors and keywords were analyzed and the corresponding knowledge map was drawed. Results A total of 1715 qualified literatures were screened and published in 386 related academic journals. Frequency statistics and collaborative network analysis revealed that 4047 researchers from 1846 institutions participated in TWM related studies. Key words analysis result showed that renal diseases, rheumatic immune diseases and immune-related skin diseases were the key areas of TWM research and application. In addition, the pharmacological effects and adverse drug reactions of TWM were also the focus of scholars’ attention. Conclusion TWM has been paid more and more attention by scholars, but the further cooperation between agencies and teams still needs to be strengthened. In the future, the research and application of TWM in nephrology, rheumatology and dermatology are worthy of further exploration.
		2021 Vol. 18 (17): 18-24 [Abstract] ( 108 ) HTML (1 KB) PDF (1709 KB) ( 28 )

	25	Expression of hBD-3 and NF-κB p65 in oral potentially malignant disorder and oral squamous cell carcinoma
		DU Yong xiu YANG Qin YANG Chenxi XU Pu
		Objective To investigate the expression and correlation of human β-defensin-3 (hBD-3) and nuclear factor kappaB (NF-κB) p65 in normal oral mucosa, oral potentially malignant disorder (OPMD), and oral squamous cell carcinoma (OSCC). Methods Clinical data and histological specimen from the Department of Pathology, Haikou Affiliated Hospital of Center South University Xiangya School of Medicine from January 2015 to December 2018, 60 patients with OPMD, 40 patients with OSCC and 15 cases of normal oral mucosa were collected. Immunohistochemical staining was applied to investigate the expression of hBD-3 and NF-κB p65 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues. The expression in different types of tissue specimens and their correlation were analyzed. Results The expression intensity of hBD-3 and NF-κB p65 in OSCC was significantly higher than those in normal group and OPMD group (P ＜ 0.05), and OPMD group was significantly higher than that in normal group (P < 0.05). The expression of hBD-3 was positively correlated with NF-κB p65 (r = 0.355，P ＜ 0.05). HbD-3 and NF-κB p65 were associated with OPMD epithelial dysplasia (P ＜ 0.05). Conclusion The expression of hBD-3 and NF-κB p65 protein is increased in the early carcinogenesis of oral mucosa and has obvious synergistic effect, suggesting that they may be involved in the occurrence and development of oral squamous cell carcinoma.
		2021 Vol. 18 (17): 25-28,35 [Abstract] ( 71 ) HTML (1 KB) PDF (755 KB) ( 100 )

	29	Study on the action mechanism of modified Huangqi Chifeng Decoction in the treatment of IgA nephropathy based on network pharmacology method
		MA Sijia ZHAO Mingming CHANG Meiying YU Yi WANG Rumeng ZHANG Yu
		Objective To explore the action target and potential mechanism of modified Huangqi Chifeng Decoction in treating IgA nephropathy by using network pharmacology knowledge. Methods Related chemical components of seven traditional Chinese medicine in modified Huangqi Chifeng Decoction and their action targets were screened out from the traditional Chinese medicine systems pharmacology database and analysis platform, and the active components of traditional Chinese medicine were screened out according to the corresponding standards. The disease targets related to IgA nephropathy were screened out through online Mendelian inheritance in man and Genecards database, and the common targets of modified Huangqi Chifeng Decoction and disease were calculated by R language. The corresponding regulatory network was plotted and constructed in Cytoscape research software. The String database was used to construct the corresponding protein-protein interaction network. The GO function and KEGG pathway enrichment analysis of the target were performed by R language to identify the possible key targets and key pathways. Results A total of 45 active components and 95 potential action targets were screened out from the modified Huangqi Chifeng Decoction. The treatment of IgA nephropathy may be related to the influence of the expression of albumin, interleukin (IL)-6, serine/threonine kinase 1, vascular endothelial growth factor A, and other genes. A total of 115 enrichment results were included in GO biofunction analysis, mainly involving phosphatase binding, heme binding, cytokine receptor binding and other processes. A total of 151 metabolic pathways were obtained by KEGG enrichment, mainly including AGE-RAGE signaling pathway, IL-17 signaling pathway, tumor necrosis factor signaling pathway, etc. Conclusion Based on the network pharmacology method, it is speculated that the modified Huangqi Chifeng Decoction can be used in the treatment of IgA nephropathy through various interventions, and has the therapeutic advantages of multiple components, multiple targets and multiple pathways, which provides theoretical reference for the future study of its pharmacodynamic substance basis and action mechanism.
		2021 Vol. 18 (17): 29-35 [Abstract] ( 103 ) HTML (1 KB) PDF (2491 KB) ( 83 )

	36	Application and evaluation of experimental animal model of hypertension
		WEN Xin ZHANG Qi▲
		Hypertension is a major risk factor for cardiovascular diseases, and the prevalence of hypertension is high, and the patients are getting younger in recent years. Nowadays, medical science is not satisfied with the treatment of hypertension and the main treatment is to control blood pressure and prolong survival time. The establishment of hypertension experimental animal models is of great significance for the study of the pathogenesis of hypertension, clinical treatment, therapeutic targets and drug development. At present, animal models are mostly used in small animals such as rats and mice, while the application of large animal models are limited under the influence of experimental cost, laboratory environment and experimental technology. In order to select suitable animal models for the study of disease in the future, this paper briefly introduces hypertension animal models such as spontaneously hypertensive rat, salt-sensitive hypertensive rat and 2-kidney-1-clip hypertensive rat.
		2021 Vol. 18 (17): 36-39 [Abstract] ( 186 ) HTML (1 KB) PDF (538 KB) ( 233 )

	40	Research progress on the mechanism of depression and anxiety of antihyperglycemics
		ZHOU Zijing YAN Shuang
		Depression is one of the risk factors for type 2 diabetes mellitus (T2DM), and the incidence of depression in T2DM patients is significantly higher than that in non-T2DM population. Depression is often accompanied by severe anxiety symptoms. There are few systematic studies on the relationship between T2DM and depression and anxiety state. There are overlapping biological effects in the pathogenesis and treatment mechanism of both. Existing studies have found that Metformin, Thiazolidinedione, GLP-1 receptor agonists, DPP-4 inhibitors, insulin and other antihyperglycemics may relieve depression and anxiety state through neurobiochemical, neuroendocrine, neuroimmune and other mechanisms. Therefore, it is of great clinical significance to explore the biological mechanism of antihyperglycemics in relieving depression and anxiety state.
		2021 Vol. 18 (17): 40-44 [Abstract] ( 132 ) HTML (1 KB) PDF (539 KB) ( 154 )

	45	Research progress on the relationship between gastric microecology, gastric diseases and gastric mucosal immunity
		QIN Heping1 YI Ping2
		Stomach microecology is closely related to gastric diseases and gastric mucosal immunity. In addition to Helicobacter pylori colonizing the gastric, there are other bacteria and fungi such as Firmicutes, Proteobacteria, Bacteroides, Fusobacteria and Actinomycetes. There are many factors influencing the gastric microecology, such as microorganisms, drugs and proton pump inhibitors, which lead to highly dynamic changes in the gastric microecology. In patients with common diseases such as functional dyspepsia, chronic gastritis, gastric ulcer and gastric cancer, the diversity of gastric flora is reduced, and the abundance of pathogenic bacteria increases accordingly, and gastric microecological imbalance occurs. When the gastric microecology is out of balance, it mainly induces gastric mucosal immunity through intrinsic lymphoid cells, causing gastric mucosal damage.
		2021 Vol. 18 (17): 45-47,57 [Abstract] ( 60 ) HTML (1 KB) PDF (901 KB) ( 196 )

	48	Analysis of the intention and influencing factors of doctors in tertiary hospitals to refer down patients in the chronic recovery period
		WANG Xia1,2 DAI Tao2▲ HUANG Ju2
		Objective To analyze clinicians’ behavioral intentions and influencing factors of refer down to patients in the chronic recovery period. Methods From October 2018 to October 2019, the Questionnaire for Clinicians’ Referral Intentions in Tertiary Medical Institutions designed based on the theory of planned behavior was used to evaluate the results of oxght tertiary general hospitals in Xuzhou of Jiangsu Province, Hangzhou of Zhejiang Province, and Jining of Shandong Province. Clinicians conducted a cross-sectional survey and recovered 442 valid questionnaires. Pearson correlation was used to analyze the relationship between the doctor’s attitude toward referral patients, subjective norms, and perceptual behavior control influencing factors and the doctor’s refer down intention. Finally, a structural equation model was established to analyze the degree of influence of various factors on the doctor’s refer down intention and the influence path. Results 76.5% of the surveyed doctors had the intention to refer down patients in the chronic recovery period, among which, the intention of the senior professional title clinician was the highest, reaching 92.7%. There was a statistically significant difference in the referral intention of clinicians with different professional titles (P < 0.01). Attitudes, subjective behavioral norms, and perceived behavioral control had a direct impact on behavioral intentions, explaining 52%, 42%, and 23% of the differences in behavioral intentions. Attitudes had the greatest influence on intentions. Conclusion Attitude and subjective norms are the most important factors influencing the downward transfer intentions of clinicians in tertiary hospitals. Attitude has the greatest impact, followed by the social pressure that doctors feel from hospital deans, department directors, and colleagues, and patients and their families. The degree of support has little effect on the doctor’s transfer. In addition, the higher the degree of completeness of the transfer standard, the more convenient the medical insurance approval system, and the higher the proportion of doctors with high professional titles, the more favorable it is to promote the refer down of doctors to patients.
		2021 Vol. 18 (17): 48-52,63 [Abstract] ( 81 ) HTML (1 KB) PDF (735 KB) ( 54 )

	53	Investigation on contraceptive status and contraceptive demand of college students of a university in Nanjing
		YANG Yuehua SUN Zhiming ZHOU Jian ZHANG Min BA Lei ZHU Xiangjun ZHUANG Yongmei LIN Jie
		Objective To understand the contraceptive ability and service demand of college students in the new era, and to improve the reproductive health education and service for college students in the future. Methods A total of 200 valid questionnaires powered by questionnaire star were collected from students of a university in Nanjing on September 25, 2020. Results The premarital sex self-report rate of college students was 18.50%, and 42.00% of the subjects were opposed to premarital sex. The top five contraceptive methods were condoms, emergency contraceptives, compound oral contraceptives, safe period contraception, and in vitro sperm drainage. The correct knowledge rate of contraceptive knowledge was 20.00%-82.00%. The most concerned features of subjects when choosing contraceptive methods were “good contraceptive effect” and “small side effects”. 69.00% of the subjects were chosed condoms. The subject’s contraceptive knowledge currently mainly came from the Internet (60.00%), but they would hope to obtain knowledge through various channels such as lectures, elective courses, exhibitions or promotional activities, and the Internet. They would also hope to obtain contraceptives through self-service sales points (36.50%). Conclusion In the new era, college students have open sex concepts, inadequate contraceptive abilities, and a surge in contraceptive demand. It is necessary to further strengthen policy guidance and demand orientation, and multi-sectoral cooperation to jointly improve the level of reproductive health education and services for college students.
		2021 Vol. 18 (17): 53-57 [Abstract] ( 73 ) HTML (1 KB) PDF (686 KB) ( 142 )

	58	Forecast and analysis of the demand and gap of nursing beds in Shunyi District, Beijing during the “14th Five-Year Plan” period
		ZHENG Gongchi1,2 ZHAO Jun2 LI Xi2 FENG Yikai1,2 CHEN Junjia1,2 WANG Fang2
		Objective To forecast the demand for nursing bed resources and the gap between supply and demand in Shunyi District, Beijing during the “14th Five-Year Plan” period, and to put forward policy recommendations for resource allocation. Methods The questionnaire survey was used to obtain data on the resident elderly population in Shunyi District from January 2015 to December 2019 and data on the allocation of nursing beds in Shunyi District in December 2019. The time series analysis method was used to predict the number of resident elderly population from 2020 to 2025. The demands and gaps of nursing beds were calculated by the elderly population, the proportion of institutionalized elderly, and the proportion of nursing beds. Results From 2020 to 2025, there will be a gap of 742-3465 nursing beds in the district, with a supply-demand ratio of 0.36-0.73. At the same time, the supply-demand ratio was generally less than one in all streets and towns, and the supply of nursing beds is difficult to meet service demand. Conclusion During the “14th Five-Year Plan” period, Shunyi District may have problems such as insufficient total nursing bed resources and uneven regional distribution. It is recommended to increase the total number of nursing bed allocations. A certain amount of resources will be given to streets and towns with large gaps in nursing beds and relatively low supply and demand. In addition, institutions should improve their elderly care service capabilities and promptly introduce regional policies and regulations related to nursing beds.
		2021 Vol. 18 (17): 58-63 [Abstract] ( 58 ) HTML (1 KB) PDF (615 KB) ( 68 )

	64	Evaluation of the current situation and screening conditions of potentially inappropriate medication use in elderly hospitalized patients by The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China
		LI Xuefeng YANG Hua▲ WANG Quandong MENG Jie YANG Xiaogang
		Objective To investigate the status of potentially inappropriate medication (PIM) in elderly hospitalized patients and determine their screening conditions. Methods The use of drugs in Several tertiary hospitals in a city from July 2019 to December 2019 were evaluate by The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China, and the screening conditions were determined by using multi factor regression analysis and area under ROC curve. Results The incidence of PIM among elderly hospitalized patients was 18.64%. The highest PIM was non-steroidal anti-inflammatory drugs (47.07%), followed by antipsychotic drugs (25.19%) and glucocorticoids (21.37%). The type of medication (OR = 64.50, 95%CI = 10.97-379.23) and comorbidities (OR = 5.12, 95%CI = 2.69-9.78) were independent risk factors for PIM in elderly hospitalized patients (P ＜ 0.05). The cut-off values for PIM prediction of medication types and comorbidities were 4.5 (sensitivity of 90.0%, specificity of 26.4%) and 3.5 (sensitivity of 84.6%, specificity of 23.8%). Among them, 59 cases had two PIM conditions, and eight cases had three PIM conditions. Conclusion Doctors should pay more attention to non-steroidal anti-inflammatory drugs, antipsychotics and glucocorticoid in clinical use, and in the case of more than five drugs or more than four comorbidities, active screening should be carried out according to the criteria for The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China, so as to reduce the incidence of PIM in elderly inpatients.
		2021 Vol. 18 (17): 64-67,72 [Abstract] ( 56 ) HTML (1 KB) PDF (907 KB) ( 59 )

	68	Changes of SYNTAX and SYNTAX Ⅱ scores in patients with coronary artery heart disease after PCI with different LDL-C level
		ZHANG Kerui1 LI Yong2
		Objective To investigate the changes of SYNTAX and SYNTAX Ⅱ scores in patients with coronary artery heart disease (CHD) after percutaneous coronary intervention (PCI) with different low-density lipoprotein cholesterol (LDL-C) level. Methods A total of 150 patients who underwent PCI for CHD in Wujin Hospital Affiliated to Jiangsu University from October 2017 to December 2019 were selected as the research objects. LDL-C level was detected after PCI, and SYNTAX and SYNTAX Ⅱ scores were calculated, and clinical data of patients were collected. According to their LDL-C levels, all research objects were divided into low LDL-C level group (LDL-C＜1.4 mmol/L, 23 cases), non-low LDL-C level group (1.4≤LDL-C ＜1.8 mmol/L, 54 cases) and substandard LDL-C group (LDL-C≥1.8 mmol/L, 73 cases). The changes of SYNTAX and SYNTAX Ⅱ scores in the three groups after PCI were compared. Results There was no significant difference in clinical data among the three groups (all P ＞ 0.05). There were statistically significant differences in SYNTAX and SYNTAX Ⅱ scores among the three groups after PCI (P ＜ 0.05). Further pair comparison showed that SYNTAX and SYNTAX Ⅱ scores of the non-low LDL-C level group and the substandard LDL-C group were higher than those of the low LDL-C level group. The scores of SYNTAX and SYNTAX Ⅱ in the substandard LDL-C group were higher than those in the non-low LDL-C level group, and the differences were statistically significant (all P ＜ 0.05). Conclusion Low LDL-C level can further delay the progression of coronary artery in patients with CHD after PCI.
		2021 Vol. 18 (17): 68-72 [Abstract] ( 68 ) HTML (1 KB) PDF (427 KB) ( 56 )

	73	Analysis of the level of perception of autonomy and its influencing factors in patients with coronary artery heart disease
		YANG Xiaolan SONG Minmin XIE Hanhua▲
		Objective To analyze of the level of perception of autonomy and its influencing factors in patients with coronary artery heart disease (CHD). Methods A total of 213 patients with CHD admitted to Suzhou Jiulong Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from April 2017 to May 2020 were selected. Simplified Chinese version of perception of autonomy scale (PEAS-SCV) was used to evaluate the level of patients’ perception of autonomy. Baseline data of patients were collected and recorded. The PEAS-SCV scores of patients with different baseline data characteristics were compared to analyze the related factors that might affect their perception of autonomy level. Results The mean PEAS-SCV score of CHD patients was 53.00（52.00，56.00） points. The PEAS-SCV scores of patients with depression, low life satisfaction and low self-efficacy were lower than those of patients without depression, normal life satisfaction and normal self-efficacy, and the differences were statistically significant (all P ＜ 0.05). The results of multiple linear regression analysis showed that depression (X1), low life satisfaction (X2) and low self-efficacy (X3) were the influencing factors of low autonomy perception level in CHD patients. The equation Y=35.179+5.493X1+11.326X2+10.188X3 was obtained (R2 = 0.384, P ＜ 0.05). Conclusion The perception of autonomy of CHD patients is generally at a medium level, which may be related to the patients’ depression emotion, life satisfaction, self-efficacy and other factors. With the aggravation of depression emotion, the decrease of life satisfaction, and the decrease of self-efficacy, the autonomy perception level of patients decreases, which should be paid clinical attention to.
		2021 Vol. 18 (17): 73-76 [Abstract] ( 132 ) HTML (1 KB) PDF (439 KB) ( 25 )

	77	Meta analysis of the efficacy and safety of Butylphthalide Injection in the treatment of patients with acute cerebral infarction
		MENG Weishan1 LAN Rui2 WANG Baoqi1
		Objective To evaluate the efficacy and safety of Butylphthalide Injection in the treatment of acute cerebral infarction. Methods Randomized controlled trials of Butylphthalide Injection in the treatment of acute cerebral infarction were searched in CNKI, Wanfang Data, VIP, CBM, PubMed, and Embase databases. The retrieval period is from January 2015 to October 2020. After independent literature screening, basic information extraction and risk assessment of study bias were conducted by two participants, RevMan 5.4 software was used for meta-analysis. Results Twelve literatures were included, including 1291 patients, including 647 in the treatment group and 644 in the control group. Meta-analysis results showed: the clinical efficacy of the treatment group was better than that of the control group (RR = 1.25,95％CI [1.16,1.35], P ＜ 0.000 01), the National Institutes of Health neurological deficit score was lower than that of the control group (MD = -2.76, 95％CI [-3.75, -1.76], P ＜ 0.000 01), the Barthel index of daily living ability was higher than that of the control group (MD = 10.08, 95％CI [6.26,13.90], P ＜ 0.000 01), and the vascular endothelial growth factor was lower than that of the control group (MD = -88.18, 95％CI [-140.62, -35.73], P = 0.001), the level of thromboxane A2 was lower than that of the control group (MD = -51.2, 95％CI [-56.39，-46.01], P < 0.000 01). There was no significant difference in the incidence of adverse reactions between two groups (RR = 1.27, 95％CI [0.78, 2.07], P = 0.34). Conclusion According to the results, Butylphthalide injection can Improve the neurological defect, enhance the ability of daily life, improve the vascular endothelial function related indicators, safety needs to be further studied.
		2021 Vol. 18 (17): 77-81 [Abstract] ( 101 ) HTML (1 KB) PDF (1528 KB) ( 46 )

	82	Correlation between frailty and cognitive dysfunction in patients with acute ischemic stroke
		WANG Ying TAO Xiangjun DONG Kaisheng SONG Haiyan HU Wenli
		Objective To explore the correlation between frailty and cognitive dysfunction in patients with acute ischemic stroke. Methods A total of 127 patients with acute ischemic stroke admitted to Beijing Chaoyang Hospital of Capital Medical University from October 2019 to June 2020 were selected. Edmonton frailty scale (EFS) was used to evaluate their frailty, and they were divided into frailty group (51 cases) and non-frailty group (76 cases) according to whether frailty occurred. General data of the two groups were collected, and the cognitive function of the two groups was evaluated using the Montreal cognitive assessment scale (MoCA). Results The age, blood glucose levels, proportion of diabetes and proportion of hypertension in the frailty group were higher than those in the non-frailty group, and the total score of MoCA and scores of all fields were lower than those in the non-frailty group, the differences were statistically significant (all P ＜ 0.05). Correlation analysis showed that total EFS score was negatively correlated with total MoCA score (r = -0.491, P ＜ 0.001), visuospatial/executive function score (r = -0.444, P ＜ 0.001), naming score (r = -0.237, P ＜ 0.001), memory score (r = -0.364, P ＜ 0.001), attention scores (r = -0.350, P ＜ 0.001), language function scores (r = -0.238, P = 0.007), abstract ability scores (r = -0.202, P = 0.023), and orientation scores (r = -0.229, P = 0.010) negatively correlated. Conclusion Patients with acute ischemic stroke are prone to frailty and cognitive dysfunction, the frailty can affect the occurrence of cognitive dysfunction.
		2021 Vol. 18 (17): 82-84,89 [Abstract] ( 97 ) HTML (1 KB) PDF (609 KB) ( 59 )

	85	Correlation between MRI total load assessment and quality of life in walking dysfunction patients with cerebral small vessel disease
		SU Cen1 JIN Biao1 ZHAO Kangren1 XIA Haiping1 REN Naiyong1 LI Feng2 PAN Yuqing2
		Objective To investigate the correlation between MRI total load assessment and quality of life in walking dysfunction patients with cerebral small vessel disease (CSVD). Methods The data of 110 patients with CSVD walking dysfunction admitted to the Department of Neurology, Zhengdong Road Community Health Center and Baota Road Community Health Center of the Fourth People’s Hospital of Zhenjiang from May 2019 to May 2020 were collected. According to the imaging characteristics of whole brain MRI, they were divided into whole brain injury low load group (total CSVD score ≤2 points, 67 cases) and whole brain injury high load group (total CSVD score＞ 2 points, 43 cases). Community population functional status scale (COOP/WONCA) was used to evaluate the quality of life in the two groups, and linear regression analysis was used to evaluate the correlation between total CSVD score and various dimensions of quality of life in walking dysfunction patients with CSVD. Results In the whole brain injury high load group, the age, the proportion of history of hypertension, and the proportion of history of type 2 diabetes were higher and Montreal cognitive assessment scale scores were lower than those in the whole brain injury low load group, the differences were statistically significant (P ＜ 0.05). The physical ability, emotion, daily activity, social activity, health change, overall health score and COOP/WONCA total score in the whole brain injury high load group were higher than those in the whole brain injury low load group, with statistical significance (P ＜ 0.05). The results of linear regression analysis showed that physical scores (β = 0.178, 95%CI: 0.010-0.345, P = 0.038) and daily activity scores (β = 0.261, 95%CI: 0.090-0.432, P = 0.003) were positively correlated with the total CSVD score, while emotion, social activity, health change and overall health score were not correlated with the total CSVD score (P ＞ 0.05). Conclusion The heavier the MRI total load of CSVD, the worse the physical ability and daily activity function of patients with walking dysfunction. Chronic disease management of walking dysfunction patients with CSVD needs to be further strengthened.
		2021 Vol. 18 (17): 85-89 [Abstract] ( 47 ) HTML (1 KB) PDF (567 KB) ( 179 )

	90	Effects of different doses of folic acid on homocysteine levels in patients with different MTHFR genotypes of ischemic stroke with hyperhomocysteinemia
		LU Xiaoyan REN Yu
		Objective To investigate the therapeutic effect of different doses of folic acid on the treatment of hyperhomocysteinemia in patients with different methylene tetrahydrofolate reductase genotypes of ischemic stroke, and to find an appropriate folic acid treatment scheme. Methods A total of 376 ischemic stroke patients with hyperhomocysteinemia who were admitted to the Department of Neurology and Rehabilitation Medicine of the First Affiliated Hospital of Xinjiang Medical University from January 2017 to December 2019 were selected. Methylene tetrahydrofolate reductase C677T site gene was detected, and they were divided into TT type, CT type and CC type. According to random number table, they were divided into high-dose folic acid group (188 cases, 5.0 mg/d) and low-dose folic acid group (188 cases, 0.8 mg/d). Blood homocysteine level was measured before treatment, four weeks after treatment, and three months after treatment. Results For CT and TT genotypes, the homocysteine level of the high-dose folic acid group was lower than that of the low-dose folic acid group after four weeks of treatment, the difference was statistically significant (P ＜ 0.05). After three months of treatment, there was no significant difference in homocysteine levels between the two groups (P ＞ 0.05). For CC genotype, there was no significant difference in homocysteine levels between the two groups before treatment, after four weeks and three months of treatment (P ＞ 0.05). For the three genotypes, after four weeks and three months of treatment, the homocysteine level in the two groups was lower than that before treatment, after three months of treatment, the homocysteine level in the two groups was lower than that after four weeks of treatment, the differences were statistically significant (P ＜ 0.017). Conclusion For patients with ischemic stroke with hyperhomocysteinemia, personalized folic acid therapy should be developed according to different methylene tetrahydrofolate reductase C677T genotypes.
		2021 Vol. 18 (17): 90-93 [Abstract] ( 53 ) HTML (1 KB) PDF (555 KB) ( 66 )

	94	Effect of Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency
		BI Mengfei ZHANG Rongzhen WANG Yajun
		Objective To investigate the effect of Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency. Methods A total of 100 patients with vertebro-basilar artery insufficiency admitted to Wuhu Hospital of Traditional Chinese Medicine in Anhui Province from January 2018 to December 2019 were selected and they were divided into observation group and control group according to random number table method, with 50 patients in each group. The control group was treated with Gastrodin on the basis of conventional treatment, and the observation group was treated with Dingxuan Granules on the basis of the control group. Both groups were treated continuously for 14 days. The clinical efficacy after treatment, the changes of blood flow velocities of left vertebral artery (LVA), right vertebral artery (RVA), basilar artery (BA), cerebral blood flow (CBF) in basal ganglia region, cerebral blood volume (CBV), mean transit time (MTT) before and after treatment were compared between the two groups, and the incidence of adverse reactions during treatment were compared between the two groups. Results The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The blood flow velocities of LVA, RVA, BA and basal ganglia region CBF and CBV in the two groups were higher than before treatment, and the MTT was shorter than before treatment. The blood flow velocities of LVA, RVA, BA and basal ganglia region CBF and CBV in the observation group were higher than those in the control group, and the MTT was shorter than that in the control group, with statistical significance (all P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency has obvious effect and good safety, which is worthy of application and promotion.
		2021 Vol. 18 (17): 94-97 [Abstract] ( 97 ) HTML (1 KB) PDF (554 KB) ( 43 )

	98	Analysis of developmental quotient and influencing factors in two-three years old children with language retardation
		YANG Yifan1 LOU Dan2 LU Yaya2
		Objective To explore the developmental quotient of two-three years old children with language retardation and to analyze the influencing factors. Methods From January 2019 to June 2020, 68 children aged two-three years old with language retardation enrolled in the First Affiliated Hospital of He’nan University of Science and Technology were selected as case group, and 50 healthy children who underwent physical examination were selected as control group. The general data of two groups were compared, and the developmental quotient of two groups were evaluated and analyzed by Gesell infant development scale. According to the grading standard of language retardation, case group was divided into mild group (30 cases), moderate group (33 cases) and severe group (5 cases). Binary logistic regression was used to analyze the risk factors of language retardation in children. Results The were statistically significant differences between two groups in father’s degree of education, used audiobooks to teach children language, the family mainly took care, accompanied the children to read children’s books/story telling time, and the children’s daily TV watching time (P < 0.05). The developmental quotient of big motor, fine motor, speech ability, material ability and human ability in case group were lower than those of control group, and the differences were statistically significant (P < 0.05). The developmental quotient of fine motor, material ability, speech ability and human ability in severe group were lower than those of mild and moderate group, and moderate group was lower than mild group, and the differences were statistically significant (P < 0.05). Binary logistic regression analysis showed that father’s degree of education of high school or below, non-parents of the family mainly took care, accompanied the children to read children’s books/story telling time＜1 h, the children’s daily watching TV time≥2 h and do not use audiobooks to teach children language were the risk factors of language retardation (OR ＞ 1, P < 0.05). Conclusion Children with language retardation are often accompanied by backward development of multiple functional areas. Pediatricians should pay attention to screening the adverse factors of language development of children with language retardation and evaluate the level of intelligent development, and give individualized guidance and comprehensive intervention.
		2021 Vol. 18 (17): 98-101 [Abstract] ( 69 ) HTML (1 KB) PDF (375 KB) ( 147 )

	102	Clinical analysis of pedicled colon transplantation in the treatment of esophageal cancer patients with a history of gastric or esophageal surgery
		YU Zhen YU Lei YU Tao ZHANG Baoxun YANG Xingguo DU Xin
		Objective To explore the feasibility and clinical outcome of pedicled colon transplantation in the treatment of esophageal cancer patients with a history of gastric or esophageal surgery. Methods A total of 112 esophageal cancer patients with a history of gastric or esophageal surgery in Beijing Tongren Hospital who underwent esophageal cancer resection and colon replacement surgery from March 1992 to March 2018 were collected. The perioperative complications and the postoperative quality of life was evaluated. Kaplan-Meier survival analysis was used to evaluate survival rates. The Log-rank test was used to compare the survival curves of patients in different TNM stages. Results The complication rate and the mortality rate within 30 days postoperation was 15.2% and 1.8%. The three year and five year survival rates of all patients were 51.35% and 23.53%, respectively. The survival rate of patients with stage Ⅰ + ⅡA was significantly higher than that of patients with stage ⅡB + Ⅲ (P = 0.003). Conclusion For patients with esophageal cancer with a history of esophagus or gastric surgery, diseased esophagectomy, colon instead of esophagus, or colon instead of esophagus and jejunum instead of stomach can be used for surgical treatment.
		2021 Vol. 18 (17): 102-105 [Abstract] ( 53 ) HTML (1 KB) PDF (664 KB) ( 98 )

	106	Expression and clinical significance of serum β-actin and G protein-coupled receptor-4 in patients with gastric cancer
		WANG Chunmei1 WANG Caisheng2
		Objective To study the expression of serum β-actin and G protein coupled receptor-4 (LGR4) in patients with gastric cancer and their diagnostic value in gastric cancer. Methods A total of 103 cases of gastric cancer patients (observation group) and 52 cases of benign gastric cancer at the same period (control group) treated in Hohhot Second Hospital were selected from February 2018 to June 2020. The expression levels of serum β-actin and LGR4 were measured by enzyme-linked immunosorbent assay and the relationship between the two indexes and clinicopathological parameters were analyzed, the ROC curve was used to analyze the diagnosis of gastric cancer. Results The expression levels of β-actin and LGR4 in serum of observation group were higher than those of control group, with statistical significance (all P < 0.05). The expression of serum β-actin and LGR4 in patients with low to medium differentiation, Ⅲ-Ⅳ stage in TNM stage and without lymph node metastasis were higher than those in patients with high differentiation, Ⅰ-Ⅱ stage and with lymph node metastasis (P < 0.05). ROC curve analysis showed that when the cut-off values of β-actin and LGR4 in serum were 3.21 and 47.62 pg/mL, the ROC-AUC for diagnosis of gastric cancer was 0.747 and 0.782, respectively, and the combined detection was 0.869. Conclusion The expression levels of β-actin and LGR4 in gastric cancer were increased, and highly expressed in patients with low to moderate differentiation, Ⅲ-Ⅳ stage in TNM stage and no lymph node metastasis. The combined detection of β- actin and LGR4 may be used as molecular markers for the diagnosis of gastric cancer.
		2021 Vol. 18 (17): 106-109 [Abstract] ( 77 ) HTML (1 KB) PDF (504 KB) ( 67 )

	110	Information processing speed and working memory in inpatients with first-diagnosed and chronic schizophrenia
		ZHANG Yangyang TANG Luping GUO Xinxin LIU Haisheng YU Xiaoman TIAN Lin▲
		Objective To investigate information processing speed and working memory and correlation analysis in in-patients with first-diagnosed schizophrenia and chronic schizophrenia. Methods First-diagnosed schizophrenia inpatients in Wuxi Mental Health Center Affiliated to Nanjing Medical University (“our hospital” for short) from February 2012 to June 2015 were selected as the FDS group (24 cases) and chronic schizophrenia inpatients as the CSz group (86 cases). During the same period, 25 healthy people matched with the FDS group were recruited as the HC-F group and 56 healthy people matched with the CSz group were recruited as the HC-C group in our hospital. The Wechsler adult intelligence scale included digit symbol test (Dsy), digit span test-backword (DSp-B), MATRICS consensus cognitive batter included verbal fluency test (VF) and trail making A test (TMA). Partial correlation analysis was used to control for age and education level. Results DSy in the FDS group was lower than that in the HC-F group, while TMA in the FDS group was higher than that in the HC-F group, and the differences were statistically significant (P < 0.05). DSy, verbal fluency test-correct, DSp-B in the CSz group were lower than those in the HC-C group, trail making A test-model (TMA-M), TMA, verbal fluency test-repetition (VF-R) were higher than those in the HC-C group, and the differences were statistically significant (P < 0.05). In the FDS group, trail making A test-error was negatively correlated with onset age (r < 0, P < 0.05), and positively correlated with the course of disease (r > 0, P < 0.05). VF-R in the CSz group was negatively correlated with the score of general pathology scale (r < 0, P < 0.05). TMA-M and TMA were positively correlated with sex (r ＞ 0, P < 0.05). Conclusion First-diagnosed schizophrenia patients have deficiency in information processing speed, while chronic schizophrenia patients have impairment in information processing speed and working memory. It is suggested that clinicians pay more attention to the effect of metabolic diseases on cognitive function with first-diagnosed schizophrenia patients, and pay more attention to the effect of gender on cognitive function with chronic schizophrenia patients.
		2021 Vol. 18 (17): 110-113,121 [Abstract] ( 79 ) HTML (1 KB) PDF (567 KB) ( 4935 )

	114	Effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorder patients
		CHEN Xiyuan1 WANG Rui2
		Objective To investigate the effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorde patients and its influence on the levels of dopamine (DA), 5-hydroxytryptamine (5-HT) and neuron specific enolase (NSE). Methods From April 2019 to April 2020, 102 cases of adolescent psychological disorder patients in Brain Hospital Affiliated to Guangzhou Medical University were selected as study objects. According to the random number table method, they were divided into observation group (51 cases) and control group (51 cases). Both groups were given psychotherapy, control group was treated with Aripiprazole, while observation group was given Shumian Capsules orally on the basis of control group. The course of treatment was eight weeks. The curative effect of two groups after eight weeks of treatment, the scores of self rating anxiety scale (SAS), self rating depression scale (SDS), Pittsburgh sleep quality index (PSQI), DA, 5-HT before and after treatment and NSE levels and the adverse reactions during the treatment were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). Before treatment, there were no significant differences in SAS and SDS scores between two groups (P > 0.05). After eight weeks of treatment, SAS and SDS scores in both groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Before treatment, there was no significant difference in PSQI score between two groups (P > 0.05). After eight weeks of treatment, PSQI scores in both groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Before treatment, there were no significant differences in serum DA, 5-HT and NSE levels between two groups (P > 0.05). After eight weeks of treatment, the levels of serum DA and 5-HT in both groups were higher than those before treatment, and observation group was higher than control group (P < 0.05); while serum NSE level was lower than that before treatment, and observation group was lower than control group (P < 0.05). No obvious adverse reactions occurred in two groups. Conclusion Shumian Capsules combined with Aripiprazole has a good effect in the treatment of adolescent psychological disorder, which can reduce the psychological disorder, improve the sleep quality, increase the levels of DA and 5-HT, and reduce the level of NSE.
		2021 Vol. 18 (17): 114-117,125 [Abstract] ( 77 ) HTML (1 KB) PDF (561 KB) ( 114 )

	118	Analysis of psychological stress status and its influencing factors in patients with gastroscopic biopsy
		JIANG Huanhuan WEI Meiying TANG Yanqing ZHOU Li’na LIAO Xuying HUANG Fengmei▲
		Objective To analyze the psychological stress (PS) status in patients with gastroscopic biopsy and its influencing factors. Methods From February 2019 to February 2020, 190 patients who selectively received gastroscopic biopsy in Affiliated Hospital of Guilin Medical College were selected as study objects, 30 minutes before examination, symptom check list-90 (SCL-90) was used to evaluate the PS status of patients. Baseline data questionnaire was designed to inquire and record relevant baseline data of patients. The influencing factors that lead to poor PS status of patients with endoscopic biopsy were analyzed. Results Among the 190 patients with gastroscopic biopsy, 63 cases (33.16%) had poor PS status. There were significant differences in educational level, psychological counseling before examination, coping style and social support between the two groups (P < 0.05). Logistics regression analysis showed that junior high school degree or below (OR = 5.450, 95%CI:2.949-10.073), routine psychological counseling before examination (OR = 66.249, 95%CI:17.315-253.479), negative coping (OR = 3.778, 95%CI:1.955-7.300) and low social support (OR = 2.645, 95%CI:1.419-4.930) were the influencing factors of poor PS status in patients with gastroscopic biopsy (P < 0.05). Conclusion The PS status of patients with gastroscopic biopsy is generally poor, which may be related to factors such as education level, psychological counseling before examination, coping style and social support. Targeted intervention program should be performed clinically according to this, in order to improve the PS status of patients with gastroscopic biopsy.
		2021 Vol. 18 (17): 118-121 [Abstract] ( 84 ) HTML (1 KB) PDF (572 KB) ( 39 )

	122	Comparison of mesenteric vascular ultrasound and CTA in the diagnosis of emergency acute mesenteric vascular embolism
		CHENG Rui1 CHEN Peipei2 LIN Chacha3 ZHENG Binbin1
		Objective To compare the diagnostic value of mesenteric vascular ultrasound and CT angiography (CTA) in emergency acute mesenteric vascular embolism, so as to provide a reference for clinical diagnosis. Methods From October 2018 to October 2020, 80 patients with suspected acute mesenteric vascular embolism admitted to Department of Emergency, Zhejiang Taizhou Hospital were selected as study objects. All patients underwent mesenteric vascular ultrasound, CTA and digital subtraction angiography (DSA) examinations. DSA diagnosis results as the gold standard, and the diagnostic value of mesenteric vascular ultrasound and CTA were analyzed. Results The sensitivity of mesenteric vascular ultrasound was 86.49%, the specificity was 100.00%, the positive predictive value was 100.00%, the negative predictive value was 37.50%, and Youden index was 0.865; the sensitivity of CTA was 97.30%, the specificity was 100.00%, and the positive predictive value was 100.00%, negative predictive value was 75.00%, Youden index was 0.973. The sensitivity of CTA in the diagnosis of acute mesenteric vascular embolism was higher than that of mesenteric vascular ultrasound, and the difference was statistically significant (P < 0.05). Conclusion Both methods are beneficial to the diagnosis of the disease types and etiology in the emergency department, and CTA is more sensitive to acute mesenteric vascular embolism than mesenteric vascular ultrasound, which is worthy of application.
		2021 Vol. 18 (17): 122-125 [Abstract] ( 91 ) HTML (1 KB) PDF (536 KB) ( 70 )

	126	Analysis on medication rule of traditional Chinese medicine in the treatment of psoriasis based on traditional Chinese medicine inheritance auxi liary platform
		WANG Zijing LIU Tao YANG Yi ZHU Shan LI Nan LI Lin XIA Qingmei
		Objective To analyze the rules of Chinese medicine treatment for psoriasis. Methods The prescriptions of psoriasis treated with traditional Chinese medicine from January 2004 to December 2019 were collected from CNKI, Wanfang data knowledge service platform and VIP. They were screened and entered into the traditional Chinese medicine inheritance auxiliary platform (V2.5). The four qi, five flavor, meridian tropism, frequency of use and common drug pairs of drugs in prescriptions were analyzed. The complex system entropy clustering algorithm was used to gene rate a new prescription. Results A total of 178 prescriptions were screened out. There were 193 kinds of drugs. The drugs with cold nature and bitter taste accounted for the largest proportion. Liver meridian was the main channel, followed by heart meridian. There were 14 drugs with frequency more than 40, 50 groups of commonly used drug pairs, and further evolved into 11 new prescriptions. Conclusion Traditional Chinese medicine treatment of psoriasis mainly focuses on clearing away heat and cooling blood, promoting blood circulation and removing blood stasis, nourishing blood and moistening dryness, as well as strengthening the spleen and dampness, detoxifying.
		2021 Vol. 18 (17): 126-129 [Abstract] ( 114 ) HTML (1 KB) PDF (785 KB) ( 106 )

	130	Discussion on the treatment of idiopathic pulmonary fibrosis accompanied by gastroesophageal reflux disease based on “acrid opening and bitter downbearing” theory
		ZHOU Hongwei1 YU Huiyong2 WANG Chengxiang2
		Idiopathic pulmonary fibrosis (IPF) is a common respiratory disease, with dyspnoea after progressive exercise and dry cough as the main symptoms, often accompanied by gastroesophageal reflux disease (GERD). The pathogenes between IPF and GERD is not clear. So far, Western medicine has no good means of treatment. The main pathogenesis of traditional Chinese medicine of IPF combined with GERD is characterized by the disease of lung, spleen, stomach and kidney, the internal obstruction of dampness-heat and phlegm-stasis, the disorder of qi activity of triple energizer, and the imbalance of yin and yang. The method of acrid opening and bitter downbearing is widely used to treat the diseases of complexity of cold and heat, disorder of ascending and descending, and combination of pathogenic factors. In view of the pathogenesis of IPF combined with GERD, the method of acrid opening and bitter downbearing can be discussed and treat this disease from the point of view of appling herbs of heat and cold nature for balance of yin and yang, ascending and descending for restoring of qi activity, dispersing damp-heat for dispelling of pathogenic factors.
		2021 Vol. 18 (17): 130-133 [Abstract] ( 124 ) HTML (1 KB) PDF (691 KB) ( 52 )

	134	Application of national medicine master Wang Lie’s idea of preventive treatment of disease in pediatric pulmonary diseases
		GUO Tingting1 SUN Liping2 WANG Lie2
		The traditional idea of “preventive treatment of disease” in traditional Chinese medicine is mainly reflected in four aspects: prevention before disease, prevention after disease, prevention and cure after change, prevention and cure after stagnation. Professor Wang Lie, a master of traditional Chinese medicine, guides the treatment of pediatric pulmonary diseases, such as asthma, wheezing cough, infantile cold caused by food accumulation (repeated respiratory tract infection), nasal asthma, and so on, and creatively put forward the theories of “asthma seedling stage”“three-stage treatment”“asthma on chronic cough”“nasal asthma”, and so on. In the specific treatment, Professor Wang Lie proposes early intervention, fine treatment and prevention, focusing on the treatment of asthma seedling stage; he proposes that repeated respiratory tract infection is mostly caused by food accumulation and lung heat, treating spleen disease to prevent lung disease, cutting off the occurrence and progress of lung disease; he proposes that rhinorrhea and asthma have the same origin, treating both rhinorrhea and asthma, seeking the root of the disease, so as to prevent the disease from rebirth. Professor Wang Lie’s idea of “preventive treatment of disease” runs through the whole process in the treatment of children’s pulmonary diseases, and the curative effect is remarkable, which is worthy of clinical reference and promotion.
		2021 Vol. 18 (17): 134-136,145 [Abstract] ( 165 ) HTML (1 KB) PDF (710 KB) ( 65 )

	137	Research on acupoint selection rule of acupuncture in the treatment of functional irregular menstruation based on data mining
		LIU Yangjie GUAN Fengli SUN Ying DU Huilan
		Objective To explore clinical acupoint selection rule of acupuncture in the treatment of functional irregular menstruation based on data mining. Methods Relevant literatures on acupuncture in the treatment of functional dysmenorrhea in CNKI, Wanfang, VIP, SinoMed database were searched. The database of acupoint selection prescription was established. Descriptive analysis, association rule analysis and cluster analysis were used to analyze the data. Results The prescription of acupuncture and moxibustion in the treatment of functional irregular menstruation involved 40 acupoints, which were distributed in 10 meridians, most of which focus on ren meridian. Sānyīnjiāo, guānyuán and qìhǎi were the most frequently used acupoints. Acupoints were mostly distributed in the chest, abdomen, lower limbs and back. In the selection of specific acupoints, intersection acupoints were used most frequently. According to the association rules analysis, sānyīnjiāo-guānyuán had the highest correlation, and five effective clusters were obtained by cluster analysis. Conclusion Through the analysis of the data, the commonly used acupoints, meridians and compatibility rules of acupuncture in the treatment of functional irregular menstruation are preliminarily obtained. In the treatment of acupuncture and moxibustion, it embodies the idea of the combination of meridian syndrome differentiation and viscera syndrome differentiation, and uses a variety of acupoint matching methods, which provides a theoretical reference for clinical practice.
		2021 Vol. 18 (17): 137-141 [Abstract] ( 102 ) HTML (1 KB) PDF (920 KB) ( 121 )

	142	Determination of the content of five components in crossbow liquid by HPLC
		ZAN Fangfang1 CUI Jin2
		Objective To establish a high performance liquid chromatography (HPLC) for the determination of five components of anabasine, catechin, chlorogenic acid, mesaconitine and hypoaconitine in crossbow liquid. Methods Chromatographic column Agilent 5 TC-C18(2) (250.0 mm×4.6 mm, 5 μm) was used, with acetonitrile-0.2% phosphoric acid aqueous solution as the mobile phase, gradient elution, flow rate was 1.0 mL/min, column temperature was 25℃ and 30℃, the detection wavelengths were 258 nm and 235 nm, and the injection volume was 10 μL. Results The anabasine, catechin, chlorogenic acid, mesaconitine and hypoaconitine showed good linear relationship in the range of 2.797-14.161, 25.816-130.694, 7.956-40.275, 2.675-13.540, 1.285-6.504 μg/mL respectively(r ≥ 0.9996); the average recovery rate was between 99.374% and 101.559%, and the RSD was between 1.144% and 2.844%. Conclusion The method is fast, efficient, sensitive and has a wide range of applications. It can provide a theoretical basis for the clinical efficacy of crossbow liquid solution.
		2021 Vol. 18 (17): 142-145 [Abstract] ( 204 ) HTML (1 KB) PDF (824 KB) ( 71 )

	146	Analysis on medication rule of traditional Chinese medicine in the treatment of lung adenocarcinoma based on data mining
		WU Ke LI Qingwei ZHENG Kun AN Lifeng
		Objective To explore the prescriptions rule of traditional Chinese medicine in the treatment of lung adenocarcinoma. Methods The medical records of lung adenocarcinoma treated with traditional Chinese medicine were collected by searching CNKI and Wanfang database from January 2010 to November 2020. The group information was extracted and inputed into excel 2013 to establish a database. SPSS 23 and SPSS Modeler 18 were used to mine the efficacy, meridian tropism, association rules and clustering of traditional Chinese medicine. Results There were 96 eligible medical records, involving 193 drugs. They were divided into 13 categories according to their efficacy. The first three categories were used frequently, which were tonic drugs, blood stasis-activating drugs and phlegm-resolving drugs. The medicines entering to lung, spleen, stomach and liver channels were mainly used. The combination of medicines with strong correlation were the heat-clearing and detoxifying medicine plus the tonic medicine, the bloodpromoting medicine. In this way, four major clusters were formed which were commonly used drug combinations including Astragali Radix, Atractylodis Macrocephalae Rhizoma, Hedyotis. Conclusion Traditional Chinese medicine treating lung adenocarcinoma is often based on the basic principle of “treating both the symptoms and the root causes, invigorating qi and removing blood stasis, and harmonizing the five zang organs”, which is combined with Chinese herbs related to supplementing qi and activating blood circulation, eliminating blood stasis and resolving stagnation, strengthening spleen and resolving phlegm.
		2021 Vol. 18 (17): 146-148,156 [Abstract] ( 121 ) HTML (1 KB) PDF (995 KB) ( 117 )

	149	Study on medication rule of traditional Chinese medicine and pharmacy prescription in the treatment of membranous nephropathy based on data mining
		LIU Weiwei1 LENG Wei2 YANG Zhaotian2 WANG Huanjing2 WANG Ning1 DU Zhifeng3
		Objective To study the medication rule of traditional Chinese medicine and pharmacy prescription in the treatment of membranous nephropathy based on data mining technology. Methods All literatures on the application of traditional Chinese medicine and pharmacy in the treatment of membranous nephropathy were searched from CNKI, Wanfang Data and VIP from the inception to October 2020. The search title, subject or key words were “membranous nephropathy” or “idiopathic membranous nephropathy” and “traditional Chinese medicine, Chinese materia medica, traditional Chinese medicine and pharmacy” or “integrated Chinese and Western medicine”. The traditional Chinese medicine inheritance assist platform was used to conduct statistics, association rule analysis and cluster analysis on the data. Results Through statistics, 125 prescriptions that met the standards were obtained, involving 230 Chinese materia medicas in total, and 23 Chinese materia medicas that were used with frequency ≥ 20. According to the classification of the included drugs, the traditional Chinese medicine and pharmacy in the treatment of membranous nephropathy mainly consists of drugs to replenish deficiency, drugs to diuresis and diffusing dampness, drugs to promoting blood circulation for removing blood stasis, etc. There were 20 drug combinations with frequency > 30. Among them, milkvetch root, Sichuan lovage rhizome, Indian bread, Chinese yam, largehead atractylodes rhizome, danshen root, Chinese angelica, earthworm and tangshen appeared many times in the prescription. Cluster analysis obtained 20 core drug combinations and 10 potential new prescriptions. Conclusion The etiology and pathogenesis of this disease is blood stasis due to qi deficiency, and the disease is asthenia in origin and asthenia in superficiality. The treatment is based on benefiting qi for activating blood circulation, and the clinical use of drugs to replenish deficiency, drugs to diuresis and diffusing dampness, drugs to promoting blood circulation for removing blood stasis.
		2021 Vol. 18 (17): 149-152 [Abstract] ( 111 ) HTML (1 KB) PDF (719 KB) ( 36 )

	153	Clinical effect of Huoluo Refu Prescription in the treatment of cervical spondylosis
		LI Chunlei1 LI Liguo2 XU Beibei2
		Objective To observe the clinical effect of Huoluo Refu Prescription in the treatment of cervical spondylosis. Methods A total of 66 patients with cervical spondylosis treated in Fuyang Hospital of Traditional Chinese Medicine of Anhui Province from February 2017 to February 2019 were selected and they were divided into hot compress group and conventional group by random number table method, with 33 cases in each group. The group received massage treatment, and the hot compress group was treated with Huoluo Refu Prescription. After four months of treatment, the clinical efficacy, neck disability index (NDI), the degree of pain in the head, neck and upper limbs arthralgia before and after treatment were observed and compared between the two groups. Results The total effective rate of the hot compress group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there were no significant differences in NDI scores, visual analogue scale (VAS) scores of neck, head and upper limb arthralgia between the two groups (P ＞ 0.05). After treatment, NDI score, neck, head and upper limb arthralgia VAS scores of the two groups were lower than before treatment, and the hot compress group was lower than the conventional group, the differences were statistically significant (all P ＜ 0.05). Conclusion Huoluo Refu Prescription has an exact effect on the treatment of cervical spondylosis, which can effectively improve the cure rate of patients, relieve the pain of neck, head and upper limbs, and promote the functional recovery of cervical vertebra.
		2021 Vol. 18 (17): 153-156 [Abstract] ( 92 ) HTML (1 KB) PDF (734 KB) ( 31 )

	157	Analysis on the composition of free antiviral drugs for AIDS treatment in China from 2009 to 2019
		MA Chuntao WANG Qiang ZHANG Yukun MENG Xianyu
		Objective To retrospectively analyze the composition of free antiretroviral therapy (ART) drugs for AIDS in China from 2009 to 2019, it provides policy reference for efficient allocation and reasonable supply of ART free drugs in China, to provide direction guidance for domestic ART drug research and development and production. Methods The information of the types, dosage forms, quantity and procurement methods of ART drugs purchased by centralized bidding with the central public health special fund from January 2009 to December 2019 was collected from the government procurement website of China, indicators such as category composition, frequency and proportion of ART drugs were analyzed annually. Results From 2009 to 2019, there were 10 kinds of free ART drugs in China, including nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIS). The Staffs was due to be discontinued in 2013, Zidovudine Lamivudine and Efevirenz 200 mg have been used since 2012 and 2018, respectively, the total frequency of drug use increased from 122 400 million in 2009 to 10 814 million in 2019, the use of three types of drugs accounted for the highest proportion of NRTIs (63.46-69.15%), NNRTIs were in the middle (25.66%-32.53%), the lowest PIS (3.15%-7.93%), the PIs class has always been Lopinaviritonavir, in the proportion of single drug dosage, Lamivudine (31.37%), Tenofovir Disofuroxate Fumarate Tablets (23.19%) and Efevirenz (23.05%) were always in the forefront. Conclusion The use of ART drugs is increasing year by year to ensure the accessibility of AIDS treatment; the efficacy of national free ART project has been significantly improved by removing prominent drugs with side effects, including high efficiency single dose and optimizing drug structure; it prompts domestic enterprises to reserve and plan in advance in terms of research and development and production capacity, and also prompts the government to further optimize the composition and policy formulation of ART drugs, and expand the multi-channel drug supply model to solve the supply problem.
		2021 Vol. 18 (17): 157-160,168 [Abstract] ( 87 ) HTML (1 KB) PDF (890 KB) ( 75 )

	161	Influence of chronic disease management led by clinical pharmacists on the therapeutic effect of patients with diabetes mellitus type 2
		LI Sijia1 LI Sainan1 PAN Ying1 CHEN Jia1 ZHAO Ling1 YANG Na2
		Objective To explore the influence of chronic disease management led by clinical pharmacists on the therapeutic effect of patients with diabetes mellitus type 2. Methods A total of 132 patients with diabetes mellitus type 2 admitted to the Third Hospital of Hebei Medical University from January 2018 to December 2019 were selected. According to random number table method, they were divided into control group (66 cases) and study group (66 cases). The control group was given traditional medical services, the study group was given chronic disease management services led by clinical pharmacists. The intervention lasted for six moths, the main indicators of diabetes mellitus type 2 control in the two groups was compared. Drug understanding and medication compliance of the two groups were evaluated. Results The levels of fasting blood glucose, two hours postprandial blood glucose, glycated hemoglobin, total cholesterol, low density lipoprotein, systolic blood pressure, and diastolic blood pressure in the two groups after intervention were lower than those before intervention, and those in the study group were lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). After intervention, high density lipoprotein levels in both groups were higher than those before treatment, and those in the study group were higher than those in the control group, with statistical significance (all P ＜ 0.05). The score of drug understanding degree in the study group was lower than that in the control group, and the score of drug compliance was higher than that in the control group, with statistical significance (all P ＜ 0.05). Conclusion Chronic disease management led by clinical pharmacists can improve blood glucose, lipid and blood pressure and medication compliance in patients with diabetes mellitus type 2.
		2021 Vol. 18 (17): 161-164 [Abstract] ( 176 ) HTML (1 KB) PDF (417 KB) ( 52 )

	165	Application of narrative medical humanistic care in perioperative period of children with occult penises
		LI Shen JIN Zonglan HU Yuanquan ZHANG Xiansheng
		Objective To explore the application effect of humanistic nursing of narrative medicine in the perioperative period of children with concealed penis. Methods A total of 120 childrens admitted to the Department of Urology of the First Affiliated Hospital of Anhui Medical University due to occlusive penis from July 2018 to August 2019 were selected as the research subjects by convenience sampling method. According to the admission time, they were divided into control group and observation group, with 60 cases in each group. Children in the control group were given urological routine nursing care, and children in the observation group were given narrative medicine humanistic nursing on the basis of routine nursing. The anxiety state, postoperative pain score, hospital compliance and nursing satisfaction of the two groups of children and their parents were compared. Results The anxiety and pain scores of the children and their parents in the observation group were lower than those of the control group, and the difference was statistically significant (P ＜ 0.05); the hospitalization compliance of the children in the observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05); the nursing satisfaction of the family members of the observation group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The implementation of narrative medicine for children with concealed penis surgery has a significant effect on humanistic nursing, which is beneficial to promote the rehabilitation of children, improve the satisfaction of children and their parents, enrich the connotation and methods of humanistic nursing, and promote the development of high-quality nursing.
		2021 Vol. 18 (17): 165-168 [Abstract] ( 50 ) HTML (1 KB) PDF (654 KB) ( 74 )

	169	Application of continuous nursing based on 4C mode in patients after radical resection of esophageal cancer
		CHEN Tingting XIE Ruhui▲
		Objective To explore the effect of 4C model based continuous nursing on self-management efficacy and quality of life of patients after radical resection of esophageal cancer. Methods A total of 90 patients after radical resection of esophageal cancer admitted to the Affiliated Huai’an NO.1 Hospital of Nanjing Medical University from January 2018 to June 2019 were selected. According to the random number table method, 45 cases were divided into the experimental group and 45 cases in the control group, and 42 cases and 38 cases were finally included. The control group was given conventional continuing care, and the experimental group was combined with continuing care intervention based on 4C model. The self-management efficacy, quality of life and complications were compared between the two groups after six months follow-up. Results After six months of follow-up, the self-efficacy scores of both groups were higher than those at discharge (P ＜ 0.05). The scores of positive attitude, self-decompression, self-decision-making and self-efficacy in the experimental group were higher than those in the control group (P ＜ 0.05); the quality of life scores in both groups were higher than those in the same group (P ＜ 0.05); the scores of physical function, emotional function, cognitive function, social function and overall quality of life in the experimental group were higher than those in the control group (P ＜ 0.05); the complication rate of the experimental group was lower than that of the control group (P ＜ 0.05). Conclusion Continuing nursing intervention based on 4C mode is helpful to improve self-management efficacy of postoperative patients with esophageal cancer, improve the quality of life of patients and reduce the incidence of complications.
		2021 Vol. 18 (17): 169-172 [Abstract] ( 86 ) HTML (1 KB) PDF (618 KB) ( 177 )

	173	Correlation between empowerment behavior level and cancer recurrence fear in convalescent breast cancer patients
		WU Xiaohong1 ZHANG Jun2▲ LI Hongmei1 DONG Shuxian3
		Objective To investigate the correlation of empowerment level and fear of cancer recurrence in convalescence breast cancer patients. Methods A total of 154 patients with breast cancer who were followed up in the surgical outpatient Department of Fenyang Hospital of Shanxi Province from February 2019 to December 2019 were selected as the research objects by convenience sampling method, the general data questionnaire, the breast cancer empowerment scale and the simplified fear of disease progression scale (FOP-Q-SF) were used to investigate the patients’ empowerment behavior and fear of cancer recurrence, pearson correlation analysis and hierarchical multiple regression were used to analyze the relationship between the two. Results FCR scores of breast cancer patients with different ages, marital status, family per capita monthly income and TNM stage were compared, and the differences were statistically significant (P ＜ 0.05). The FCR score was negatively correlated with the empowerment behavior and the scores of each dimension (r ＜ 0, P ＜ 0.01). The results of stratified multiple regression analysis showed that age, marital status, family per capita monthly income, TNM stage and empowerment behavior were the influencing factors of FCR in patients with breast cancer in the recovery period (P ＜ 0.05), the total variation of FCR level was 67.6%, of which the empowerment behavior could explain 44.2%. Conclusion Empowerment behavior is an important influencing factor of FCR in convalescent breast cancer patients. Medical staff should strengthen patients’ empowerment, reduce their FCR and improve patients’ quality of life.
		2021 Vol. 18 (17): 173-176 [Abstract] ( 116 ) HTML (1 KB) PDF (658 KB) ( 102 )

	177	Application of diversified video education in health education for patients after endoscopic submucosal dissection
		LI Juan XU Dan LI Wen
		Objective To analyze the application effect of diversified video education in patients undergoing endoscopic submucosal dissection. Methods A total of 91 cases of endoscopic submucosal dissection patients admitted to Nanjing Drum Tower Hospital from January 2019 to February 2020 were selected. According to the length of hospital stay, they were divided into 47 cases in the treatment group (August 2019-February 2020) and 44 cases in the control group (January-July 2019). The control group used conventional health education, and the treatment group jointly applied diversified video education. After six months of follow-up, the two groups disease uncertainty, self-care ability, and satisfaction with health education methods were compared between the two groups. Results After six months of follow-up, the uncertainty in illness scale (MUIS) scores of the two groups were significantly lower than those before education (P ＜ 0.05). The ambiguity score, inconsistency score, complexity score and MUIS total score of the treatment group were significantly lower than those of the control group (P ＜ 0.01); after six months of follow-up, the exercise of self-care agency (ESCA) scores of the two groups were significantly higher than those before education (P ＜ 0.05). The health knowledge level, self-concept, self-responsibility, self-care skill score and ESCA total score of the treatment group were significantly higher than those of the control group (P ＜ 0.05); the treatment group satisfaction with health education methods was higher than the control group (P ＜ 0.05). Conclusion Diversified video education helps to resolve the uncertainty of disease in patients undergoing endoscopic submucosal dissection, promote the development of self-care ability, and improve patient satisfaction.
		2021 Vol. 18 (17): 177-180 [Abstract] ( 90 ) HTML (1 KB) PDF (617 KB) ( 77 )

	181	Application of continuous rehabilitation intervention mode based on WeChat in urinary incontinence patients after radical resection of prostate cancer
		LIU Dan XIE Tingting
		Objective To investigate the effect of WeChat-led continuous rehabilitation intervention mode on urodynamics and quality of life of patients with urinary incontinence after radical resection of prostate cancer. Methods From July 2017 to June 2018, 120 patients with urinary incontinence after robot-assisted radical prostatectomy admitted to Huai’an First People’s Hospital were admitted. According to the operation time, they were randomly divided into 62 cases in the treatment group (January-June 2018) and 58 cases in the control group (July-December 2017). The control group was given routine continuous rehabilitation care, and the treatment group was given a continuous rehabilitation intervention model based on WeChat. Followed up for three months, the clinical efficacy, urodynamics and quality of life were compared between the two groups. Results Followed-up was performed for three months. The effective rate in the treatment group was significantly higher than in the control group (P ＜ 0.05); the urodynamic indexes of the two groups were significantly higher than those before discharge (P ＜ 0.01), the maximum urine flow, Valsalva leak point pressure, maximum urethral closure pressure, and maximum bladder volume in the treatment group were significantly higher than those in the control group (P ＜ 0.01); the quality of life score of two groups was significantly higher than that of the same group at discharge (P ＜ 0.01), pain, physical strength, appetite, constipation, urination, and overall sensory score were significantly higher than those of the control group (P ＜ 0.01). Conclusion Continuous rehabilitation care based on WeChat is helpful to promote urodynamic recovery of patients with urinary incontinence after radical prostatectomy, improve clinical efficacy, and improve the quality of life of patients.
		2021 Vol. 18 (17): 181-184 [Abstract] ( 56 ) HTML (1 KB) PDF (618 KB) ( 64 )

	185	Application of crisis nursing management theory in patients with premature rupture of membranes
		WANG Luying WANG Hong
		Objective To explore the application effect of crisis nursing management theory in patients with premature rupture of membranes (PROM), to guide the optimization of nursing program for patients with PROM. Methods A total of 112 patients with PROM in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from March 2018 to February 2019 were selected, according to random number table method, they were divided into control group and observation group, with 56 cases in each group. The control group was received routine nursing, while the observation group was received nursing based on crisis nursing management theory on the basis of the control group. The delivery outcomes and crisis events were recorded and compared between the two groups, the self rating anxiety scale (SAS), self rating depression scale (SDS) scores were evaluated and compared before nursing and seven days after delivery. Results The cesarean section rate of the observation group was lower than the control group, and the spontaneous labor rate was higher than the control group, the differences were significant statistically (P ＜ 0.05); the incidence of crisis events in the observation group was lower than that in the control group, the difference was significant statistically (P ＜ 0.05); seven days after delivery, SAS, SDS scores of both groups were lower than before nursing, and the observation group was lower than the control group, the differences were significant statistically (all P ＜ 0.05). Conclusion The application of crisis nursing management theory in patients with PROM can reduce the occurrence of crisis events, relieve the maternal crisis psychology, improve the psychological state, and reduce the cesarean section rate.
		2021 Vol. 18 (17): 185-188 [Abstract] ( 116 ) HTML (1 KB) PDF (656 KB) ( 49 )

	189	Intervention effect of continuous nursing based on IMB model in hemodialysis patients with chronic renal failure
		XU Aiqun YU Xiping LI Jin TANG Xiaofei▲
		Objective To explore the intervention effect of continuous nursing based on information motivation behavior (IMB) model in patients with chronic renal failure undergoing hemodialysis. Methods A total of 80 patients with chronic renal failure who received hemodialysis in Ma’anshan People’s Hospital of Anhui Province from October 2017 to may 2020 were selected as the study subjects. According to the random number table method, they were divided into control group (40 cases) and study group (40 cases). The control group was given routine nursing and the study group was given continuous nursing based on IMB model. The blood urea nitrogen (BUN), serum creatinine (Scr), complication rate and nursing satisfaction were compared between the two groups after three months of nursing, and the nursing effect was evaluated. Results Before nursing, there was no significant difference in BUN and Scr between the two groups (P ＞ 0.05). After nursing, BUN and Scr of the two groups were lower than before nursing, and the study group was lower than the control group, the differences were all statistically significant (all P ＜ 0.05). After nursing, the complication rate of the study group was lower than the control group, the difference was statistically significant (P ＜ 0.05). The nursing satisfaction of the study group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion The application of continuous nursing intervention based on IMB model in hemodialysis patients with chronic renal failure can improve the awareness rate of health knowledge and improve the quality of life of patients, which is worthy of clinical promotion and application.
		2021 Vol. 18 (17): 189-192,196 [Abstract] ( 83 ) HTML (1 KB) PDF (685 KB) ( 104 )

	193	Effect of mind map nursing on psychological status and prognosis of patients after radical operation of cervical cancer
		LIU Wenjuan WU Xuehua▲ ZHENG Hongxia
		Objective To analyze the influence of mind map nursing on psychological status and prognosis of patients with cervical cancer after radical operation. Methods A total of 80 patients with cervical cancer undergoing radical hysterectomy in Huangshan People’s Hospital of Anhui Province from August 2017 to August 2020 were selected as the research subjects, and they were divided into observation group and control group according to random number table method, with 40 cases in each group. The control group was given routine intervention such as supervised medication and drainage tube nursing, while the observation group was given routine intervention combined with mind map nursing. One month later, self-rating anxiety scale (SAS), self-rating depression scale (SDS), the time of drainage tube pulling out, the time of first anal exhaust, the length of hospital stay, the recovery rate of bladder function, complications (incision infection, urinary tract infection, urinary retention and frequency of urination) and the nursing satisfaction of the two groups were observed and compared. Results Before intervention, there was no statistical significance in SAS and SDS scores between the two groups (P ＞ 0.05). After intervention, SAS and SDS scores of the two groups were significantly decreased, and the observation group was lower than the control group, with statistical significance (P ＜ 0.05). The time of hospitalization, first anal exhaust and drainage tube pulling out in the observation group was shorter than those in the control group, while the recovery rate of bladder function was better than that in the control group, the differences were statistically significant (all P ＜ 0.05). After intervention, the total nursing satisfaction in the observation group was higher than that in the control group, while the incidence of complications was lower than that in the control group, with statistical significance (all P ＜ 0.05). Conclusion Mind map nursing for cervical cancer patients after radical operation of rehabilitation nursing effect is significant, can significantly improve the patient’s anxiety, depression, reduce complications, is worth promoting and applying.
		2021 Vol. 18 (17): 193-196 [Abstract] ( 285 ) HTML (1 KB) PDF (735 KB) ( 51 )

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