首诊及慢性精神分裂症住院患者信息处理速度及工作记忆相关研究

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (567 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate information processing speed and working memory and correlation analysis in in-patients with first-diagnosed schizophrenia and chronic schizophrenia. Methods First-diagnosed schizophrenia inpatients in Wuxi Mental Health Center Affiliated to Nanjing Medical University (“our hospital” for short) from February 2012 to June 2015 were selected as the FDS group (24 cases) and chronic schizophrenia inpatients as the CSz group (86 cases). During the same period, 25 healthy people matched with the FDS group were recruited as the HC-F group and 56 healthy people matched with the CSz group were recruited as the HC-C group in our hospital. The Wechsler adult intelligence scale included digit symbol test (Dsy), digit span test-backword (DSp-B), MATRICS consensus cognitive batter included verbal fluency test (VF) and trail making A test (TMA). Partial correlation analysis was used to control for age and education level. Results DSy in the FDS group was lower than that in the HC-F group, while TMA in the FDS group was higher than that in the HC-F group, and the differences were statistically significant (P < 0.05). DSy, verbal fluency test-correct, DSp-B in the CSz group were lower than those in the HC-C group, trail making A test-model (TMA-M), TMA, verbal fluency test-repetition (VF-R) were higher than those in the HC-C group, and the differences were statistically significant (P < 0.05). In the FDS group, trail making A test-error was negatively correlated with onset age (r < 0, P < 0.05), and positively correlated with the course of disease (r > 0, P < 0.05). VF-R in the CSz group was negatively correlated with the score of general pathology scale (r < 0, P < 0.05). TMA-M and TMA were positively correlated with sex (r ＞ 0, P < 0.05). Conclusion First-diagnosed schizophrenia patients have deficiency in information processing speed, while chronic schizophrenia patients have impairment in information processing speed and working memory. It is suggested that clinicians pay more attention to the effect of metabolic diseases on cognitive function with first-diagnosed schizophrenia patients, and pay more attention to the effect of gender on cognitive function with chronic schizophrenia patients.

Key words： Schizophrenia Information processing speed Working memory Cognitive impairment

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Yangyang TANG Luping GUO Xinxin LIU Haisheng YU Xiaoman TIAN Lin▲

Cite this article:

ZHANG Yangyang TANG Luping GUO Xinxin LIU Haisheng YU Xiaoman TIAN Lin▲. Information processing speed and working memory in inpatients with first-diagnosed and chronic schizophrenia[J]. 中国医药导报, 2021, 18(17): 110-113,121.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I17/110

[1] van Hooren S，Versmissen D，Janssen I，et al. Social cognition and neurocognition as independent domains in psychosis [J]. Schizophr Res，2008，103（1/3）：257-265.
[2] 张荣荣，闫伟，吕兰兰，等.精神分裂症首发及前驱期认知功能研究[J].中国医药导报，2018，15（13）：42-46.
[3] Rodriguez-Sanchez JM，Crespo-Facorro B，Gonzalez-Blanch C，et al. Cognitive dysfunction in first-episode psychosis：the processing speed hypothesis [J]. Br J Psychiatry Suppl，2007，51：S107-S110.
[4] Kern RS，Gold JM，Dickinson D，et al. The MCCB impairment profile for schizophrenia outpatients：results from the MATRICS psychometric and standardization study [J]. Schizophr Res，2011，126（1/3）：124-131.
[5] Organization WH. The ICD-10 classification of mental and behavioural disorders：diagnostic criteria for research [M]. World Health Organization：Geneva，1993.
[6] 龚耀先.中国修订韦氏成人智力量表（WASI-RC）[M].长沙：湖南地图出版社，1992.
[7] 邹义壮，崔界峰，王健，等.精神分裂症认知功能成套测验中文版临床信度及效度的研究[J].中华精神科杂志，2009，42（1）：29-33.
[8] 胡荣亮，陈颂玲，任雪芹，等.遗忘型轻度认知功能障碍人群听觉语言工作记忆和执行功能特点[J].中国实用医药，2020，15（20）：61-63.
[9] 司天梅，杨建中，舒良，等.阳性和阴性症状量表（PANSS，中文版）的信、效度研究[J].中国心理卫生杂志，2004，18（1）：45-47.
[10] 王健，邹义壮，崔界峰，等.韦氏成人智力量表第四版中文版的信度和结构效度[J].中国心理卫生杂志，2013， 27（9）：692-697.
[11] 彭焱，李薇，杜君，等.长期住院精神分裂症患者认知功能相关研究[J].中国健康心理学杂志，2014，22（9）：1301-1303.
[12] Mattai AK，Hill JL，Lenroot RK. Treatment of early-onset schizophrenia [J]. Curr Opin Psychiatry，2010，23（4）：304-310.
[13] 赵指亮，李小青，范大庆，等.儿童期与青少年期起病的精神分裂症临床比较[J].临床研究，2019，27（1）：26-27.
[14] 王金东，周田田，陈晓芹，等.首发精神分裂症血清神经调节蛋白-1、脑电图γ活动及认知功能相关研究[J].中国医药导报，2020，17（23）：57-61.
[15] 谢穗峰，叶芬，郭月平，等.哌罗匹隆与阿立哌唑治疗精神分裂症对认知功能的影响[J].中国医药科学，2019，9（16）：23-25，29.
[16] 胡茂荣，陈晋东，李乐华，等.精神分裂症首次发病患者及其健康同胞认知功能的比较研究[J].中华精神科杂志，2011，44（4）：208-211.
[17] 董倩，董莹莹，贾敏，等.精神分裂症患者症状特征与认知功能的关系[J].西安交通大学学报：医学版，2019，40（4）：604-607.
[18] 杨丽敏，王妍，孙萌萌，等.首发精神分裂症患者的信息处理速度及其影响因素[J].山东大学学报：医学版，2013，51（9）：100-104.
[19] 牛雅娟，吴承京，吉中孚，等.首发精神分裂症患者认知功能相关因素的5年随访[J].中国神经精神疾病杂志，2007，33（8）：449-454.
[20] Nemoto T，Niimura H，Ryu Y，et al. Long-term course of cognitive function in chronically hospitalized patients with schizophrenia transitioning to community-based living [J]. Schizophr Res，2014，155（1/3）：90-95.
[21] 夏晓伟，李雷俊，陈忠城，等.首发未服药精神分裂症外周血补体水平与认知功能的相关性[J].中华医学杂志，2020，100（39）：3081-3085.
[22] 李惠，李春波，王洪艳，等.首发和慢性精神分裂症患者神经认知功能的性别差异[J].神经疾病与精神卫生，2019，19（4）：358-361.
[23] Ayesa-Arriola R，de la Foz VO，Setien-Suero E，et al. Understanding sex differences in long-term outcomes after a first episode of psychosis [J]. NPJ Schizophr，2020， 6（1）：1-8
[24] 陈声云，刘雅茜，张桂灿，等.稳定期精神分裂症患者神经认知功能损害特征及影响因素分析[J].国际精神病学杂志，2020，47（5）：904-909.
[25] Bioque M，Paz Garcia-Portilla M，Garcia-Rizo C，et al. Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis [J]. Schizophr Res，2018，193：188-196.