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Evaluation of the current situation and screening conditions of potentially inappropriate medication use in elderly hospitalized patients by The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China |
LI Xuefeng YANG Hua▲ WANG Quandong MENG Jie YANG Xiaogang |
Department of Geriatrics, the First People’s Hospital of Lianyungang, Jiangsu Province, Lianyungang 222000, China |
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Abstract Objective To investigate the status of potentially inappropriate medication (PIM) in elderly hospitalized patients and determine their screening conditions. Methods The use of drugs in Several tertiary hospitals in a city from July 2019 to December 2019 were evaluate by The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China, and the screening conditions were determined by using multi factor regression analysis and area under ROC curve. Results The incidence of PIM among elderly hospitalized patients was 18.64%. The highest PIM was non-steroidal anti-inflammatory drugs (47.07%), followed by antipsychotic drugs (25.19%) and glucocorticoids (21.37%). The type of medication (OR = 64.50, 95%CI = 10.97-379.23) and comorbidities (OR = 5.12, 95%CI = 2.69-9.78) were independent risk factors for PIM in elderly hospitalized patients (P < 0.05). The cut-off values for PIM prediction of medication types and comorbidities were 4.5 (sensitivity of 90.0%, specificity of 26.4%) and 3.5 (sensitivity of 84.6%, specificity of 23.8%). Among them, 59 cases had two PIM conditions, and eight cases had three PIM conditions. Conclusion Doctors should pay more attention to non-steroidal anti-inflammatory drugs, antipsychotics and glucocorticoid in clinical use, and in the case of more than five drugs or more than four comorbidities, active screening should be carried out according to the criteria for The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China, so as to reduce the incidence of PIM in elderly inpatients.
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Cite this article: |
LI Xuefeng YANG Hua▲ WANG Quandong MENG Jie YANG Xiaogang. Evaluation of the current situation and screening conditions of potentially inappropriate medication use in elderly hospitalized patients by The Judgment Criteria for Potentially Inappropriate Use of Drugs for the Elderly in China[J]. 中国医药导报, 2021, 18(17): 64-67,72.
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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I17/64 |
[1] 王鹏,王青,李放,等.潜在不适当用药与衰弱老年人不良结局的相关分析[J].中华老年多器官疾病杂志,2019, 18(8):573-577.
[2] 赵丽艳,赵忠鹏,程艳芹,等.老年人不适当用药的研究进展[J].中国医药导报,2019,16(21):47-50.
[3] 蹇在金,王翼.老年人多重用药的评估与干预[J].中华老年医学杂志,2019,38(10):1097-1100.
[4] 刘夏,潘琴,徐迅科,等.基于《中国老年人潜在不适当用药判断标准(2017版)》的老年患者不适当用药评价研究[J].药学实践杂志,2019,37(3):283-288.
[5] 徐姗姗,宋智慧,韩芙蓉,等.综合内科老年住院患者潜在不适当用药发生情况及影响因素分析[J].药物不良反应杂志,2020,22(11):625-630.
[6] 李燕华,李仲昆,夏洪颖,等.三种常用的老年人潜在不适当用药评估标准的比较[J].中国医药导报,2020,17(33):165-169.
[7] 中国老年保健医学研究会老年合理用药分会,中华医学会老年医学分会,中国药学会老年药学专业委员会,等.中国老年人潜在不适当用药判断标准(2017年版)[J].药物不良反应杂志,2018,20(1):2-8.
[8] 刘倩,李小霞,黄旭,等.社区老年人慢性疼痛现状及心理健康状况分析[J].中国社会医学杂志,2019,36(1):80-83.
[9] 任怡荣,杨晨光,陈浩,等.药物基因学引导下的汉族老年人华法林稳态剂量模型研究[J].中华老年医学杂志,2020,39(4):380-385.
[10] 李雪冰,王鹏.斋堂社区老年人潜在不适当用药及其相关因素[J].中华老年多器官疾病杂志,2020,19(5):340-344.
[11] 陈金,马建霞,于晓峰,等.老年人非甾体抗炎药相关性上消化道出血的临床特点[J].中国临床药学杂志,2020, 29(3):177-181.
[12] 李蒙,禹洁,蓝高爽,等.依据Beers标准(2019版)调查某三甲医院老年住院患者潜在不适当用药情况及分析评价[J].中国医院药学杂志,2020,40(17):1874-1880.
[13] 章陈怡,潘志刚,陈实,等.上海社区老年慢性病患者潜在不适当用药情况及影响因素[J].中华全科医师杂志,2020,19(4):324-328.
[14] 高翔,黄婷,陈杰,等.老年高血压住院患者潜在不适当用药调查[J].中国老年学杂志,2019,39(5):1223-1226.
[15] 何丹,吴晓燕,董娜,等.基于2019年版Beers标准分析评价某院老年住院患者潜在不适当用药[J].中国医院药学杂志,2019,39(19):1993-1999.
[16] 向伟,陈妍,钱时兴,等.二甲双胍对老年住院精神分裂症患者奥氮平治疗后体重增加的干预效果[J].中国医师杂志,2020,22(4):598-601.
[17] 乐海峰,王岳锋,陈家和,等.奥氮平联合盐酸多奈哌齐对老年痴呆患者日常生活能力的影响[J].现代实用医学,2020,32(8):959-961.
[18] 余茜,李端超,钟时勋.糖皮质激素在治疗突发性耳聋中的应用[J].中华耳科学杂志,2020,18(2):394-398.
[19] 杜延安.大剂量糖皮质激素辅助治疗重症支气管哮喘的临床研究[J].中外医学研究,2021,19(8):128-130.
[20] 丁钰川,周志轩,李建国.重组人生长激素在糖皮质激素相关矮小中的应用研究进展[J].中国医药,2020,15(3):469-472.
[21] 李卿,谢剑锋,刘玲.不同类型糖皮质激素治疗对感染性休克患者预后影响的Meta分析[J].中华内科杂志,2020,59(6):451-459.
[22] Morillo R,Robustillo MA,Abdel L,et al. Determination of a cutoff value for medication regimen complexity index to predict polypharmacy in HIV+ older patient [J]. Rev Esp Quimioter,2019,32(5):458-464.
[23] Kumar S,Wong PS,Hasan SS,et al. The relationship between sleep quality in appropriate medication use and frailty among older adults in aged care homes in Malaysia [J]. PLoS One,2018,14(10):222-232.
[24] Andres TM,McGrane T,McEvoy MD,et al. Geriatric Pharmacology:An Update [J]. Anesthesiol Clin,2019,37(3):475-492.
[25] Gyurmey T,Kwiatkowski J. Program of All-Inclusive Care for the Elderly(PACE):Integrating Health and Social Care Since 1973 [J]. R I Med J(2013),2019,102(5):30-32.
[26] Wang K,Shen J,Jiang D,et al. Development of a list of high-risk perioperative medications for the elderly:a Delphi method [J]. Expert Opin Drug Saf,2020,18(9):853-859.
[27] Mosnier S,Videau MN,Lafargue A,et al. Benefit of the geriatric mobile unit’s intercession on the quality of medical prescriptions for the elderly:Past year assessment [J]. Ann Pharm Fr,2019,77(2):136-145.27 |
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