急性缺血性脑卒中患者衰弱与认知功能障碍的相关性

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (609 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the correlation between frailty and cognitive dysfunction in patients with acute ischemic stroke. Methods A total of 127 patients with acute ischemic stroke admitted to Beijing Chaoyang Hospital of Capital Medical University from October 2019 to June 2020 were selected. Edmonton frailty scale (EFS) was used to evaluate their frailty, and they were divided into frailty group (51 cases) and non-frailty group (76 cases) according to whether frailty occurred. General data of the two groups were collected, and the cognitive function of the two groups was evaluated using the Montreal cognitive assessment scale (MoCA). Results The age, blood glucose levels, proportion of diabetes and proportion of hypertension in the frailty group were higher than those in the non-frailty group, and the total score of MoCA and scores of all fields were lower than those in the non-frailty group, the differences were statistically significant (all P ＜ 0.05). Correlation analysis showed that total EFS score was negatively correlated with total MoCA score (r = -0.491, P ＜ 0.001), visuospatial/executive function score (r = -0.444, P ＜ 0.001), naming score (r = -0.237, P ＜ 0.001), memory score (r = -0.364, P ＜ 0.001), attention scores (r = -0.350, P ＜ 0.001), language function scores (r = -0.238, P = 0.007), abstract ability scores (r = -0.202, P = 0.023), and orientation scores (r = -0.229, P = 0.010) negatively correlated. Conclusion Patients with acute ischemic stroke are prone to frailty and cognitive dysfunction, the frailty can affect the occurrence of cognitive dysfunction.

Key words： Acute ischemic stroke Frailty Cognitive dysfunction Correlation

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Ying TAO Xiangjun DONG Kaisheng SONG Haiyan HU Wenli

Cite this article:

WANG Ying TAO Xiangjun DONG Kaisheng SONG Haiyan HU Wenli. Correlation between frailty and cognitive dysfunction in patients with acute ischemic stroke[J]. 中国医药导报, 2021, 18(17): 82-84,89.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I17/82

[1] Muscedere J，Kim PM，Afilalo J，et al. Proceedings of the Canadian Frailty Network Workshop：Identifying Biomarkers of Frailty to Support Frailty Risk Assessment，Diagnosis and Prognosis [J]. J Frailty Aging，2019，8（3）：106-116.
[2] Xu L，Zhang J，Shen S，et al. Clinical Frailty Scale and Biomarkers for Assessing Frailty in Elder Inpatients in China [J]. J Nutr Health Aging，2021，25（1）：77-83.
[3] Samlan RA，Black MA，Abidov M，et al. Frailty Syndrome，Cognition，and Dysphonia in the Elderly [J]. J Voice，2020，4（1）：e15-160.e23.
[4] Furtado GE，Letieri R，Hogervorst E，et al. Physical Frailty and cognitive performance in older populations，partⅠ：systematic review with meta-analysis [J]. Cien Saude Colet，2019，24（1）：203-218.
[5] Shi D，Chen X，Li Z. Diagnostic test accuracy of the Montreal Cognitive Assessment in the detection of post-stroke cognitive impairment under different stages and cutoffs：a systematic review and mata-analysis [J]. Neurol Sci，2018， 39（4）：705-716.
[6] Zheng G，Zheng Y，Xiong Z，et al. Effect of Baduanjin exercise on cognitive function in patients with post-stroke cognitive impairment：study protocol for a reandomised conterolled trial [J]. BMJ Open，2018，8（6）：e20954.
[7] Stroke——1989.Recommendations on stroke prevention，diagnosisi，and therapy.Report of the WHO Task Forceon Stroke and Other Cerebrovascular Disorders [J]. Stroke，1989，20（10）：1407-1431.
[8] Nasreddine ZS，Phillips NA，Bédirian V，et al. The Montreal Cognitive Assessment，MoCA：a brief screening tool for mild cognitive impairment [J]. J Am Geriatr Soc，2005， 53（4）：695-699.
[9] Rolfson DB，Majumdar SR，Tsuyuki RT，et al. Validity and reliability of the Edmonton Frail Scale [J]. Age Ageing，2006，35（5）：526-529.
[10] Appleton JP，Woodhouse LJ，Adami A，et al. Imaging markers of small vessel disease and brain frailty，and outcomes in acute stroke [J]. Neurology，2020， 94（5）：e439-e452.
[11] Kanai M，Noguchi M，Kubo H，et al. Pre-Stroke Frailty and Stroke Severity in Elderly Patients with Acute Stroke [J]. J Stroke Cerebrovasc Dis，2020，29（12）：105346.
[12] 尚晓峰，张莹，李虹，等.老年急性缺血性脑卒中患者衰弱与卒中后抑郁的相关性研究[J].中国全科医学，2020， 23（30）：3834-3838.
[13] 杨帆，陈庆伟.老年住院患者衰弱状态及其影响因素分析研究[J].中国全学，2018，2（21）：173-179.
[14] 李灵艳，王青，张少景，等.老年住院患者共病及多重用药与衰弱关系的分析[J].北京医学，2018，1（40）：8-11.
[15] Cossec CL，Perrine AL，Beltzer N，et al. Pre-Frailty，Frailty，and Multimorbidity：Prevalences and Associated Characteristics from Two French National Surveys [J]. J Nutr Health Aging，2016，20（8）：860-869.
[16] Vetrano DL，Palmer K，Marengoni A，et al. Frailty and Multimorbidity：A Systematic Review and Meta-analysis [J]. J Gerontol A Biol Sci Med Sci，2019，74（5）：659-666.
[17] 孟丽，谭潇，石婧，等.老年人衰弱分布及其影响因素的初步研究[J].中国临床保健杂志，2017，20（5）：481-485.
[18] 方向阳，陈清，侯原平，等.社区老年人衰弱相关因素[J].中国老年学杂志，2019，39（2）：467-470.
[19] Kawada T. Sleep quality，frailty and cognition in middle aged to older adults [J]. Int Psychogeriatr，2020，32（5）：661-661.
[20] Uchikado Y，Ikeda Y，Ohishi M. Current Understanding of the Role of Frailty in Cardiovascular Disease [J]. Circ J，2020，84（11）：1903-1908.
[21] Lee JSW，Auyeung T，Leung J，et al. Transitions in Frailty States Among Community-Living Older Adults and Their Associated Factors [J]. J Am Med Dir Assoc，2014，15（4）：281-286.
[22] Song X，Zhang W，Hallensleben C，et al. Associations Between Obesity and Multidimensional Frailty in Older Chinese People with Hypertension [J]. Clin Interv Aging，2020，15：811-820.
[23] Francis L，Minh VTT，Kathleen C，et al. Benefits of Physical Exercise Training on Cognition and Quality of Life in Frail Older Adults [J]. J Gerontol B Psychol Sci Soc Sci，2012，16（1）：55-61.
[24] Zhào H，Wei W，Liu Y，et al. Cognitive Frailty Among Elderly Chinese Patients With Cerebral Small Vessel Disease：A Structural MRI Study [J]. Front Med（Lausanne），2020，4（7）：397.
[25] Tsung-Jen H，Hsing-Yi C，I-Chien W，et al. Independent association between subjective cognitive decline and frailty in the elderly [J]. PLos One，2018，13（8）：e0201351.