舒眠胶囊联合阿立哌唑治疗青少年心理障碍患者的效果

Abstract
Figure/Table
References (28)
Related Citation (14)

Download: PDF (561 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorde patients and its influence on the levels of dopamine (DA), 5-hydroxytryptamine (5-HT) and neuron specific enolase (NSE). Methods From April 2019 to April 2020, 102 cases of adolescent psychological disorder patients in Brain Hospital Affiliated to Guangzhou Medical University were selected as study objects. According to the random number table method, they were divided into observation group (51 cases) and control group (51 cases). Both groups were given psychotherapy, control group was treated with Aripiprazole, while observation group was given Shumian Capsules orally on the basis of control group. The course of treatment was eight weeks. The curative effect of two groups after eight weeks of treatment, the scores of self rating anxiety scale (SAS), self rating depression scale (SDS), Pittsburgh sleep quality index (PSQI), DA, 5-HT before and after treatment and NSE levels and the adverse reactions during the treatment were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). Before treatment, there were no significant differences in SAS and SDS scores between two groups (P > 0.05). After eight weeks of treatment, SAS and SDS scores in both groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Before treatment, there was no significant difference in PSQI score between two groups (P > 0.05). After eight weeks of treatment, PSQI scores in both groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Before treatment, there were no significant differences in serum DA, 5-HT and NSE levels between two groups (P > 0.05). After eight weeks of treatment, the levels of serum DA and 5-HT in both groups were higher than those before treatment, and observation group was higher than control group (P < 0.05); while serum NSE level was lower than that before treatment, and observation group was lower than control group (P < 0.05). No obvious adverse reactions occurred in two groups. Conclusion Shumian Capsules combined with Aripiprazole has a good effect in the treatment of adolescent psychological disorder, which can reduce the psychological disorder, improve the sleep quality, increase the levels of DA and 5-HT, and reduce the level of NSE.

Key words： Shumian Capsules Aripiprazole Adolescent psychological disorder Dopamine 5-hydroxytryptamine Neuron specific enolase

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Xiyuan1 WANG Rui2

Cite this article:

CHEN Xiyuan1 WANG Rui2. Effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorder patients[J]. 中国医药导报, 2021, 18(17): 114-117,125.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I17/114

[1] Eman H，Alaa D，Reham I，et al. Psychological status of school-aged children and adolescents with dyslalia [J]. J Cur Med Res Pract，2020，5（2）：217-224.
[2] 王梦瑶，肖牟尼，胡兰，等.自杀未遂青少年抑郁症患者脑网络分析[J].中国医学影像技术，2020，36（7）：981-985.
[3] Lea T，Courtney E，Ellen K. BSW students and interviewing：physiological，psychological，and pedagogical perspectives from Canada [J]. Soc Work Educ，2019，38（8）：1010-1024.
[4] 董莹盈，占建华，何为民，等.青少年情绪障碍的积极心理学管理范式研究[J].浙江临床医学，2017，19（10）：1852-1854.
[5] 孙庆芳，王亚平.阿立哌唑联合度洛西汀治疗抑郁症的临床研究[J].现代药物与临床，2020，35（4）：712-716.
[6] 刘娅萍，柴春艳，王甜，等.舒眠胶囊联合右佐匹克隆治疗失眠症的临床研究[J].现代药物与临床，2017，32（11）：2108-2111.
[7] 中华医学会精神科学会.CCMD-3中国精神障碍分类与诊断标准[M].3版.济南：山东科学技术出版社，2001：118-119.
[8] 国药中医药管理局.中医病症诊断疗效标准[S].南京：南京大学出版社，1994：31-33.
[9] 汤毓华.汉密尔顿抑郁量表[J].上海精神医学，1984，2（2）：61-64.
[10] 王征宇，迟玉芬.抑郁自评量表（SDS）[J].上海精神医学，1984（2）：19-20.
[11] 王征宇，迟玉芬.焦虑自评量表（SAS）[J].上海精神医学，1984（2）：21-22.
[12] 刘贤臣，唐茂芹.匹慈堡睡眠质量指数的信度和效度研究[J].中华精神科杂志，1996，29（2）：103-107.
[13] 路光辉，高丽红.舍曲林联合高频重复经颅磁刺激对首发青少年抑郁症患者疗效及认知功能的影响[J].中国健康心理学杂志，2020，28（5）：663-668.
[14] 曹潇云，周旭辉，朱锁，等.首发青少年抑郁症血清甲状腺激素水平研究[J].国际精神病学杂志，2020，47（2）：271-274.
[15] Michiel FN，Jacqueline GH，Sasja DH，et al. Psychological Symptoms and Quality of Life After Simultaneous Kidney and Pancreas Transplantation [J]. Trans Direct，2020，6（5）：9-13.
[16] 张嫚茹，王国强，刘健，等.家庭环境、教养方式和人格对青少年心理障碍的影响路径[J].中华行为医学与脑科学杂志，2018，27（4）：361-365.
[17] 董莹盈，占建华.青少年情绪障碍的积极心理学干预治疗效果[J].中国现代医生，2017，55（30）：23-27.
[18] 柯晓燕.儿童青少年心理障碍评估与诊断要点[J].中国实用儿科杂志，2017，32（4）：249-252.
[19] 王科平，邢文静，韩宇扬.阿立哌唑联合草酸艾司西酞普兰在重度抑郁症治疗中的应用分析[J].川北医学院学报，2020，35（1）：42-44.
[20] 李燕华，蒋婉丽.喹硫平或阿立哌唑联合丙戊酸钠治疗BPD抑郁发作疗效观察[J].西南国防医药，2018，28（11）：1010-1012.
[21] 姜海军，李福金，刘兰兰.舍曲林联合阿立哌唑治疗精神分裂症合并抑郁症状的疗效观察[J].中国医院用药评价与分析，2018，18（6）：779-781.
[22] 张琎.度洛西汀与艾司西酞普兰治疗抑郁症患者临床效果及安全性的比较[J].中国当代医药，2021，28（1）：59-62.
[23] 陈海琴，胡丽英，陈慧琴.舒眠胶囊联合心理干预治疗抑郁症睡眠障碍临床研究[J].新中医，2019，51（12）：268-271.
[24] 胡楠楠，孙继军.老年抑郁症患者神经递质、炎症因子水平与认知功能的关系[J].中国老年学杂志，2020，40（12）：2604-2606.
[25] 马丽娟，赵媛，关圆圆，等.落新妇苷对抑郁症小鼠脑内单胺递质多巴胺和5-羟色胺水平的影响[J].新乡医学院学报，2018，35（1）：12-15，21.
[26] 高岩，赵亚明，马辛.米氮平与度洛西汀对老年抑郁症失眠者的疗效及5-HT的影响[J].西北药学杂志，2018， 33（2）：241-244.
[27] 朱炼，李春萍.重复低频经颅磁刺激联合阿戈美拉汀治疗老年抑郁症的效果及其对血清NE、5-HT水平的影响[J].中外医学研究，2020，18（29）：55-57.
[28] 李涛，胡晓科，范超望，等.首发性抑郁症患者血清GFAP、NSE、Hcy水平与认知功能的关系[J].检验医学与临床，2017，14（24）：3601-3604.