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2021 Vol. 18, No. 12
Published: 2021-04-25
 
 
4 Technical criterion and specification for collection, storage and management of bio-specimen in respiratory diseases
Bio-specimen Biobank Expert Group of National Clinical Research Center For Respiratory Diseases
In addition to the common series, the bio-specimens related to respiratory diseases include sputum, pleural effusion, bronchoalveolar lavage fluid, pharyngeal swab infusion, bronchial mucosal biopsy tissue, needle aspiration biopsy and other specialized specimens. The collection and storage of specimens should follow the corresponding standard operating procedures. The construction of bio-specimen biobank for respiratory diseases in China is still in its initial stage, with no uniform standards of operation process. The statement focuses on technical criterion and specification for collection, storage and management of bio-specimen for respiratory diseases.
2021 Vol. 18 (12): 4-10 [Abstract] ( 116 ) HTML (1 KB)  PDF (893 KB)  ( 121 )
11 Study of inhibitory effect of formononetin on human renal carcinoma cell 786-O and its mechanism
CHEN Qing1 LI Haihong2 OU Weining1 ZHANG Xing3
Objective To observe the inhibitory effect of formononetin on human renal carcinoma cell 786-O and its mechanism. Methods Human renal carcinoma cell 786-O cultured with different doses of formononetin. They were divided into control group (0 μmol/L, group A), formononetin low-dose group (20 μmol/L, group B), formononetin medium-dose group (40 μmol/L, group C), and formononetin high-dose group (80 μmol/L, group D) according to drug dose. CCK8 method was used to detect the proliferation of four group; apoptosis was detected by flow cytometry and Hoechst staining; the expression of miR-155 was detected by RT-PCR; the protein expressions of P-PI3K and P-AKT were detected by Western blot. Results After 72 h of culture, the inhibitory rate of cell proliferation in groups B, C and D were higher than those in 24 and 48 h of culture. After 48 h of culture, the inhibitory rate of cell proliferation in groups B, C and D were higher than those in 24 h of culture, and the differences were statistically significant (all P < 0.05). After 24, 48 and 72 h of culture, the inhibitory rate of cell proliferation in groups B, C and D were higher than those in group A; groups C and D were higher than that in group B; and group D was higher than that in group C, and the differences were statistically significant (all P < 0.05). The apoptosis rate of four groups were statistically significant (P < 0.05). In group B, C and D, cell shrinkage and nucleus were observed， and the higher the drug dose was, the more obvious the cell apoptosis was; the nucleus of group A was complete and full in morphology. The expression of miR-155 level and P-PI3K and P-AKT proteins levels in groups B, C and D were lower than those in group A, the expression miR-155 level and P-PI3K and P-AKT proteins levels in groups C and D were lower than those in group B, and the expression miR-155 level and P-PI3K and P-AKT proteins levels in group D was lower than that in group C, and the differences were statistically significant (all P < 0.05). Conclusion Formononetin can significantly inhibit proliferation and induce apoptosis in human renal carcinoma cell 786-O, and the mechanism may be related to the down-regulation of miR-155 expression to inhibit the activation of PI3K/AKT signaling pathway.
2021 Vol. 18 (12): 11-15,19 [Abstract] ( 117 ) HTML (1 KB)  PDF (825 KB)  ( 80 )
15 Study on the network pharmacology of Scutellariae Radix in the treatment of hypertension
DONG Mingyue1 HUANG Yan2 ZHOU Lihua2▲
Objective To analyze the potential mechanism of Scutellariae Radix in the treatment of hypertension through network pharmacology. Methods The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was used to screen the chemical components and targets of Scutellariae Radix; GeneCards, OMIM, TTD, and DrugBank databases were used to screen out the disease targets of hypertension; Cytoscape 3.7.2 software was used to construct the “active component-disease target” network of Scutellariae Radix in the treatment of hypertension. The protein-protein interaction (PPI) network was constructed with the help of String database; finally, the R language was used to perform GO annotation analysis and KEGG pathway analysis on the target. Results A total of 86 targets of interaction between Scutellariae Radix and hypertension were identified, among which, CCND1, CDKN1A, ESR1, and others were the core genes. GO functional enrichment mainly included cell response to chemical stress, oxidative stress and adrenergic receptor activity. Among the KEGG pathways, Kaposi sarcoma associated herpesvirus infection, human cytomegalovirus infection and PI3K-Akt signaling pathway were the most significant. Conclusion Thirty-one active components of Scutellariae Radix act on 86 targets to reduce blood pressure, which reflects the characteristics of Scutellariae Radix in the treatment of hypertension through multi-component, multi-target and multi-channel.
2021 Vol. 18 (12): 15-19 [Abstract] ( 169 ) HTML (1 KB)  PDF (1900 KB)  ( 62 )
20 Study on microbial limit test methods of different rhubarb preparations
YI Wei LU Yin WU Jingjing SU Hua LI Si▲
Objective To establish a convenient, effective and simple method for microbial limit test of three kinds of rhubarb preparations, namely Baoshen Tablets, Xinbaoshen Tablets and Shenyanning Tablets. Methods The microbial limit test methods of three kinds of rhubarb preparations were studied by plate method, dilution method, membrane filtration method and neutralization method. The antibacterial activities of three kinds of rhubarb preparations were compared by dilution method, membrane filtration method and neutralization method. Results Baoshen Tablets and Xinbaoshen Tablets had certain inhibitory effect on Staphylococcus aureus. The antimicrobial activity could be eliminated by dilution method or by using 3% polysorbate 80 and 0.3% lecithin as neutralizer. Shenyanning Tablets had strong antibacterial effect, the 1∶10 test solution of Shenyanning Tablets still had antibacterial activity when the neutralizer was used, so the 1∶50 dilution test solution was needed to eliminate the antibacterial activity. Conclusion 3% polysorbate 80 and 0.3% lecithin can be used as neutralizer for the microbial limit test of three rhubarb preparations.
2021 Vol. 18 (12): 20-22 [Abstract] ( 149 ) HTML (1 KB)  PDF (684 KB)  ( 72 )
24 Comprehensive evaluation of traditional Chinese medicine service ability in provincial regions based on entropy TOPSIS method
Ranna·Ahati LUO Xian LI Ruifeng
Objective To evaluate traditional Chinese medicine service ability in 31 provincial regions of our country in 2018, and to provide the basis for promoting the development of traditional Chinese medicine in various regions. Methods The relevant data from the 2019 China Health Statistics Yearbook and 2018 National Chinese Medicine Statistics Abstracts was selected. Entropy weight method and technique for order preference by similarity to an ideal solution (TOPSIS) method were used to comprehensively evaluate the development of traditional Chinese medicine in 31 provincial regions of our country. Results The development level of traditional Chinese medicine services in provincial regions was quite different in 2018. The average levels of comprehensive evaluation of traditional Chinese medicine services in North China, East China, Central South, South China, Southwest, Northwest, and Northeast were 0.3709, 0.3562, 0.3222, 0.2859, 0.2853, 0.2645, 0.2336, respectively. Conclusion The overall service capacity of traditional Chinese medicine is generally not high, and the implementation of policies should be strengthened. There are large regional differences in traditional Chinese medicine service capacity, and we should focus on optimizing the distribution of traditional Chinese medicine resources. The level of economic development is not the decisive factor affecting the service capacity of traditional Chinese medicine, but the key factor is the importance of local governments to traditional Chinese medicine. Human resource is the key to the service ability of traditional Chinese medicine, so we should strengthen the construction of talents.
2021 Vol. 18 (12): 24-26,32 [Abstract] ( 113 ) HTML (1 KB)  PDF (709 KB)  ( 62 )
28 Study on the mechanism of new type of topical anesthetic in oral mucosal anesthesia of New Zealand rabbits
ZENG Dong1 NIU Jiao2 LI Changyi3 CHANG Jin4 NIU Guangliang1▲
Objective To investigate the mechanism of oral mucosal surface anesthesia with new type of oral topical anesthetic which as Lidocaine hydrochloride lysine-linoleic acid modified dextran polymeric lipid vesicles (LID-LLD-PLVs). Methods Twenty-four New Zealand rabbits aged eight months were randomly divided into four groups randomly according to body weight layer according to the random number table method, and six in each group, which were blank control group (no administration), 0.5 mL LID-LLD-PLVs were applied on the gingival surface of mandibular anterior teeth, then the group was divided into LD-LD-PLVS 30 min, 60 min and 90 min groups according to the action time. Then the anterior mucosa of each group was injected with 25 μL of 10% formalin solution for 60 min, and the gingiva, ipsilateral trigeminal ganglion and medulla oblongata were extracted. Real-time PCR was used to quantitatively analyze the mRNAs of substance P (SP), calcitonin gene related peptide (CGRP) and c-fos in gingival, trigeminal ganglion and medulla oblongata. Results The mRNA quantitative of SP, CGRP and c-fos in the gingival, trigeminal ganglion and medulla oblongata of LID-LLD-PLVs 30 min, 60 min and 90 min groups were all lower than that of the control group, and the differences were statistically significant (all P ＜ 0.05). Conclusion The mechanism of LID-LLD-PLVs may be related to the inhibition of the expression levels of SP, CGRP and c-fos in gingival, trigeminal ganglion and medulla oblongata.
2021 Vol. 18 (12): 28-32 [Abstract] ( 123 ) HTML (1 KB)  PDF (932 KB)  ( 79 )
33 Correlation analysis of ADAM33 gene S2 locus and TGF-β1, ERK levels in children with bronchial asthma in Urumqi area
JIANG Ting YAN Xiaowei WANG Jianrong
Objective To explore the correlation between disintegrin-metalloproteinase 33 (ADAM33) gene S2, transforming growth factor-β1 (TGF-β1), and extracellular signal-regulated kinase (ERK) levels in Han nationality children with bronchial asthma in Urumqi. The level provides new ideas and targets for the prevention and treatment of asthma. Methods Outpatients and admissions of the Fifth Affiliated Hospital and First Affiliated Hospital of Xinjiang Medical University from July 2018 to July 2019 were selected, a total of 78 children with bronchial asthma in the Han nationality aged 3 to 14 were selected as the asthma group, and the same period when the preventive health care department was selected 45 cases of non-asthmatic children of Han nationality were regarded as non-asthmatic group. The ADAM33 S2 was typed by polymerase chain reaction, and the levels of IgE, TGF-β1 and ERK were detected by enzyme-linked immunosorbent assay. The differences of genotype and allele frequency between asthma group and non-asthma group were compared, and their correlation were analyzed. Results Comparison of ADAM33 S2 genotype and allele frequency between the two groups was statistically significant (P < 0.05). The levels of IgE, TGF-β1, and ERK in the non-asthmatic group were lower than those in the asthma group, and the differences were statistically significant (P < 0.05 or P < 0.01). TGF-β1 was positively correlated with ADAM33 S2 and ERK (r > 0, P < 0.05), and ADAM33S gene S2 was not correlated with ERK (P > 0.05). Conclusion One of the susceptibility genes in Han nationality children with asthma in Urumqi may be ADAM33 gene S2. The indicators of IgE, TGF-β1 and ERK in the asthma group are higher than those in the non-asthma group. TGF-β1 may up-regulate the expression of ADAM33 gene S2 in Han nationality children with asthma. ERK may up-regulate the secretion of TGF-β1.
2021 Vol. 18 (12): 33-36 [Abstract] ( 124 ) HTML (1 KB)  PDF (745 KB)  ( 35 )
37 Research progress of inositol and insulin resistance in patients with polycystic ovary syndrome
LI Yangyang1 HOU Lihui2▲ LI Yan2 SUN Miao2 HAO Songli2 XIA Xiaoyan3
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in women. Typical clinical manifestations include oligo-ovulation and/or anovulation, excess androgens, and polycystic ovaries. PCOS is associated with an increased risk of diabetes mellitus type 2 and cardiovascular disease, and its main pathological mechanism is insulin resistance (IR). IR is a pathological association between PCOS metabolism and reproductive abnormalities. In the past decade, inositol has been increasingly used in the treatment of PCOS due to its natural, non-toxic, and effective properties. Compared with Metformin, insulin sensitizers containing inositol are recommended for the treatment of patients with PCOS. This review intends to discuss it from the point of view of inositol in the treatment of PCOS-IR.
2021 Vol. 18 (12): 37-40 [Abstract] ( 226 ) HTML (1 KB)  PDF (599 KB)  ( 243 )
41 Research progress of nanotechnology in dermatology department
HAN Bingyu LEI Tiechi
Nanoscience and nanotechnology are the research and application of tiny things. Nanotechnology is science, engineering and technology at the nanoscale of 1 to 100 nanometers. In recent years, nanotechnology has produced a huge and far-reaching influence in the research of various disciplines. Nanotechnology is widely used in dermatology, playing an important role in the diagnosis and treatment of many skin diseases, as well as dermatological surgery and cosmetology. For example, nanotechnology has improved the efficacy of drugs to treat common dermatological diseases such as psoriasis, androgen alopecia, and psoriasis. It helps the rapid diagnosis and localization of skin diseases. In dermatological surgery, nanoparticles can promote wound healing and serve as an effective substitute for suture lines. In terms of skin beauty, it is widely used in several topical skin care products, such as sunscreen. This paper introduces the concept of nanotechnology, summarizes the application of nanotechnology in the diagnosis and treatment of various skin diseases as well as dermatology surgery and cosmetology, and finally expounds the existing problems of nanotechnology.
2021 Vol. 18 (12): 41-44,52 [Abstract] ( 102 ) HTML (1 KB)  PDF (620 KB)  ( 140 )
45 Progress in the treatment of rectocele
JIA Chen1 PAN Huayang1 HUO Xiaoyan2 MENG Qinghui1
Rectocele is one of the important causes of obstructive defecation syndrome, its typical clinical symptoms include difficulty in defecation, obvious sense of incomplete defecation and anal obstruction, as well as perineal swelling and pain, etc. It severely reduces the quality of life. Presently, the treatment of rectocele is mainly through medical non-surgical treatment or surgical intervention. Among them, medical non-surgical treatment mainly includes medication, diet, exercise, etc, while surgical treatment methods includes transanal, transvaginal, transperineal and transabdominal. In addition, the multidisciplinary team treatment method that has emerged in recent years may play a significant role in the treatment of patients with rectocele. At present, there are various treatment methods for patients with rectocele, but the gold standard is still controversial. In order to make the way of advanced surgical treatment of rectocele more clearly and widely understood, this article will focus on the developments in the rectocele treatment in recent years.
2021 Vol. 18 (12): 45-48,56 [Abstract] ( 130 ) HTML (1 KB)  PDF (656 KB)  ( 137 )
49 Research progress of nutritional therapy for fatty liver
CHEN Qiao LI Ling LI Suyun
Fatty liver is a common clinical liver disease, which seriously affects life health of mankind. The imbalance of daily nutrition intake and the neglect of dietary nutrition management can lead to the excessive accumulation of fat and abnormal metabolic function in the liver, leading to fatty liver. Therefore, scientific nutrition management and dietary nutrition collocation can effectively prevent and treat fatty liver. In this paper, the pathogenesis of fatty liver was briefly introduced, and  reasonable restriction of energy and dietary fat intake, control of saturated fatty acid intake, and appropriate increase of monounsaturated fatty acid intake were emphasize, which can effectively prevent and improve fatty liver. In addition, the reasonable collocation of nutritional supplements and scientific exercise management also have a positive impact on the prevention and treatment of fatty liver.
2021 Vol. 18 (12): 49-52 [Abstract] ( 127 ) HTML (1 KB)  PDF (597 KB)  ( 82 )
53 Research progress of the relationship between intestinal flora and cardiovascular disease
DOU Wenting1 LI Xiaohui2
Trimethylamine-N-oxide (TMAO), a metabolite of intestinal flora, promotes the occurrence and development of atherosclerosis through the activation of PKC/NF-κB pathway or stimulating foam cell formation. Elevated plasma TMAO can be used as a risk stratification index of poor prognosis in patients with heart failure. Short chain fatty acids, the metabolites of intestinal flora, affect the blood pressure level of host by binding to G-protein-coupled receptors. Meanwhile, intestinal flora can regulate blood pressure by affecting sympathetic nervous, which is the hypothesis of “brain-gut-bone marrow axis”. The abundance and structure of intestinal flora in children with Kawasaki disease have changed. Some special bacteria in the intestine have superantigen activity and can produce heat shock protein. These factors may involve in the occurrence and development of Kawasaki disease by affecting the release of inflammatory factors.
2021 Vol. 18 (12): 53-56 [Abstract] ( 321 ) HTML (1 KB)  PDF (599 KB)  ( 42 )
57 Research progress on the effect of substrate stiffness on cell biological behavior
DENG Bo’er KONG Weimin
Stiffness is an important parameter of micro nano mechanics, which can be divided into cell stiffness and substrate stiffness. Substrate stiffness can be understood as the elastic modulus or hardness of tissue, which provides support and specific physical signals for cell growth. With the development of atomic force microscope, the substrate stiffness can be measured at present. Substrate stiffness plays an important role in many biological behaviors of cells, such as cell morphology, cell migration, cell phenotype and function, and regulation of stem cell differentiation. These phenomena exist in both normal cells and tumor cells, and have different meanings. In tumor tissue, substrate stiffness may also affect the invasiveness of tumor and the sensitivity of anti-tumor drugs. Understanding the mechanism of these phenomena may provide new ideas for the prognosis and treatment of tumors.
2021 Vol. 18 (12): 57-60 [Abstract] ( 253 ) HTML (1 KB)  PDF (595 KB)  ( 270 )
61 Research progress of inflammatory factors and their inhibitors on cerebral ischemia-reperfusion injury
REN Jingming TIAN Hongqi
Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process and seriously endanger human health, in which inflammatory reaction is one of the important factors to induce CIRI. A large number of inflammatory factors effect neuronal apoptosis or necrosis, mediate microvascular dysfunction, and lead to cerebral hemorrhage or cerebral edema, causing irreversible damage to the body. Therefore, it is of great significance to seek effective prevention and treatment strategies for CIRI. This review introduces the physiological functions of inflammatory factors such as interleukin (IL)-1, tumor necrosis factor α and IL-6 in the process of CIRI, and lists the drugs and natural extracts related to inflammatory factors in recent years, so as to provide evidence for the clinical treatment of CIRI.
2021 Vol. 18 (12): 61-64 [Abstract] ( 220 ) HTML (1 KB)  PDF (628 KB)  ( 120 )
65 Analysis of nursing satisfaction of inpatients in department of cardiovascular medicine and its influencing factors
YANG Shiyu1 LONG Yuanxiong2 YONG Su’nan2 PENG Tingyun3
Objective To study the influencing factors of nursing satisfaction of inpatients in the Department of Cardiovascular Medicine, to provide references for improving the quality of hospital nursing services. Methods Patients who were hospitalized in the Department of Cardiovascular Medicine in the First Affiliated Hospital of Hu’nan University of Chinese Medicine from January to December 2019 and met the inclusion criteria were selected as the research objects. Basic data and nursing satisfaction survey scale were used, logistic regression analysis and other methods were taken to study the influencing factors of nursing satisfaction of patients. Results The overall satisfaction rate of cardiovascular medical nursing services was 72.8%, but the satisfaction rate was relatively low in terms of patient psychological support, nurse-patient communication, and value expectations. There was a statistically significant difference in the overall satisfaction of patients with different ages, education levels, economic income and medical payment methods (P ＜ 0.05). Education level (OR = 2.617, 1.941, 1.426), economic income (OR = 0.325, 0.372, 0.513), and medical payment method (OR = 0.186) were the influencing factors of nursing satisfaction of cardiovascular inpatients (P ＜ 0.05). Conclusion Educational background, economic income, and medical payment methods are related to satisfaction; improving nursing environment and service attitude, strengthening nurse-patient communication, providing psychological support, improving nursing service efficiency and technical level are the fundamental guarantees for improving nursing satisfaction of cardiovascular inpatients.
2021 Vol. 18 (12): 65-68 [Abstract] ( 130 ) HTML (1 KB)  PDF (622 KB)  ( 66 )
69 Analysis of the current status and influencing factors of cervical spine sub-health of medical students
WANG Zhen1 WANG Chao1 YANG Ling2 LU Haifeng2 REN Yanyu1 YANG Binbin1
Objective To investigate the current status and influencing factors of cervical sub-health of medical students. Methods Using general information questionnaire, visual analog pain scale, cervical spine dysfunction index questionnaire, and cervical sub-health influencing factor questionnaire, a questionnaire survey was conducted among 418 medical students of Shandong University of Traditional Chinese Medicine from April to November 2019. Results Cervical sub-health of medical students was reported by 17.9%. Single factor analysis showed that there were statistically significant differences in pillow height, studying or playing games until 2 o’clock in the evening, the longest reading period without rest, the average daily time of using computer or mobile phone, head posture when reading or surfing the Internet, weekly exercise time, history of neck injury between people with or without cervical sub-health (P ＜ 0.05). Daily use of computer or mobile phone time, head posture when reading in class or surfing the Internet, and history of neck injuries were risk factors affecting medical students’ cervical sub-health (OR ＞ 1, P ＜ 0.05), while weekly exercise time was a protective factor (OR ＜ 1, P ＜ 0.05). Conclusion Frequent cervical sub-health was reported in medical students. The use of electronic products, incorrect head posture and history of neck injury are risk factors, while physical exercise is a protective factor.
2021 Vol. 18 (12): 69-73 [Abstract] ( 253 ) HTML (1 KB)  PDF (637 KB)  ( 37 )
74 Study on the current status of talents team career development and the influencing factors of career development satisfaction of township health centers in Western China
LIU Junlin1 FENG Gong2 DU Zhiqian3
Objective To understand the current status of talents team career development of township health centers in the Western region, to explore the existing problems and factors affecting career development satisfaction, and to provide scientific suggestions for the construction of the talents team of township health centers in the Western region. Methods From December 2019 to August 2020, using the stratified sampling method, a questionnaire survey of 1727 medical workers in township hospitals in Shaanxi Province was conducted. The current situation of talents team career development of the township health talent team and the factors affecting the satisfaction of talents team career development of the township health center was analyzed. Results There were 1727 valid questionnaires in this survey, and the effective response rate was 99.5%. The professional development satisfaction of the talent team in township hospitals was 76.78%, the average unit satisfaction score was (2.03±0.52) points, and the average job satisfaction score was (1.98±0.45) points. There were statistically significant differences in the professional development satisfaction of talents in township hospitals of different genders, highest educational backgrounds, working years, qualifications, professional and technical titles, positions, entry channels, unit satisfaction, and job satisfaction (P ＜ 0.05). Gender (OR = 1.332), highest degree (OR = 1.354), whether there is a qualification certificate (OR = 0.847), entry path (OR = 1.178), unit satisfaction (OR = 1.208) and job satisfaction (OR = 1.423) were independent influencing factors of career development satisfaction (P ＜ 0.05). Conclusion The status quo of career development of the talents team in township hospitals: mostly women and temporary hires; low educational background, professional title, and income; unreasonable qualification structure; low job satisfaction. Female, low-educated, free medical orientation students trained in rural areas, high unit satisfaction and job satisfaction, grassroots medical workers have high career development satisfaction, and those without a qualification certificate have low career development satisfaction. It is recommended to rationalize the introduction of talents, make efforts to retain talents, and cultivate talents through multiple channels.
2021 Vol. 18 (12): 74-77,89 [Abstract] ( 145 ) HTML (1 KB)  PDF (639 KB)  ( 100 )
78 Analysis of professional identity of psychiatrists
SUN Haishan1 JIANG Jingtao2
Objective To analyze the status quo of psychiatrists’ professional identity and influencing factors, and to put forward some targeted countermeasures and suggestions on this basis. Methods From June to August 2020, a simple random sampling method was used to survey 160 psychiatrists from three psychiatric hospitals in Z city with a self-compiled scale questionnaire. A total of 152 valid questionnaires were returned, and the effective recovery rate was 95.00%. The professional identification scores of psychiatrists with different indicators were analyzed, and multiple linear regression was used to analyze its influencing factors. Results The total score of psychiatrists’ occupational identity was (3.82±0.51) points, among which the score of professional behavior was the highest and the score of professional belief was the lowest. There was a statistically significant difference in the professional identification scores of psychiatrists with different educational backgrounds, professional titles, whether they were teachers, income status, and professional motivation (P ＜ 0.05). Multiple regression analysis showed that whether they were teachers, income status, and professional motivation were the main factors that affected the level of psychiatrists’ professional identity (R2 = 0.311, P ＜ 0.05). Conclusion The overall level of psychiatrists’ professional identity is relatively high, and there is still room for improvement. Professional motivation, whether they are teachers, and income status are the main factors affecting their professional identity. This can be done by increasing training channels, optimizing job division and income structure, and paying attention to it. Clinical teaching to improve the level of professional recognition.
2021 Vol. 18 (12): 78-81 [Abstract] ( 206 ) HTML (1 KB)  PDF (619 KB)  ( 47 )
82 Status quo and influencing factors of infectious disease knowledge learning among the floating population in Beijing
SHAO Shuang1 ZHANG Huirong2 CHEN Xiaolei1 DU Juan1
Objective To investigate and understand the knowledge rate, learning status and influencing factors of infectious diseases among the floating population in the urban-rural fringe area of Beijing, and to provide a reference for further improving the prevention and control of infectious diseases. Methods From 2016 to 2017, a stratified cluster random sampling method was used to select 863 floating population aged ≥18 years from four communities in Haidian District and Fengtai District. During the period in Beijing, the study group took various ways to learn about infectious diseases, and others as the unlearned group, and conducted face-to-face questionnaire surveys, including basic information, knowledge of infectious diseases, and awareness rates. Results The differences of age, household registration, marital status, education level, income level, time in Beijing, whether you plan to stay in Beijing for a long time, having children in Beijing, work status, housing situation, working hours, exercise, whether to obtain health knowledge, chronic disease status, and with self-perceived health status between two groups were statistically significant (P ＜ 0.05). 53.0% of the floating population who had studied infectious diseases during their stay in Beijing. 6.6% and 55.5% answered that the types and transmission routes of infectious diseases were all correct. The results of multivariate analysis showed that 35 to less than 45 years old (OR = 0.471), 45 to less than 55 years old (OR = 0.374), more than 55 years old (OR = 0.071), working hours were 8 h(OR = 0.305), more than 8 h (OR = 0.176), self-perceived poor health (OR = 0.429) were less likely to learn about infectious diseases (P ＜ 0.05); high school or technical secondary school (OR = 5.006), junior college or above (OR = 5.071), purchase a house (OR = 1.886), physical exercise (OR = 1.905) were more likely to learn about infectious diseases (P ＜ 0.05). Conclusion The overall awareness rate of the floating population’s infectious disease knowledge needs to be improved, and targeted health education can be carried out.
2021 Vol. 18 (12): 82-85 [Abstract] ( 152 ) HTML (1 KB)  PDF (622 KB)  ( 79 )
86 Investigation on the prevalence of myopia and analysis of influencing factors among primary and middle school students in compulsory education
WANG Xiaojie LI Jing▲
Objective To investigate and analyze the prevalence and influencing factors of myopia in primary and secondary school students in compulsory education, and to formulate corresponding preventive measures. Methods From January 2017 to January 2020, a total of 3000 primary and middle school students in a community in Xi’an were selected as the research objects. The basic data of primary and middle school students were collected by community census, the prevalence rate of myopia in primary and middle school students were counted. The students were divided into groups based on whether the students had myopia or not, and the factors affecting myopia were analyzed. Results The prevalence of myopia among 3000 elementary and middle school students was 44.13%. The prevalence of myopia in elementary school students was 14.27%, and that of junior high school students was 29.86%. The proportion of myopia group age ≥12 years old, parents with the same medical history, assignment of homework more than 80 min, mobile phone TV time more than 2 h, partial eclipse, reading and lying down position, daily exercise time less than 1 h were significantly higher than those in the normal vision group, and the differences were statistically significant (P ＜ 0.05). The amount of homework assigned (OR = 2.046), time spent watching mobile TV (OR = 2.380), reading posture (OR = 2.361), daily exercise time (OR = 2.115) were independent risk factors affecting myopia in primary and middle school students (P ＜ 0.05). Conclusion The occurrence of myopia in elementary and middle school students is closely related to age, whether their parents had the same medical history, the amount of homework assigned, the time spent on mobile phones and TV, whether they are partial eclipse, the posture of reading books, and the time of daily exercise. In this regard, preventive intervention measures should be combined with the above factors to reduce the prevalence of myopia in primary and secondary school students.
2021 Vol. 18 (12): 86-89 [Abstract] ( 244 ) HTML (1 KB)  PDF (582 KB)  ( 121 )
90 Design and implementation of intelligent circulating infusion system
LIN Yanli1 WU Rong2
Through the design of the management platform of transfusion control, the information technology is used to realize the remote control of multi-channel circulation transfusion. According to the logical setting of infusion sequence, functions such as infusion preset, intelligent control and automatic alternation between multiple bottles of different liquids, remote drip adjustment and clamping, online monitoring and tracking of infusion process can be achieved. At the same time, patients or their family members can know the infusion progress in real time on their mobile phones. It can effectively avoid the incompatibility of drugs, reduce the adverse reaction of infusion, and improve the safety of infusion. Significantly reduce the workload of nursing, improve work efficiency, realize remote intelligent infusion, improve the comfort of the ward, reduce cross-infection, and improve the patient’s medical experience.
2021 Vol. 18 (12): 90-93,102 [Abstract] ( 121 ) HTML (1 KB)  PDF (1704 KB)  ( 218 )
94 Clinical observation of transurethral enucleation of prostate in the treatment of elderly patients with benign prostatic hyperplasia
YANG Lei1 SUN Hongfang2
Objective To investigate clinical effect of transurethral enucleation of prostate (TUEP) in the treatment of benign prostatic hyperplasia (BPH) in the elderly. Methods Sixty-two elderly patients with BPH hospitalized in the Second Hospital of Traditional Chinese Medicine of Wuxi City of Jiangsu Province from January 2017 to December 2018 were selected as research objects. They were divided into transurethral resection of prostate (TURP) group of 27 cases and TUEP group of 35 cases according to the different treatment methods. The operation time, weight of resected tissue, blood loss, extubation time, postoperative complications, IPSS score, QOL score, IIEF-5 score, Qmax and RUV were compared between two groups. Results The operation time and extubation time of TUEP group were shorter than those of TURP group, the weight of resected tissue of TUEP group was larger than that of TURP group, and the amount of bleeding of TUEP group was less than that of TURP group, the differences were statistically significant (P < 0.05). There was no significant difference in total incidence of postoperative complications between two groups (P > 0.05). Three months after operation, IPSS and QOL scores of two groups were lower than those before operation, IIEF-5 score of TURP group was lower than that before operation and TUEP group, the differences were statistically significant (P < 0.05). Three months after operation, Qmax of two groups was higher than that before operation, RUV of two groups was less than that before operation, and Qmax of TUEP group was higher than that of TURP group, the differences were statistically significant (P < 0.05). Conclusion The efficacy of TUEP in the treatment of BPH is exact, with fewer complications and less influence on sexual function after operation. It is worth popularizing and applying.
2021 Vol. 18 (12): 94-97 [Abstract] ( 151 ) HTML (1 KB)  PDF (381 KB)  ( 98 )
98 Clinical effect on acupuncture of Lingshu Kaihe in the treatment of knee osteoarthritis with cold-dampness blockage pattern
YUAN Yundong1 WANG Yanjun2 QI Liqing1
Objective To observe the efficacy on acupuncture of Lingshu Kaihe in the treatment of knee osteoarthritis with cold-dampness blockage pattern. Methods A total of 117 patients with knee osteoarthritis with cold-dampness blockage pattern admitted to the Third Department of Orthopedics, the First Affiliated Hospital of Hebei University of Chinese Medicine from February 2018 to February 2020 were selected. They were randomly divided into two groups by computer. There were 59 cases in the treatment group (acupuncture of Lingshu Kaihe), and 58 cases in the control group (ordinary acupuncture treatment), all of which were treated for two weeks. Visual analogue scale (VAS), Western Ontario and McMaster Universities osteoarthritis index (WOMAC) scale scores, interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α) levels were recorded before and after treatment to evaluate knee pain and improvement of knee symptoms in the two groups. The clinical efficacy of the two groups was compared. Results After treatment, VAS, the score of WOMAC scale, and the levels of IL-1 and TNF-α in both groups were lower than those before treatment, and VAS and the score of WOMAC scale in the treatment group were lower than those in the control group, with statistical significance (all P ＜ 0.05). There were no significant differences in IL-1 and TNF-α between the two groups after treatment (P ＞ 0.05). The total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Acupuncture of Lingshu Kaihe has a definite clinical effect in the treatment of knee osteoarthritis with cold-dampness blockage pattern, and its effect is superior to ordinary acupuncture treatment in relieving symptoms.
2021 Vol. 18 (12): 98-102 [Abstract] ( 279 ) HTML (1 KB)  PDF (632 KB)  ( 104 )
103 Safety and efficacy of mini rivet combined with Kirschner wire in the treatment of mallet finger
XU Yong CAI Wei YU Yifan ZUO Wenshan▲
Objective To study the safety and efficacy of mini rivet combined with Kirschner wire in the treatment of mallet finger. Methods A total of 120 patients with mallet finger admitted to Huai’an First Hospital Affiliated to Nanjing Medical University from July 2016 to July 2018 were selected, they were divided into observation group and control group by random number table method, with 60 cases in each group. The control group was treated with Kirschner wire operation, and the observation group was treated with mini rivet on the basis of the control group. The clinical efficacy and incidence of complications were compared between the two groups. Finger joint recovery (extension angle, active flexion angle, range of motion) and visual analogue scale (VAS) were compared between the two groups at six months and 12 months after operation. The peak systolic velocity (PSV), diastolic peak velocity (EDV) and resistance index (RI) of digital ventral artery were compared between the two groups before and 12 months after operation. Results The clinical excellent and good rate in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). At 6, 12 months after operation, the active flexion angle and range of motion in the observation group were higher than those in the control group, while the extension angle was lower than that in the control group, with statistical significance (all P ＜ 0.05). Twelve months after operation, PSV and EDV in the observation group were higher than before operation, RI was lower than before operation, EDV in the control group was higher than before operation, RI in the control group was lower than lower than before operation, and PSV and EDV in the observation group were higher than those in the control group, RI was lower than that in the control group, the differences were statistically significant (all P ＜ 0.05). There was no significant difference in PSV between before and 12 months after operation in the control group (P ＞ 0.05). There was no significant difference in the total incidence of complications between the two groups (P ＞ 0.05). Conclusion Mini rivet combined with Kirschner wire has better efficacy and safety in the treatment of mallet finger.
2021 Vol. 18 (12): 103-106 [Abstract] ( 108 ) HTML (1 KB)  PDF (573 KB)  ( 25 )
107 Comparison of fracture healing time and complications between proximal femoral anti-rotation intramedullary nail and dynamic hip screw in the treatment of elderly intertrochanteric fracture
WANG Dayu CHENG Zhongwu ZHANG Benjie
Objective To investigate the effects of fracture healing time and complications between proximal femoral anti-rotation intramedullary nail (PFNA) and dynamic hip screw (DHS) in the treatment of elderly intertrochanteric fracture. Methods Eighty-four elderly patients with intertrochanteric fracture admitted to Suzhou First People’s Hospital, Anhui Province from October 2016 to October 2019 were selected and they were divided into observation group (42 cases) and control group (42 cases) according to the random number table method. PFNA treatment was used in the observation group, and DHS treatment was used in the control group. Operation-related indicators (operative time, intraoperative blood loss, incision length, fracture healing time, activity time out of bed, and hospitalization time) were compared between the two groups. The visual analogue scale (VAS) before and two weeks after operation, the situation of hip function at two weeks after operation and the incidence of complications at one year after operation were compared between the two groups. Results The incision length, operative time, fracture healing time, activity time out of bed and hospitalization time in the observation group were shorter than those in the control group, and the intraoperative blood loss was lower than that in the control group, with statistical significance (all P ＜ 0.05). After operation, VAS in both groups was lower than that before operation, and observation group was lower than control group, the differences were statistically significant (all P ＜ 0.05). The excellent and good rate of Harris hip score in the observation group was higher than that in the control group, and the total incidence of complications was lower than that in the control group, with statistical significance (all P ＜ 0.05). Conclusion The fracture healing time of elderly patients with intertrochanteric fracture treated by PFNA is shorter than that of DHS treatment, and can effectively reduce the incidence of complications.
2021 Vol. 18 (12): 107-110 [Abstract] ( 189 ) HTML (1 KB)  PDF (612 KB)  ( 85 )
111 Effect of acupuncture combined with medicine on lumbar disc herniation
HONG Qiuyang LIU Xiaojing WANG Guiling
Objective To observe the clinical efficacy of acupuncture combined with medicine in the treatment of lumbar disc herniation. Methods A total of 80 patients with lumbar disc herniation admitted to Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine from June 2017 to June 2019 were divided into observation group and control group by random number table method, with 40 cases in each group. The control group was given Duhuo Jisheng Decoction orally; the observation group was treated with “Wang’s lumbago eight needles” on the basis of the control group. The changes of visual analogue scale (VAS), Japanese orthopaedic association acores (JOA), Oswestry disability index score (ODI), and the level of pain related mediators in serum were observed and compared between the two groups before treatment, after two weeks of treatment and tree months of follow-up. Results The JOA, ODI and VAS scores in both groups after two weeks of treatment and three months of follow-up were higher than those before treatment, and observation group was higher than control group (all P ＜ 0.05). After treatment, serum PGE2 and 5-HT levels in two groups were lower than before treatment, and β-EP levels in two groups were higher than before treatment (all P ＜ 0.05). After treatment, PGE2 and 5-HT levels in observation group were lower than control group, and serum β-EP level was higher than control group, the differences were all statistically significant (all P ＜ 0.05). The total effective rate of observation group was higher than control group (P ＜ 0.05). Conclusion Acupuncture combined with Duhuo Jisheng Decoction can significantly improve the clinical symptoms of patients with lumbar disc herniation, regulate the level of pain mediators, and has a good long-term effect.
2021 Vol. 18 (12): 111-114 [Abstract] ( 240 ) HTML (1 KB)  PDF (575 KB)  ( 51 )
115 Application of continuous static stretching combined with passive exercise training in patients after elbow joint fracture surgery
WANG Xueling XU Hui
Objective To explore the application of continuous static stretching combined with passive exercise training in patients after elbow joint fracture surgery. Methods A total of 70 patients with elbow fractures from January 2018 to January 2020 in West China Hospital of Sichuan University were selected as the research objects. According to the random number table method, they were divided into the control group and the observation group, with 35 cases in each group. The control group was received passive exercise training, and the observation group was received continuous static stretching combined with passive exercise training. The elbow function and range of motion of the two groups at each time point were evaluated and compared before and two weeks, six weeks, 12 weeks and 24 weeks after surgery. Postoperative recovery time and complications during hospitalization were recorded in both groups. Results Overall analysis showed that there were significant differences in Mayo elbow function scoring standard score and interaction between group, time point and group time point of elbow motion between two groups (P ＜ 0.05). The improvement time of elbow function and fracture healing time in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no occurrence of complications in both groups. Conclusion Continuous static stretching combined with passive exercise training have high safety in the treatment of elbow joint fracture surgery, which can improve the function of the patient’s elbow joint and the range of motion of the elbow joint, and promote the postoperative recovery of patients.
2021 Vol. 18 (12): 115-118 [Abstract] ( 133 ) HTML (1 KB)  PDF (610 KB)  ( 84 )
119 Effect of serum phIGFBP-1 levels on pregnant women and fetuses with intrahepatic cholestasis of pregnancy
JIANG Su’e1 ZHANG Shuxuan2 ZHENG Xiaoxiao3▲
Objective To investigate the effect of serum phosphorylated sulin-like growth factor binding protein-1 (phIGFBP-1) levels on pregnant women and fetuses with intrahepatic cholestasis of pregnancy (ICP). Methods Retrospective analysis was conducted on 42 cases with ICP patients in Huai’an Maternal and Child Health Care Hospital of Jiangsu Province (hereinafter referred to as “our hospital”) from March 2019 to January 2020 as the experimental group. During the same period, 42 cases of normal pregnant women in our hospital were the control group. The levels of total bile acid (TBA), aspartate amino transferase (AST), alanine aminotransferase (ALT) and serum phIGFBP-1 were compared between the two groups. According to the serum phIGFBP-1 level, the experimental group was divided into 20-35 ng/mL group and >35 ng/mL group. The incidence of premature birth, postpartum hemorrhage, 1 min Apgar score, fetal distress and neonatal asphyxia were compared among different serum levels of phIGFBP-1. The correlation between serum phIGFBP-1 level and TBA, AST, ALT, fetal heart rate, fetal umbilical artery resistive index (RI), pulsatility index (PI), and umbilical venous ductus shunt rate were observed. Results TBA, AST, ALT, phIGFBP-1 levels and fetal heart rate, RI, PI and umbilical venous ductus shunt rate in the experimental group were higher than those in the control group (all P < 0.05). The incidence of premature birth, fetal distress and neonatal asphyxia in > 35 ng/mL group were higher than those in 20-35 ng/mL group, while 1 min Apgar score was lower than 20-35 ng/mL group (P < 0.05) . The serum phIGFBP-1 level was positively correlated with fetal heart rate, RI, PI, and umbilical venous ductus shunt rate (P < 0.05). Conclusion Serum phIGFBP-1 level can provide prognosis evaluation for ICP pregnant women, and provide diagnostic reference for fetal distress.
2021 Vol. 18 (12): 119-122 [Abstract] ( 141 ) HTML (1 KB)  PDF (572 KB)  ( 52 )
123 Clinical effect of electrical stimulation biofeedback method in the treatment of postpartum pelvic floor dysfunction
QIAN Hui1 SUN Hongmei2 LIU Fenghua2 NIE Yanping3
Objective To study the effect of electrical stimulation biofeedback method in the treatment of postpartum pelvic floor dysfunction (PFD). Methods A total of 150 cases primiparas of PFD admitted to Xuancheng People’s Hospital of Anhui Province from March to December 2019 were selected as research objects. They were divided into the study group （75 cases）and the control group（75 cases） according to the random number table method. The control group was given Kegel’s exercise plus vagina dumbbell pelvic floor muscle exercise. The study group was given Kegel’s exercise method plus electrical stimulation biofeedback method plus vagina dumbbell pelvic floor muscle exercise. The pelvic floor muscle fiber muscle voltage, endurance contraction and ultrasonic examination before and after treatment were compared between the two groups. The clinical symptoms of the two groups were compared before and after treatment. Results After treatment, the muscle voltage and endurance contraction of pelvic floor muscle Ⅰ, Ⅱ fiber of the two groups were higher than those before treatment, and the study group was higher than the control group, and the differences were statistically significant (all P < 0.05). After treatment, the bladder neck-symphyseal distance (BSD) at rest, posterior urethrovesical angle at rest and pressure status and bladder neck descent of the two groups were lower than those before treatment, and the study group was lower than the control group, and the differences were statistically significant (all P < 0.05); BSD at pressure status after treatment was higher than that before treatment, and the study group was higher than the control group, and the differences were statistically significant (all P < 0.05). After treatment, The urinary incontinence questionnaire brief table score, 3 cm distance from the midline of the anterior vaginal wall to the margin of the hymen, the farthest end of the apex of the vagina after a cervix or hysterectomy and visual analogue scale score of the two groups were lower than those before treatment, and the study group was lower than the control group, and the differences were statistically significant (all P < 0.05). Conclusion The clinical effect of electrical biofeedback method on postpartum PFD is significant, which can improve the quality of postpartum life.
2021 Vol. 18 (12): 123-127 [Abstract] ( 158 ) HTML (1 KB)  PDF (603 KB)  ( 80 )
127 Effect and safety of Longdan Xiegan Decoction in the treatment of female genital tract Ureaplasma urealyticum infection
CHEN Lei MA Chong
Objective To explore the effect and safety of Longdan Xiegan Decoction in the treatment of female genital tract Ureaplasma ureaplasma infection. Methods A total of 110 female patients with Ureaplasma urealyticum infection admitted to Shandong Provincial Third Hospital from April 2018 to April 2020 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 55 cases in each group. Control group was treated with Doxycycline, and observation group was treated with Longdan Xiegan Decoction on the basis of control group. The clinical efficacy, Ureaplasma urealyticum conversion rate, traditional Chinese medicine syndrome score, adverse reactions and the total recurrence rate of 3 months follow-up were compared between two groups. Results The total clinical efficacy rate and Ureaplasma urealyticum conversion rate of observation group were higher than those of control group，and the differences were statistically significant (all P < 0.05). The scores of traditional Chinese medicine syndrome in two groups after treatment were lower than those before treatment，and observation group was lower than control group, and the differences were statistically significant (all P < 0.05). The total incidence of adverse reactions and the total recurrence rate of 3 months follow-up in observation group were lower than those in control group, and the differences were statistically significant (all P < 0.05). Conclusion Longdan Xiegan Decoction can improve the clinical efficacy of female genital tract Ureaplasma urealyticum infection without increasing adverse reactions, and reduce the recurrence rate during follow-up.
2021 Vol. 18 (12): 127-130 [Abstract] ( 172 ) HTML (1 KB)  PDF (572 KB)  ( 111 )
131 Compliance and influencing factors analysis of nebulizer therapy in asthma children with acute stage
DU Jing LIANG Juan▲
Objective To analyze the related factors affecting compliance of nebulizer therapy in asthma children with acute stage. Methods A total of 100 asthma children with acute stage who received nebulizer therapy in the First Affiliated Hospital of  the Chinese People’s Liberation Army Air Force Military Medical University (Xijing Hospital) from January 2018 to January 2019 were retrospectively analyzed. All children were assessed with medication adherence report scale for ssthma (MARS-A), and univariate and multivariate were used to identify the influencing factors for poor atomization compliance in asthma children with acute stage. Results There were 74 cases (74.00%) had poor compliance with nebulizer therapy. There were statistically significant differences between two groups in the degree of understanding of nebulizer therapy related knowledge, psychological state of children, nebulization method, type of nebulization drugs, and parents’ distrust of medical personnel between two groups(all P < 0.05). Poor understanding of nebulization knowledge by parents, poor psychological state of children, air pressure nebulization, use of glucocorticoids, and parents’ distrust of medical personnel were the influencing factors of poor nebulization compliance in asthma children with acute stage (OR > 1, P < 0.05). Conclusion Some asthma children with acute stage have poor compliance with nebulizer therapy, which may be affected by the poor understanding of nebulizer therapy related knowledge by parents, poor psychological state of children, air pressure nebulization and other factors. Clinical attention should be paid to the early assessment of asthma children with acute stage, and reasonable intervention should be carried out according to risk factors.
2021 Vol. 18 (12): 131-134 [Abstract] ( 182 ) HTML (1 KB)  PDF (600 KB)  ( 46 )
135 Influencing factors of patient-ventilator asynchrony in children with mechanical ventilation in PICU
QIAO Pingping ZHU Liping YANG Shaohua
Objective To observe the occurrence of patient-ventilator asynchrony in children with mechanical ventilation in pediatric intensive care unit (PICU), and to analyze the influencing factors of patient-ventilator asynchrony. Methods A total of 84 children with mechanical ventilation treated in PICU of Fuyang People’s Hospital from January 2018 to May 2020 were selected as study objects. Univariate and multivariate analyses were used to identify the influencing factors of patient-ventilator asynchrony in children with mechanical ventilation in PICU. Results Twenty children had patient-ventilator asynchrony, and the incidence rate was 23.81% (20/84). There were statistically significant differences in the amount of airway secretions, the incidence of airway spasm, ventilator-related causes, crying and noisy, and improper position of tracheal intubation between two groups (all P < 0.05). Airway spasm, ventilator-related causes, crying and noisy, improper position of tracheal intubation and excessive airway secretion were the influencing factors of patient-ventilator asynchrony in children with mechanical ventilation in PICU (OR > 1, P < 0.05). Conclusion The presence of airway spasm and ventilator-related causes in children with mechanical ventilation in PICU may increase the risk of patient-ventilator asynchrony. Clinical attention should be paid to early preventive intervention in children with mechanical ventilation in PICU with the above risk factors, which may have positive significance in reducing the occurrence of patient-ventilator asynchrony.
2021 Vol. 18 (12): 135-137,141 [Abstract] ( 195 ) HTML (1 KB)  PDF (905 KB)  ( 41 )
138 Effect of surgical excision combined with limbal stem cell transplantation in the treatment of pterygium and its effect on tear film and visual function
LI Shan PEI Bei SUN Ali JIANG Maohua
Objective To investigate the effect of surgical excision combined with limbal stem cell transplantation in the treatment of pterygium and its effect on tear film and visual function. Methods A total of 64 patients with pterygium treated in the Department of Ophthalmology, Wuhu Second People’s Hospital, Anhui Province from June 2017 to April 2020 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 32 cases in each group. The control group was treated with surgical excision, and the observation group was treated with surgical excision combined with limbal stem cell transplantation. Clinical efficacy, breakup time of tear film (BUT), schirmer I test (SIT), naked eye vision, corneal horizontal curvature, corneal vertical curvature and astigmatism were compared between the two groups. Results The total effective rate of observation group was higher than control group, and the difference was statistically significant (P ＜ 0.05). After treatment, BUT, SIT, naked eye vision, corneal horizontal curvature and corneal vertical curvature in the observation group were higher than those in the control group, while astigmatism was lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). Conclusion Surgical excision combined with limbal stem cell transplantation is effective in the treatment of pterygium and can improve tear film and visual function.
2021 Vol. 18 (12): 138-141 [Abstract] ( 103 ) HTML (1 KB)  PDF (502 KB)  ( 98 )
142 Effect of Qianli Fumigation Decoction in the treatment of lipid deficiency dry eye combined with obstructive meibomian gland dysfunction
LI Dong1 YI Qiong1 WEI Qiping2 ZHU Chengyi1
Objective To evaluate the clinical effect of Qianli Fumigation Decoction in the treatment of lipid deficiency dry eye combined with obstructive meibomian gland dysfunction (OMGD). Methods A total of 150 patients diagnosed as mild to moderate lipid deficiency dry eye combined with mild to moderate OMGD in Beijing Hepingli Hospital from April to November 2019 were selected and they were divided into control group and treatment group by random number table method, with 75 cases in each group. Both groups were treated with Pralprofen Eye Drops, Sodium Hyaluronate Eye Drops and meibomian gland massage. At the same time, the control group was treated with distilled water fumigation, and the treatment group was treated with Qianli Fumigation Decoction fumigation. One treatment course was once a week in both groups, and there were four courses in total. After four weeks, the clinical efficacy and changes of ocular surface disease index (OSDI) scale score, non-invasive first breakup time of tear film (NIBUTf), non-invasive average breakup time of tear film (NIBUTav), tear meniscus hight (TMH), meibomian gland score, eye red analysis and fluorescein stain score (FSS) of the two groups were observed and analyzed. Results During the study period, two patients in both groups dropped out, 146 patients were finally completed the study. Before treatment, there were no significant differences in OSDI scale score, NIBUTf, NIBUTav, TMH, meibomian gland score, eye red analysis and FSS between the two groups (P ＞ 0.05). After treatment, the clinical efficacy of the treatment group was better than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, OSDI scale score, meibomian gland score, eye red analysis and FSS in both groups were significantly lower than those before treatment, and the treatment group was lower than the control group, the differences were statistically significant (all P ＜ 0.05). NIBUTf, NIBUTav and TMH in both groups were significantly increased compared with before treatment, and the treatment group was significantly higher than the control group, the differences were statistically significant (all P ＜ 0.05). Conclusion Qianli Fumigation Decoction can effectively relieve the dry eye symptoms of patients with mild to moderate lipid deficiency dry eye combined with mild to moderate OMGD, restore the function of meibomian gland, improve the microenvironment of eye surface, and restore the tear film steady state.
2021 Vol. 18 (12): 142-145,158 [Abstract] ( 160 ) HTML (1 KB)  PDF (811 KB)  ( 72 )
146 Clinical effect of acupuncture on primary open-angle glaucoma
LI Ruiling1 YU Ying2 LI Yijing3 LU Xinling1
Objective To observe the clinical effect of acupuncture on primary open-angle glaucoma (POAG). Methods A total of 40 cases (69 eyes) of POAG patients were selected from the Department of Ophthalmology and Acupuncture, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2019 to May 2020. According to the random number table method, they were divided into control group (20 cases, 34 eyes) and acupuncture group (20 cases, 35 eyes). The control group was treated with Prostaglandin Eye Drops and Micoraphenol routine treatment. Acupuncture group was combined with acupuncture treatment on the basis of Prostaglandin Eye Drops and Micoraphenol routine treatment. Bilateral hégǔ (LI4), jīngmíng (BL1) and qiúhòu (EX-HN07) of patients were collected. Acupuncture was performed three times a week for 12 consecutive times as a course of treatment. The improvement of visual acuity, intraocular pressure, visual field and quality of life in the two groups before and after treatment were observed. Results Before treatment, there were no significant differences in intraocular pressure and visual acuity between the two groups (P ＞ 0.05). After treatment, intraocular pressure in both groups was decreased compared with before treatment, the difference was statistically significant (P ＜ 0.05). There was no significant difference in intraocular pressure between the two groups (P ＞ 0.05). There were no significant differences in visual acuity and visual field between the two groups before and after treatment (P ＞ 0.05). Before treatment, there was no significant difference in glaucoma quality of life (GQL-15) scores between the two groups (P ＞ 0.05). After treatment, GQL-15 scores in both groups were lower than before treatment, and the acupuncture group was lower than the control group, the differences were statistically significant (all P ＜ 0.05). The total effective rate of acupuncture group was higher than that of acupuncture group, and the difference was statistically significant (P ＜ 0.05). Conclusion Acupuncture at specific acupoints can effectively improve POAG induced intraocular pressure and patients’ self-symptoms in the life scale, but the improvement of visual acuity and visual field is not obvious, there is a trend of improvement, which may be related to the treatment course and the sample size.
2021 Vol. 18 (12): 146-149 [Abstract] ( 168 ) HTML (1 KB)  PDF (506 KB)  ( 107 )
150 Literature analysis on severe adverse drug reactions of digestive system by Erlotinib
ZHOU Ran FANG Yuting SU Dan LI Min SHEN Aizong
Objective To explore the occurrence and clinical characteristics of serious adverse drug reactions (ADRs) of the digestive system caused by Erlotinib, and to provide references for clinical rational use of drugs. Methods The literature on ADRs of the digestive system caused by Erlotinib contained in the Chinese national knowledge infrastructure (CNKI), VIP, PubMed, Medline, and Web of Science from the establishment of the database to January 2020 were searched, while they were performed statistical analysis. Results There were 25 cases of severe ADRs in the digestive system caused by Erlotinib; the age distribution was 51 to 80 years old (20 cases, 80%); most of them occur within 8 weeks after medication (19 cases, 76%); it was more common with gastrointestinal perforation (24%), drug-induced liver injury (52%), and new serious ADRs such as reflex reminiscence gastritis. Conclusion Clinicians and pharmacists need to strengthen their understanding and monitoring of severe ADRs in the digestive system caused by Erlotinib, and carefully evaluate the treatment risks of re-dose to ensure safe and effective clinical use.
2021 Vol. 18 (12): 150-153 [Abstract] ( 161 ) HTML (1 KB)  PDF (452 KB)  ( 32 )
154 Efficacy of probiotics in the treatment of Helicobacter pylori positive gastric ulcer and its effect on intestinal flora distribution and serum inflammatory factors
WANG Huixia ZHANG Caifeng ZHANG Chaoqun JI Juanjuan HAN Yu
Objective To explore the effect of probiotics on the distribution of intestinal flora and serum inflammatory factors in patients with Helicobacter pylori (Hp) positive gastric ulcer. Methods A total of 170 patients with Hp positive gastric ulcer admitted to the First Affiliated Hospital of Xinxiang Medical College from May 2016 to October 2019 were selected and divided into observation group (85 cases) and control group (85 cases) according to the random number table method. The control group was given quadruple therapy, and the observation group was treated with Bifidobacterium and Lactobacillus triple live bacteria tablets on the basis of the control group. The clinical efficacy, Hp eradication rate, intestinal flora distribution, serum C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA) levels before and after treatment and the incidence of adverse reactions were compared between the two groups. Results The clinical effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). The eradication rate of Hp in the observation group was significantly higher than that in the control group (P ＜ 0.05). Four weeks after completion of treatment, the intestinal Bifidobacterium and Lactobacillus in the observation group were significantly higher than those in the control group (P ＜ 0.05). Four weeks after completion of treatment, the levels of serum CRP and SAA in the two groups were lower than those before treatment, and those in the observation group were significantly lower than those in the control group (P ＜ 0.05). There was no significant difference in the serum PCT of the two groups (P ＞ 0.05). There was no significant difference in incidence of adverse reaction between two groups (P ＞ 0.05). Conclusion Probiotics combined with quadruple therapy can improve the curative effect of Hp positive gastric ulcer patients, and its mechanism may be related to the regulation of intestinal flora and reduction of inflammatory reaction.
2021 Vol. 18 (12): 154-158 [Abstract] ( 209 ) HTML (1 KB)  PDF (505 KB)  ( 66 )
159 Effcet of the combination of Chinese and Western medicine in the treatment of the static psoriasis of blood stasis type
CAO Yongping SHAN Yunyun▲
 Objective To explore the effect of psoriasis No.2 and Chinese medicine medicated bath combined with narrow-band ultra violet B irradiation on the static psoriasis of blood stasis type. Methods A total of 100 patients with the static psoriasis of blood stasis type were selected at the Hangzhou Third People’s Hospital from January 2019 and January 2020, they were divided into control group and observation group according to random number table method, with 50 patients in each group. Both of them were received Mei-neng and Vitamin E Urethra Cream. The control group were treated with narrow-band ultra violet B irradiation, and the observation group were treated with psoriasis No.2 and Chinese medicine medicated on the basis of the treatment method of the control group, the treatment time was two weeks, and psoriasis area and severity index (PASI) scores, itching levels were compared before and after treatment. Results There were no significant differences in PASI score and pruritus score between the two groups before treatment (P ＞ 0.05). After treatment, PASI scores and itching scores of the two groups were lower than those before treatment, and the observation group was lower than that of the control group, with statistical significance (P ＜ 0.05). Conclusion The treatment of the static psoriasis of blood stasis type with psoriasis No.2 and Chinese medicine medicated bath combined with narrow-band ultra violet B can improve the symptoms and the therapeutic effect．
2021 Vol. 18 (12): 159-161,181 [Abstract] ( 106 ) HTML (1 KB)  PDF (799 KB)  ( 56 )
162 Thought of Professor Liu Jianhua in treating Ménière’s disease based on syndrome differentiation
ZHU Yajing LIU Jianhua YAN Zhanfeng JIAO Lulu LIU Siming LIU Lili ZHANG Linjing WANG Xin
Ménière’s disease is a common clinical disease of the inner ear. Because of its vertigo, it is easy to relapse, which leads to hearing loss and seriously affects life and work of people. Professor Liu Jianhua believes that the etiology and pathogenesis of this disease is often due to deficiency of liver, spleen and kidney, with endogenous wind, fire and phlegm drink, so as to blind the orifices and cause dizziness. Professor Liu Jianhua advocates the staging treatment. At the acute stage, the treating principle focuses on eliminating wind, fire and phlegm, while also pays attention to strengthening spleen and dispersing stagnated liver qi liver. At the chronic stage, the treating principle is to invigorate spleen to reduce watery phlegm, and nourishing liver and kidney as the key. It is the good use of paired herbal medicines to enhance the efficacy and simplify the formulas in clinical treatment. This paper summarizes Professor Liu Jianhua’s experience in the long-term treatment of Ménière’s disease based on syndrome differentiation, and expounds the typical clinical cases in order to provide reference for the treatment of Ménière’s disease by traditional Chinese medicine.
2021 Vol. 18 (12): 162-165 [Abstract] ( 129 ) HTML (1 KB)  PDF (684 KB)  ( 73 )
166 Effect of Yizhi Anshen Decoction combined with Yinxingye Tablets in the treatment of vascular dementia
SUN Fengqin HUANG Wei
Objective To explore the effect of Yizhi Anshen Decoction combined with Yinxingye Tablets in the treatment of vascular dementia (VD). Methods Ninety patients with VD admitted to the Third People’s Hospital of Yun’nan Province from May 2017 to December 2019 were selected and divided into control group and experimental group according to random number table method, 45 cases in each group. Control group was treated with Yinxingye Tablets, and experimental group was treated with Yizhi Anshen Decoction combined with Yinxingye Tablets. The course of treatment was three months. Clinical efficacy, MMSE score, NIHSS score, serological indexes and adverse reactions were compared between two groups. Results Total effective rate of experimental group was significantly higher than that of control group (P < 0.05). After treatment, MMSE scores of two groups were higher than those before treatment, and experimental group was higher than that control group, NIHSS scores of two groups were lower than those before treatment, and experimental group was lower than that control group, the differences were statistically significant (P < 0.05). After treatment, the serum BDNF levels of two groups were higher than those before treatment, and experimental group was higher than that control group, the serum neuron specific enolase and homocysteine levels of two groups were lower than those before treatment, and experimental group was lower than that control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Yizhi Anshen Decoction combined with Yinxingye Tablets can improve the treatment efficiency of VD patients, improve neurological symptoms, reduce nerve cell damage, which has high safety.
2021 Vol. 18 (12): 166-169 [Abstract] ( 107 ) HTML (1 KB)  PDF (685 KB)  ( 116 )
170 Clinical study of long needle stabbing nèiguān combined with oral Shensong Yangxin Capsules in the treatment of ventricular arrhythmias
MENG Hongmei1 LIU Haiyong2 ZHANG Yingna3 SHEN Hongyu4 ZHOU Yilin4 ZHOU Guofang5
Objective To investigate the effect of long needle stabbing nèiguān combined with oral Shensong Yangxin Capsules in the treatment of ventricular arrhythmia. Methods Ninety patients with ventricular arrhythmia treated in Department of Traditional Chinese Medicine in Sanhe Hospital of Hebei Province from September 2019 to September 2020 were selected as the research objects and divided into treatment group (45 cases) and control group (45 cases) according to random number table method. Treatment group was treated with long needle stabbing nèiguān combined with oral Shensong Yangxin Capsules, and control group was treated with oral Shensong Yangxin Capsules. QRS duration, standard deviation of all normal sinus intervals (SDNN), root mean square difference of adjacent sinus intervals (RMSSD), standard deviation of mean sinus intervals every five minutes (SDANN) and clinical efficacy were compared between two groups. Results After treatment, QRS duration of treatment group was longer than that before treatment and that of control group (P < 0.05). After treatment, SDNN, RMSSD and SDANN of two groups were longer than those before treatment, and treatment group was longer than that of control group, the differences were statistically significant (P < 0.05). Total effective rate of treatment group was higher than that of control group (P < 0.05). Conclusion The effect of long needle stabbing nèiguān combined with oral Shensong Yangxin Capsules in the treatment of ventricular arrhythmia is more obvious than that of single drug treatment, and the method is more diverse, which provides a new choice for clinical treatment of ventricular arrhythmia.
2021 Vol. 18 (12): 170-173 [Abstract] ( 172 ) HTML (1 KB)  PDF (714 KB)  ( 130 )
174 Analysis on medication rules of traditional Chinese medicine in treating diabetic neurogenic bladder based on data mining
LIU Zhaowen YAO Yu YU Huilan MA Ru SONG Shuqi
Objective To analyze the medication rules of traditional Chinese medicine in treating diabetic neurogenic bladder based on data mining. Methods All relevant prescriptions were searched on CNKI, Wanfang, VIP, SinoMed from the databases establishment to March 2020, those met the criteria were transferred to the traditional Chinese medicine inheritance support platform (V2.5). The frequency of drug use, four qi and five flavor, meridian tropism were statistically analyzed. Results A total of 226 prescriptions were screened out. The tastes of the medicine were mainly sweet, bitter and pungent, and the properties of the medicine were mostly warm and cold, followed by mild. Kidney and bladder was the first in zang and fu about meridian tropism respectively. Milkvetch root, Indian bread and Oriental waterplantain rhizome were the most frequently used. Five new prescriptions were obtained by association rules and cluster analysis. Conclusion This disease is located in the bladder, and is closely related to the kidney. The treatment should focus on the recovery of bladder gasification. The core of the prescriptions is Jingui Shenqi Pills or Wuling Powder.
2021 Vol. 18 (12): 174-177 [Abstract] ( 102 ) HTML (1 KB)  PDF (909 KB)  ( 102 )
178 Exploration and practice of application mechanism of traditional Chinese medicine emotional therapy in disabled elderly at home
LI Xiuqin OUYANG Jing JIA Lili BAI Simin
The problem of aging in China is becoming increasingly prominent. Among the elderly, disabled elderly also account for a certain proportion. The phenomenon of “physical and mental illness” of the disabled elderly at home is increasing day by day, which puts forward new challenges for the mental health and disease care of the elderly. According to the traditional Chinese medicine emotional therapy, emotional factors are not only the cause of disease, but also the important factors causing the pathogenesis and disease fluctuation. Therefore, active traditional Chinese medicine emotional therapy for disabled elderly can not only improve their mental health level, but also improve their body function and enhance their sense of life and happiness. In the clinical nursing practice of the disabled elderly at home, the family members of the disabled elderly, social workers and relevant health service institutions can work together to provide multi-party assistance for the disabled elderly in home-based care from the aspects of relieving mood, establishing self-confidence, making up each other’s emotions, being positive and optimistic, adjusting self-confidence, calming down and tapping advantages year.
2021 Vol. 18 (12): 178-181 [Abstract] ( 118 ) HTML (1 KB)  PDF (683 KB)  ( 89 )
182 Effect of Yinqi Guiyuan Moxibustion combined with air wave pressure in treating elderly patients with venous thromboembolism and its influence on coagulation factors
SU Shunmei LIN Qiaoli CHEN Liqin▲ CHEN Jiankun▲
Objective To explore the effect of Yinqi Guiyuan Moxibustion combined with air wave pressure in treating elderly patients with venous thromboembolism (VTE). Methods One hundred elderly patients with VTE hospitalized in Department of Geriatrics of Guangdong Provincial Hospital of Traditional Chinese Medicine from February 2018 to March 2020 were selected and divided into control group and observation group according to random number table method, with 50 cases in each group. Control group was given air wave pressure treatment and conventional treatment, while observation group was given Yinqi Guiyuan Moxibustion treatment on the basis of control group for 14 days. The incidence of deep venous thrombosis, femoral venous blood flow velocity, plasma D-dimer, fibrinogen, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and adverse symptoms were compared between two groups. Results After treatment, the incidence of deep venous thrombosis in observation group was lower than that in control group, and the difference was statistically significant (P < 0.05). After treatment, the blood flow velocity of deep femoral vein in two groups was faster than that before treatment, and observation group was faster than that of control group, the differences were statistically significant (P < 0.05). After treatment, the levels of D-dimer and fibrinogen in two groups were lower than those before treatment, and those in observation group were lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, PT, APTT and TT of two groups were longer than those before treatment, and observation group was longer than that of control group, the differences were statistically significant (P < 0.05). There was no significant difference in the positive symptoms of deep venous thrombosis between two groups (P > 0.05). Conclusion The effect of Yinqi Guiyuan Moxibustion combined with air wave pressure in treating elderly patients with VTE is significant, which can improve the venous blood flow velocity and blood stasis state, and significantly reduce the incidence of limb deep venous thrombosis in elderly medical inpatients.
2021 Vol. 18 (12): 182-185 [Abstract] ( 181 ) HTML (1 KB)  PDF (686 KB)  ( 63 )
186 The effect of Yiqi Huoxue Huatan Tongluo Decoction in the treatment of ischemic stroke
XING Liangfei ZHOU Hui MA Kuijun▲
Objective To study the effect of Yiqi Huoxue Huatan Tongluo Decoction in the treatment of ischemic stroke (meridians and collaterals). Methods One hundred and two patients with ischemic stroke (meridians and collaterals) admitted to Department of Encephalopathy of Bozhou Hospital of Traditional Chinese Medicine in Anhui Province from April 2018 to April 2020 were selected as research objects. They were divided into control group and observation group according to the random number table method, with 51 cases in each group. Control group was given conventional treatment, and observation group was treated with Yiqi Huoxue Huatan Tongluo Decoction on the basis of control group, they were treated for four weeks. Clinical efficacy, NIHSS score, Barthel index score, Chinese medicine syndrome score, serum high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), homocysteine (Hcy) levels and adverse reactions were compared between two groups. Results Total effective rate of observation group was higher than that of control group (P < 0.05). After treatment, NIHSS scores of two groups were lower than those before treatment, Barthel index scores of two groups were higher than those before treatment, and NIHSS score of observation group was lower than that of control group, Barthel index score of observation group was higher than that of control group, the differences were statistically significant (P < 0.05). After treatment, Chinese medicine syndrome scores of two groups were lower than those before treatment, and observation group was lower than that control group, the differences were statistically significant (P < 0.05). After treatment, the serum hs-CPR, IL-6, TNF-α and Hcy levels of two groups were lower than those before treatment, and observation group was lower than that control group, the differences were statistically significant (P < 0.05). Conclusion Yiqi Huoxue Huatan Tongluo Decoction is a significant effect in the treatment of ischemic stroke (meridians and collaterals), which is worthy of application and promotion.
2021 Vol. 18 (12): 186-189 [Abstract] ( 288 ) HTML (1 KB)  PDF (684 KB)  ( 70 )
190 Drug-induced thrombocytopenia induced by Fucididic Acid: a case report and literature review
XIAO Kun ZHANG Cuiling
Drug-induced thrombocytopenia (DITP) refers to a disease in which the platelet count is lower than the normal range (<100×109/L) caused by drugs, resulting in bleeding and other symptoms. A patient who the author accepted with pulmonary infection caused by methicillin resistant Staphylococcus aureus developed thrombocytopenia during the course of anti-infection treatment with conventional Fusidic Acid (FA), and was diagnosed as DITP. After treatment with discontinuance of medication and intensive monitoring, the platelet count returned to the reference range. The prognosis of this patient is good, but it is worth clinical reflection and experience summary: first of all, there have been many case reports on DITP caused by cephalosporins and Linezolid, but there are few reports on FA induced thrombocytopenia, and case reports are needed to improve clinical vigilance; secondly, both severe infection and antibiotics can cause thrombocytopenia, so it is necessary to discuss the causal relationship, judge and summarize the clinical features to make a good diagnosis and differential diagnosis; thirdly, the occurrence of DITP includes multiple mechanisms, and the treatment methods for DITP caused by different mechanisms are different, so it is necessary to analyze the mechanism of DITP caused by FA and explore its treatment plan. Therefore, this paper reports the diagnosis and treatment of one patient and reviews the relevant literature, introduces the diagnosis, clinical features, treatment, prognosis and pathogenesis of DITP caused by FA, in order to improve the awareness and vigilance of clinicians, so as to make early diagnosis, timely treatment and improve the prognosis.
2021 Vol. 18 (12): 190-192,196 [Abstract] ( 146 ) HTML (1 KB)  PDF (651 KB)  ( 63 )
193 Application research of minimally invasive surgical smart medical collaborative working platform from the perspective of integrated health care system
CHEN Mingzhuang WANG Zhuoyun LU Chao
Integrated health care system is an important mean and measure to guide the subsidence of superior medical resources and stimulate the vitality of primary medical institutions. But in the actual construction process, the medical information between medical institutions can not be effectively interconnected has become a prominent problem for the medical alliance to play a further role. This study taking minimally invasive surgery as a breakthrough point and combining the diagnosis and treatment procedures of minimally invasive surgery and the latest achievements of hospital informatization construction, this study explored the construction and application of the smart medical cooperation platform for minimally invasive surgery within medical consortium, with a view to promoting the subsidence of advantageous medical resources, promoting the sharing of medical information, and improving the ability of primary medical services.
2021 Vol. 18 (12): 193-196 [Abstract] ( 120 ) HTML (1 KB)  PDF (363 KB)  ( 85 )
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