|
|
|
| Drug-induced thrombocytopenia induced by Fucididic Acid: a case report and literature review |
| XIAO Kun ZHANG Cuiling |
| The Affiliated Brain Hospital of Guangzhou Medical University, Guangdong Province, Guangzhou 510000, China |
|
|
|
Abstract Drug-induced thrombocytopenia (DITP) refers to a disease in which the platelet count is lower than the normal range (<100×109/L) caused by drugs, resulting in bleeding and other symptoms. A patient who the author accepted with pulmonary infection caused by methicillin resistant Staphylococcus aureus developed thrombocytopenia during the course of anti-infection treatment with conventional Fusidic Acid (FA), and was diagnosed as DITP. After treatment with discontinuance of medication and intensive monitoring, the platelet count returned to the reference range. The prognosis of this patient is good, but it is worth clinical reflection and experience summary: first of all, there have been many case reports on DITP caused by cephalosporins and Linezolid, but there are few reports on FA induced thrombocytopenia, and case reports are needed to improve clinical vigilance; secondly, both severe infection and antibiotics can cause thrombocytopenia, so it is necessary to discuss the causal relationship, judge and summarize the clinical features to make a good diagnosis and differential diagnosis; thirdly, the occurrence of DITP includes multiple mechanisms, and the treatment methods for DITP caused by different mechanisms are different, so it is necessary to analyze the mechanism of DITP caused by FA and explore its treatment plan. Therefore, this paper reports the diagnosis and treatment of one patient and reviews the relevant literature, introduces the diagnosis, clinical features, treatment, prognosis and pathogenesis of DITP caused by FA, in order to improve the awareness and vigilance of clinicians, so as to make early diagnosis, timely treatment and improve the prognosis.
|
|
|
|
|
|
[1] George JN，Aster RH. Drug-induced thrombocytopenia：pathogenesis，evaluation，and management [J]. Hematology Am Soc Hematol Educ Program，2009：153-158.
[2] Danese E，Montagnana M，Favaloro EJ，et al. Drug-Induced Thrombocytopenia：Mechanisms and Laboratory Diagnostics [J]. Semin Thromb Hemost，2020，46（3）：264-274.
[3] 唐巧云，黄丽，罗圣平.等.264例药源性血小板减少症分析[J].中国药物应用与监测，2017，14（1）：41-44.
[4] American Thoracic Society，Infectious Diseases Society of America. Guidelines for the Management of Adults with Hospital-acquired，Ventilator-associated，and Healthcare-associated Pneumonia [J]. Am J Respir Crit Care Med，2005，171（4）：388-416.
[5] 李佳玲，王明贤，孙淑慧.Naranjo Score与WHO-UMC Causality Criteria用于药物不良反应评估之相关性分析[J].台湾临床药学杂志，2015，23（1）：51-57.
[6] Leibowitz GS，Golan D，Yeshurun D，et al. Leukopenia and thrombocytopenia due to fusidic acid [J]. Postgrad Med J [J]. 1991，67（788）：591-592.
[7] Br J Haematol. Fusidic acid induced acute immunologic thrombocytopenia [J]. Br J Haematol，1996，93：427-431.
[8] Liao YM，Chiu CF，Ho MW，et al. Fusidic acid-induced leukopenia and thrombocytopenia [J]. J Chin Med Assoc 2003，66（7）：429-432.
[9] He ZF，Chen L，Zhang JP，et al. Hepatotoxicity and hematologic complications induced by fusidic acid in a patient with hepatitis B cirrhosis：A case report [J]. Medicine（Baltimore），2019，98（45）：e17852.
[10] Liao YM，Chiu CF，Ho MW，et al. Fusidic acid-induced leukopenia and thrombocytopenia [J]. J Chin Med Assoc 2003，66（7）：429-432.
[10] 张民，李秀娟.夫西地酸钠致血小板减少1例分析[J].甘肃医药，2012，31（10）：800-801.
[11] 陈静静，钱佩佩，曹凯，等.我国药品不良反应关联性评价方法与诺氏评估量表法的对比与分析[J].中国药事，2020，34（8）：138-142.
[12] 杜文民，王永铭，程能能.药品不良反应的判定与其研究方法（续完）[J].中国药物警戒，2005，2（1）：11-13.
[13] 王攀，蔺亚东，武曲星，等.免疫性血小板减少症气不摄血证小鼠外周血小板活化功能的研究[J].中国比较医学杂志，2020，30（7）：45-50.
[14] 葛岩.大剂量地塞米松治疗小儿免疫性血小板减少症的临床效果[J].中国现代医生，2020，58（26）：105-107.
[15] Harker LA，Slichter SJ. The bleeding time as a screening test for evaluation of platelet function [J]. N Engl J Med，1972，287（4）：155-159. |
|
|
|
