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| Effect of Yizhi Anshen Decoction combined with Yinxingye Tablets in the treatment of vascular dementia |
| SUN Fengqin HUANG Wei |
| Department of Neurology, the Third People’s Hospital of Yun’nan Province, Yun’nan Province, Kunming 650011, China |
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Abstract Objective To explore the effect of Yizhi Anshen Decoction combined with Yinxingye Tablets in the treatment of vascular dementia (VD). Methods Ninety patients with VD admitted to the Third People’s Hospital of Yun’nan Province from May 2017 to December 2019 were selected and divided into control group and experimental group according to random number table method, 45 cases in each group. Control group was treated with Yinxingye Tablets, and experimental group was treated with Yizhi Anshen Decoction combined with Yinxingye Tablets. The course of treatment was three months. Clinical efficacy, MMSE score, NIHSS score, serological indexes and adverse reactions were compared between two groups. Results Total effective rate of experimental group was significantly higher than that of control group (P < 0.05). After treatment, MMSE scores of two groups were higher than those before treatment, and experimental group was higher than that control group, NIHSS scores of two groups were lower than those before treatment, and experimental group was lower than that control group, the differences were statistically significant (P < 0.05). After treatment, the serum BDNF levels of two groups were higher than those before treatment, and experimental group was higher than that control group, the serum neuron specific enolase and homocysteine levels of two groups were lower than those before treatment, and experimental group was lower than that control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Yizhi Anshen Decoction combined with Yinxingye Tablets can improve the treatment efficiency of VD patients, improve neurological symptoms, reduce nerve cell damage, which has high safety.
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