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| Research progress of inflammatory factors and their inhibitors on cerebral ischemia-reperfusion injury |
| REN Jingming TIAN Hongqi |
| Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin 300192, China |
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Abstract Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process and seriously endanger human health, in which inflammatory reaction is one of the important factors to induce CIRI. A large number of inflammatory factors effect neuronal apoptosis or necrosis, mediate microvascular dysfunction, and lead to cerebral hemorrhage or cerebral edema, causing irreversible damage to the body. Therefore, it is of great significance to seek effective prevention and treatment strategies for CIRI. This review introduces the physiological functions of inflammatory factors such as interleukin (IL)-1, tumor necrosis factor α and IL-6 in the process of CIRI, and lists the drugs and natural extracts related to inflammatory factors in recent years, so as to provide evidence for the clinical treatment of CIRI.
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