中国医药导报

关闭×

中国医药导报

Home

中文

中国医药导报

Forthcoming Articles

Advanced Search

Download Articles

Quick Search


2021 Vol. 18, No. 5 Published: 2021-02-15

	4	Regulation effect of leech on farnesol X receptor pathway in rat model of intrahepatic cholestasis
		LIU Yuqing1 CAI Xin1 QIN Renwu2 WANG Yao3 LUO Lei4 YANG Fan5
		Objective To study the regulatory effect of leech on farnesol X receptor (FXR) pathway in rat model of intrahepatic cholestasis. Methods Forty SPF male SD rats aged eight weeks were selected and divided into normal group, model group, ursodeoxycholic acid (UDCA) group, leech high-dose group and leech low-dose group according to random number table method, with eight rats in each group. The UDCA group was intragastrically administered with UDCA solution at a dose of 60 mg/kg, and the leech high-dose and low-dose groups were intragastrically administered with Leech Granules at a dose of 50 mg/kg and 20 mg/kg, once a day, for consecutive seven days，the normal group and the model group were given the same amount of normal saline. Except normal group, rats in other groups were given 100 mg/kg α-isothiocyanate (ANIT) on the fifth day of intragastric administration for model formation. Gastric administration for three days, once a day, the normal group was given the same amount of normal saline. Blood samples were collected from the abdominal aorta 24 h after the last administration, and serum levels of alanine aminotransferase (ALT), ascorbic aminotransferase (AST), total bilirubin (TBil) and total bile acid (TBA) were detected. Hepatic tissue was collected for microscopic examination by HE staining to observe the pathological conditions of the liver. The mRNA and protein expressions of FXR and its downstream small heterodimer chaperone receptor (SHP), uridine diphosphate glucuronide transfer 2B4 (UGT2B4) and bile salt output pump (BSEP) were detected by real-time fluorescence quantitative PCR and Western blot. Results The levels of ALT, AST and TBil in serum of leech high-dose group were lower than those in model group, with statistically significant differences (all P ＜ 0.05). There was no statistical significance in TBA level between leech high-dose group and model group (P ＞ 0.05). The levels of serum AST, TBA and TBil in leech low-dose group were lower than those in model group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in ALT level between leech low-dose group and model group (P ＞ 0.05). The serum AST level of UDCA group was lower than that of model group, and the difference was statistically significant (all P ＜ 0.05). There were no statistically significant differences in ALT, TBA and TBil levels between UDCA group and model group (P ＞ 0.05). Compared with model group, liver tissue damage of rats in leech high-dose and low-dose groups was alleviated. The mRNA expressions of FXR, BSEP, UGT2B4 and SHP in leech high-dose and low-dose groups and UDCA group were higher than those in model group, with statistically significant differences (all P ＜ 0.05). The protein expressions of FXR, BSEP, UGT2B4 and SHP in leech high-dose and low-dose groups were higher than those in model group, and the differences were statistically significant (all P ＜ 0.05). There was no statistically significant difference in protein levels between UDCA group and model group (P ＞ 0.05). Conclusion Leech can relieve intrahepatic cholestasis induced by ANIT and alleviate liver tissue damage. Leech can protect liver cells by upregulating FXR gene expression, promoting the upregulation of SHP, UGT2B4 and BSEP gene expression and inhibiting cholestasis pathway, thus providing effective drugs for clinical treatment of intrahepatic cholestasis.
		2021 Vol. 18 (5): 4-9 [Abstract] ( 116 ) HTML (1 KB) PDF (1219 KB) ( 14 )

	10	Effect of Irbesartan on blood pressure of spontaneously hypertensive rats and analysis of renal RAS gene expression
		CHEN Sisi1 XUE Xiaomin2 LI Yu2 ZHU Bing’er3 CHEN Lihao3 WU Yue3 WU Renzhao1
		Objective To explore the effect of Irbesartan on blood pressure of spontaneously hypertensive rats (SHR) and the influence on renal Renin-angiotensin system(RAS) related gene expression. Methods The SHR rats were randomly divided into model group (15 mg/[kg·d], drinking water), Irbesartan group (15 mg/[kg·d], Irbesartan), six rats in each group; another six Wistar rats were served as normal control group (15 mg/[kg·d], drinking water) and each group was administered for eight weeks. The blood pressure changes of rats at three hours and 24 h after administration of each week were measured by the non-invasive blood pressure meter; RT-qPCR was used to detect the expression of angiotensin converting enzyme 2 (ACE2), angiotensin Ⅱ receptor-1 (AT1R) and AT2R mRNA in kidney tissue. Results The systolic blood pressure (SBP) of the Irbesartan group and model group at three hours and 24 h after administration showed highly statistically significant difference (P ＜ 0.01). Among them, SBP in the Irbesartan group was lower than that in the model group at three hours and 24 h after administration at the first time, two, four, six and eight weeks, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The difference in diastolic blood pressure (DBP) between the Irbesartan group and model group at three hours and 24 h after administration was highly statistically significant (P ＜ 0.01). Among them, the DBP of the Irbesartan group was lower than that of the model group three hours after administration at the first time, while were lower than those of the model group at three hours and 24 h after administration at two, four, six, and eight, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Compared with the model group, the relative expression of ACE2 mRNA in the Irbesartan group was decreased, while the relative expression of AT2R mRNA was increased, and the differences were statistically significant (P ＜ 0.05). Conclusion Irbesartan has a significant effect on lowering blood pressure. After Irbesartan reduces blood pressure, the body produces a protective effect of blood pressure regulation, so that the expression of ACE2 is reduced. Moreover, AT1R and AT2R have a functional interaction in blood pressure regulation. Blocking AT1R reduces blood pressure, and may lead to the stimulating and elevating effect of opposite AT2R.
		2021 Vol. 18 (5): 10-13 [Abstract] ( 269 ) HTML (1 KB) PDF (596 KB) ( 106 )

	14	Effect of SCH23390 on Morphine withdrawal response and synaptophysin expression
		TANG Shan ZHOU Shengquan LIU Qiaofeng▲
		Objective To study the effect of dopamine D1 receptor antagonist SCH23390 on Morphine withdrawal response and synaptophysin (SYN) expression. Methods According to the random number table method, 40 rats were divided into control group, Morphine group, SCH23390 group and SKF38393 group, with 10 rats in each group. Rats in Morphine group, SCH23390 group and SKF38393 group were injected with Morphine in increasing doses for 5 days to establish Morphine-exposure animal models. Rats in SCH23390 group and SKF38393 group were injected with 0.5 μL 10 mmol/L SCH23390 or 0.5 μL 5 mmol/L SKF38393 into the midbrain periaqueductal gray 15 min before intraperitoneal Morphine injections on the mornings of days 1-4. On the 5th day, all rats were injected with Naloxone to observe withdrawal response, and SYN level was detected by immunohistochemistry and Western blotting. Results Withdrawal response total score and scores of tooth tremor, diarrhea, abnormal posture, squinting and wet dog shaking in Morphine group were higher than those in control group, and the differences were statistically significant (P < 0.05 or P < 0.01). Withdrawal response total scores and scores of tooth tremor and diarrhea in SCH23390 group were lower than those in Morphine group, and the differences were highly statistically significant (P < 0.01). There was no significant difference in withdrawal response total scores and scores of tooth tremor, diarrhea, squinting and wet dog shaking between SKF38393 group and Morphine group (P > 0.05); while score of abnormal posture of SKF38393 group was higher than that of Morphine group, and the difference was statistically significant (P < 0.05). The expression level of SYN protein in Morphine group was higher than that in control group, and the difference was highly statistically significant (P < 0.01). The expression level of SYN protein in SCH23390 group was lower than that in Morphine group, and the difference was statistically significant (P < 0.05). The expression level of SYN protein in SKF38393 group was higher than that in Morphine group, and the difference was statistically significant (P < 0.05). The number of SYN positive neurons in Morphine group was higher than that in control group, and the difference was highly statistically significant (P < 0.01). The number of SYN positive neurons in SCH23390 group was lower than that in Morphine group, and the difference was statistically significant (P < 0.05). The number of SYN positive neurons in SKF38393 group was higher than that in Morphine group, and the difference was statistically significant (P < 0.05). Conclusion SCH23390 reduces the Morphine withdrawal response, possibly by downregulating SYN.
		2021 Vol. 18 (5): 14-17 [Abstract] ( 177 ) HTML (1 KB) PDF (685 KB) ( 28 )

	18	Correlation between EMX1, miR-124a-3, NKX6-1 methylation and gastric cancer precancerous diseases
		SUN Liangxu1,2 PENG Lijun2▲ GUO Anbing2 ZHANG Yanqing2 LU Lin2 JI Buxi2
		Objective To investigate the correlation between EMX1, miR-124a-3, NKX6-1 methylation and gastric cancer precancerous diseases. Methods From June 2015 to February 2020, 192 patients who underwent gastroscopy with pathological examination at Endoscopy Center of Linyi People’s Hospital of Shandong Province were selected as study objects. They were divided into chronic non-atrophic gastritis group (95 cases), chronic atrophic gastritis group (86 cases), and gastric cancer group (11 cases) according to the development model of gastric cancer (Correa cascade); according to different degrees of chronic gastritis atrophy (pathology), they were divided into low atrophy group (104 cases) and high atrophy group (77 cases); according to the degree of intestinal metaplasia of chronic atrophic gastritis, they were divided into low intestinal metaplasia group (31 cases) and high intestinal metaplasia group (55 cases); according to the Kimura-Takemoto classification of chronic atrophic gastritis under endoscopy, They were divided into low atrophy group (24 cases), moderate atrophy group (48 cases), and high atrophy group (14 cases). The methylation levels at different sites of EMX1, miR-124A-3 and NKX6-1 genes in each group were compared. Results The methylation levels of EMX1 gene (72920455, 72920466 and 72920469) and miR-124a-3 gene (63178433, 63178444 and 63178452) sites in chronic atrophic gastritis group were higher than those in chronic non-atrophic gastritis group, and the differences were all statistically significant (all P < 0.05). The methylation levels of NKX6-1 gene (84496988, 84496933, 84496882, 84496840) sites in gastric cancer group were lower than those in chronic non-atrophic gastritis group and chronic atrophic gastritis group; the methylation levels of NKX6-1 gene (84496988, 84496933 and 84496882, 84496840) sites in chronic atrophic gastritis group were higher than those in chronic non-atrophic gastritis group, and the differences were all statistically significant (all P < 0.05). The methylation levels of EMX1 gene (72920466, 72920469 and 72920484), miR-124a-3 gene (63178433, 63178452 and 63178485) and NKX6-1 gene (84497016, 84496979, 84496975) sites in high atrophy group were higher than those in low atrophy group, and the differences were all statistically significant (all P < 0.05). The methylation levels of EMX1 gene (72920455, 72920466 and 72920469), miR-124a-3 gene (63178334, 63178377 and 63178433) and NKX6-1 gene (84497016, 84496979 and 84496975) sites in high intestinal metaplasia group were higher than those in low intestinal metaplasia group, and the differences were all statistically significant (all P < 0.05). The methylation levels of EMX1 gene (72920581, 72920627 and 72920639) sites in high atrophy group were higher than those in low atrophy group and moderate atrophy group, and the differences were all statistically significant (all P < 0.05); the methylation levels of miR-124a-3 gene (63178345, 63178383 and 63178444) and NKX6-1 gene (84496965, 84496893 and 84496884) sites in high atrophy group were higher than those in low atrophy group, and the differences were all statistically significant (all P < 0.05). Conclusion Methylation of EMX1, miR-124a-3 and NKX6-1 genes may play an important role in the development of precancerous atrophy and intestinal metaplasia of gastric cancer. However, its specific mechanism remains to be further explored.
		2021 Vol. 18 (5): 18-22 [Abstract] ( 348 ) HTML (1 KB) PDF (643 KB) ( 99 )

	23	Correlation analysis of coronary artery stenosis degree and depression mood in patients with coronary heart disease
		WANG Can1 LUO Qiuhu1 QIN Chunyu1 LI Gaoye2 CHEN Wuxian2
		Objective To investigate the correlation between the degree of coronary artery stenosis and depression mood in patients with coronary heart disease. Methods A total of 223 patients with coronary heart disease treated in the First Affiliated Hospital of Guangxi Medical University from April to December 2019 were selected as the research subjects. According to the self-rating depression scale (SDS) score, they were divided into non-depressed group (162 cases, SDS index ＜ 50 points) and depressed group (61 cases, SDS index ≥ 50 points). The depressive group was divided into mild depression group (49 cases, 50 points≤SDS index ＜ 60 points) and moderate and severe depression group (12 cases, SDS index ≥ 60 points). According to the results of coronary angiography, the degree of coronary artery stenosis was evaluated by Gensini score. Multivariate logistic regression was used to analyze the relationship between the degree of coronary artery stenosis and depression. Results The proportion of female, single, type D personality in patients and age, Pittsburgh sleep quality index (PSQI) score, Gensini score, coefficient variation of red blood cell distribution width (RDW-CV) level in the depressed group were higher than those in the non-depressed group, red blood cell count and hemoglobin levels were lower than those in the non-depressed group, with statistically significant differences (all P ＜ 0.05). The levels of body mass index, PSQI score and RDW-CV level in moderate and severe depression group were higher than those in mild depression group, with statistically significant differences (all P ＜ 0.05). Binary logistic regression analysis was conducted with the occurrence of depression as the dependent variable, and the results showed that: single (OR = 5.31, 95%CI [1.54-18.35]), type D personality (OR = 5.67, 95%CI [2.42-13.29]), PSQI score (OR = 1.40, 95%CI [1.24-1.58]), RDW-CV(OR = 2.07, 95%CI [1.30-3.32]) and Gensini score were independent influencing factors for the occurrence of depression (all P < 0.05), in which the risk of depression increased by 13% for every 10 points increase in Gensini score (95%CI: 1.02-1.25, P = 0.019). Ordered multi-classification logistic regression analysis was conducted with nil，mild，moderate to severe depression as dependent variables, and the results showed that: single (OR = 5.07, 95%CI [1.65-15.57]), type D personality (OR = 5.04, 95% CI [2.25-11.31]), PSQI score (OR = 1.46, 95%CI [1.30-1.63]), RDW-CV(OR = 2.55, 95%CI [1.64-3.95]) and Gensini score were independent influencing factors for the occurrence of depression (all P < 0.05), in which the risk of depression increased by 12% for every 10 points increase in Gensini score (95%CI：1.02-1.23，P = 0.020). Conclusion Patients with coronary heart disease with more severe coronary artery lesions are more likely to be accompanied by depression, so mental health assessment should be carried out in time for this part of the population.
		2021 Vol. 18 (5): 23-27,32 [Abstract] ( 360 ) HTML (1 KB) PDF (679 KB) ( 60 )

	28	Associations between triple-negative breast cancer gene copy number variation and clinicopathological characteristic on the prognosis of patients
		LI Yuxiang FENG Jinchun WU Tao Aziguli·Abudureheman YU Luyue ZHU Liping
		Objective To understand the gene copy number variation (CNV) in triple-negative breast cancer tissues and adjacent tissues, and to explore the relationship between CNV and the clinicopathological characteristics and prognosis of patients with triple-negative breast cancer. Methods From January 2014 to January 2016, the cancer tissue and adjacent tissue or 86 patients with triple-negative breast cancer who underwent surgery in the Tumor Hospital Affiliated to Xinjiang Medical University were collected. The whole exome high-throughput parallel sequencing technology was used to detect the condition of CNV in the samples, while clinical pathological data were combined and follow-up was recorded for comprehensive analysis. Results As of January 2020, after five years of follow-up, the recurrence rate was 34.88%. The difference of CNV in cancer tissues in 86 pairs of samples was significantly higher than that in adjacent tissues, and the difference was highly statistically significant (P ＜ 0.01). Chromosome 8 had the most frequent CNV amplification, and chromosome 17 had the most frequent CNV loss and heterozygous regions; the five-year survival rate of CNV patients on chromosomes 8 and 17 were lower than those of patients without CNV, and the differences were statistically significant (P ＜ 0.05). Age, primary tumor size, lymph node metastasis and CNV status were linearly correlated (r = -0.87, 0.92, 0.94, P ＜ 0.05); TNM staging was positively correlated with CNV status (r = 0.83, P ＜ 0.05). Cox multivariate regression analysis showed that CNV status and TNM staging were independent factors affecting the prognosis of patients with triple-negative breast cancer (HR = 0.456, 1.927, P ＜ 0.05). Conclusion The difference of CNV in cancer tissue and adjacent tissues of TNBC patients is related to age, primary tumor size, lymph node metastasis and TNM stage. In addition, CNV status and TNM staging affect the prognosis of patients.
		2021 Vol. 18 (5): 28-32 [Abstract] ( 403 ) HTML (1 KB) PDF (739 KB) ( 94 )

	33	Research progress on the interaction between atopic dermatitis and neuropsychiatric factors
		LIN Wei1 ZHOU Qiongyan2 HUANG Jing1 ZHAO Keyu2,3 XU Suling2
		Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like rash, dry skin, and severe itching. AD can affect the mental health of patients. In severe cases, emotional abnormalities such as anxiety and depression can occur, and even suicide. Long-term mental stress or anxiety, depression and other neurological diseases may also induce or aggravate AD. This article reviews AD-related psychiatric symptoms and the influence of neuropsychiatric diseases on AD, and discusses the possible mechanisms of the interaction between the them. A vicious circle may be formed between AD and neuropsychiatric factors. Therefore, doctors should pay attention to the screening of neuropsychiatric diseases and intervene in time during the diagnosis and treatment of AD.
		2021 Vol. 18 (5): 33-36 [Abstract] ( 239 ) HTML (1 KB) PDF (407 KB) ( 35 )

	37	Progress in diagnosis and treatment of the third space of digestive tract
		CHEN Siwei LI Yingchao
		The third space of the digestive tract refers to the space in the wall of the digestive tract, which can be exposed only after endoscopic dissection and dissection, and interstitial tissue and interstitial fluid exist in it. The diagnosis and treatment technology of the third space is a minimally invasive technology developed on the basis of the endoscopy. The third space has important implications for some digestive system diseases diagnosis, such as gastrointestinal submucosal lesion biopsy, interstitial fluid detection, etc. At the same time, the third space also has the therapeutic value of diseases, such as endoscopic surgery, laparoscopic endoscopic cooperative surgery, micro-device and drug pump implantation, digestive tract micro-plastic surgery, etc. This article reviews the progress of diagnosis and treatment of the third space.
		2021 Vol. 18 (5): 37-40 [Abstract] ( 398 ) HTML (1 KB) PDF (405 KB) ( 26 )

	41	Design of evaluation index system for nursing quality of endocrinology specialty based on three-dimensional quality structure
		LOU Nan1 SONG Yang1▲ HUANG Xiantao2
		Objective To design endocrinology specialist nursing quality evaluation indicators based on a scientific and standardized three-dimensional quality structure, in order to provide a theoretical basis for the improvement and development of nursing quality in endocrinology specialist hospitals. Methods From January to April 2020, a total of 25 experts from endocrinology specialists in dozens of tertiary hospitals across the country were selected, including clinical nursing, nursing management, hospital quality management and other fields. Taking the three-dimensional quality evaluation model as the theoretical framework, through reviewing literature and theoretical research methods, the prototype of the endocrinology specialist nursing quality evaluation system was initially constructed, and the Delphi method was used to conduct two rounds of expert consultation and to evaluate the authority, enthusiasm and coordination of opinions Establish an evaluation index system for nursing quality of endocrinology specialists. Results A total of 50 questionnaires were sent out in the two rounds of this survey. Most experts were able to complete the survey on time. The questionnaires in the two rounds of correspondence were effectively recovered 50 and 44. The effective recovery rates were 100.00% and 88.00%, respectively. Expert authority coefficient were 0.915 and 0.839 respectively, and the coordination coefficients of expert opinions were 0.171 and 0.110 respectively. The final indicators for the first, second and third levels were 3, 12 and 37 respectively. Conclusion Based on the three-dimensional quality structure, a set of scientific and objective endocrinology specialist nursing quality evaluation indicators with comprehensive content coverage and weight setting are constructed to provide a direction for the development of endocrine specialist nursing quality and lay a certain theoretical foundation.
		2021 Vol. 18 (5): 41-44 [Abstract] ( 270 ) HTML (1 KB) PDF (463 KB) ( 74 )

	45	Current status and correlation analysis of psychological resilience response and compassion fatigue of clinical front-line medical staff fighting against corona virus disease
		FENG Jing1 CHEN Xueyu2 FU Li2 LIU Chunmei2 FENG Shiping2 LEI Limei2 LUO Dongxia3▲
		Objective To investigate the situation between mental resilience and compassion fatigue of clinical front-line medical staff fighting the new corona virus disease, and to understand the correlation between the them. Methods A questionnaire survey was conducted among 98 first-line medical workers fighting against corona virus disease through general information questionnaire, Connor-Davidson resilience scale (CD-RISC), and Chinese version of the short scale of compassion fatigue, and the correlation was analyzed by Pearson correlation. Results Ninety front-line medical staff participated in the survey, while their mental toughness score was (87.12±16.64) points, and compassion fatigue score was (43.21±24.63) points. There were no statistically significant differences in the scores of psychological resilience and compassion fatigue of clinical frontline medical staff with different gender, occupation, age, education, marital status, working years, professional title, and average monthly income (P ＞ 0.05). The psychological toughness of clinical front-line medical staff was higher than that of domestic general medical staff, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the mental resilience of clinical front-line medical staff and domestic oncology nurses (P ＞ 0.05). The total scores and scores of various dimensions of clinical first-line medical staff were negatively correlated with the total scores of compassion fatigue and each dimension (r ＜ 1, P ＜ 0.01). Conclusion The psychological resilience of clinical front-line medical staff fighting the new corona virus disease is at a high level, while compassion fatigue is at a low level, and they are negatively correlated. Medical managers should pay attention to the psychological resilience level and compassion perception ability of clinical front-line medical staff.
		2021 Vol. 18 (5): 45-48 [Abstract] ( 157 ) HTML (1 KB) PDF (462 KB) ( 64 )

	49	Study on the correlation between Nt-proBNP, apolipoprotein and the degree of coronary artery stenosis
		LI Rongli1 ZHANG Jing2 DONG Songwu3
		Objective To study the correlation between serum N-terminal pro-brain natriuretic peptide (NT-proBNP), apolipoprotein A (ApoA), apolipoprotein B (ApoB) and the degree of coronary artery stenosis. Methods A total of 100 patients with coronary artery disease admitted to Bozhou People’s Hospital from June 2018 to September 2019 were enrolled. According to the degree of coronary artery stenosis, they were divided into mild stenosis group (34 cases) and moderate stenosis group (39 cases), severe stenosis group (27 cases), while another 40 cases of outpatient health examination during the same period were selected as the control group. The serum NT-proBNP, ApoA, ApoB, ApoB/ApoA, total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), white blood cell count (WBC), platelet count (PLT), red blood cell count (RBC), hemoglobin (Hb), hematocrit (HCT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBil) level of four groups were compared, while the correlation between the above indicators and the degree of coronary artery stenosis were analyzed. Results Serum NT-proBNP, ApoA, ApoB, ApoB/ApoA, TC, TG, LDL-C, HDL-C, AST and ALT levels were compared in each group, and the differences were statistically significant (P ＜ 0.05). Gensini score was positively correlated with serum NT-proBNP, TC, LDL-C, ApoB and ApoB/ApoA (r ＞ 0, P ＜ 0.05), and negatively correlated with ApoA (r ＜ 0, P ＜ 0.05). Conclusion The degree of coronary artery stenosis is correlated with serum NT-proBNP, TC, LDL-C, ApoA, ApoB and ApoB/ApoA.
		2021 Vol. 18 (5): 49-52 [Abstract] ( 145 ) HTML (1 KB) PDF (447 KB) ( 69 )

	53	Correlation analysis of non-invasive hemodynamic parameters and cardiac structure changes in patients with essential hypertensions
		WANG Zhanxian LUO Hongmin JIANG Xingjuan
		Objective To study the correlation between non-invasive hemodynamic parameters and cardiac structure changes in patients with essential hypertension. Methods A total of 300 patients with essential hypertension who were followed up at Wuzhou Traditional Chinese Medicine Hospital in Guangxi Zhuang Autonomous Region from June 2017 to June 2019 were selected as the research group, and a total of 100 healthy people who received outpatient physical examination during the same period were selected as the control group. The differences in general clinical data, non-invasive hemodynamic parameters and cardiac structural changes between the two groups were compared, and the correlation between non-invasive hemodynamic parameters and cardiac structural changes related parameters was analyzed. Results There were no statistically significant differences between the two groups in age, gender, history of smoking, drinking, diabetes, coronary heart disease, low-density lipoprotein and creatinine (P ＞ 0.05). The left atrium diameter, left ventricular end diastolic diameter, left ventricular end systolic diameter, left ventricular posterior wall thickness, ventricular septal thickness and left ventricular mass index in the study group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05); the left ventricular ejection fraction was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The peripheral vascular resistance and peripheral vascular resistance index of the study group were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); the stroke volume, stroke index, cardiac output, heart index and left heart work index of the study group were significantly lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Peripheral vascular resistance and peripheral vascular resistance index were positively correlated with left ventricular end-systolic inner diameter, left ventricular posterior wall thickness, and left atrial inner diameter (r ＞ 0, P ＜ 0.05); while they were negatively correlated with left ventricular ejection fraction, stroke volume, stroke index and cardiac output and cardiac index (r ＜ 0, P ＜ 0.05). Conclusion The non-invasive hemodynamic parameters of patients with essential hypertension have a good correlation with the related parameters of the heart structure, which can be used as a reference index for evaluating changes in the heart structure.
		2021 Vol. 18 (5): 53-56,60 [Abstract] ( 327 ) HTML (1 KB) PDF (785 KB) ( 73 )

	57	Risk factors analysis of total imaging burden of cerebral small vessel disease in acute ischemic stroke patients
		LIU Ruofan1 ZHANG Genming2 MA Lifang2▲
		Objective To explore the risk factors of total imaging burden of cerebral small vessel disease (CSVD) in acute ischemic stroke (AIS) patients. Methods From January 2019 to January 2020, a total of 62 patients with AIS in Dongzhimen Hospital of Beijing University of Chinese Medicine were selected as the research subjects. They were divided into group 0-1 (36 cases) and group 2-4 (26 cases) according to CSVD total imaging burden score. The general data and clinical data of two groups were compared. Results Age and plasma homocysteine (Hcy) level in group 2-4 were higher than those in group 0-1, and the differences were statistically significant (all P ＜ 0.05). Logistic regression analysis showed that age and Hcy level were independent risk factors for the severity of total burden of CSVD in AIS patients (OR >1, P < 0.05). Conclusion The total burden of CSVD imaging in AIS patients with advanced age and high blood Hcy level are heavier.
		2021 Vol. 18 (5): 57-60 [Abstract] ( 208 ) HTML (1 KB) PDF (610 KB) ( 16 )

	61	Relationship between serum UA level and intracranial / extracranial atherosclerotic stenosis in patients with cerebral infarction
		YUAN Baowen1 LI Chouzhong2 CHEN Yufeng3 WEI Ling3
		Objective To analyze the relationship between serum uric acid (UA) level and intracranial/extracranial atherosclerotic stenosis (ICAS/EAS) in patients with cerebral infarction. Methods A total of 216 patients with cerebral infarction who were followed up in Guizhou Orthopedic Hospital from January 2019 to January 2020 were selected as the research objects. According to the presence or absence of ICAS/EAS, the patients were divided into the stenosis group (150 cases) and the control group (66 cases). The differences of serum UA level and general clinical data between the two groups were compared. The expression of serum UA levels in patients with different severity of ICAS/EAS were analyzed, and the relationship between UA level and ICAS/EAS severity were analyzed, the influencing factors of ICAS/EAS in patients with cerebral infarction was explored. Results The UA level, age, body mass index (BMI), total cholesterol (TC), low density lipoprotein (LDL) and the proportion of hypertension in the stenosis group were higher than those of the control group, while the serum high density lipoprotein (HDL) level was lower than that of the control group (all P ＜ 0.05). The UA levels of severe, moderate and mild group were higher than that of the control group, the severe, moderate group were higher than that of the mild group, and the severe group was higher than that of the moderate group (all P ＜ 0.05). Spearman correlation analysis showed that serum UA level was positively correlated with ICAS/EAS severity (rs = 0.634, P ＜ 0.001). Logistic regression analysis showed that UA (OR = 3.748), age (OR = 2.895), hypertension (OR = 3.024), TC (OR = 2.668), and LDL (OR = 2.349) were all risk factors for ICAS/EAS in patients with cerebral infarction (all P ＜ 0.05). Conclusion Serum UA level can better reflect the severity of ICAS/EAS in patients with cerebral infarction, and it is an independent risk factor of ICAS/EAS.
		2021 Vol. 18 (5): 61-64 [Abstract] ( 436 ) HTML (1 KB) PDF (628 KB) ( 83 )

	65	Effects of visual feedback balance training on balance function and fall risk of patients with leukoencephalopathy
		ZHANG Min ZHANG Hongxia LI Yongping WEN Mingming YOU Hong
		Objective To observe the effect of visual feedback balance training using Pro-Kin balance system on balance function and the risk of patients with leukoencephalopathy (WMLs). Methods Forty WMLs patients who November hospitalized in the Department of Sino-French Neurological Rehabilitation of Gansu Provincial Hospital from 2018 to November 2019 were selected. According to the random number table method, they were divided into the treatment group and the control group with 20 cases in each group. Both groups were given regular balance training, and the treatment group was additionally given Pro-Kin balance system visual feedback balance training. Before and after treatment, the Berg balance scale (BBS) and Pro-Kin balance system were used to assess balance ability, functional ambulation classification (FAC) was used to assess walking ability, and Barthel index (BI) was used to assess ability of daily living (ADL), and the risk of fall were assessed with the BBS. Results Before treatment, there were no statistically differences in the BBS score, FAC score, BI score, length and area of movement under eyes closed between the two groups (all P ＞ 0.05). After four weeks of treatment, BBS score, FAC score and BI score in both groups were significantly higher than before treatment, and the treatment group was higher than the control group (all P ＜ 0.05). The length and area of movement when opening and closing eyes in both groups were significantly reduced compared with that before treatment, the ereament group was smaller than the control group (all P ＜ 0.05). The risk of fall in treatment group was lower than that in the control group (P ＜ 0.05). Conclusion Pro-Kin balance system visual feedback balance training can more effectively improve the balance ability of patients with WMLs and reduce the risk of falls.
		2021 Vol. 18 (5): 65-68 [Abstract] ( 96 ) HTML (1 KB) PDF (563 KB) ( 26 )

	69	Clinical study on the changes of serum MMP-9 and BDNF expression levels and prognosis in patients with acute cerebral infarction
		LI Youjia HAN Xiaoyan HUANG Yan LUO Songbao HUANG Genlin HUANG Huiqin CHEN Ying WU Zhenmei
		Objective To study the changes of serum matrix metalloproteinase-9 (MMP-9) and brain-derived neurotrophic factor (BDNF) expression levels in patients with acute cerebral infarction (ACI) and their correlation with prognosis. Methods Forty-two patients who were diagnosed with ACI and completed the three-month follow-up at the First People’s Hospital of Zhaoqing, Guangdong Province from January to June 2019 were selected as the study group, and 40 healthy people with physical examination during the same period were selected as the control group. The serum MMP-9 and BDNF levels in the study group on the first day (T1), the second day (T2) and the fifth day (T5) were detected, and the serum MMP-9 and BDNF levels in the control group were detected during physical examination. The study group was followed up for three months. According to the prognosis, the study group was divided into good prognosis group (24 cases) and poor prognosis group (18 cases). The levels of MMP-9 and BDNF were compared between the study group and the control group, the good prognosis group and the poor prognosis group. Results At T1 time point, the serum MMP-9 and BDNF levels of the study group were higher than those of the control group, the differences were statistically significant (all P ＜ 0.05). According to the prognosis, the MMP-9 levels in the good prognosis group and the poor prognosis group were analyzed by repeated measures analysis of variance. Comparison and interaction between the two groups showed statistically significant differences (all P ＜ 0.05), while time point comparison showed no statistically significant difference (P ＞ 0.05). Further analysis showed that the level of MMP-9 in the poor prognosis group was higher than that in the good prognosis group at T5 time point, the difference was statistically significant (P ＜ 0.05). The BDNF levels of the two groups were analyzed, comparison of time point and interaction between the two groups showed statistically significant differences (all P ＜ 0.05), while there was no statistically significant difference between the two groups (P ＞ 0.05). Further analysis showed that the BDNF level at T2 time point was higher than that at T1 time point in the good prognosis group, and the BDNF level at T5 time point was higher than that at T2 time point, the differences were statistically significant (all P ＜ 0.05). The BDNF level at T2 time point and T5 time point in the poor prognosis group was lower than that at T1 time point, the differences were statistically significant (all P ＜ 0.05). Conclusion The changes of MMP-9 and BDNF are closely related to the prognosis of ACI patients. In the initial stage of onset, a high level of BDNF may indicate a poor prognosis. After several days of treatment, a high level of MMP-9 and a decrease in BDNF level may indicate a poor prognosis.
		2021 Vol. 18 (5): 69-72 [Abstract] ( 430 ) HTML (1 KB) PDF (565 KB) ( 77 )

	73	Risk factors of early cognitive impairment in patients with acute cerebral infarction
		MA Shanshan1 WANG Ruiping1 PENG Fei1 XING Yanhui1 HU Xiaoying1 WANG Xiufang2
		Objective To explore the risk factors of early cognitive impairment in patients with acute cerebral infarction. Methods From August 2016 to August 2019, a total of 148 patients with acute cerebral infarction in Jin Qiu Hospital of Liaoning Province were involved as study objects. According to mini-mental state examination (MMSE), they were divided into cognitive impairment group (71 cases) and cognitive normal group (77 cases). The clinical data of two groups were compared; and multivariate analysis was performed using logistic regression analysis. Results There were statistically significant differences in age, stroke history, diabetes history, carotid artery plaque, national institutes of health stoke scale (NIHSS) score, Barthel index, cerebral infarction type of Oxfordshire community stroke project (OCSP) and infarction lesions number between the two groups (all P < 0.05). Age ≥65 year olds (OR = 4.400, 95%CI: 1.791-10.809, P = 0.001), carotid artery plaque (OR = 3.361, 95%CI: 1.151-9.815, P = 0.027), NIHSS score ≥5 points (OR = 3.205, 95%CI: 1.094-9.386, P = 0.034), OCSP anterior circulation infarction (OR = 2.378, 95%CI: 1.111-5.090, P = 0.026), stroke history (OR = 2.284, 95%CI: 1.026-5.088, P = 0.043) and multiple cerebral infarction (OR = 2.151, 95%CI: 1.003-4.613, P = 0.049) were risk factors for cognitive impairment. Conclusion The advanced age, carotid artery plaque, NIHSS score, OCSP type, stroke history and cerebral infarction number are independent risk factors for early cognitive impairment after acute cerebral infarction.
		2021 Vol. 18 (5): 73-75,79 [Abstract] ( 392 ) HTML (1 KB) PDF (580 KB) ( 55 )

	76	Relationship between TIBI classification, vascular recanalization, neurological function and short-term prognosis in patients with acute anterior circulation cerebral infarction treated with rt-PA intravenous thrombolysis
		LIU Jianhuai WANG Benxiao WANG Junjun
		Objective To study the relationship between TIBI classification, vascular recanalization, neurological function and short-term prognosis in patients with acute anterior circulation cerebral infarction treated with recombinant tissue-type plasminogen activator(rt-PA) intravenous thrombolysis. Methods A total of 102 patients with acute anterior circulation cerebral infarction who received intravenous thrombolysis from July 2018 to December 2019 in Anhui Wanbei Coal-Electricity Group General Hospital were selected as study objects. All patients were treated with rt-PA intravenous thrombolysis, and the patients were divided into good prognosis group (44 cases) and poor prognosis group (58 cases) according to the modified Rankin scale (mRS) score after treatment. The clinical baseline data were compared; logistic regression analysis was used for multivariate analysis, and Pearson correlation coefficient analysis was used for correlation analysis. Results Age and national institutes of health stoke scale (NIHSS) score of good prognosis group were lower than those of poor prognosis group, and the differences were statistically significant (P < 0.05). TIBI grade and total vascular recanalization rate in good prognosis group were higher than those in poor prognosis group (P < 0.05). TIBI grade, total vascular recanalization rate and NIHSS score were independent risk factors for short-term prognosis (OR >1, P < 0.05). There was a positive correlation between mRS score and NIHSS score (r = 0.278, P < 0.01), and a negative correlation between mRS score and TIBI grade and total vascular recanalization rate (r = -0.527, -0.372, P < 0.01). Conclusion The TIBI classification, vascular recanalization rate and NIHSS score of patients with acute anterior circulation cerebral infarction rt-PA intravenous thrombolysis are independent risk factors that affect the short-term prognosis of patients after treatment, and the patient’s mRS score was positively correlated with NIHSS score, but negatively correlated with TIBI grade and vascular recanalization rate.
		2021 Vol. 18 (5): 76-79 [Abstract] ( 207 ) HTML (1 KB) PDF (607 KB) ( 84 )

	80	Clinical effect and effective dose of L-T4 replacement therapy in pregnant patients with SCH
		LIU Minglan1 XIAO Liming1 SHI Weihong2
		Objective To explore the initial dose selection and effect of Levothyroxine (L-T4) replacement therapy in pregnant patients with subclinical hypothyroidism (SCH). Methods A total of 100 pregnant patients with SCH diagnosed in Rugao People’s Hospital of Jiangsu Province from January 2016 to February 2018 were selected as the research subjects. They were divided into high-dose group (initial dose 50 μg, once a day) and low-dose group (initial dose 25 μg, once a day) according to drug dose, with 50 cases in each group. The levels of free triiodothyrogenine (FT3), free thyroxine (FT4), thyrotropin (TSH), folic acid (FA), nitric oxide (NO), endothelin-1 (ET-1), arterial flow mediated endothelium-dependent dilation (FMD), pregnancy outcome and perinatal outcome of two groups were compared before and after treatment. Results There were no significant differences in thyroid function and FA level between two groups before treatment (P > 0.05). After treatment, TSH level was lower than that before treatment, and FA level was higher than that before treatment; TSH level of high-dose group was lower than that of low-dose group, and FA level of high-dose group was higher than that of low-dose group, with statistical significances (all P < 0.05); and there were no significant differences in FT3 and FT4 levels between two groups (P > 0.05). Before treatment, there were no significant differences in NO, ET-1 and FMD levels between two groups (P > 0.05). After treatment; ET-1 level of two groups was lower than that before treatment, NO and FMD levels were higher than those before treatment. ET-1 level in high-dose group was lower than that in low-dose group, and NO and FMD levels in high-dose group were higher than those in low-dose group, with statistical significances (all P < 0.05). The incidence of obstetric complications in high-dose group was lower than that in low-dose group, with statistical significances (P < 0.05). The total incidence of fetal and perinatal adverse outcomes in high-dose group was lower than that in low-dose group, with statistical significances (P < 0.05). Conclusion L-T4 replacement therapy of 50 μg is more effective in regulating thyroxine level and endothelial function in pregnant patients with SCH than that of 25 μg, and has a positive effect on reducing the incidence of obstetric complications and fetal and perinatal adverse outcomes.
		2021 Vol. 18 (5): 80-83 [Abstract] ( 229 ) HTML (1 KB) PDF (422 KB) ( 81 )

	84	Gender difference of anal distance and its correlation with gestational age
		GUO Yonghua XIAO Baojun LI Mingzhong YU Yangyang YI Na LIU Jingyan ZHANG Rui
		Objective To investigate the gender difference of the distance between anus and external genitalia (“anal distance” for short) and its correlation with gestational age. Methods A total of 1488 fetuses with gestational age ≥20 weeks were selected from Daxing Hospital Affiliated to Capital Medical University from January to September 2019. According to gender, they were divided into male fetus group (933 cases) and female fetus group (555 cases). According to gestational age, they were divided into 20-24 weeks group (390 cases) and 24+-28 weeks group (240 cases), 28+-32 week group (296 cases), 32+-36 week group (216 cases) and >36 week group (346 cases). The anal distance of different gender fetuses group in the same gestational age and the anal distance of different gestational age fetuses group in the same gender were compared; and correlation between gestational age and anal distance of different gender fetuses were analyzed. Results The anal distance of male fetuses group in the same gestational age was higher than that of female fetuses group, and the difference was statistically significant (P < 0.05). There was statistically significant difference in the anal distance between different gestational ages group in the same gender fetuses (P < 0.05). Anal distance of male and female fetuses were positively correlated with gestational age (r = 0.872, 0.820, P < 0.01). The regression equation between anal distance and gestational age of male fetuses was Y = 0.103X-1.213. The regression equation between anal distance and gestational age of female fetuses was Y = 0.056X-0.623. Conclusion Gestational age and gender of fetus should be considered in clinical evaluation of anal distance.
		2021 Vol. 18 (5): 84-87 [Abstract] ( 190 ) HTML (1 KB) PDF (658 KB) ( 78 )

	88	Efficacy of Aripitan combined with Dexamethasone and Dorasetron in the treatment of nausea and vomiting caused by EP regimen chemotherapy for small cell lung cancer
		GAO Jian XU Ximing CHEN Jiayu
		Objective To evaluate the efficacy of Aripitant combined with Dexamethasone and Dolasetron in the treatment of nausea and vomiting caused by EP regimen chemotherapy for small cell lung cancer. Methods Clinical data of 40 small cell lung cancer patients with initial treatment and definite pathological diagnosis from December 2017 to December 2019 in Cancer Center of Renmin Hospital of Wuhan University were retrospectively analyzed. All patients were divided into control group and experimental group according to random number table method, 20 cases in each group. All patients were given Etoposide and Cisplatin combined chemotherapy, control group was given preventive antiemetic therapy of intravenous drip of Dorasetron and oral Dexamethasone 30 minutes before chemotherapy, experimental group was given preventive antiemetic therapy of intravenous infusion of Dorasetron, oral Dexamethasone and Aripiptan 30 minutes before chemotherapy. Control of nausea and vomiting induced by chemotherapy in acute, delayed and whole stage and adverse reactions were compared between two groups. Results There were no significant differences in total effective rate of nausea control in acute phase, delayed phase and overall phase between two groups (P > 0.05). There was no significant difference in total effective rate of vomiting control in acute phase and overall phase between two groups (P > 0.05). Total effective rate of vomiting control in experimental group was higher than that in control group, and the difference was statistically significant (P < 0.05). The common adverse reactions of two groups were grade Ⅰ-Ⅱ, and there were no grade Ⅲ-Ⅳ adverse reactions. Conclusion Aripitan combined with Dexamethasone and Dorasetron has a good effect in the treatment of nausea and vomiting caused by EP regimen for small cell lung cancer, and the adverse reactions are small, especially it is effective for delayed vomiting.
		2021 Vol. 18 (5): 88-92,108 [Abstract] ( 333 ) HTML (1 KB) PDF (644 KB) ( 125 )

	93	Study on heart rate variability of patients with gastrointestinal tumors during perioperative period
		ZHI Mengwei1 JIANG Zhiwei2 DAI Xinjuan3 XU Shanshan3
		Objective To observe the changes of heart rate variability (HRV) in patients undergoing laparoscopic gastrointestinal tumor resection. Methods A total of 76 patients underwent laparoscopic gastrointestinal tumor resection at Jiangsu Provincial Hospital of Chinese Medicine from April to October 2019 were selected as research subjects, and 24-hour ambulatory ECG monitoring was performed from one day before surgery to five days after surgery. HRV indexes [standard diviation of NN intervals (SDNN), triangle index, the number of pairs of successive NNs that differ by more than 50 ms (pNN50), low frequency (LF), high frequency(HF), low frequency/high frequency(LF/HF)] were recorded at one day before surgery (T0), one day after surgery (T1), two days after surgery (T2), three days after surgery (T3), four days after surgery (T4), five days after surgery (T5). Results Overall analysis showed that there were significant differences in LnSDNN, Ln triangle index and LnLF/HF at different time points (P < 0.01), it was suggested that SDNN, trigonometric index and LF/HF change before and after operation. Further pairwise comparison, compared with T0, LnSDNN decreased at T1-2 (P < 0.01), Lntriangle index decreased at T1, T2 and T5 (P < 0.05), and LnLF/HF decreased at T1-4 (P < 0.01). Overall analysis showed that there were no significant differences in LnpNN50, LnLF and LnHF at different time points (P > 0.05), it was suggested that the changes of pNN50, LF and HF before and after operation were not obvious. Conclusion Early postoperative HRV decreases in patients with laparoscopic gastrointestinal tumor resection, the autonomic nerve function is impaired and unbalanced, and returns to the preoperative level on five days after surgery.
		2021 Vol. 18 (5): 93-96 [Abstract] ( 199 ) HTML (1 KB) PDF (588 KB) ( 64 )

	97	Effect of Compound Cantharidin Capsules combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer
		CHI Xu1 LIU Lijiao2 WANG Ye1 WANG Yan3
		Objective To investigate the efficacy of Compound Cantharidin Capsules combined with Gemcitabine and Cisplatin (GP) chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Eighty-two patients with advanced NSCLC admitted to Part Two in the First Hospital of Jilin University from January 2017 to December 2019 were selected, they were divided into control group (n = 41) and study group (n = 41) by random number table method. Control group was treated with GP chemotherapy regimen. Study group was treated with Compound Cantharidin Capsules on this basis. Clinical efficacy, immune function and tumor markers related indicators of two groups were compared，and the occurrence of adverse reactions of two groups was recorded. Results Total effective rate of study group was higher than that of control group (P < 0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+ and NK cells in two groups were lower than those before treatment, and the level of CD8+ was higher than that before treatment, but the levels of CD3+, CD4+, CD4+/CD8+ and nature killer (NK) cells in study group were higher than those in control group, and the level of CD8+ was lower than that in control group (P < 0.05). After treatment, the levels of carcinoembryonic antigen, squamous cell carcinoma associated antigen and cytokeratin 19 fragment in two groups were lower than those before treatment, and those in study group were lower than those in control group (P < 0.05). The incidence rate of adverse reactions in study group was lower than that in control group (P < 0.05). Conclusion Compound Cantharidin Capsules combined with GP chemotherapy is effective in the treatment of advanced NSCLC. It can effectively alleviate immune suppression, improve the level of relevant tumor markers, and reduce the incidence of adverse reactions. It has high clinical value.
		2021 Vol. 18 (5): 97-100,112 [Abstract] ( 343 ) HTML (1 KB) PDF (610 KB) ( 30 )

	101	The value of serum CA153 and miR-10b in the diagnosis of early breast cancer
		CHENG Wen1 PAN Guangrui2 ZENG An’gui1 WANG Yi1 LI Pan1
		Objective To investigate the value of serum carbohydrate antigen 153 (CA153) and microRNA-10b (miR-10b) in the diagnosis of early breast cancer. Methods Seventy-nine patients with early breast cancer diagnosed and treated in Affiliated Hospital of Panzhihua University (“our hospital” for short) from February 2018 to February 2020 were selected as breast cancer group, and 42 healthy subjects underwent physical examination in our hospital during the same period were selected as control group. Serum CA153 level was detected by enzyme-linked immunosorbent assay, serum miR-10b level was detected by real-time fluorescent quantitative PCR, and the diagnostic value of serum CA153 and miR-10b in early breast cancer was analyzed by receiver operating characteristic curve. Results The serum levels of CA153 and miR-10b in breast cancer group were significantly higher than those in control group (P < 0.05). There were significant differences in serum CA153 levels of breast cancer patients with different estrogen receptor (ER), histological differentiation and TNM stages (P < 0.05). The expression levels of serum miR-10b of breast cancer patients with different HER2 and TNM stages were significantly different (P < 0.05). The area under the curve, sensitivity and specificity of CA153 combined with miR-10b in the diagnosis of early breast cancer were higher than those of CA153 and miR-10b alone. Conclusion Serum levels of CA153 and miR-10b are significantly increased in patients with early breast cancer, ER expression, degree of differentiation and TNM stage are correlated with serum CA153 level, and HER2 expression and TNM stage are correlated with serum miR-10b level. The combined detection of the two is of certain clinical value in the diagnosis of early breast cancer.
		2021 Vol. 18 (5): 101-104,116 [Abstract] ( 405 ) HTML (1 KB) PDF (1043 KB) ( 113 )

	105	Analysis of risk factors for venous thromboembolism in tumor patients
		XIE Ruijie CHEN Shipeng LI Junming LU Zhuoli CAO Lijuan LIU Daihua
		Objective To analyze the risk factors of patients with venous thromboembolism (VTE) and malignant tumor in Liuzhou People’s Hospital (“our hospital” for short) and find out the risk factors, so as to establish the risk assessment model of VTE and prevent the occurrence of VTE. Methods One hundred and eight patients with malignant tumor and VTE hospitalized in our hospital from March 2018 to September 2019 were selected as VTE group, while 105 patients with simple malignant tumor hospitalized in the same period were selected as non VTE group. Clinical characteristics and hematological indexes of two groups were compared, and the risk factors of VTE were analyzed by multivariate regression analysis. Results There were significant differences in tumor type and radiotherapy between two groups (P < 0.05). There were significant differences in white blood cell count, hemoglobin, prothrombin time (PT) and D-dimer between two groups (P < 0.05). Multivariate regression analysis showed that radiotherapy (OR = 0.176, 95%CI:0.047-0.661), tumor progression (OR = 4.120, 95%CI:1.689-10.054), venous catheterization (OR = 0.308, 95%CI:0.124-0.764), PT > 12.8 s (OR = 12.998, 95%CI:1.507-112.086), D-dimer ≥ 1.44 μg/mL (OR = 1.251, 95%CI:1.091-1.435) were the independent influencing factors of VTE (P < 0.05). Conclusion Radiotherapy, PT > 12.8 s and D-dimer ≥ 1.44 μg/mL are independent risk factors for tumor VTE, but the effect of PT extension on VTE is excluded after analysis.
		2021 Vol. 18 (5): 105-108 [Abstract] ( 161 ) HTML (1 KB) PDF (583 KB) ( 86 )

	109	Efficacy and safety of anterior mediastinal tumors treated by laparoscopic thoracoscopic surgery under the xiphoid and lateral position
		WU Kai YANG Dabin REN Qiang
		Objective To explore the effect and safety of anterior mediastinal tumors treated by laparoscopic thoracoscopic surgery under the xiphoid and lateral position, and provide basis for diagnosis and treatment of patients. Methods Ninety patients with anterior mediastinal tumors admitted to Department of Cardiothoracic Surgery of Huaibei Miners General Hospital in Anhui Province from May 2016 to June 2020 were selected as research objects, and they were divided into two groups according to random number table method, with 45 cases in each group. Control group was treated with lateral decubitus anterior mediastinum tumor resection, and observation group was treated with anterior mediastinum tumor resection through the subxiphoid approach in lithotomy position. The operation condition, visual analogue score (VAS), the time of using analgesic pump and postoperative complication were compared between two groups. Results There were significant differences in operation time, blood loss, incision length, postoperative drainage volume, drainage time and ventilator use time between two groups (P < 0.05). Overall analysis showed that there were significant differences of VAS in group comparison, time point comparison and interaction (P < 0.05). Further pairwise comparison, VAS of observation group was lower than that of control group at three and five days after operation (P < 0.05), VAS at three and five days after operation was lower than that at one day after operation in two groups (P < 0.05). The number of time of using analgesia pump in observation group was less than that in control group, and the difference was statistically significant (P < 0.05). Total incidence rate of complications in observation group was lower than that in control group (P < 0.05). Conclusion The effect of thoracoscopic surgery through xiphoid process approach in lithotomy position for anterior mediastinal tumor is ideal, which can promote the rapid recovery of patients, relieve pain and has high safety.
		2021 Vol. 18 (5): 109-112 [Abstract] ( 407 ) HTML (1 KB) PDF (584 KB) ( 63 )

	113	Effect of Fluoxetine combined with Olanzapine in the treatment of patients with negative symptoms of schizophrenia
		ZHANG Chengzhen SHI Shi SONG Gaofeng
		Objective To investigate the clinical effect of Fluoxetine combined with Olanzapine in the treatment of patients with negative symptoms of schizophrenia. Methods Eighty patients diagnosed with negative symptoms of schizophrenia admitted to Suzhou City Second People’s Hospital, Anhui Province from February 2019 to February 2020 were selected as the research objects, and were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with Olanzapine, and the observation group was treated with Fluoxetine combined with Olanzapine. Bothgroups were treated for one month. The negative symptom rating scale (SANS) and the adverse reaction symptom scale during drug treatment were used to compare the treatment efficacy and safety of the two groups before and after one month of treatment. Results Before treatment, there was no statistically significant difference in SANS scores between the two groups (P > 0.05). After one month of treatment, SANS scores in the two groups were decreased compared with before treatment, and the observation group was lower than the control group, with statistically significant differences (all P ＜ 0.05). There was no statistical significance in the comparison of adverse reactions such as drowsiness, insomnia and sedentary inability between the two groups (P ＞ 0.05), but the proportion of cases of weight gain in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Fluoxetine combined with Olanzapine treatment for patients with negative symptoms of schizophrenia can effectively improve their negative symptoms and improve the therapeutic effect.
		2021 Vol. 18 (5): 113-116 [Abstract] ( 251 ) HTML (1 KB) PDF (552 KB) ( 24 )

	117	Effects of core muscle strength training combined with pulsation therapy instrument in the treatment of waist myofascitis
		SHI Fang1 LI Fuliang1 LYU Zeping2
		Objective To investigate the effects of core muscle strength training combined with pulsation therapy instrument in the treatment of waist myofasciitis. Methods A total of 92 patients with waist myofasciitis admitted to Dongcheng District First People’s Hospital of Beijing from July 2016 to July 2019 were divided into observation group and control group by envelope method, with 46 patients in each group. The control group was treated with pulsation therapy instrument, while the observation group was treated with core muscle strength training and pulsation therapy instrument. The curative effect, inflammatory factors, changes in pain, physical damage after treatment were compared between the two groups and the recurrence rate was recorded. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of tumor necrosis factor α and interleukin-6 and the each dimension score and total score of Japanese orthopaedic association score and physical damage index rating scale score were lower in both groups than before treatment, while the observation group was lower than the control group, the differences were statistically significant (all P ＜ 0.05). The recurrence rate of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Core muscle strength training combined with pulsation therapy instrument has a better effect in the treatment of waist myofascitis, which can significantly reduce the body inflammatory response and body damage, improve the symptoms of patients with low back pain, and is worthy of clinical promotion and application.
		2021 Vol. 18 (5): 117-120 [Abstract] ( 456 ) HTML (1 KB) PDF (555 KB) ( 110 )

	121	The value of CT Bhalla score in evaluating the prognosis of patients with bronchiectasis
		ZHOU Jie1 WEN Ting2 GAO Wei2
		Objective To explore the estimated value of the prognosis of patients with bronchiectasis by CT Bhalla score. Methods A total of 80 patients with bronchiectasis admitted to Suqian People’s Hospital of Nanjing Drum-Tower Hospital Group from January 2016 to December 2018 were included. After admission, all patients received CT Bhalla score. Clinical data of the patients were collected, including gender, age, body mass index, risk grade, smoking history, duration of disease, number of acute exacerbations, Pseudomonas aeruginosa positiveness, percentage of forced expiratory volume in the first second to the predicted value (FEV1%pred), and the relationship between CT Bhalla score and clinical characteristics of the patients was analyzed. The patients were followed up for 12 months to analyze the prognosis, and were divided into good group (16 cases) and bad group (64 cases) according to the conditions of prognosis. CT Bhalla score was compared between the two groups, and receiver operating characteristic curve (ROC) was drawn to analyze the predictive value of CT Bhalla score in the prognosis of patients with bronchiectasis. Results CT Bhalla scores ranged from five to seventeen, with an average score of (9.27±1.26). There were statistically significant differences in CT Bhalla scores among patients with different ages, risk grade, duration of disease, number of acute exacerbations, Pseudomonas aeruginosa positiveness and FEV1%pred (all P ＜ 0.05). Among them, the CT Bhalla scores of high risk patients were significantly higher than those of medium risk patients and low risk patients, and medium risk patients were higher than those of low risk patients, and patients with acute exacerbations ≥three times per year were significantly higher than those with acute exacerbations two times per year and those with acute exacerbations one time per year. Patients with acute exacerbations two time sper year were significantly higher than those with acute exacerbations one time per year, with statistically significant differences (all P ＜ 0.05). CT Bhalla score in the bad group was significantly higher than those in the good group, and the difference was highly statistically significant (P ＜ 0.01). The AUC of CT Bhalla score for poor prognosis was 0.731 (standard error = 0.065, 95%CI = 0.603-0.859, P = 0.002), the best cutoff was 9.490 scofres, the sensitivity was 72.70%, and the specificity was 65.90%. Conclusion CT Bhalla score has a certain predictive value for the prognosis of patients with bronchiectasis.
		2021 Vol. 18 (5): 121-124,138 [Abstract] ( 391 ) HTML (1 KB) PDF (1089 KB) ( 65 )

	125	Effects of high-frequency repetitive transcranial magnetic stimulation on the emotional and cognitive functions of alcohol dependent patients
		WEI Dandan DENG Hongdu WANG Jiali WANG Chuansheng
		Objective To investigate the effects of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on the emotional and cognitive function of alcohol dependent patients. Methods A total of 79 male patients admitted to the Second Affiliated Hospital of Xinxiang Medical College from March to July 2019 were selected and divided into study group (40 cases) and control group (39 cases) according to random number table method. A total of 64 cases were finally completed in this study. Among them, there were 33 cases in the study group, seven cases of shedding, 31 cases in the control group, eight cases of shedding. The enrolled patients were given Sertraline and other conventional alcohol abstinence therapy after acute abstinence period, while the study group added HF-rTMS treatment. The score of Hamilton anxiety and depression scale and the cognitive function scale, which included the simple mental status scale, the number span test, the word fluency test, and the revised version of the Hopkins word learning test, were assessed before and 21 days after Sertralin treatment, respectively. The changes of indexes before and after treatment were compared beween the two groups. Results There were no significant differences in the scores of Hamilton anxiety and depression scale and cognitive function scale between the two groups before treatment (P ＞ 0.05). After treatment, Hamilton anxiety and depression scale score of two groups was lower than before treatment, cognitive function scale score was higher than before treatment, the Hamilton anxiety and depression scale scores in the study group were lower than those in the control group, the number span test, word fluency test and the Hopkins word learning test scores in the study group were higher than those in the control group, with statistically significant differences (all P < 0.05). After treatment, there was no significant difference in the scores of the simple mental symptom scale between the two groups (P ＞ 0.05). The Hamilton anxiety and depression scale, number span test, word fluency test and the Hopkins word learning test reduction rate in the study group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Conclusion The effect of high-frequency repetitive transcranial magnetic stimulation is better than that of conventional symptomatic support therapy.
		2021 Vol. 18 (5): 125-128,142 [Abstract] ( 275 ) HTML (1 KB) PDF (1062 KB) ( 81 )

	129	Effects of Liberman rehabilitation therapy and acupoint application on executive function and social function in patients with schizophrenia
		ZHI Pu TIAN Yumei XUE Xiaobao WANG Guodong▲
		Objective To compare the effects of Liberman rehabilitation therapy and acupoint application on executive function and social function in patients with schizophrenia. Methods Sixty patients with schizophrenia in Xi’an Mental Health Center from June 2018 to June 2019 were selected as the research subjects. According to the random number table method, they were divided into rehabilitation group and acupoint group, with 30 patients in each group. On the basis of conventional drug therapy in the department of psychiatry, the rehabilitation group was treated with Liberman rehabilitation treatment, and the acupoint group was treated with acupoint application. The treatment courses were all 12 weeks. Cognitive function rating (Stroop) and social function rating scale (SDSS) were compared between the two groups before and after treatment. Results Before treatment, there was no statistical significance in Stroop scores between the two groups (P ＞ 0.05). After treatment, the scores of Stroop words and Stroop color words in the rehabilitation group were higher than those before treatment, with statistically significant differences (all P ＜ 0.05), while there was no statistical significance in Stroop word color in the rehabilitation group compared with before treatment (P ＞ 0.05). There was no significant difference in Stroop scores in the acupoint group compared with before treatment (P ＞ 0.05). After treatment, the scores of Stroop words and Stroop color words in the rehabilitation group were higher than those in the acupoint group, with statistically significant differences (all P ＜ 0.05), while there was no significant difference in Sroop word color between the two groups (P ＞ 0.05). Before and after treatment, there was no statistical significance in SDSS scores between the two groups (P ＞ 0.05). After treatment, the scores of social withdrawal, social activities within the family, social activities outside the family, social activities within the family and family function in the rehabilitation group were all lower than before treatment, with statistically significant differences (all P ＜ 0.05). Social withdrawal in acupoint group was lower than that before treatment, and the difference was statistically significant (P ＜ 0.05). Conclusion Both Liberman rehabilitation training and acupoint application can improve the patients’ executive function and social function, but the effect of Liberman rehabilitation training is better than acupoint application.
		2021 Vol. 18 (5): 129-132 [Abstract] ( 250 ) HTML (1 KB) PDF (580 KB) ( 53 )

	133	Study on the mechanism of “seaweed-tangle” in the treatment of goiter based on network pharmacology
		YANG Fuchen ZHANG Shichao
		Objective To explore the material basis and action mechanism of seaweed and tangle in the treatment of goiter through network pharmacology research methods. Methods The main active components of seaweed and tangle were searched in pharmacology database of traditional Chinese medicine system pharmacology database and analysis platform (TCMSP), and the targets of action were predicted. The disease targets related to goiter were searched by DisGeNET, OMIM and GeneCards databases, and the intersection with traditional Chinese medicine targets was obtained to screen the common targets. The protein protein interaction (PPI) network was drawn based on String platform, and the core targets were selected by topology analysis of Cytoscape software. The biological function of GO-BP and the enrichment of KEGG pathway were analyzed by metascape software. Results According to database analysis, seaweed contained four active compounds and 225 targets, tangle contained six active compounds and 145 action targets. After taking the intersection with the goiter target, a total of 70 targets were obtained. GO-BP bioaccumulation and KEGG pathway analysis showed that seaweed and tangle could regulate cell protein localization, G1/S transition of mitotic cell cycle, synthesis of nitrogen compounds, response of hormone stimulation and acidic chemicals, MAPK cascade and other biological processes, as well as p53 signal pathway, adhesive plaque, ErbB signal pathway, VEGF signal pathway and Jak-STAT signal pathway, etc. Conclusion This study explores the material basis and action mechanism of seaweed and tangle in the treatment of goiter from multiple perspectives such as compounds, targets, pathways, and provides a new scientific basis for future clinical trials and basic experimental research.
		2021 Vol. 18 (5): 133-138 [Abstract] ( 463 ) HTML (1 KB) PDF (2015 KB) ( 25 )

	139	Clinical experience of the treatment of coronavirus disease 2019 based on syndrome differentiation
		JIANG Lei WANG Fei YANG Jing LI Meifang WANG Cui JIN Yu
		The coronavirus disease 2019 coronavirus disease 2019 epidemic is spreading all over the world with strong infectivity and epidemic. It belongs to the category of “pestilence” disease of TCM. According to the pathogenesis and clinical features of coronavirus disease 2019, with “dampness-toxicity and pestilence” as the pathogenesis, “lunge” and “spleen” as the cores of the disease, and dampness, heat, toxicity, blood stasis and qi deficiency as the main syndrome points, through three cases of “diarrhea”, “cough” and “short breath and chest distress”, this paper expounds that coronavirus disease 2019 patients without fever should be treated according to the traditional Chinese medicine thinking of one-person-one-prescription and treatment based on syndrome differentiation. Huoxiang Zhengqi Powder, Sangbei Zhisou Powder, Xiaoxian Xiong Decoction, Tingli Dazao Xiefei Decoction and Qianjin Weijing Decoction are used to improve the symptoms of patients, reduce the toxin, cut off and reverse the course of disease, and mobilize the body’s own resistance to disease. Traditional Chinese medicine treatment based on syndrome differentiation of coronavirus disease 2019has unique advantages in improving clinical symptoms, reducing complications and improving quality of life.
		2021 Vol. 18 (5): 139-142 [Abstract] ( 236 ) HTML (1 KB) PDF (688 KB) ( 21 )

	143	Professor Li Haisong’s experience in the treatment of testicular microlithiasis based on the “micro-accumulation” theory
		WANG Jisheng1 DAI Hengheng1 DENG Sheng1 BAO Binghao1 LONG Zhongwen1 FENG Junlong1 WANG Bin2 LI Haisong2
		Testicular microlithiasis is a relatively rare disease in clinical practice. At present, there is no unified opinion on the pathogenesis and treatment of testicular microlithiasis in modern medicine. Professor Li Haisong, based on traditional Chinese medicine theory, proposes the pathogenesis theory of “micro-accumulation” of testicular microlithiasis and believes that testicular microlithiasis belongs to the category of “accumulation” in the traditional medicine. Although there are no visible “accumulation” with the naked eye, with the help of modern diagnosis and treatment methods, such as ultrasound, light microscopy, electron microscopy, etc., can be observed to distribute the tiny stones. Thus, testicular microlithiasis belongs to the category of “micro-accumulation”. Deficiency of the kidney, blood stasis and phlegm are the basic pathogenesis of “micro-accumulation” of testis, in which deficiency of the kidney is the root cause and phlegm and blood stasis are the manifestations. In terms of treatment, it suggests that benefitting the kidney should be gentle and the medication should be light. Do not wrongly use heavy agents to cause yang heat to turn into fire and hinder sperm motility. At the same time, it also pays attention on eliminating accumulation and dispersing mass, eliminating phlegm and softening hardness. It has achieved certain curative effect in clinical practice and is worth popularizing.
		2021 Vol. 18 (5): 143-145,149 [Abstract] ( 157 ) HTML (1 KB) PDF (714 KB) ( 170 )

	146	Discussion on the method of treating water diseases according to time in Linzheng Zhinan Yi’an
		YIN Yue1 WANG Qingyu2▲ WU Wenjie2
		This paper discusses the regularity and characteristics of Ye Tianshi’s treatment of water diseases due to “time” in Linzheng Zhinan Yi’an. A total of 220 medical cases are recorded in the categories of dampness, phlegm, phlegm and fluid retention, swelling in the Linzheng Zhinan Yi’an, among which 39 cases of medication due to “time” are recorded. This paper discusses Ye Tianshi’s emphasis on the selection of prescription and the guidance of drug use according to the difference of season, day and night and extra-annual rhythm, and put forward the opinion of dividing day and night and dividing time for drug use, and the concept and method of treating water disease according to the characteristics of children in the brief section of Linzheng Zhinan Yi’an.
		2021 Vol. 18 (5): 146-149 [Abstract] ( 152 ) HTML (1 KB) PDF (725 KB) ( 76 )

	150	Analysis on the medication rules of traditional Chinese medicine in treating cervical spondylotic myelopathy based on data mining
		QIN Xiaokuan1 SUN Kai1 ZHU Liguo1,2 CHEN Xin1 WEI Xu1 YIN He1 YANG Bowen1 CHEN Lin3
		Objective To discuss the medication rules of traditional Chinese medicine in treating cervical spondylotic myelopathy based on the traditional Chinese medicine inheritance support system (V2.5) software. Methods The literatures related to the treatment of cervical spondylotic myelopathy with traditional Chinese medicine were collected from CNKI, VIP and Wanfang Data. The time limit for retrieval was from inception to December 2019. Data statistics and analysis were conducted by association rule analysis and other methods of traditional Chinese medicince inheritance support system. Results Seventy-three prescriptions of traditional Chinese medicine in treating cervical spondylotic myelopathy were collected, involving a total of 134 traditional Chinese medicine. The top five in the list of drug frequency were Radix Angelicae Sinensis, Radix Astragali seu Hedysari, Rhizoma Ligustici Chuanxiong, Radix Salviae Miltiorrhizae and Flos Carthami. The medication categories were mainly drugs of tonifying deficiency and promoting blood circulation. Twenty-eight rules of drug association were obtained by using the rule of composition. Further analysis evolved 18 core combinations and nine new prescriptions. Conclusion The traditional Chinese medicine for the treatment of cervical spondylotic myelopathy is mainly tonifying deficiency, as well as promoting blood circulation for removing blood stasis. The correlation between drugs is mainly based on the formula of Buyang Huanwu Decoction. The analysis results can provide theoretical basis for clinical use of prescriptions and drugs, and the development and research of new drug.
		2021 Vol. 18 (5): 150-154 [Abstract] ( 493 ) HTML (1 KB) PDF (885 KB) ( 79 )

	155	Analysis on the main active ingredients and potential targets of Simiao Powder in treating hyperuricemia based on network pharmacology
		YE Wenjing LIN Daobin CHENG Yawei QIU Xiaotang
		Objective To study the main active ingredients and potential targets of Simiao Powder in the treatment of hyperuricemia (HUA) by means of network pharmacology. Methods The traditional Chinese medicine systems pharmacology database and analysis platform was used to screen the active ingredients of Simiao Powder, the DRAR-CPI platform and the Uniprot database were used to screen target genes, and the GeneCards database was used to search for the disease genes of HUA. Venn analysis was conducted to find the potential targets of drugs, so as to construct the active ingredient-target interaction network. Meanwhile, gene ontology (GO) function annotation, enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed. Results Fifty active ingredients and eight target sites for HUA were identified in this study. GO analysis clarified 26 items, and KEGG analysis revealed a total of 11 pathways. Conclusion This study initially explores the pharmacological effects and related mechanisms of Simiao Powder in treating HUA, at the same time establishes a framework for clinical application of the prescription and related experimental research.
		2021 Vol. 18 (5): 155-158,167 [Abstract] ( 522 ) HTML (1 KB) PDF (1366 KB) ( 101 )

	159	Analysis on the medication rules of traditional Chinese medicine in treating poststroke depression based on traditional Chinese medicine inheritance support system
		YUAN Minjiao1 YUAN Jie2 HAN Zucheng2
		Objective To explore the medication rules of traditional Chinese medicine in treating poststroke depression by “traditional Chinese medicine inheritance support system (V2.5)”. Methods The literatures related to the treatment of poststroke depression with traditional Chinese medicine in CNKI, CBM, VIP and Wanfang Data were collected, the time limit for retrieval was from inception to February 2020. The effective prescriptions after screening were entered into the traditional Chinese medicine inheritance support system, to establish a prescription database for treating poststroke depression. Data mining methods such as association rules, complex system entropy clustering and unsupervised entropy hierarchical clustering were used to analyze the data. Results A total of 269 effective prescriptions were included, involving 177 kinds of Chinese medicine. The main nature of drugs were warm, cold and calm, and the main flavors were bitter and pungent, followed by the sweet. The main drugs were belonged to liver, heart and spleen channels. Eighteen kinds of Chinese medicine with a frequency more than 57. The top five Chinese medicines were Radix Bupleuri, Radix Curcumae, Rhizoma Ligustici Chuanxiong, Radix Angelicae Sinensis and Radix Paeoniae Alba. The top five core drug combinations were Rhizoma Ligustici Chuanxiong - Radix Bupleuri, Radix Curcumae - Radix Bupleuri, Radix Angelicae Sinensis - Radix Bupleuri, Radix Paeoniae Alba - Radix Bupleuri, Radix Bupleuri - Poria. Fourteen core drug combinations and seven new prescriptions were obtained through complex system entropy clustering. Conclusion In the treatment of poststroke depression, traditional Chinese medicine for dispersing the stagnated liver-energy and invigorating the spleen is often used, which is often combined with the products for regulating vital energy, nourishing the heart and calming the nerves.
		2021 Vol. 18 (5): 159-162 [Abstract] ( 410 ) HTML (1 KB) PDF (755 KB) ( 128 )

	163	Analysis of diabetes diet research hotspots based on PubMed database
		LUO Gan1 XIA Yinfang2 LI Ruihong3 GE Wenxian2 HAN Yuqin4 ZHENG Limei5
		Objetive This study intends to draw a series of scientific maps and use bibliometric analysis and social network analysis to evaluate the hot spots and trends of diabetes diet research. Methods The journal papers collected in PubMed from January 2000 to December 2019 were retrieved by using the theme term “diabetic diet”. The bibliographic item co-occurrence system (BICOMB) was used to screen the high-frequency major theme terms and construct the co-occurrence matrix, and the bibliometric results were presented in Tableau 2019.2. Topic trends were identified using the graphical clustering toolkit gCLUTO and social network analysis software ucinet 6.0. Results A total of 1010 literatures were included, and 23 major high-frequency topics and 5 research hotspots were statistically obtained; diabetic diet (including vegetables and meat); holiday cooking and dietary fat, dietary habits, intake, dietary restriction and obesity; effects of low carbohydrate diet and low glycemic index diet (combined with hypoglycemic agents) on blood glucose and insulin, diet care for type 1 and type 2 diabetes mellitus patients (including self-care behavior, health education, compliance). Conclusion This study summarizes five hotspots of diabetes diet research. Looking at the past 20 years, diabetes diet is still an important and ongoing research value in improving the condition of patients. Besides, lifestyle intervention with weight loss exercise and proper diet as the core is still the focus of research on diabetes diet, and the research on diet nursing for diabetic patients is becoming increasingly popular.
		2021 Vol. 18 (5): 163-167 [Abstract] ( 332 ) HTML (1 KB) PDF (807 KB) ( 108 )

	168	Meta-integration of the study on the quality rescarch of treatment experience of first-line nurses in China against COVID-19
		HUANG Lu1 ZENG Ren1 YU Yanlan2 CAI Zheyi3 CHEN Xinyu4
		Objective To evaluate the real experience of Chinese nurses participating in COVID-19 treatment work. Methods The VIP, Wanfang, CNKI, PubMed, Medline and CBM databases were searched, and the retrieval time was from December 1, 2019 to April 30, 2020. A qualitative study on the treatment experience of Chinese nurses participating in the treatment of COVID-19 in China was conducted. Meta integration method was used to integrate the results. Results A total of 14 literatures were included, and 56 results, 9 categories and 3 integrated results were extracted, the front-line nurses in the fight against COVID-19 were under pressure from many sides. The front-line nurses in the fight against COVID-19 expect support and guidance from many aspects. The professional identity and sense of value of front-line nurses against COVID-19 were satisfied. Conclusion Chinese nurses are under great physical and mental pressure during the treatment of COVID-19 in China. The government and society should provide all-round support and guidance to encourage them to devote themselves to the front line of fighting COVID-19 and give full play to personal professional and social values.
		2021 Vol. 18 (5): 168-171,184 [Abstract] ( 286 ) HTML (1 KB) PDF (799 KB) ( 17 )

	172	Application of peer support diversified social support intervention in patients after artificial total knee arthroplasty
		YAN Lijia ZHANG Jing▲
		Objective To explore the influence of diversified social support based on peer support on the self-care ability and rehabilitation effect of patients with artificial total knee arthroplasty (TKA). Methods A total of 110 TKA patients who were admitted to the Second People’s Hospital of Lianyungang from July 2018 to June 2019 were selected. According to the operation time, they were divided into 57 cases in the treatment group (January to June 2019) and 53 cases in the control group (July to December 2018). The control group was given routine nursing intervention, and the treatment group was combined with a diversified social support intervention based on peer support. After six months of follow-up, the self-care ability, knee joint function and complications within six months after operation were compared between the two groups. Results After six months of follow-up, the self-care ability scores of the two groups were higher than those before intervention (P ＜ 0.01). The total scores of health knowledge, self-concept, self-responsibility, self-care skill scores and self-care ability of the treatment group were higher than those of the control group (P ＜ 0.01); the knee function scores of the two groups were higher than those before intervention (P ＜ 0.01), and the pain, function, muscle strength, stability scores and total knee function scores of the treatment group were higher than those of the control group (P ＜ 0.01); the incidence of complications was significantly lower than that of the control group (P ＜ 0.05). Conclusion Diversified social support based on peer support can help improve the self-care ability of patients undergoing artificial TKA, promote postoperative knee function recovery, and reduce postoperative complications.
		2021 Vol. 18 (5): 172-175 [Abstract] ( 351 ) HTML (1 KB) PDF (695 KB) ( 99 )

	176	Influence of mental health education on self-perceived burden and quality of life of patients after intracranial aneurysm surgery
		FENG Chi GUO Jingpeng▲ MA Jinju HE Jingjing WANG Huailiang
		Objective To investigate the influence of mental health education on self-perceived burden and quality of life in patients after intracranial aneurysm surgery. Methods A total of 78 patients admitted to Fuyang People’s Hospital of Anhui Province from April 2018 to September 2019 were divided into treatment group (January-September 2019) with 42 patients and control group (April-December 2018) with 36 patients. The control group was given routine nursing care, and the treatment group was combined with mental health education. After three months follow-up, self-perceived burden, quality of life and patient satisfaction were compared between the two groups. Results The total score and scores of all dimensions of the self-perceived burden of the two groups of patients were lower than those of the same group before the intervention (P ＜ 0.01), and the scores of physical burden, emotional burden and self-perceived burden total scores of the treatment group were lower than those of the control group (P ＜ 0.05); the scores of each dimension of the quality of life and the overall quality of life of the two groups were higher than those of the same group before the intervention (P ＜ 0.01), and the scores of physical function, mental function, social function and overall quality of life total scores of the treatment group were higher than those of the control group (P ＜ 0.01); patient satisfaction of treatment group was higher than that of the control group (P ＜ 0.05). Conclusion Mental health education can help relieve the burden of self-feeling of patients after intracranial aneurysm surgery, improve the quality of life of patients, and increase patient satisfaction.
		2021 Vol. 18 (5): 176-179 [Abstract] ( 407 ) HTML (1 KB) PDF (657 KB) ( 116 )

	180	Effects of quantitative activity intervention on postoperative rehabilitation and cancer-induced fatigue in patients undergoing radical gastrectomy for gastric cancer
		ZHOU Yuefeng HONG Shengqi DING Yuan
		Objective To explore the effect of quantitative activity intervention in patients undergoing radical gastrectomy for gastric cancer, focusing on the analysis of postoperative rehabilitation and cancer-induced fatigue, so as to guide the formulation of reasonable intervention plan after radical gastrectomy for gastric cancer in the future. Methods A total of 100 patients with gastric cancer who received radical gastrectomy for gastric cancer in Xuancheng People’s Hospital of Anhui Province from June 2016 to May 2020 were selected, the group was divided into experimental group and control group by random number table method, with 50 cases in each group. The control group received conventional care, the experimental group received conventional nursing combined with quantitative activity intervention, all of them were from postoperative intervention to discharge. The recovery of gastrointestinal function and clinical indexes of the two groups were recorded. Before and after the intervention, the piper fatigue correction scale (RPFS) was used to evaluate cancer-induced fatigue in both groups; the incidence of postoperative complications was recorded. Results The recovery time of intestinal sound, exhaust time, diet recovery time and defecation time in the experimental group were shorter than those in the control group (P ＜ 0.05); the catheter removal time, activity time out of bed, postoperative hospital stay and total hospital stay of the experimental group were shorter than those of the control group (P ＜ 0.05); after intervention, RPFS scores of all dimensions in both groups were lower than those before intervention, and the experimental group was lower than the control group (P ＜ 0.05); there were no significant differences in incidence of incision infection, pulmonary infection and anastomotic fistula between the two groups (P ＞ 0.05); the incidence of postoperative bleeding and abdominal distension in the experimental group were lower than those in the control group (P ＜ 0.05). Conclusion The quantitative activity intervention effect of radical gastrectomy for patients with gastric cancer is definite, which is beneficial to improve the gastrointestinal function of patients, reduce the symptoms of cancer-induced fatigue, and reduce postoperative complications, and is worthy of popularization and application.
		2021 Vol. 18 (5): 180-184 [Abstract] ( 406 ) HTML (1 KB) PDF (707 KB) ( 64 )

	185	Application of nursing based on improved early warning scores in cesarean section women
		YAO Chunfang WAN Li
		Objective To observe the effect of nursing based on modified early warning scores (MEWS) on postpartum hemorrhage in patients with cesarean section. Methods Clinical data of 124 patients with cesarean section who completed delivery and follow-up in Nanjing Hospital, Nanjing Medical University from January 2018 to December 2019 were retrospectively analyzed and collected. According to the time of case collection, 61 patients admitted to hospital from January 2018 to December 2018 were selected as the control group for routine nursing intervention. Sixty-three patients admitted to the hospital from January to December 2019 were selected as the observation group, and MEWS based nursing intervention was implemented. Both groups were treated until the end of discharge, and the rate of postpartum bleeding, postoperative related indicators and the incidence of complications were recorded and compared between the two groups; Negative emotions in the two groups were assessed before intervention and one day before discharge (self-rating depression scale [SDS] and self-rating anxiety scale [SAS] were used to evaluate the negative emotions). Results The rate of postpartum hemorrhage in the observation group was lower than that in the control group, and the time of lactation initiation, anal ventilation duration and hospital stay in the observation group were shorter than those in the control group, the differences were statistically significant (P ＜ 0.05); one day before discharge, SDS and SAS scores in both groups were lower than before intervention, and observation group was lower than control group, the differences were statistically significant (P ＜ 0.05); there was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion Nursing intervention based on MEWS for patients with cesarean section can reduce the rate of postpartum bleeding, shorten the beginning time of lactation, anal ventilation time and length of hospital stay, and is more conducive to improving patients’ negative emotions such as anxiety and depression, with high application value.
		2021 Vol. 18 (5): 185-188,196 [Abstract] ( 445 ) HTML (1 KB) PDF (682 KB) ( 86 )

	189	Effect of nursing intervention and self-management in patients with gestational diabetes mellitus based on the model of nursing and patient compliance
		BO Lu GE Dongling
		Objective To explore the effect of nursing intervention and self-management for patients with gestational diabetes based on the model of nursing and patient compliance, and to provide reference for the nursing methods of clinical patients with gestational diabetes. Methods A total of 80 patients with gestational diabetes mellitus who were treated in the Department of Endocrinology of the First People’s Hospital of Huainan City, Anhui Province from January 2018 to December 2020 were selected as the subjects. All patients were divided into study group (40 cases) and control group (40 cases) according to random number table method. The control group was given routine gestational diabetes mellitus care nursing methods, and the research group was given nursing intervention based on the standard model of nursing and patient. The blood glucose compliance rate, blood glucose biochemical indexes and self-management efficacy before and after nursing were compared between the two groups. Results After nursing, the compliance rates of fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPBG), HBA1c and 2hPBG after dinner in the study group were significantly higher than those in the control group (P ＜ 0.05). The scores of blood glucose detection, medication as prescribed by doctors, foot care, diet control, regular exercise, and prevention and treatment of hypoglycemia in both groups were significantly lower than those before intervention, in addition, the scores of blood glucose detection, medication as prescribed by doctors, foot care, diet control, regular exercise, and prevention and treatment of hypoglycemia in the study group were significantly lower than those in the control group (P ＜ 0.05). FPG, 2hPBG and HBA1c in the two groups were lower than before intervention, FPG, 2hPBG and HBA1c in the study group were significantly lower than those in the control group (P ＜ 0.05). Conclusion Nursing intervention based on the nursing and patient target model can effectively improve the control efficiency of blood glucose level in patients with gestational diabetes mellitus and improve the efficacy of self-management of patients.
		2021 Vol. 18 (5): 189-192 [Abstract] ( 361 ) HTML (1 KB) PDF (657 KB) ( 74 )

	193	Effect of nursing intervention on prevention of intraoperative stress injury and resuscitated agitation in the treatment of central hemiplegia by transposition of healthy side cervical 7 nerve through anterior vertebral esophagus and posterior access
		CHEN Yan LI Gendi
		Objective To explore the effect of nursing intervention on the prevention of intraoperative stress injury and resuscitated agitation during the treatment of central limb hemiplegia by the anterior and posterior vertebral esophagus access healthy side cervical 7 nerve transposition (“ modified contralateral cervical 7 nerve transposition ”). Methods A total of 18 patients with central hemiplegia who received improved contralateral cervical 7 nerve transposition in Huashan Hospital Affiliated to Fudan University from March 2018 to January 2019 were selected, take effective nursing intervention measures, including preoperative and intraoperative stress injury assessment. The pictures / videos to help patients with the operating room environment to reduce fear / anxiety were used. Temperature control and effective protection of the compression site were taken to prevent pressure injury during operation. In the postoperative recovery period, the patient’s condition was closely paid attention to, timely counseling and comfort were given, and the occurrence of intraoperative stress injury and restlessness in the recovery period was observed. Results After perioperative nursing intervention, all 18 patients successfully completed the modified contralateral cervical 7 nerve transposition, without intraoperative stress injury and serious resuscitated agitation. Conclusion Systemic nursing intervention can effectively prevent intraoperative stress injury and prevent / reduce resuscitated agitation during the operation of contralateral cervical 7 nerve transposition on the healthy side through the anterior vertebral esophagus and posterior access.
		2021 Vol. 18 (5): 193-196 [Abstract] ( 271 ) HTML (1 KB) PDF (695 KB) ( 32 )

Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech