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| Effects of high-frequency repetitive transcranial magnetic stimulation on the emotional and cognitive functions of alcohol dependent patients |
| WEI Dandan DENG Hongdu WANG Jiali WANG Chuansheng |
| The Fifth Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical College, He’nan Province, Xinxiang 453000, China |
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Abstract Objective To investigate the effects of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on the emotional and cognitive function of alcohol dependent patients. Methods A total of 79 male patients admitted to the Second Affiliated Hospital of Xinxiang Medical College from March to July 2019 were selected and divided into study group (40 cases) and control group (39 cases) according to random number table method. A total of 64 cases were finally completed in this study. Among them, there were 33 cases in the study group, seven cases of shedding, 31 cases in the control group, eight cases of shedding. The enrolled patients were given Sertraline and other conventional alcohol abstinence therapy after acute abstinence period, while the study group added HF-rTMS treatment. The score of Hamilton anxiety and depression scale and the cognitive function scale, which included the simple mental status scale, the number span test, the word fluency test, and the revised version of the Hopkins word learning test, were assessed before and 21 days after Sertralin treatment, respectively. The changes of indexes before and after treatment were compared beween the two groups. Results There were no significant differences in the scores of Hamilton anxiety and depression scale and cognitive function scale between the two groups before treatment (P ＞ 0.05). After treatment, Hamilton anxiety and depression scale score of two groups was lower than before treatment, cognitive function scale score was higher than before treatment, the Hamilton anxiety and depression scale scores in the study group were lower than those in the control group, the number span test, word fluency test and the Hopkins word learning test scores in the study group were higher than those in the control group, with statistically significant differences (all P < 0.05). After treatment, there was no significant difference in the scores of the simple mental symptom scale between the two groups (P ＞ 0.05). The Hamilton anxiety and depression scale, number span test, word fluency test and the Hopkins word learning test reduction rate in the study group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Conclusion The effect of high-frequency repetitive transcranial magnetic stimulation is better than that of conventional symptomatic support therapy.
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