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| Efficacy of Aripitan combined with Dexamethasone and Dorasetron in the treatment of nausea and vomiting caused by EP regimen chemotherapy for small cell lung cancer |
| GAO Jian XU Ximing CHEN Jiayu |
| Cancer Center, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Objective To evaluate the efficacy of Aripitant combined with Dexamethasone and Dolasetron in the treatment of nausea and vomiting caused by EP regimen chemotherapy for small cell lung cancer. Methods Clinical data of 40 small cell lung cancer patients with initial treatment and definite pathological diagnosis from December 2017 to December 2019 in Cancer Center of Renmin Hospital of Wuhan University were retrospectively analyzed. All patients were divided into control group and experimental group according to random number table method, 20 cases in each group. All patients were given Etoposide and Cisplatin combined chemotherapy, control group was given preventive antiemetic therapy of intravenous drip of Dorasetron and oral Dexamethasone 30 minutes before chemotherapy, experimental group was given preventive antiemetic therapy of intravenous infusion of Dorasetron, oral Dexamethasone and Aripiptan 30 minutes before chemotherapy. Control of nausea and vomiting induced by chemotherapy in acute, delayed and whole stage and adverse reactions were compared between two groups. Results There were no significant differences in total effective rate of nausea control in acute phase, delayed phase and overall phase between two groups (P > 0.05). There was no significant difference in total effective rate of vomiting control in acute phase and overall phase between two groups (P > 0.05). Total effective rate of vomiting control in experimental group was higher than that in control group, and the difference was statistically significant (P < 0.05). The common adverse reactions of two groups were grade Ⅰ-Ⅱ, and there were no grade Ⅲ-Ⅳ adverse reactions. Conclusion Aripitan combined with Dexamethasone and Dorasetron has a good effect in the treatment of nausea and vomiting caused by EP regimen for small cell lung cancer, and the adverse reactions are small, especially it is effective for delayed vomiting.
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