|
|
Gender difference of anal distance and its correlation with gestational age |
GUO Yonghua XIAO Baojun LI Mingzhong YU Yangyang YI Na LIU Jingyan ZHANG Rui |
Department of Ultrasound, Daxing Hospital Affiliated to Capital Medical University, Beijing 102600, China |
|
|
Abstract Objective To investigate the gender difference of the distance between anus and external genitalia (“anal distance” for short) and its correlation with gestational age. Methods A total of 1488 fetuses with gestational age ≥20 weeks were selected from Daxing Hospital Affiliated to Capital Medical University from January to September 2019. According to gender, they were divided into male fetus group (933 cases) and female fetus group (555 cases). According to gestational age, they were divided into 20-24 weeks group (390 cases) and 24+-28 weeks group (240 cases), 28+-32 week group (296 cases), 32+-36 week group (216 cases) and >36 week group (346 cases). The anal distance of different gender fetuses group in the same gestational age and the anal distance of different gestational age fetuses group in the same gender were compared; and correlation between gestational age and anal distance of different gender fetuses were analyzed. Results The anal distance of male fetuses group in the same gestational age was higher than that of female fetuses group, and the difference was statistically significant (P < 0.05). There was statistically significant difference in the anal distance between different gestational ages group in the same gender fetuses (P < 0.05). Anal distance of male and female fetuses were positively correlated with gestational age (r = 0.872, 0.820, P < 0.01). The regression equation between anal distance and gestational age of male fetuses was Y = 0.103X-1.213. The regression equation between anal distance and gestational age of female fetuses was Y = 0.056X-0.623. Conclusion Gestational age and gender of fetus should be considered in clinical evaluation of anal distance.
|
|
|
|
|
[1] 张涛,张胜逆,李靖华,等.人类后肠及肛门直肠胚胎发育中凋亡及细胞增殖的时空分布研究[J].河北医药,2014, 36(23):3541-3544.
[2] 陈小朋,杨艳芳,李骥,等.男性儿童尿道下裂与先天性直肠肛门畸形相关性分析[J].国际医药卫生导报,2017, 23(3):344-347.
[3] Glintborg D,Jensen RC,Jensen AV,et al. Anogenital distance in children born of mothers with polycystic ovary syndrome:the Odense Child Cohort [J]. Human reproduction,2019,34 (10):2061-2070.
[4] 王欣,吴勇,孟庆亚,等.尿道下裂的基因特点及其研究进展[J].国际生殖健康/计划生育杂志,2019,38(3):253-256.
[5] 刘芳利,周柳英,林永红,等.尿直肠隔序列征的产前超声诊断及文献复习[J].中国超声医学杂志,2017,33(4):371-373.
[6] 张爱青,刘朝辉,郭丽娟,等.胎儿外生殖器畸形的超声诊断病例分析[J].中华医学超声杂志:电子版,2017,14(11):834-840.
[7] Chitayat D,Glanc P. Diagnostic approach in prenatally detected genital abnormalities [J]. Ultrasound Obstet Gynecol,2010,35(6):637-646.
[8] 史红阳,邓文静,张玉萍,等.胚胎发育相关基因-1对人肺癌细胞增殖及凋亡的影响[J].山西医科大学学报,2016,47(1):26-30.
[9] Nievelstein RA,van der Werff JF,Verbeek FJ,et al. Normal and abnormal embryonic development of the anorectum in human embryos [J]. Teratology,1998,57(2):70-78.
[10] 傅煜,李岭.泌尿生殖系统的发育过程及其先天畸形的相关基因[J].中国优生与遗传杂志,2008,16(5):1-3, 99.
[11] 张昭玉,马林,李昀谦,等.孕期双酚A暴露对子代雄性大鼠生殖发育的影响[J].沈阳医学院学报,2018,20(4):373-376.
[12] 许洁,范奇元,胡斌丽,等.妊娠期壬基酚暴露对于雄性子鼠生长发育的影响[J].环境与健康杂志,2017,24(11):901-904.
[13] 张建平,金杭美.女性生殖结构胚胎发育学研究[J].中国实用妇科与产科杂志,2005,8(21):463-464.
[14] Nikolaev VV,Solontsov YN. Epidemiology and theories of the origin of hypospadias [J]. Urologiia,2018(3):141-145.
[15] 孙悦,杨柳,史弘毅,等.锌对邻笨二甲酸酯类暴露致雄性生殖毒性的干预作用[J].温州医科大学学报,2019, 49(9):649-653.
[16] 刘振,叶亚,王念蓉,等.某市男性婴儿性质发育的调查[J].中国医药指南,2018,16(16):52-53.
[17] 陈瑶,李娟,王剑,等.Bardet-Biedl综合征1例报告并文献复习[J].临床儿科杂志,2017,35(1):28-32.
[18] 潘袁,奚琦,姜雨婷,等.嵌合型男性Turner综合征合并Y染色体微缺失一例[J].中华医学遗传学杂志,2018, 35(6):931.
[19] 黄乐文,周爱云,齐祥飞.尿直肠隔畸形序列.征产前超声表现1例[J].中国医学影像技术,2019,35(4):635.
[20] 袁鹰,李胜利,华轩,等.女性尿直肠隔畸形序列征产前超声表现[J].中华医学超声杂志:电子版,2014,11(9):737-742.
[21] 骆迎春,田艾军,周启昌.三维超声对胎儿尿道下裂诊断的应用价值[J].中国医师杂志,2014,16(7):977-979.
[22] 李奎,颜国辉,郑伟增,等.胎儿尿道下裂产前MRI检查的产前价值分析[J].中华妇产科杂志,2019,54(8):548-551.
[23] Gilboa Y,Perlman S,Kivilevitch Z,et al. Prenatal anogenital distance is shorter in fetuses with hypospadias [J]. J Ultrasound Med,2017,36(1):175-182.
[24] Jain VG,Goyal V,Chowdhary V,et al. Anogenital distance is determined during early gestation in humans [J]. Hum Reprod,2018,33(9):1619-1627.
[25] Gilboa Y,Kivilevitch Z,Oren M,et al. Anogenital distance in male and female fetuses at 20 to 35 weeks of gestation:centile charts and reference ranges [J]. Prenat Diagn,2014,34(10):946-951. |
|
|
|