胃肠肿瘤围术期患者心率变异研究

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Abstract Objective To observe the changes of heart rate variability (HRV) in patients undergoing laparoscopic gastrointestinal tumor resection. Methods A total of 76 patients underwent laparoscopic gastrointestinal tumor resection at Jiangsu Provincial Hospital of Chinese Medicine from April to October 2019 were selected as research subjects, and 24-hour ambulatory ECG monitoring was performed from one day before surgery to five days after surgery. HRV indexes [standard diviation of NN intervals (SDNN), triangle index, the number of pairs of successive NNs that differ by more than 50 ms (pNN50), low frequency (LF), high frequency(HF), low frequency/high frequency(LF/HF)] were recorded at one day before surgery (T0), one day after surgery (T1), two days after surgery (T2), three days after surgery (T3), four days after surgery (T4), five days after surgery (T5). Results Overall analysis showed that there were significant differences in LnSDNN, Ln triangle index and LnLF/HF at different time points (P < 0.01), it was suggested that SDNN, trigonometric index and LF/HF change before and after operation. Further pairwise comparison, compared with T0, LnSDNN decreased at T1-2 (P < 0.01), Lntriangle index decreased at T1, T2 and T5 (P < 0.05), and LnLF/HF decreased at T1-4 (P < 0.01). Overall analysis showed that there were no significant differences in LnpNN50, LnLF and LnHF at different time points (P > 0.05), it was suggested that the changes of pNN50, LF and HF before and after operation were not obvious. Conclusion Early postoperative HRV decreases in patients with laparoscopic gastrointestinal tumor resection, the autonomic nerve function is impaired and unbalanced, and returns to the preoperative level on five days after surgery.

Key words： Gastrointestinal tumor Surgery Heart rate variability Stress response

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	ZHI Mengwei1 JIANG Zhiwei2 DAI Xinjuan3 XU Shanshan3

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ZHI Mengwei1 JIANG Zhiwei2 DAI Xinjuan3 XU Shanshan3. Study on heart rate variability of patients with gastrointestinal tumors during perioperative period[J]. 中国医药导报, 2021, 18(5): 93-96.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I5/93

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