急性脑梗死患者早期认知功能障碍的相关危险因素

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Abstract Objective To explore the risk factors of early cognitive impairment in patients with acute cerebral infarction. Methods From August 2016 to August 2019, a total of 148 patients with acute cerebral infarction in Jin Qiu Hospital of Liaoning Province were involved as study objects. According to mini-mental state examination (MMSE), they were divided into cognitive impairment group (71 cases) and cognitive normal group (77 cases). The clinical data of two groups were compared; and multivariate analysis was performed using logistic regression analysis. Results There were statistically significant differences in age, stroke history, diabetes history, carotid artery plaque, national institutes of health stoke scale (NIHSS) score, Barthel index, cerebral infarction type of Oxfordshire community stroke project (OCSP) and infarction lesions number between the two groups (all P < 0.05). Age ≥65 year olds (OR = 4.400, 95%CI: 1.791-10.809, P = 0.001), carotid artery plaque (OR = 3.361, 95%CI: 1.151-9.815, P = 0.027), NIHSS score ≥5 points (OR = 3.205, 95%CI: 1.094-9.386, P = 0.034), OCSP anterior circulation infarction (OR = 2.378, 95%CI: 1.111-5.090, P = 0.026), stroke history (OR = 2.284, 95%CI: 1.026-5.088, P = 0.043) and multiple cerebral infarction (OR = 2.151, 95%CI: 1.003-4.613, P = 0.049) were risk factors for cognitive impairment. Conclusion The advanced age, carotid artery plaque, NIHSS score, OCSP type, stroke history and cerebral infarction number are independent risk factors for early cognitive impairment after acute cerebral infarction.

Key words： Acute cerebral infarction Early cognitive impairment Mini-mental state examination Oxfordshire community stroke project Risk factors

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	MA Shanshan1 WANG Ruiping1 PENG Fei1 XING Yanhui1 HU Xiaoying1 WANG Xiufang2

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MA Shanshan1 WANG Ruiping1 PENG Fei1 XING Yanhui1 HU Xiaoying1 WANG Xiufang2. Risk factors of early cognitive impairment in patients with acute cerebral infarction[J]. 中国医药导报, 2021, 18(5): 73-75,79.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I5/73

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