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| The value of serum CA153 and miR-10b in the diagnosis of early breast cancer |
| CHENG Wen1 PAN Guangrui2 ZENG An’gui1 WANG Yi1 LI Pan1 |
1.Thyroid and Breast Surgery Department, Affiliated Hospital of Panzhihua University Panzhihua Integrated Hospital of Traditional Chinese and Western Medicine, Sichuan Province, Panzhihua 617067, China;
2.Breast Surgery Department, Kangjiancheng District of Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou 646000, China |
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Abstract Objective To investigate the value of serum carbohydrate antigen 153 (CA153) and microRNA-10b (miR-10b) in the diagnosis of early breast cancer. Methods Seventy-nine patients with early breast cancer diagnosed and treated in Affiliated Hospital of Panzhihua University (“our hospital” for short) from February 2018 to February 2020 were selected as breast cancer group, and 42 healthy subjects underwent physical examination in our hospital during the same period were selected as control group. Serum CA153 level was detected by enzyme-linked immunosorbent assay, serum miR-10b level was detected by real-time fluorescent quantitative PCR, and the diagnostic value of serum CA153 and miR-10b in early breast cancer was analyzed by receiver operating characteristic curve. Results The serum levels of CA153 and miR-10b in breast cancer group were significantly higher than those in control group (P < 0.05). There were significant differences in serum CA153 levels of breast cancer patients with different estrogen receptor (ER), histological differentiation and TNM stages (P < 0.05). The expression levels of serum miR-10b of breast cancer patients with different HER2 and TNM stages were significantly different (P < 0.05). The area under the curve, sensitivity and specificity of CA153 combined with miR-10b in the diagnosis of early breast cancer were higher than those of CA153 and miR-10b alone. Conclusion Serum levels of CA153 and miR-10b are significantly increased in patients with early breast cancer, ER expression, degree of differentiation and TNM stage are correlated with serum CA153 level, and HER2 expression and TNM stage are correlated with serum miR-10b level. The combined detection of the two is of certain clinical value in the diagnosis of early breast cancer.
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