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| Analysis on the main active ingredients and potential targets of Simiao Powder in treating hyperuricemia based on network pharmacology |
| YE Wenjing LIN Daobin CHENG Yawei QIU Xiaotang |
| Department of Endocrinology, Hainan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Hainan Province, Haikou 570100, China |
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Abstract Objective To study the main active ingredients and potential targets of Simiao Powder in the treatment of hyperuricemia (HUA) by means of network pharmacology. Methods The traditional Chinese medicine systems pharmacology database and analysis platform was used to screen the active ingredients of Simiao Powder, the DRAR-CPI platform and the Uniprot database were used to screen target genes, and the GeneCards database was used to search for the disease genes of HUA. Venn analysis was conducted to find the potential targets of drugs, so as to construct the active ingredient-target interaction network. Meanwhile, gene ontology (GO) function annotation, enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed. Results Fifty active ingredients and eight target sites for HUA were identified in this study. GO analysis clarified 26 items, and KEGG analysis revealed a total of 11 pathways. Conclusion This study initially explores the pharmacological effects and related mechanisms of Simiao Powder in treating HUA, at the same time establishes a framework for clinical application of the prescription and related experimental research.
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