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| Clinical study on the changes of serum MMP-9 and BDNF expression levels and prognosis in patients with acute cerebral infarction |
| LI Youjia HAN Xiaoyan HUANG Yan LUO Songbao HUANG Genlin HUANG Huiqin CHEN Ying WU Zhenmei |
| Department of Neurology, the First People’s Hospital of Zhaoqing, Guangdong Province, Zhaoqing 526000, China |
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Abstract Objective To study the changes of serum matrix metalloproteinase-9 (MMP-9) and brain-derived neurotrophic factor (BDNF) expression levels in patients with acute cerebral infarction (ACI) and their correlation with prognosis. Methods Forty-two patients who were diagnosed with ACI and completed the three-month follow-up at the First People’s Hospital of Zhaoqing, Guangdong Province from January to June 2019 were selected as the study group, and 40 healthy people with physical examination during the same period were selected as the control group. The serum MMP-9 and BDNF levels in the study group on the first day (T1), the second day (T2) and the fifth day (T5) were detected, and the serum MMP-9 and BDNF levels in the control group were detected during physical examination. The study group was followed up for three months. According to the prognosis, the study group was divided into good prognosis group (24 cases) and poor prognosis group (18 cases). The levels of MMP-9 and BDNF were compared between the study group and the control group, the good prognosis group and the poor prognosis group. Results At T1 time point, the serum MMP-9 and BDNF levels of the study group were higher than those of the control group, the differences were statistically significant (all P ＜ 0.05). According to the prognosis, the MMP-9 levels in the good prognosis group and the poor prognosis group were analyzed by repeated measures analysis of variance. Comparison and interaction between the two groups showed statistically significant differences (all P ＜ 0.05), while time point comparison showed no statistically significant difference (P ＞ 0.05). Further analysis showed that the level of MMP-9 in the poor prognosis group was higher than that in the good prognosis group at T5 time point, the difference was statistically significant (P ＜ 0.05). The BDNF levels of the two groups were analyzed, comparison of time point and interaction between the two groups showed statistically significant differences (all P ＜ 0.05), while there was no statistically significant difference between the two groups (P ＞ 0.05). Further analysis showed that the BDNF level at T2 time point was higher than that at T1 time point in the good prognosis group, and the BDNF level at T5 time point was higher than that at T2 time point, the differences were statistically significant (all P ＜ 0.05). The BDNF level at T2 time point and T5 time point in the poor prognosis group was lower than that at T1 time point, the differences were statistically significant (all P ＜ 0.05). Conclusion The changes of MMP-9 and BDNF are closely related to the prognosis of ACI patients. In the initial stage of onset, a high level of BDNF may indicate a poor prognosis. After several days of treatment, a high level of MMP-9 and a decrease in BDNF level may indicate a poor prognosis.
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