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2019 Vol. 16, No. 2
Published: 2019-01-15
 
 
4 Study on the experimental conditions for DDAH2 gene rs805304 polymorphism detection with PCR-RFLP
SHI Rou1 DONG Rongjing1 LIU Hua2 LI Huifang1▲
Objective To investigate the optimum experimental conditions for dimethylarginine dimethylamine hydrolase 2 (DDAH2) gene rs805304 polymorphism by polymerase chain reaction - restricted fragment length polymorphism (PCR-RFLP). Methods The DDAH2-rs805304 locus polymorphism in 182 T2DM cases admitted to the First Affiliated Hospital of Kunming Medical University from January 2016 to March 2017 and 147 healthy controls were detected by PCR-RFLP. The main factors influencing PCR-RFLP were studied. Results The optimum conditions: annealing temperature was 58℃, denaturation temperature was 95℃, 2× Power Taq PCR Master Mix concentration was 12.5 μL, primer concentration was 0.8 μmo/L, the effective system was 15 μL including 8 μL DNA solution and 5 U restriction enzyme BstUI. Conclusion The exploration of optimal experimental conditions has laid a foundation for the subsequent research.
2019 Vol. 16 (2): 4-7 [Abstract] ( 223 ) HTML (1 KB)  PDF (681 KB)  ( 135 )
8 Protective effect of epidermal growth factor-coordination pretreatment on cerebral ischemia reperfusion in rats
QU Jing XU Na AO Ting ZHANG Jun ZHANG Qin XIAO Shuying ZHANG Ruihua▲
Objective To study the effect of epidermal growth factor-coordination (EGF-c) on cerebral ischemia reperfusion (IR) in rats as well as its mechanism. Methods Thirty male SD rats were divided into sham group, ischemia reperfusion group (IR group), EGF-c pretreatment and IR group (EGF-c group) by random number table method. The middle cerebral artery occlusion (MCAO) model of rats was made by suture method. 24 hours after operation, the cerebral infarction volume was detected by 2% triphenyl tetrazolium chloride (TTC) staining, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in brain tissue were measured by enzyme-linked immunosorbent assay (ELISA), the expression of high mobility group protein 1 (HMGB1) was examined by Western blot. Results Compared with sham group, the infarction volume was increased (P ＜ 0.01), the SOD activity was decreased (P ＜ 0.01), the contents of MDA and HMGB1 were increased in IR group (P ＜ 0.01). Compared with IR group, the infarction volume was decreased (P ＜ 0.05), SOD activity was increased (P ＜ 0.01), the content of MDA was decreased (P ＜ 0.01), the expression of HMGB1 was decreased in EGF-c group (P ＜ 0.05). Conclusion EGF-c pretreatment may play a protective effect on IR of rats by improving the SOD activity, decreasing the content of MDA and the expression of HMGB1.
2019 Vol. 16 (2): 8-11,16 [Abstract] ( 404 ) HTML (1 KB)  PDF (752 KB)  ( 120 )
12 Inhibitory effect of ABT-263 on cisplatin-resistant esophageal cancer cells
LIN Qinghuan1 DING Rong1 BI Tingting1 LIN Jian2 DENG Guihua1
Objective To investigate the effect of ABT-263 on cisplatin-resistant esophageal cancer cell line of EC109/CDDP. Methods The cytotoxicity of ABT-263 in the cisplatin-resistant cell line EC109/CDDP and its parental cell line EC109 was measured by MTT assay. Colony formation assay was used to determine the effect of ABT-263 on cell renewable capacity of esophageal cancer cells. Flow cytometry was adopted to detect cell apoptosis. Western blot was used to investigate the changes of protein expression of PARP. Results MTT assay results showed that ABT-263 significantly inhibited the cell viability of EC109 and EC109/CDDP. Colony formation assay indicated that ABT-263 inhibited the cell renewable capacity of esophageal cancer cells (P ＜ 0.01). Flow cytometry analysis revealed that ABT-263 induced apoptosis of esophageal cancer cells (P ＜ 0.01). Western blot results showed that ABT-263 significantly increased the protein expression of cleavage PARP (P < 0.05 or P ＜ 0.01). Conclusion ABT-263 exhibits cytostatic and cytotoxic effects on cisplatin-resistant esophageal cancer cell line EC109/CDDP and its parental cell line EC109, while it induces apoptosis.
2019 Vol. 16 (2): 12-16 [Abstract] ( 267 ) HTML (1 KB)  PDF (1098 KB)  ( 123 )
17 Experimental study on the efficiency of bFGF promoting direct reprogramming-induced transdifferentiation of fibroblasts into cardiomyocytes
REN Jie ZHAO Long▲ SONG Zhenxiang LI Wei
Objective To investigate the effects of basic fibroblast growth factor (bFGF) on the transformation of direct reprogramming-induced transdifferentiation of fibroblasts into cardiomyocytes. Methods Direct reprogramming was performed to induce rat tail fibroblasts into cardiomyocytes by defined factors GATA-4, Mef2c and Tbx5. Then the cells were divided into two groups, one group was cultured normally, and the other group was cultured with 50 μg/L bFGF. Two weeks later, the differentiation of cardiomyocytes was identified by detection of the expression of cardiac specific protein such as cardiac troponin T (cTNT), α-myosin heavy chain (α-MHC), GATA binding protein 4 antibody (GATA-4) and connexin 43 (CX43) and analysis of electrophysiology. And the differentiation rates of the two groups were compared. Results Western blot and immunofluorescence test showed that the expression of cTNT, α-MHC, GATA-4 and CX43 significantly up-regulated after exposure to bFGF (P ＜ 0.01). And the further analysis of electrophysiology revealed that the electrophysiological characteristics of these cells were very similar to those of cardiomyocytes, which was identified as cardiac differentiation. Conclusion Fibroblasts can be induced by direct reprogramming to differentiate into cardiomyocytes, which can be promoted by bFGF. This study may provide a new method to harvest cardiomyocytes.
2019 Vol. 16 (2): 17-19,28 [Abstract] ( 271 ) HTML (1 KB)  PDF (962 KB)  ( 243 )
20 Current situation and development trends of medical mall at home and abroad
GOU Zhengxian1 XIONG Chuanyin1 YAN Xing2 ZHANG Wenwei1 WU Jiamin1 HE Yulin1
Medical mall is a mode of "commercial + medical", which has appeared abroad for many years, and has already developed into a mature mode. In contrast, domestic medical mall has appeared for a short time, and stays at the exploratory stage currently. There exists some problems of domestic medical mall. For example, it is not included in the coverage of basic health insurance, and lacks the experience of property development and operation management. Besides, it is difficult to decide the main responsible body of medical treatment and manage hospital infection. However, medical mall meets the demand of modern people′s health and lifestyle, and has a bright prospect. In the future, medical mall will present the development trends of promoting the pattern of "privately build and publicly operate", broadening the scope of medical services, realizing the share of medical resources. Therefore, it will help to meet the diversified demands of medical treatment, improve patients′ medical experience, and effectively alleviate the difficulty of getting medical services.
2019 Vol. 16 (2): 20-23,36 [Abstract] ( 299 ) HTML (1 KB)  PDF (628 KB)  ( 289 )
24 Research progress on the pathogenesis of post-stroke depression
LIU Zengxue LU Jingjue ZHOU Yixin
Post-stroke depression is one of the common complications after stroke. The incidence is high and its pathogenesis is complex and changeable. Scholars at home and abroad mainly believe that there are two theories: biological mechanism and social psychological mechanism. Biological mechanism includes neurotransmitter, inflammatory cytokines, lesion site, homocysteine, gene mutation, nerve growth factors, which is correlated to the post-stroke depression. Social and psychological factors, including demographic factors, insomnia, social support, family relations, way of life and adverse life events, all can affect the occurrence and development of post-stroke depression. The explanation of TCM etiology and pathogenesis is also closely related to the occurrence of post-stroke depression. However, the formation mechanism of post-stroke depression has not yet been clearly concluded. People still need to further study the role and relationship between related factors and disease occurrence.
2019 Vol. 16 (2): 24-28 [Abstract] ( 210 ) HTML (1 KB)  PDF (587 KB)  ( 67 )
29 The present situation and prospect of Buyang Huanwu Decoction combined with interventional therapy for diabetic foot
LIU Wenbin1 WANG Jianbo2 GUI Dingkun3
Diabetic foot is a common complication of diabetes and the main cause of amputation in diabetic patients. Traditional Chinese medicine, as a traditional medical means in China, has a good effect on the treatment of diabetic foot ulcer, foot vascular stenosis and diabetic peripheral neuropathy, and intervention, as a new emerging technology in recent years, has a good effect on the treatment of diabetic peripheral blood vessel stenosis and occlusion. In recent years, many hospitals have achieved good results in the innovative application of traditional Chinese medicine prescriptions of invigorating qi and strengthening the body, invigorating blood circulation and resolving blood stasis combined with interventional therapy for diabetic feet. Buyang Huanwu Decoction has been widely used in the clinical application of diabetic foot as a classical prescription for invigorating qi and activating blood circulation to clear collaterals. This paper introduces the current situation of Buyang Huanwu Decoction combined with interventional therapy for diabetic foot and its treatment prospect from four aspects: the establishment of collateral circulation, the change of peripheral nerves, the speed of wound healing and the improvement of blood glucose and lipid.
2019 Vol. 16 (2): 29-32 [Abstract] ( 231 ) HTML (1 KB)  PDF (577 KB)  ( 137 )
33 Study on the development status of mixed-ownership hospitals
CHEN Hong YU Qian▲
More and more medical institutions are exploring new models of development, as countries continue to introduce policies to encourage social doctors in recent years and public hospital reform into deep water. Medical institutions held in the form of public-private partnerships as a new development way are gradually brought into focus, but as a new medical pattern, now it is still in the continuously exploratory stage, because of different property right structures, diversity of cooperation modes. Different management mode produces different economic and social benefits. Through consulting relevant literatures, the related concept is explained, the present situations of mixed-ownership hospitals of our country are summarized, and the existing operation mode has been carried on the summary, and this paper finds that the mixed ownership hospital also has its limitations because of the current imperfect policy. However, it is necessary to develop mixed ownership hospitals to control the number of public hospitals, optimize the allocation of medical resources, meet the medical needs of different levels and form a diversified medical pattern.
2019 Vol. 16 (2): 33-36 [Abstract] ( 205 ) HTML (1 KB)  PDF (571 KB)  ( 156 )
37 Relationship between subliminal depression and social relationship quality in newly diagnosed breast cancer patients
CHEN Jianjian1 WANG Hong2 DING Juan2 ZHANG Haiyuan1
Objective To investigate the status of subthreshold depression and the quality of social relations in patients preliminarily diagnosed with breast cancer, and to explore their relationship. Methods From January to December 2017, a total of 210 patients newly diagnosed with breast cancer in Jingzhou Central Hospital were selected as research subjects. The general questionnaire, Center for Epidemiological Studies Depression Scale (CES-D), Hamilton Rating Scale for Depression (HAMD-17) were used to investigate the subthreshold depression in the newly diagnosed breast cancer patients, and Social Relational Quality Scale (SQRS) was used to evaluate the social relationship quality, and correlation analysis was performed. Results The subthreshold depression detection rate was 48.6% of patients newly diagnosed with breast cancer. The SQRS scores in non-depression patients was higher than that of patients with subthreshold depression (P ＜ 0.01). The CES-D scores was significantly negatively correlated to the total scores and every factor scores of SRQS (P ＜ 0.01). Conclusion The incidence of subthreshold depression in newly diagnosed breast cancer patients is high, and it is closely related to the quality of social relations. Psychological status of newly diagnosed breast cancer patients should be paid attention to, psychological intervention should be increased in time, to improve the social relation quality, and then improve quality of life.
2019 Vol. 16 (2): 37-40 [Abstract] ( 218 ) HTML (1 KB)  PDF (386 KB)  ( 106 )
41 Relationship between visfatin, NF-κB and platelet activation parameters in unstable angina patients
SUN Xin1 WU Yanqiang2
Objective To investigate the relationship between platelet activation parameters of serum Visfatin, nuclear factor-κB (NF- κB) and unstable angina pectoris (UA). Methods From April 2017 to September 2018, in the Second Hospital of Handan, 108 UA patients were selected as angina group, at the same time, 108 healthy patients underwent physical examination were selected as the health group. In the two groups, blood samples were collected on the day of admission to detect serum Visfatin, NF-κB and platelet granule membrane protein (CD63), platelet membrane glycoproteinⅡb-Ⅲa (PAC-1), platelet alpha particle surface membrane glycoprotein (CD62P). Serum Visfatin, NF-κB and platelet activation parameters of low, middle and high risk patients were compared. The correlation between serum Visfatin and NF-κB and platelet activation parameters in UA patients was observed by Pearson linear correlation analysis. Results The levels of serum Visfatin, NF-κB and CD63, PAC-1 and CD62P in angina pectoris group were higher than those in healthy group, the differences were statistically significant (P < 0.01). Serum levels of Visfatin, NF-κB and CD63, PAC-1 and CD62P in the low risk group were lower than those in the middle risk group and high-risk group, and these in the middle risk group were lower than the high risk group, the differences were statistically significant (P < 0.05). Pearson linear correlation analysis showed that serum visfatin and NF-κB were positively correlated with CD63 and PAC-1 (r = 0.671, 0.591, 0.507, 0.460, P < 0.05). There was no significant correlation between the two and CD62P (P > 0.05). Conclusion Visfatin and NF-κB were correlated with platelet activation parameters CD63 and PAC-1 in patients with UA. Visfatin, NF-κB and platelet activation parameters can be used as an important indicator for evaluating the condition of UA patients.
2019 Vol. 16 (2): 41-44,62 [Abstract] ( 238 ) HTML (1 KB)  PDF (877 KB)  ( 180 )
45 Correlation between epicardialadipose quantification and adipose factor levels and vulnerability of coronary atherosclerotic plaques
CHEN Yuxiang1 WU Xiaoqiu1 LING Yun2 WU Qixin1▲ LI Xingyang1 HUANG Bin1
Objective To observe the epicardial adipose tissue volume (EATV) and the levels of adiponectin in patients with coronary heart disease (CHD), and analyze the relationship with the vulnerability of coronary atherosclerotic plaques. Methods From January 2015 to December 2017, in Chongzuo People's Hospital, 100 patients with coronary heart disease were selected as CHD group, and 50 healthy people were selected as control group. The EATV, coronary artery stenosis (Gensini integral) and positive reconstruction rate the serum levels of adiponectin, resistin and visfatin in two groups were compared, the related risk factors of the vulnerability of coronary atherosclerotic plaques were analyzed. Results The EATV, the Gensini integral and the positive reconstruction rate of the CHD group were higher than the control group (P < 0.01). The serum level of adiponectin of the CHD group was lower than the control group (P < 0.01), the levels of serum resistin and visfatin of the CHD group were higher than the control group (P < 0.01). The EATV > 107.20 cm3, the serum level of adiponectin < 2.90 μg/mL, the serum level of resistin > 11.39 ng/mL, the serum level of visfatin > 32.50 ng/mL, hypertension were independent risk factors for vulnerable coronary atherosclerotic plaques (P < 0.01). Conclusion The levels of EATV and adipose factors in CHD patients are obviously abnormal, and there are many risk factors for vulnerable atherosclerotic plaque, and the prevention and control measures should be formulated accordingly.
2019 Vol. 16 (2): 45-48 [Abstract] ( 182 ) HTML (1 KB)  PDF (586 KB)  ( 121 )
49 Interpretation of the effect of recombinant brain natriuretic peptide on cardiac output in patients with heart failure by venous reflux curve
LIU Jianling YANG Huizhao MING Jianqing LI Jiemin WEN Zhenjie CHEN Jun ZHANG Ming Lin Qinhan ZHOU Haibo
Objective To explore the effect of recombinant brain natriuretic peptide on cardiac output (CO) in patients with heart failure by using venous reflux curve. Methods From July 2014 to May 2017, in ICU, Qingyuan People′s Hospital, 45 patients with congestive heart failure were selected, and the basic information before the treatment were recorded, all patients with congestive heart failure were given the conventional treatment (such as diuretics, digitalis, etc.), and on this basis of conventional treatment, the recombinant brain natriuretic peptide was administered by continuous intravenous infusion for 24 h at the loading dose. The mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), central venous pressure (CVP), mean systemic filling pressure (Pmsf), resistance for venous return (RVR), systemic vascular resistance (SVR), stroke volume variation (SVV) were recorded before 0 min and 30 min, 3 h after the treatment. The collected hemodynamic parameters were used to calculate the indicators to draw the venous reflux curve. Other data were analyzed by statistical analysis before and after comparison. Results Compared with 0 min before drug administration, CO increased and SVR decreased 30 min after drug administration, the differences were statistically significant (P < 0.05 or P < 0.01); CO and CVP increased, while RVR and SVR decreased 3 h after drug administration, the differences were statistically significant (P < 0.05 or P < 0.01). Compared with 30 min after drug administration, CVP increased, MAP, Pmsf and RVR decreased 3 h after drug administration, the differences were statistically significant (P < 0.05 or P < 0.01). The venous reflux curve shows that with the continuous increasing of CVP, the CO of patients with recombinant brain natriuretic peptide decrease continuously at 0 min before drug administration and 30 min and 3 h after drug administration. Conclusion Recombinant human brain natriuretic peptide can increase CO in patients with acute heart failure, possibly by reducing peripheral circulatory resistance and reducing cardiac after load. At the later stage, the effect of peripheral circulation resistance has decreased, but RVR has decreased, thus increasing the venous reflux and increasing the patients′ CO.
2019 Vol. 16 (2): 49-53 [Abstract] ( 271 ) HTML (1 KB)  PDF (598 KB)  ( 131 )
54 Expression and clinical significance of serum CysC, hs-CRP and Lp (a) in patients with acute coronary syndrome
GUO Qing CHENG Xin YAN Jieting YE Hong
Objective To explore the expression and clinical significance of serum Cystatin C (CysC), high sensitivity C reactive protein (hs-CRP), lipoprotein a [Lp (a)] in patients with acute coronary syndrome. Methods From October 2016 to May 2018, in Huangshi Central Hospital, Edong Healthcare Group, 106 patients with acute coronary syndrome were selected as the study group, at the same time, 106 healthy persons were selected as the control group. At the second morning, 4 mL fasting venous blood was taken from all subjects. Serum Lp (a) levels were measured by immunoturbidimetry and serum CysC and hs-CRP levels were measured by enzyme-linked immunosorbent assay. The levels of serum CysC, hs-CRP and Lp (a) in the study group and control group, patients with different pathological types of acute coronary syndrome, patients with different pathological changes of acute coronary syndrome, and patients with different severity of acute coronary syndromes were observed. The correlation between serum CysC, hs-CRP, Lp (a) and the severity of acute coronary syndrome was analyzed. And the efficacy of serum CysC, hs-CRP and Lp (a) alone and combined in the diagnosis of acute coronary syndrome were compared. Results The levels of serum CysC, hs-CRP and Lp(a) in the study group were higher than those in the control group, the differences were statistically significant (P < 0.01). There were statistically significant differences in serum levels of CysC, hs-CRP and Lp (a) in patients with different pathological types of acute coronary syndrome (P < 0.01). The serum levels of CysC, hs-CRP and Lp (a) in patients with unstable angina pectoris were higher than patients with stable angina, the levels of serum CysC, hs-CRP and Lp (a) in patients with acute myocardial infarction were higher than patients with unstable angina pectoris, the differences were statistically significant (P < 0.01). There were statistically significant differences in serum levels of CysC, hs-CRP and Lp(a) in patients with different coronary artery lesions (P < 0.05). The levels of serum CysC, hs-CRP and Lp (a) in patients with double vessel disease were higher than those in single vessel disease, and the levels of serum CysC, hs-CRP and Lp (a) were higher in three vessel lesions than double vessel lesions, the differences were statistically significant (P < 0.01). There were statistically significant differences in serum levels of CysC, hs-CRP and Lp (a) in patients with different severity of acute coronary syndrome (P < 0.05). The serum levels of CysC, hs-CRP and Lp (a) in moderate patients were higher than those in mild patients, the levels of serum CysC, hs-CRP and Lp (a) in severe patients were higher than those in moderate patients, the differences were statistically significant (P < 0.05). Pearson test showed that the level of serum CysC, hs-CRP, Lp (a) and the degree of acute coronary syndrome were positively correlated with the degree of acute coronary syndrome (r = 0.663, 0.691, 0.652, P < 0.05). Combined diagnostic sensitivity (95.28%) and accuracy (95.28%) were higher than serum CysC (79.25%, 88.68%), hs-CRP (80.19%, 87.74%), Lp (a) (78.30%, 87.26%) alone, the differences were statistically significant (P < 0.05). There was no significant difference between the combined diagnostic specificity (95.28%) and serum CysC (98.11%), hs-CRP (95.28%), Lp (a) (96.23%) alone (P > 0.05). Conclusion The serum levels of CysC, hs-CRP and Lp (a) in patients with acute coronary syndromes are very high, and there are significant differences in different pathological types. With the increase of the number of diseases and the severity of the disease, the serum levels are increasing. The diagnosis and evaluation of the disease can be effectively identified by the combined detection of the above indexes.
2019 Vol. 16 (2): 54-58 [Abstract] ( 275 ) HTML (1 KB)  PDF (560 KB)  ( 122 )
59 Thrombolytic effect of Alteplase combined with Heparin in treatment of acute ST segment elevation myocardial infarction
WANG Hui MA Ganfang
Objective To discuss the therapeutic effect of Heparin combined with Aheplase as the intravenous thrombolytic therapy treating acute STEMI. Methods From July 2017 to April 2018, in Department of Emergency, Beijing Ditan Hospital, Capital Medical University, 137 patients with acute STEMI were selected, they were divided into the control group (67 cases) and the observation group (70 cases) according to the random number table method. The control group was treated with urokinase as the intravenous thrombolysis, and the observation group was treated with Heparin and Aheplase. The changes of electrocardiogram, the changes of myocardial enzymes, the degree of remission of the symptoms and the arrhythmia of reperfusion after thrombolytic treatment were observed, the preliminary judgement whether the blood vessels were reconnected after thrombolytic, and further remedial PCI was performed to determine the recanalization condition indeed, the monitor the incidence of cardiogenic shock, malignant arrhythmia, heart failure and death were continuously given during the period of hospitalization. Results The total efficacy in the observation group was higher  than the control group, the difference was statistically significant (P < 0.01); the incidence of cardiovascular events in the observation group was lower than in the control group, the difference was statistically significant (P < 0.01). Conclusion Heparin combined with alteplase as the intravenous thrombolytic therapy is superior to urokinase, and can also reduce the incidence of cardiovascular events in STEMI patients.
2019 Vol. 16 (2): 59-62 [Abstract] ( 223 ) HTML (1 KB)  PDF (548 KB)  ( 51 )
63 Clinical study of Tianma Gouteng Granules combined with Madopar in the treatment of Parkinson disease
WANG Zheng1 LAI Tianbao2 WANG Xiaoxi3 LI Xiaofeng4
Objective To study the clinical efficacy of Tianma Gouteng Granules combined with Madopar in the treatment of Parkinson disease (PD). Methods From April 2016 to February 2018, 174 patients with PD admitted in Hangzhou Seventh People′s Hospital were selected. According to the random number table method, the patients were divided into observation group and control group, 87 cases in each group. The control group was treated with Madopar and the observation group was treated with Tianma Gouteng Granules on the basis of the control group. The two groups were treated for 3 months, 3 months was 1 course of treatment. The efficacy, inflammatory index, oxidative stress index, unified parkinson disease rating scale (UPDRS), mini mental state examination (MMSE) and medication safety were compared. Results The total effective rate of the observation group was 96.55%, which was significantly higher than 88.51% of the control group, the difference was statistically significant (P ＜ 0.05). After 3 months of treatment, the level of nterleukin-4 and superoxide dismutase in both groups was higher than that before treatment, and the level in the observation group was higher than that in the control group, tumor necrosis factor-α and malonaldehyde level in the two groups was lower than before treatment, and the observation group was lower than the control group, the differences were statistically significant(all P ＜ 0.05). After 3 months of treatment, the MMSE score of the two groups was significantly higher than that before treatment, and the observation group was higher than that of the control group, the UPDRS scores of the two groups were significantly lower than those before treatment, and the observation group was lower than that of the control group, the differences were statistically significant (all P ＜ 0.05). The total incidence of adverse reactions in the observation group was 6.90%, compared with 9.20% of the control group, the difference was not statistically significant (P ＞ 0.05). Conclusion Tianma Gouteng Granules combined with Madopar is effective in the treatment of PD. It can effectively improve the inflammatory state and oxidative stress level of patients, and improve their cognitive function. The drug is safe and worthy of promotion.
2019 Vol. 16 (2): 63-66,71 [Abstract] ( 229 ) HTML (1 KB)  PDF (518 KB)  ( 192 )
67 Effect of Xiaoshuan Enteric-dissolution Capsules on nerve injury, cerebral blood perfusion, serum CRP and Hcy in convalescent patients with ischemic stroke
DING Huiyan1 ZHANG Shuqin1 DENG Lijun1 HAN Yufu2
Objective To observe the effect of Xiaoshuan Enteric-dissolution Capsules on nerve injury, cerebral blood perfusion, serum C-reactive protein (CRP) and serum homocysteine (Hcy) in convalescent patients with ischemic stroke. Methods Ninety-two convalescent patients with ischemic stroke admitted to the Department of Neurology of Wuhan Sixth Hospital from January to October 2017 were selected as the research objects. According to the random number table, they were divided into the observation group and the control group. Forty-six patients in the control group were treated with conventional Western medicine, and forty-six patients in the observation group were treated with Xiaoshuan Enteric-dissolution Capsules on the basis of the treatment in the control group. After 4 weeks of treatment, the cerebral blood flow perfusion [peak systolic velocity (PSV), mean velocity (TMV), resistance index (RI)], nerve injury, [ubiquitin carboxyl terminal hydrolase - 1 (UCH L1), neuron specific enolization enzyme (NSE) and glial fibrillar acidic protein (GFAP), called S100B protein (called S100B)], Hcy and CRP levels, changes of two groups were observed, clinical curative effect was counted, medication safety during treatment was compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, PSV and TMV levels in both groups were significantly higher than those before treatment (all P ＜ 0.05), RI levels were significantly lower than those before treatment (all P ＜ 0.05), and the improvement of the above cerebral blood perfusion indexes in the observation group was significantly better than that in the control group (all P ＜ 0.05). After treatment, UCH-L1, NSE, GFAP and S100B levels in both groups were significantly lower than before treatment (all P ＜ 0.05), and the above nerve injury indexes in the observation group were significantly lower than those in the control group (all P ＜ 0.05). Serum CRP and Hcy levels in both groups after treatment were significantly lower than those before treatment (P ＜ 0.05), and CRP and Hcy levels in the observation group were significantly lower than those in the control group (P ＜ 0.05); blood routine, urine routine, stool routine, liver and kidney function, electrocardiogram, electrolyte were not significantly abnormal during the treatment of the two groups, and no serious adverse reactions occurred. Conclusion Xiaoshuan Enteric-dissolution Capsules can significantly improve cerebral blood perfusion, inhibit the expression of serum Hcy and CRP, reduce inflammatory injury of brain tissue, optimize nerve function, and help improve the degree of nerve function defect in the convalescent period of ischemic stroke, and promote the outcome of the disease.
2019 Vol. 16 (2): 67-71 [Abstract] ( 293 ) HTML (1 KB)  PDF (483 KB)  ( 118 )
72 Effects of testosterone in serum and follicular fluid on pregnancy outcomes of IVF-ET
LU Zhenhua1,2 HU Xingwen3▲ ZHENG Jie4 XIA Min4 XIA Qi3
Objective To investigate the effects of estradiol, progesterone and testosterone in serum and follicular fluid on pregnancy outcomes of in vitro fertilization - embryo transfer (IVF-ET). Methods From January to December 2013, 176 patients who received IVF-ET in the Reproductive Center of Hubei Maternal and Child Health Hospital were selected. According to clinical pregnancy outcome, clinical pregnancy group and non-clinical pregnancy group. The levels of estradiol, progesterone and testosterone concrtilization-embryo ttansfer, estradiol, progesterone and testosterone of daily basal serum, HCG daily serum, the serum on the day of ovulation and follicular fluid of two groups were detected. Results The levels of estradiol and testosterone in HCG daily serum  in the clinical pregnancy group were higher than that in the non-clinical pregnancy group, and the differences were significant (P < 0.05). The concentration of testosterone in the clinical pregnancy group was higher than that in the non-clinical pregnancy group, and the difference was significant (P < 0.05). The concentration levels of estradiol, progesterone and testosterone in the serum on the day of ovulation were positively correlated with the concentration levels in the follicular fluid (r = 0.236, 0.216, 0.426, P < 0.01). Conclusion The testosterone in follicular fluid can promote the maturation of oocytes and facilitate the clinical pregnancy of IVF-ET.
2019 Vol. 16 (2): 72-74,84 [Abstract] ( 242 ) HTML (1 KB)  PDF (498 KB)  ( 108 )
75 Analysis of changes of amniotic fluid and blood biochemical characteristics in patients with abnormal idiopathic amniotic fluid volume
YANG Chunyan WU Jiping
Objective To investigate the changes of amniotic fluid and blood biochemical characteristics in patients with advanced idiopathic amniotic fluid. Methods From January 2017 to June 2018, 33 pregnant women with idiopathic oligohydramnios in late pregnancy who underwent prenatal examination and delivered in Zhuozhou Hospital of Hebei Province were selected as group A, and 43 pregnant women with idiopathic hydramnios in late pregnancy were selected as group B, 52 pregnant women with normal amniotic fluid volume were selected as group C at the same period. The levels of potassium, sodium, chlorine, calcium, urea nitrogen, creatinine, carbon dioxide binding capacity, glucose, total protein and osmotic pressure in werum and amniotic fluid of three groups were observed. Results There was no significant difference in amniotic fluid potassium, chlorine, carbon dioxide binding capacity, urea nitrogen and total protein levels among the three groups (P > 0.05). The levels of amniotic fluid sodium, calcium, glucose and osmotic pressure in group A were lower than those in group B and C, and the levels of creatinine were higher than those in group B and group C, and the differences were statistically significant (P < 0.05). There was no significant difference in serum potassium, sodium, chlorine, calcium, carbon dioxide binding capacity, glucose, urea nitrogen, creatinine, total protein and osmotic pressure among the three groups (P > 0.05). Conclusion The idiopathic amniotic fluid (IAF) is not associated with serum and amniotic fluid biochemical changes in pregnant women, and there are abnormal changes in amniotic fluid biochemical components in IAF pregnant women, but the detailed mechanism remains to be further studied.
2019 Vol. 16 (2): 75-77 [Abstract] ( 200 ) HTML (1 KB)  PDF (501 KB)  ( 84 )
78 Clinical- efficacy comparison of Nifedipine and Magnesium Sulfate in the treatment of preterm labor
YANG Fan LIU Zhengfei LI Yanjiao
Objective To analyze clinical effects, maternal and infant outcomes and adverse events of magnesium sulfate and Nifedipine on premature delivery. Methods Clinical data of 98 preterm pregnant women from March 2017 to February 2016 in the First People′s Hospital of Yibin City in Sichuan Province were retrospectively analyzed, and they were divided into two groups according to the treatment scheme, 49 patients treated with Nifedipine were set up as the study group, 49 patients treated with Magnesium Sulfate were set up as the control group. The clinical curative effect, the maternal and infant outcome and the adverse reaction of the two groups were compared. Results In the study group, the proportion of pregnant women whose duration of gestational age longer than 7 d, gestational age longer than 2 d, and the success rate of fetus preservation were higher than those of control group, and the effective time was shorter than that of the control group, the total incidence of adverse reactions was lower than that of the control group, the differences were statistically significant (P < 0.05). There was no statistically difference in newborn weight, Apgar score, pregnancy week, and the time of uterine contraction after the first drug use between the two groups (P > 0.05). Conclusion Treatment with Nifedipine for preterm pregnant women can improve the success rate of pregnancy preservation and prolong the gestational weeks, and the incidence of adverse reactions of drug is low, with a certain clinical application and research value.
2019 Vol. 16 (2): 78-80 [Abstract] ( 219 ) HTML (1 KB)  PDF (473 KB)  ( 79 )
81 Effect of umbilical cord ligature on neonatal complications
LI Jing LIU Weihua WANG Bei GUO Leilei LIU Yanxia
Objective To investigate the different effect of umbilical cord methods on neonatal complications. Methods A total of 150 newborns from January 2016 to October 2017 in Huairou District Maternal and Child Health Care Hospital of Beijing City were retrospectively analyzed, and they were divided into early cord clamping (ECC) group, squeezed umbilical cord clamping group and delayed cord clamping (DCC) group according to ligating methods, with 50 newborns in each group. The occurrence of Hb, Hct and complications of newborns in three groups 12-24 h after delivery were compared. Results The Hb of DCC group was higher than that of squeezed umbilical cord clamping group and ECC group, squeezed umbilical cord clamping group was higher than that of ECC group, the differences were statistically significant (P < 0.05). Levels of Hct inDCC group and squeezed umbilical cord clamping group were higher than that in ECC group, the differences were statistically significant (P < 0.05), but there was no statistical significance between the DCC group and squeezed umbilical cord clamping group (P > 0.05). The incidence of anemia in DCC group and squeezed umbilical cord clamping group was lower than ECC group, the differences were statistically significant(P < 0.05), but there was no statistical significance between squeezed umbilical cord clamping group and DCC group (P > 0.05). The incidence of hyperbilirubin and erythremia in each groups showed no statistically significant difference (P > 0.05). Conclusion DCC and squeezed umbilical cord clamping can reduce part of complications those occur in neonatal, especially the squeezed umbilical cord clamping, it is easy to operate and improve the health of neonatal prognosis, it is conducive to clinical promotion in primary hospitals.
2019 Vol. 16 (2): 81-84 [Abstract] ( 176 ) HTML (1 KB)  PDF (512 KB)  ( 73 )
85 Relationship between peripheral blood circulating tumor cells and pathological parameters and prognosis of patients with renal cancer
LI Hao1 CHEN Congbo1 YAO Qisheng1 GONG Xiaofang2▲
Objective To explore the relationship between peripheral blood circulating tumor cells (CTCs) and pathological paramets, and prognosis of renal cancer. Methods One hundred and seven patients with renal cell carcinoma admitted to Taihe Hospital of Shiyan in Hubei Province, from February 2014 to December 2017 and 20 healthy volunteers who performed physical examination were enrolled in the study. The immunomagnetic enrichment and immunofluorescence staining methods were used to count peripheral blood CTCs. The relationship between the positive rate of CTCs and age, gender, clinical stage, T stage, Fuhrman grade, clinical parameters such as neutrophils, serum calcium and platelets were analyzed. The relationship between peripheral blood CTCs and the prognosis of renal cancer was explored. Results The detection rate of CTCs in patients with renal cancer was 66.35%. No CTCs were found in peripheral blood of healthy volunteers. The positive rate of CTCs was related to the T stage, clinical stage and increase of neutrophils (P ＜ 0.05). Logistic regression analysis showed that T stage was an independent risk factor (OR = 1.816, 95%CI: 0.814-4.052, P ＜ 0.05). All the patients were followed up for 60-627 d. The median survival time of CTCs positive patients was shorter than that of CTCs negative patients (P ＜ 0.05). Conclusion The positive rate of CTCs in peripheral blood is related to T stage, clinical stage and increase of neutrophils in patients with renal cancer. The T stage of tumor is an independent risk factor for peripheral blood CTCs. Peripheral blood CTCs can be used as auxiliary information for judging the prognosis of patients with renal cancer.
2019 Vol. 16 (2): 85-88 [Abstract] ( 239 ) HTML (1 KB)  PDF (476 KB)  ( 173 )
89 Meta-analysis of radiofrequency ablation and surgical resection in treatment of colorectal liver metastases
LIU XiangDong SU Song LUO De CHEN Xinpei ZHOU Pengcheng LI Bo
Objective To compare the therapeutic efficacy between radiofrequency ablation (RFA) and hepatic resection(HR) for colorectal liver metastases (CRLM). Methods Systematic literature search of clinical trials was carried out to compare RFA and HR for colorectal liver metastasis in Cochrane library, PubMed, Embase, CNKI, Wanfang and VIP from database inception to May 2018. The quality of the included studies was assessed and the data analysis was performed by software RevMan 5.3 from Cochrane library. Results Finally 26 trials including 3738 cases were included, with 1447 cases in RFA group and 2291 cases in HR group. The results of Meta-analysis showed: 5-year overall survival and 5-year disease-free survival were significantly lower in RFA group than HR group (OR = 2.42, 95%CI: 1.64-3.57, P ＜ 0.000 01; OR = 2.33, 95%CI: 1.37-3.98, P = 0.002). Local recurrence and intrahepatic recurrence rates were significantly higher in RFA group than HR group (OR = 9.29, 95%CI: 6.88-12.54, P ＜ 0.000 01; OR = 2.03, 95%CI: 1.45-2.83, P ＜ 0.0001). RFA had significantly lower postoperative complication rate than HR group (OR = 0.47, 95%CI: 0.29-0.76, P = 0.002). Conclusion The complication rate in patients treated by RFA is significantly lower than HR, but survival rate is lower and recurrence rate is higher by RFA than HR. HR is still the preferred treatment for CRLM.
2019 Vol. 16 (2): 89-93,101 [Abstract] ( 235 ) HTML (1 KB)  PDF (1584 KB)  ( 90 )
94 Expression of CEACAM-1 in colorectal carcinoma and correlation with tumor angiogenesis and metastasis
XIA Longfei1 LIU Yujun1 ZHANG Junmin1 HAN Junyi2
Objective To investigate the expression of CEACAM-1 and the correlation with the tumor angiogenesis and metastasis, and explore feasibility as a monitoring indicator for the diagnosis, treatment and prognosis in evaluating colorectal carcinoma. Methods Fifty specimens of colorectal adenomacarcinoma tissues and 50 specimens of normal colorectal tissues from January 2016 to January 2017 in the Department of General Surgery, Maternal and Child Health Hospital of Zhoushan City were collected. The expression of CEACAM-1, VEGF was detected by immunohistochemistry method, and the value of micro-vascular density (MVD) was observed. The correlation between clinicopathologic features of tumors and expression of CEACAM-1, VEGF and MVD value, as well as the correlation among the three indices was analyzed. Results The positive expression of CEACAM-1 and VEGF in colorectal carcinoma tissues were significantly higher than those in normal tissues, and the differences were highly significant (P = 0.000); MVD value in colorectal carcinoma tissues was significantly higher than that of normal tissue, and the difference was highly significant (P = 0.000); the expression of CEACAM-1, VEGF and MVD value were correlated to degree of colorectal tumor differentiation, tumor serous membrane infiltration, TNM staging, vascular infiltration, lymph node metastasis and liver metastasis (P ＜ 0.05); MVD value of CEACAM-1 and VEGF positive expression groups was significantly higher than that of the negative group in colorectal carcinoma tissues (P ＜ 0.01); the expression of CEACAM-1 and VEGF were positively correlated in colorectal carcinoma tissues (r = 0.483, P ＜ 0.001). Conclusion The high expression of CEACAM-1 can induce the formation of tumor microvasculature, and is closely related to the tumor infiltration and metastasis. CEACAM-1 can be used as a potential molecular biological indicator for early diagnosis and prognosis in monitoring colorectal carcinoma.
2019 Vol. 16 (2): 94-97 [Abstract] ( 240 ) HTML (1 KB)  PDF (443 KB)  ( 169 )
98 Clinical study of Shugan Jieyu Capsules combined with Escitalopram in treatment for patients with somatic diseases
WEN Yan YANG Hui
Objective To explore clinical efficacy and safety of Shugan Jieyu Capsules combined with Escitalopram in treatment for patients with somatic diseases. Methods A total of 87 patients with somatic diseases in Chongqing Mental Health Center from January 2015 to December 2017 were selected and they were divided into control group and treatment group by the random number table method, with 43 cases in the control group and 44 cases in the treatment group. Control group was treated with Escitalopram, while the treatment group was treated with Shugan Jieyu Capsules combined with Escitalopram. The two groups were treated for 3 months continously. The self-rating depression scale (SDS), self-rating anxiety scale (SAS) scores and symptom check-list 90 (SCL-90) scores of the two groups before and after treatment were evaluated and compared. The treatment compliance rate, medication adherence rate, check compliance rate, rehabilitation exercise adherence rate were compared between the two groups. Adverse reaction rate of the two groups during the treatment were compared. Results After treatment, the SDS, SAS and SCL-90 scores of the two groups were significantly lower than those before treatment, and those of the treatment group were significantly lower than the control group (P ＜ 0.05). Treatment compliance rate, medication adherence rate, check compliance rate and rehabilitation exercise adherence rate of the treatment group were significantly higher than the control group (P ＜ 0.05). The adverse reaction rate of the treatment group during treatment was significantly lower than that of the control group (P ＜ 0.05). Conclusion Shugan Jieyu Capsules combined with Escitalopram can improve the symptoms of anxiety and depression in patients with somatic diseases, and improve the treatment compliance, which has good security and is worthy clinical promotion.
2019 Vol. 16 (2): 98-101 [Abstract] ( 204 ) HTML (1 KB)  PDF (698 KB)  ( 122 )
102 Influence of standardized follow-up procedures on self-management behavior of post-operative patients with mechanical heart valve replacement
YANG Mengjiao CHEN Rong WANG Yali▲
Objective To investigate the influence of standardized follow-up procedures on self-management behavior of post-operative patients with mechanical heart valve replacement. Methods A total of 123 cases that underwent mechanical valve replacement in Affiliated Hospital of North Sichuan Medical College from January to December 2016 were collected and according to the random number table method, they were divided into experimental group (61 cases) and control group (62 cases), respectively. Considering some cases fatal or lost to fouow-up, finally 58 cases in the experimetal group and 53 cases in the control group had finished. The control group was given conventional guidance, and the experimental group was given standardized follow-up procedures. The scores of self-management behavior between the two groups after discharge for 6 months and 1 year were compared. The scores between the two groups were compared in three dimensions—exercise, cognitive symptoms management, the communication with doctors. Results Scores of the communication with doctors and self management behavior after discharge for 6 months and 1 year in the experimental group had differences, and the differences were remarkably statistically significant (P ＜ 0.01), while there was no significant difference in exercise or cognitive symptoms management (P ＞ 0.05); scores in all the dimensions of the control group after discharge for 6 months and 1 year had remarkably significant differences (P ＜ 0.01). The scores of all dimensions of self-management behavior in experimental group after discharge for 6 months and 1 year were both higher than the control group, and the differences were remarkably significant (P ＜ 0.01). Conclusion The standardized follow-up procedures can significantly improve the self-management behavior of post-operative patients with mechanical heart valve replacement.
2019 Vol. 16 (2): 102-105 [Abstract] ( 239 ) HTML (1 KB)  PDF (645 KB)  ( 80 )
106 Clinical efficacy of treating maxillary protrusion deformity by titanium microscrew implant
ZHANG Hongtao LEI Zhimin
Objective To explore clinical efficacy of treating maxillary protrusion deformity by titanium microscrew implant. Methods Clinical data of 100 cases with maxillary protrusion deformity in Department of Stomatology, Renmin Hospital of Wuhan University from February 2016 to February 2017 was analyzed. All the cases were divided into control group and observation group by different treating methods with 50 cases in each group. The control group was treated by conventional anchorage method and the observational group was treated by titanium microscrew implant. The X-ray head shadow measurement difference after treatment were observed. Clinical efficacy and adverse reaction rate of the patients with maxillary protrusion deformity were compared. Results Before treatment, the U1-Y, SNB, U6-Y, U1-SN, ANB, U1-L1 of the two groups had no significant difference (P ＞ 0.05). After treatment, U1-Y, U1-SN, ANB of the two groups were lower than those before treatment, U1-L1 of the two groups was higher than that before treatment. U1-Y, U1-SN, ANB in the observation group were lower than those in the control group and U1-L1 was higher than that in the control group (P ＜ 0.05). The total effective rate in the observation group was higher than that in the control group, and the adverse reaction rate was lower than that in the control group (P ＜ 0.05). Conclusion The maxillary protrusion deformity patients treating by titanium microscrew implant has good improvement in clinical manifestation, and the efficacy is significant with few complications, which is worth clinical promotion.
2019 Vol. 16 (2): 106-108,112 [Abstract] ( 187 ) HTML (1 KB)  PDF (717 KB)  ( 90 )
109 Comparison of the efficacy of “quadruple” and “quintuplicate” in the eradication of Helicobacter pylori in patients with liver cirrhosis and positive Helicobacter pylori
ZHANG Jicheng
Objective To compare the efficacy of “quadruple” and “quintuplicate” in the eradication of Helicobacter pylori (Hp) in patients with liver cirrhosis and positive Hp. Methods A total of 180 Hp positive patients with liver cirrhosis admitted to Baoding Second Central Hospital of Heibei Province from November 2017 to April 2018 were selected as the research objects, and they were divided into the control group (90 cases) and the research group (90 cases) according to the random number table method. The control group was treated with “quadruple” therapy, and the study group was treated with “quintuplicate” therapy. The eradication effect, mucosal repair, incidence of adverse reactions, liver function before and after treatment, and indexes of liver fibrosis in the two groups were observed and studied. Results The eradication rate and mucosal repair of patients in the study group were significantly better than those in the control group (P < 0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group (P < 0.05). The liver function of the study group was significantly better than that of the control group (P < 0.05). The indexes of liver fibrosis in the study group were significantly better than those in the control group (P < 0.05). Conclusion Both “quadruple” and “quintuplicate” have certain curative effect in the eradication of Hp in the treatment of Hp positive patients with liver cirrhosis. The treatment effect of “quintuplicate” is more obvious and the clinical value is more prominent, which is worthy of further promotion and application in clinical practice.
2019 Vol. 16 (2): 109-112 [Abstract] ( 275 ) HTML (1 KB)  PDF (704 KB)  ( 99 )
113 HRCT volume measurement of emphysema in patients with bronchial asthma complicated with chronic obstructive pulmonary disease and its correlation with pulmonary function
HUANG Aixia1 YAO Guoxiang2 JIN Chongwu1 LIU Hongwei1 LIU Wenjuan1 ZHANG Huawei1 ZHANG Yan1 LU Liwen1
Objective To analyze the degree of emphysema on chest high-resolution CT (HRCT) in patients with bronchial asthma complicated with chronic obstructive pulmonary disease (ACO) and to explore its correlation with lung function. Methods From March 2013 to March 2015, in Respiratory Clinic of South Campus of the Sixth People′s Hospital Affiliated to Shanghai University of Medicine & Health Sciences, 69 patients with preliminary diagnosis of bronchial asthma and/or chronic obstructive pulmonary disease (COPD) were collected, according to the GOLD and GINA guide diagnosis standard, they were divided into three groups: asthma group (18 cases), COPD group (37 cases), ACO group (14 cases). All patients underwent lung function measurement and chest HRCT scan. Myrian software carried out three-dimensional reconstruction of the CT image, identified the lung tissue and the low-density region, and calculates the proportion of the low-density region (LAA%) whose CT value was less than -950 Hu. Results The LAA% of left lung, LAA% of right lung and LAA% of whole lung were highly statistically significant in asthma group, COPD group and ACO group (P ＜ 0.01), while the LAA% of left lung, LAA% of right lung and LAA% of whole lung were not statistically significant in ACO group and COPD group (P ＞ 0.05). In ACO group, LAA% of left lung, LAA% of right lung and LAA% of whole lung were negatively correlated with predicted values of FEV1% (r = -0.611, -0.635, -0.672) and FEV1/FVC% (r = -0.699, -0.673, -0.745) (all P ＜ 0.05). There was a positive correlation with RV/TLC% (r = 0.451, 0.381, 0.446, all P ＜ 0.05). Conclusion HRCT of ACO patients shows emphysema similar to that of COPD patients, which is significantly more severe than that of asthma patients. HRCT images of ACO patients with emphysema can reflect the pulmonary ventilation function to a certain extent.
2019 Vol. 16 (2): 113-116 [Abstract] ( 211 ) HTML (1 KB)  PDF (853 KB)  ( 101 )
117 Meta-analysis on comparison of clinical effect of harmonic scalpel and electro-cautery in mixed hemorrhoid surgery
XIONG Caiwen1 ZENG Xiangyun1▲ LUO Zhanbin2 GU Haimei1
Objective To compare and analyze the clinical effect of harmonic scalpel and electro-cautery in the treatment of mixed hemorrhoids. Methods Domestic and foreign randomized controlled trial literatures on the treatment of mixed hemorrhoids with harmonic scalpel and electro-cautery were collected by searching domestic and foreign databases (PubMed, Medline, Embase, CNKI, Vip, Wanfang, etc), websites (The british library, etc), grey literatures and retrospecting literatures, which were published from January 2001 to December 2008. According to the article evaluation quality and screening methods, qualified articles were filtered, relevant clinical effect indexes were extracted. RevMan 5.2 software was used for Meta-analysis. Results A total of 8 randomized controlled trials (854 patients with mixed hemorrhoids) were included, the Meta-analysis showed that the average operation time, hospitalization time, postoperative pain time in the harmonic scalpel group were shorter than those in the electro-cautery group, the amount of bleeding in the operation, pain scores at day 1 and 3 after surgery were lower than those in the electro-cautery group, the incidence of short-term postoperative complications (urinary retention, anal edema, postoperative secondary bleeding, anal distenation) and postoperative anal stenosis were lower than those in the electro-cautery group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). However, there was no statistically significant difference in the incidence of anus incontinence between the two groups (P ＞ 0.05). Conclusion Compared with electro-cautery, harmonic scalpel has the advantages of short operation time, less intraoperative blood loss, low incidence of postoperative complications and short hospitalization time in the treatment of mixed hemorrhoids, it is safer and more effective, and is worthy of clinical application.
2019 Vol. 16 (2): 117-122 [Abstract] ( 234 ) HTML (1 KB)  PDF (1810 KB)  ( 98 )
123 Evaluation value of immature granulocytes combined with SOFA score on prognosis in patients with sepsis
GUO Junchuan Mutalifu·Maihemuti XIAO Dong
Objective To evaluate the value of immature granulocytes combined with sepsis related organ failure assessment (SOFA) score in the prognosis of patients with sepsis. Methods From October 2016 to December 2017, 88 patients with sepsis who were treated in People′s Hospital of Xinjiang Uygur Autonomous Region and met the inclusion and exclusion criteria were selected. After 28 days of observation, the patients were divided into survival group and death group. The acute physiology and chronic health evaluation (APACHEⅡ) score, SOFA score, clinical parameters related to disease severity, and procalcitonin (PCT), C-reactive protein (CRP), absolute value of immature granulocytes (IG#) and percentage of immature granulocytes (IG%) at admission were compared between the two groups. The ROC curve was used to compare IG#, IG%, SOFA score, and the value of combined detection in predicting the prognosis of sepsis. Results There were 56 cases in the final survival group and 32 cases in the death group. There were statistically significant differences between the two groups in APACHEⅡ score, SOFA score, septic shock, mechanical ventilation, mechanical ventilation time, vasoactive drugs and continuous renal replacement therapy (CRRT) (all P ＜ 0.05). IG% and IG# were positively correlated with SOFA scores (r = 0.630, 0.574, all P ＜ 0.001). ROC analysis showed that the area under the curve (AUC) of SOFA was significantly larger than IG# and IG%. The AUC of SOFA score combined with IG# and IG% was significantly larger than any other single indicator. Conclusion The immature granulocyte is a useful index to predict the prognosis of sepsis patients. Immature granulocytes combined with SOFA score detection has a higher sensitivity and specificity for the assessment of poor prognosis.
2019 Vol. 16 (2): 123-126 [Abstract] ( 198 ) HTML (1 KB)  PDF (763 KB)  ( 103 )
127 Association of CETP gene I405V and 1696G/A polymorphisms with Simvastatin efficacy
LI Juntao1 GUO Zhibin2 CHEN Zhichao1 BAO Zeqing1 WANG Min1 ZHENG Keqin3
Objective To explore the association between the lipid-regulating effect of Simvastatin with I405V and 1696G/A polymorphisms in cholesteryl ester transfer protein (CETP) gene. Methods Two hundred and thirty-three cases of patients with dyslipidemia treated in Affiliated Hospital of Guangdong Medical University from February 2008 to June 2010 were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect the genotype frequency distribution of I405V and 1696G/A polymorphisms, and the change of each blood-fat index among different genotypes was compared before and after Simvastatin treatment. Results The distribution of II, IV and VV genotype of I405V polymorphism were 63 cases, 101 cases and 69 cases respectively. The GG, GA and AA genotype distribution of 1696G/A polymorphism were 167 cases, 45 cases and 21 cases respectively. After Simvastatin treatment, the decline of triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) in II genotype patients was the most obvious (P ＜ 0.05 or P ＜ 0.01). There was no statistically significant difference in the change of blood lipid levels among all kinds of 1696G/A genotype patients (P ＞ 0.05). Conclusion The effect of Simvastatin on blood lipid is related to the I405V polymorphism of CETP gene.
2019 Vol. 16 (2): 127-130 [Abstract] ( 185 ) HTML (1 KB)  PDF (744 KB)  ( 98 )
131 Pharmaceutical care performed by clinical pharmacists for one case of Salmonella Typhi bloodstream infection with suspected catheter associated infection
PENG Jiabing1,2 SHI Weifeng1 LIU Gaolin1 FAN Guorong1 XU Hongbing1▲
Clinical pharmacists performed pharmaceutical care for one patient of Salmonella Typhi bloodstream infection with suspected catheter associated infection to provide clinical rational drug use. According to the basic condition of the patient, antibiotic resistance situation, the characteristics of anti-infection drugs, and so on, pharmacists assisted clinicians in formulating anti-infection treatment, and monitoring the curative effect and adverse reactions. The infection was effectively controlled, no obvious adverse drug reactions occurred, and the effectiveness and safety of the patient′s medication were improved.
2019 Vol. 16 (2): 131-134 [Abstract] ( 231 ) HTML (1 KB)  PDF (445 KB)  ( 160 )
135 Analysis and participation of clinical pharmacists in medical order check
LIU Pengpeng ZHAO Huanyu SONG Zhihui
Objective To promote rational drug use in the clinic through analysis of the clinical pharmacists intervening in irrational medical orders. Methods From April 2017 to March 2018, the data about clinical pharmacists intervening in irrational medical orders in Department of Neurology, Neurosurgery and Orthopedics in the Southern District of Beijing Tongren Hospital, Capital Medical University were collected for statistical analysis with regard to the category of irrational medical orders and each department. Results There were 116 cases of intervention records of irrational medical orders and success rate of intervention was 100%. Top 3 types of irrational medical orders were medicine selection (21.6%), dosage (14.7%), route of administration (12.1%). 50 cases, 36 cases and 30 cases medical orders given by Department of Neurology, Neurosurgery and Orthopedics were found to be irrational, accounting for 43.10%, 31.03% and 25.86% respectively. Conclusion Checking medical order is an effective method for clinical pharmacists to promote rational drug use.
2019 Vol. 16 (2): 135-138 [Abstract] ( 231 ) HTML (1 KB)  PDF (470 KB)  ( 107 )
139 Influence of collaborative nursing mode combined with continuous health education on self- management ability and living quality in patients with ovarian cancer
YU Zhifang ZHANG Liping
Objective To observe the effect of cooperative nursing combined with continuous health education on postoperative self-management and quality of life of ovarian cancer patients. Methods Selected from January 2016 to December 2017, the First Hospital Affiliated to Hebei North University of 50 cases of postoperative patients with ovarian cancer as the research object, according to random number table method, they were divided into observation group and control group, with 25 cases in each group. The observation group was given collaborative nursing, health education continuously, the control group, routine nursing and education. Evaluation of patients of two groups before and after the nursing education on the self management ability, chealth knowledge, ability of self care the sense of responsibility and self care, self concept), quality of life and satisfaction of nursing level, way was carried out. Results There was no significant difference in self-management ability score and quality of life score between the two groups before nursing education (P ＞ 0.05). The scores of health knowledge, self-care responsibility, self-care skills and self-concept of patients in the observation group after nursing education were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The scores of quality of life in the observation group after nursing education were higher than those in the control group, and the difference was statistically significant (P ＜ 0.05). The satisfaction of the observation group with the nursing level and methods was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Cooperative nursing combined with continuous health education can significantly improve postoperative self-management status and quality of life of ovarian cancer patients, it is recommended to promote.
2019 Vol. 16 (2): 139-142 [Abstract] ( 242 ) HTML (1 KB)  PDF (408 KB)  ( 81 )
143 The application effect of Orem self-care theory in patients with cerebral infarction
LIN Zhi
Objective To investigate the application of Orem self-care theory in patients with cerebral infarction. Methods The clinical data of 110 cases of cerebral infarction patients admitted to the Rehabilitation Department of the Second People′s Hospital of Neijiang City in Sichuan Province from February 2016 to February 2018 were retrospectively analyzed. According to different rehabilitation nursing methods, they were divided into 50 cases in the control group and 60 cases in the observation group. Patients in the two groups were observed for their attitude towards rehabilitation training after nursing, Barthel index and Fugl-Meyer score before and after nursing, clinical effects, complications and 3-month recurrence rate of patients in the two groups. Reuslts The attitude of rehabilitation training after nursing in the observation group was better than that in the control group, and the difference was statistically significant (P ＜ 0.05). The Barthel index and Fugl-Meyer score between the two groups before treatment had no statistically significant difference (P ＞ 0.05), After nursing, Barthel index and Fugl-Meyer score higher than before treatment, and the Barthel index and Fugl-Meyer scores of observation group were higher than the control group, the difference were statisticant (P < 0.05), the clinical total effective rate of observation group was higher than the control group, the incidence of complications and 3 months recurrence rates of observation group were lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The application of Orem self-care theory in patients with cerebral infarction can improve patients′ attitude towards rehabilitation training, improve Barthel index, Fugl-Meyer score and clinical effect, and reduce their complications and 3-month recurrence rate.
2019 Vol. 16 (2): 143-146 [Abstract] ( 198 ) HTML (1 KB)  PDF (450 KB)  ( 91 )
147 A case of paraplegia after Stanford type B aortic dissection thoracic endovascular aortic repair and literature review
GE Jing1,2 ZHANG Qiang1,2 ZHANG Yongheng1 LIU Jianping1 TANG Xiaojiao1 JIANG Jiduan3
In Department of Cardiothoracic Surgery, Suining Central Hospital, a patient with Stanford type B aortic dissection was treated by thoracic endovascular aortic repair (TEVAR), which resulted in paraplegia. After cerebrospinal fluid drainage treatment (CSFD) combined with intracranial dehydration, improved spinal cord blood supply, anticoagulation, controlled hypertension and other comprehensive treatment, the patient recovered well without serious complications, such as intraventricular hemorrhage, infection, fluid leakage, cerebral hernia, etc. This paper summarizes the clinical data, treatment course and reviews related literature.
2019 Vol. 16 (2): 147-150 [Abstract] ( 187 ) HTML (1 KB)  PDF (482 KB)  ( 144 )
151 Pre-pregnancy health consultation for elderly couples  
HUANG Shuifen ZHOU Yanjie▲
Since the opening of the comprehensive two-child policy in China, the common problems of the pre-pregnancy health counseling for elderly couples have been the decline of fertility, the increase of obstetrical complications, the increase of the birth defects of newborns and others. Specifically, age is an independent factor affecting fertility. The decline in fertility of the elderly couples is characterized by a decrease in pregnancy rates, an increase in abortion rates, an increase in obstetric complications and other complications among elderly women, and a greater vulnerability to environmental factors. The birth defect of the newborn significantly increases, and there is a significant mental and psychological abnormality of the offspring. Special attention should be paid to the prevention and control of the high incidence of the endemic genetic disease thalassemia for Nanning City. For the elderly couples, we should strengthen the prenatal eugenic examination, balance the nutrition intake before pregnancy and maintain mental health, pay attention to the prenatal screening and the prenatal diagnosis during pregnancy, prevent the occurrence of the congenital defects such as severe thalassemia in infants, and give a good birth and good care to improve the quality of the birth population.
2019 Vol. 16 (2): 151-154 [Abstract] ( 185 ) HTML (1 KB)  PDF (691 KB)  ( 105 )
155 The research status of health status and its influencing factors of the rural elderly in China under the background of population aging
WANG Bo WU Qiong ZHANG Ping CHEN Lijun
With the rapid development of the aging population in China, the phenomenon of rural elderly people to follow their children to the city is becoming more and more common, but the rural elderly as a new type of new edge of the vulnerable groups, poor adaptability, facing various challenges in the process of integration into urban life, physical and mental health is also facing a huge threat. However, the research on the elderly in China started late. Therefore, this paper combs out the health status of the rural elderly in three aspects of physiology, psychology and society, and summarizes the influencing factors of their health from the three aspects of family support, social support and other aspects. The aim is to arouse people′s attention to the physical and mental health of the disadvantaged group, to guide the family, community and society to give them more support and protection of their emotions and policies, and to provide a reference and guidance for improving the health status of the elderly in the rural areas and promoting their better and faster integration into the urban life.
2019 Vol. 16 (2): 155-158 [Abstract] ( 204 ) HTML (1 KB)  PDF (735 KB)  ( 151 )
159 Screening on the target genes of chronic atrophic gastritis based on KEGG pathway and genetic network
WANG Jiahui1 ZHENG Yang1 WANG Jiaru2 LI Weimin3
Objective By means of DAVID database, the information related to pathway and gene was obtained, the function and distribution of important gene was analyzed, the target gene related to chronic atrophic gastritis (CAG) was screened, so as to promote the research on CAG pathogenesis and the development of new drug. Methods By taking “chronic atrophic gastritis” as key words, the gene related to CAG was retrieved in NCBI database in June 2018 and the obtained gene data was imported into DAVID database, then the pathway of gene enrichment was figured out. Next, 15 pieces of non-redundant gene enrichment were analyzed on 20 KEGG pathways. Besides, 15 genes were input into String database to draw interaction network diagram, another network diagram for the key genes of enrichment on pathway was also made, the two network diagrams were compared. Results In the two network diagrams, the top-ranked genes in terms of relational hierarchy turned out to be FASLG, FAS, ICAM1, IL1B, AKT1, STAT3, TGFβ1, IL4R, IL11 and IL23A, etc. Conclusion The five genes of STAT3, ICAM1, IL1B, TGFβ1 and AKT1 have something to do with CAG and an in-depth research should be conducted. Moreover, the diagram which shows the interaction between the pathway and the genes related to CAG should be analyzed, which can do good to the understanding on the pathogenesis of CAG and can provide reliable target for the development of new drug.
2019 Vol. 16 (2): 159-163,173 [Abstract] ( 299 ) HTML (1 KB)  PDF (2432 KB)  ( 109 )
164 The exploration and reflection of National Certification Commission for Acupuncture and Oriental Medicine certification requirements
LENG Wenjie WU Feng CUI Yu LIU Wei
Based on the survey of first-hand information released on the public website of National Certification Commission for Acupuncture and Oriental Medicine (NCCAOM), qualification categories for NCCAOM qualification certificates applicants and distribution of current registered physicians in each state are summed up and sorted out. Meanwhile, NCCAOM examination and qualification authentication are analyzed. It can be concluded that Western medicine still occupies a large proportion in the teaching and examination of traditional Chinese medicine (Acupuncture) and Western medicine is of significant reference value to the development of traditional Chinese medicine. Development of traditional Chinese medicine in each US state is unbalanced and development space in the lag-behind states is immense. Prospects of the simple apprenticeship education model are not optimistic and the exploration of new apprenticeship education model for traditional Chinese medicine is an important issue faced by development of traditional Chinese medicine career. Medical qualification for traditional Chinese medicine practitioners in US is very severe, forming higher trade barrier for the service trade of traditional Chinese medicine.
2019 Vol. 16 (2): 164-168 [Abstract] ( 215 ) HTML (1 KB)  PDF (964 KB)  ( 132 )
169 Influence of information asymmetry on doctor-patient relationship and countermeasures-taking citizen participation as the main point of view
LU Xufeng ZHANG Shan
As doctors have mastered a lot of professional knowledge and a lot of information about medical programs, and the common patients are in a passive position because of lack of medical expertise, there are typical information asymmetry in the medical field, which has an important influence on the relationship between doctors and patients, and is also an important source of the contradiction between doctors and patients. Among the reasons for information asymmetry, the lack of citizen participation in health decision-making is a key factor that is easy to be ignored: the ordinary citizen has no opportunity to understand the information of health decision-making, and is always in a passive acceptance in the process of diagnosis and treatment. In order to reduce the negative impact of information asymmetry on the relationship between doctors and patients, we must focus on these aspects: firstly, build an open health decision-making participation mechanism; secondly, to build a common diagnosis and treatment model based on doctor and patient communication; thirdly, to improve the medical insurance system and the doctors′ salary system, and finally to strengthen the propaganda of disease knowledge.
2019 Vol. 16 (2): 169-173 [Abstract] ( 210 ) HTML (1 KB)  PDF (696 KB)  ( 382 )
174 Drug quality management and safety of inpatient dispensary
JING Ziwei PEI Jianying DU Shuzhang
Drug quality management of inpatient dispensary is one of the most important parts of pharmacy administration. The department of pharmacy draws up the drug safety management systems and strengthens cooperation with medical staff to ensure the quality of drugs and the safety of inpatients, which leads to the reducing of the medical risk caused by drug quality. Based on the relevant literature and daily work experience, this paper analyzes and summarizes several aspects of drug safety management measurements in inpatient dispensary of the hospital, including drug quality supervision group, management of expiration date and batch number of drug, storage and use of the light repellent drug, management of the refrigerated drug and cool preserved drug, supervision of the special drug, management of the drugs in intelligent medicine cabinet and crash truck of wards. It can provide reference for the implementation and improvement of drug safety management system, so as to improve the drug quality and safety of hospitalized patients.
2019 Vol. 16 (2): 174-177 [Abstract] ( 202 ) HTML (1 KB)  PDF (678 KB)  ( 136 )
178 Problems and countermeasures in the development of traditional Chinese medicine in Zhoukou
ZHANG Guangdong
To find out the difficulties and problems in the development of traditional Chinese medicine in Zhoukou, and put forward relevant countermeasures and suggestions for the decision of the party committee and government. In December 2017, the Health and Family Planning Commission conducted an in-depth study on the development of traditional Chinese medicine medical institutions. As the results of the surveys, the development of traditional Chinese medicine in the city still exists problems such as the support policy not being satisfactorily implemented, shortage of technicians, lacking of confidence in the development of traditional Chinese medicine and lacking of attention on traditional Chinese medicine in the general hospital. It can be solved through the method of Perfecting the development policy of traditional Chinese medicine, promoting the construction of Chinese medicine service system, Strengthening the construction of the talent team and strengthening the confidence of traditional Chinese medicine.
2019 Vol. 16 (2): 178-181 [Abstract] ( 177 ) HTML (1 KB)  PDF (874 KB)  ( 217 )
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