疏肝解郁胶囊联合艾司西酞普兰治疗躯体疾病患者的临床研究

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Abstract Objective To explore clinical efficacy and safety of Shugan Jieyu Capsules combined with Escitalopram in treatment for patients with somatic diseases. Methods A total of 87 patients with somatic diseases in Chongqing Mental Health Center from January 2015 to December 2017 were selected and they were divided into control group and treatment group by the random number table method, with 43 cases in the control group and 44 cases in the treatment group. Control group was treated with Escitalopram, while the treatment group was treated with Shugan Jieyu Capsules combined with Escitalopram. The two groups were treated for 3 months continously. The self-rating depression scale (SDS), self-rating anxiety scale (SAS) scores and symptom check-list 90 (SCL-90) scores of the two groups before and after treatment were evaluated and compared. The treatment compliance rate, medication adherence rate, check compliance rate, rehabilitation exercise adherence rate were compared between the two groups. Adverse reaction rate of the two groups during the treatment were compared. Results After treatment, the SDS, SAS and SCL-90 scores of the two groups were significantly lower than those before treatment, and those of the treatment group were significantly lower than the control group (P ＜ 0.05). Treatment compliance rate, medication adherence rate, check compliance rate and rehabilitation exercise adherence rate of the treatment group were significantly higher than the control group (P ＜ 0.05). The adverse reaction rate of the treatment group during treatment was significantly lower than that of the control group (P ＜ 0.05). Conclusion Shugan Jieyu Capsules combined with Escitalopram can improve the symptoms of anxiety and depression in patients with somatic diseases, and improve the treatment compliance, which has good security and is worthy clinical promotion.

Key words： Somatic disease Shugan Jieyu Capsules Escitalopram Anxiety Depression Clinical study

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WEN Yan YANG Hui. Clinical study of Shugan Jieyu Capsules combined with Escitalopram in treatment for patients with somatic diseases[J]. 中国医药导报, 2019, 16(2): 98-101.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I2/98

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