射频消融与手术治疗结直肠癌肝转移疗效的Meta分析

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Abstract Objective To compare the therapeutic efficacy between radiofrequency ablation (RFA) and hepatic resection(HR) for colorectal liver metastases (CRLM). Methods Systematic literature search of clinical trials was carried out to compare RFA and HR for colorectal liver metastasis in Cochrane library, PubMed, Embase, CNKI, Wanfang and VIP from database inception to May 2018. The quality of the included studies was assessed and the data analysis was performed by software RevMan 5.3 from Cochrane library. Results Finally 26 trials including 3738 cases were included, with 1447 cases in RFA group and 2291 cases in HR group. The results of Meta-analysis showed: 5-year overall survival and 5-year disease-free survival were significantly lower in RFA group than HR group (OR = 2.42, 95%CI: 1.64-3.57, P ＜ 0.000 01; OR = 2.33, 95%CI: 1.37-3.98, P = 0.002). Local recurrence and intrahepatic recurrence rates were significantly higher in RFA group than HR group (OR = 9.29, 95%CI: 6.88-12.54, P ＜ 0.000 01; OR = 2.03, 95%CI: 1.45-2.83, P ＜ 0.0001). RFA had significantly lower postoperative complication rate than HR group (OR = 0.47, 95%CI: 0.29-0.76, P = 0.002). Conclusion The complication rate in patients treated by RFA is significantly lower than HR, but survival rate is lower and recurrence rate is higher by RFA than HR. HR is still the preferred treatment for CRLM.

Key words： Colorectal liver metastasis Radiofrequency ablation Hepatic resection Meta-analysis

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	LIU XiangDong SU Song LUO De CHEN Xinpei ZHOU Pengcheng LI Bo

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LIU XiangDong SU Song LUO De CHEN Xinpei ZHOU Pengcheng LI Bo. Meta-analysis of radiofrequency ablation and surgical resection in treatment of colorectal liver metastases[J]. 中国医药导报, 2019, 16(2): 89-93,101.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I2/89

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