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| HRCT volume measurement of emphysema in patients with bronchial asthma complicated with chronic obstructive pulmonary disease and its correlation with pulmonary function |
| HUANG Aixia1 YAO Guoxiang2 JIN Chongwu1 LIU Hongwei1 LIU Wenjuan1 ZHANG Huawei1 ZHANG Yan1 LU Liwen1 |
| 1.Department of Respiratory, South Campus, the Sixth People′s Hospital Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201499, China; 2.Department of Surgery, South Campus, the Sixth People′s Hospital Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201499, China |
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Abstract Objective To analyze the degree of emphysema on chest high-resolution CT (HRCT) in patients with bronchial asthma complicated with chronic obstructive pulmonary disease (ACO) and to explore its correlation with lung function. Methods From March 2013 to March 2015, in Respiratory Clinic of South Campus of the Sixth People′s Hospital Affiliated to Shanghai University of Medicine & Health Sciences, 69 patients with preliminary diagnosis of bronchial asthma and/or chronic obstructive pulmonary disease (COPD) were collected, according to the GOLD and GINA guide diagnosis standard, they were divided into three groups: asthma group (18 cases), COPD group (37 cases), ACO group (14 cases). All patients underwent lung function measurement and chest HRCT scan. Myrian software carried out three-dimensional reconstruction of the CT image, identified the lung tissue and the low-density region, and calculates the proportion of the low-density region (LAA%) whose CT value was less than -950 Hu. Results The LAA% of left lung, LAA% of right lung and LAA% of whole lung were highly statistically significant in asthma group, COPD group and ACO group (P ＜ 0.01), while the LAA% of left lung, LAA% of right lung and LAA% of whole lung were not statistically significant in ACO group and COPD group (P ＞ 0.05). In ACO group, LAA% of left lung, LAA% of right lung and LAA% of whole lung were negatively correlated with predicted values of FEV1% (r = -0.611, -0.635, -0.672) and FEV1/FVC% (r = -0.699, -0.673, -0.745) (all P ＜ 0.05). There was a positive correlation with RV/TLC% (r = 0.451, 0.381, 0.446, all P ＜ 0.05). Conclusion HRCT of ACO patients shows emphysema similar to that of COPD patients, which is significantly more severe than that of asthma patients. HRCT images of ACO patients with emphysema can reflect the pulmonary ventilation function to a certain extent.
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| Cite this article: |
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HUANG Aixia1 YAO Guoxiang2 JIN Chongwu1 LIU Hongwei1 LIU Wenjuan1 ZHANG Huawei1 ZHANG Yan1 LU Liwen1. HRCT volume measurement of emphysema in patients with bronchial asthma complicated with chronic obstructive pulmonary disease and its correlation with pulmonary function[J]. 中国医药导报, 2019, 16(2): 113-116.
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| http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I2/113 |
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