血清内脏脂肪素、核因子-κB与不稳定型心绞痛患者血小板活化参数的关系

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Abstract Objective To investigate the relationship between platelet activation parameters of serum Visfatin, nuclear factor-κB (NF- κB) and unstable angina pectoris (UA). Methods From April 2017 to September 2018, in the Second Hospital of Handan, 108 UA patients were selected as angina group, at the same time, 108 healthy patients underwent physical examination were selected as the health group. In the two groups, blood samples were collected on the day of admission to detect serum Visfatin, NF-κB and platelet granule membrane protein (CD63), platelet membrane glycoproteinⅡb-Ⅲa (PAC-1), platelet alpha particle surface membrane glycoprotein (CD62P). Serum Visfatin, NF-κB and platelet activation parameters of low, middle and high risk patients were compared. The correlation between serum Visfatin and NF-κB and platelet activation parameters in UA patients was observed by Pearson linear correlation analysis. Results The levels of serum Visfatin, NF-κB and CD63, PAC-1 and CD62P in angina pectoris group were higher than those in healthy group, the differences were statistically significant (P < 0.01). Serum levels of Visfatin, NF-κB and CD63, PAC-1 and CD62P in the low risk group were lower than those in the middle risk group and high-risk group, and these in the middle risk group were lower than the high risk group, the differences were statistically significant (P < 0.05). Pearson linear correlation analysis showed that serum visfatin and NF-κB were positively correlated with CD63 and PAC-1 (r = 0.671, 0.591, 0.507, 0.460, P < 0.05). There was no significant correlation between the two and CD62P (P > 0.05). Conclusion Visfatin and NF-κB were correlated with platelet activation parameters CD63 and PAC-1 in patients with UA. Visfatin, NF-κB and platelet activation parameters can be used as an important indicator for evaluating the condition of UA patients.

Key words： Unstable angina NF-κB Visfatin Platelet activation parameters

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	SUN Xin1 WU Yanqiang2

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SUN Xin1 WU Yanqiang2. Relationship between visfatin, NF-κB and platelet activation parameters in unstable angina patients[J]. 中国医药导报, 2019, 16(2): 41-44,62.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I2/41

[1] 黄琛，徐戈，吕静，等.阿托伐他汀强化治疗对不稳定型心绞痛患者PCI围术期心肌梗死及白介素水平的影响[J].广西医科大学学报，2017，34（2）：202-205.
[2] 万洪峰，杨晓卿.不稳定型心绞痛患者冠脉钙化积分与血管性血友病因子及QT间期离散度的关系[J].广西医学，2016，38（8）：1088-1090.
[3] Kume T，Akasaka T，Kaji S，et al. Relation between angina pectoris and coronary flow reserve in patients with aortic stenosis and normal coronary artery [J]. Anal Chim ACTA, 2016，912（2）：165-168.
[4] 王庆丽，宋成伟，卢颖，等.血清内脏脂肪素、脂肪细胞型脂肪酸结合蛋白对冠状动脉粥样硬化程度的评估价值[J].山东医药，2016，56（17）：41-43.
[5] 邓世芳，陈威，卞伟，等.芪棱汤对脑梗死患者visfatin水平及颈动脉粥样硬化程度的影响[J].广州中医药大学学报，2018，35（1）：1-6.
[6] 刘凌琳，司良毅.氯吡格雷对老年冠心病合并糖尿病患者冠脉介入治疗后YKL-40、NF-κB的影响[J].中国医药导报，2016，13（6）：153-156.
[7] 郑频频，傅华.冠心病个体危险度评估模型[J].中国健康教育，2003，19（2）：77-80.
[8] 中华医学会心血管病学分会.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志，2007，35（4）：295-304.
[9] Fadaei R，Parvaz E，Emamgholipour S，et al. The mRNA expression and circulating levels of visfatin and their correlation with coronary artery disease severity and 25-hydroxyvitamin D [J]. Horm Metab Res，2016，48（4）：269-274.
[10] Liakos CI，Sanidas EA，Perrea DN，et al. Apelin and visfatin plasma levels in healthy individuals with high normal blood pressure [J]. Am J Hypertens，2016，29（5）：549-552.
[11] Lai JL，Liu YH，Liu C，et al. Indirubin inhibits LPS-induced inflammation via TLR4 abrogation mediated by the NF-κB and mapk signaling pathways [J]. Inflammation，2017，40（1）：1-12.
[12] 郑妩媚，初海平，王燕，等.力竭运动后不同时相大鼠心肌p-p38MAPK、NF-κB、COX-2表达的动态变化[J].中国应用生理学杂志，2016，32（1）：88-91.
[13] 朝鲁门其其格，全雪莹，张琪，等.TNF-其对人冠状动脉内皮细胞中的NF-kB mRNA表达的影响[J].内蒙古医科大学学报，2017，39（4）：322-324.
[14] Rousan TA，Mathew ST，Thadani U. Drug therapy for stable angina pectoris [J]. Drugs，2017，77（3）：265-284.
[15] 温太阳，王芳群，王颢，等.基于二尖瓣时变电阻模型的左心血液循环系统建模与仿真[J].中国生物医学工程学报，2015，34（3）：370-375.
[16] 王芳群，徐庆，吴振海，等.基于左心辅助的血液循环系统的控制研究[J].生物医学工程学杂志，2016，33（6）：1075-1083.
[17] Jolly SS，Devereaux PJ. Does knowledge of the coronary anatomy save lives in patients with unstable angina? [J]. Ann Intern Med，2017，166（11）：848-849.
[18] Linde JJ，S?覬rgaard M，Kühl JT，et al. Prediction of clinical outcome by myocardial CT perfusion in patients with low-risk unstable angina pectoris [J]. Int J Cardiovas Imag，2017，33（2）：1-10.
[19] 崔巍，贾秋蕾，胡元会，等.血小板微粒膜表面功能蛋白与不稳定型心绞痛相关性[J].中华实用诊断与治疗杂志，2017，31（6）：550-553.
[20] 刘海宁，孙金玲，夏尉珉.不稳定型心绞痛患者血清内脏脂肪素水平的变化及与血管内皮细胞黏附分子的相关性[J].中国动脉硬化杂志，2016，24（10）：1027-1030.