血清CysC、hs-CRP、Lp（a）在急性冠脉综合征患者中的表达及临床意义

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Abstract Objective To explore the expression and clinical significance of serum Cystatin C (CysC), high sensitivity C reactive protein (hs-CRP), lipoprotein a [Lp (a)] in patients with acute coronary syndrome. Methods From October 2016 to May 2018, in Huangshi Central Hospital, Edong Healthcare Group, 106 patients with acute coronary syndrome were selected as the study group, at the same time, 106 healthy persons were selected as the control group. At the second morning, 4 mL fasting venous blood was taken from all subjects. Serum Lp (a) levels were measured by immunoturbidimetry and serum CysC and hs-CRP levels were measured by enzyme-linked immunosorbent assay. The levels of serum CysC, hs-CRP and Lp (a) in the study group and control group, patients with different pathological types of acute coronary syndrome, patients with different pathological changes of acute coronary syndrome, and patients with different severity of acute coronary syndromes were observed. The correlation between serum CysC, hs-CRP, Lp (a) and the severity of acute coronary syndrome was analyzed. And the efficacy of serum CysC, hs-CRP and Lp (a) alone and combined in the diagnosis of acute coronary syndrome were compared. Results The levels of serum CysC, hs-CRP and Lp(a) in the study group were higher than those in the control group, the differences were statistically significant (P < 0.01). There were statistically significant differences in serum levels of CysC, hs-CRP and Lp (a) in patients with different pathological types of acute coronary syndrome (P < 0.01). The serum levels of CysC, hs-CRP and Lp (a) in patients with unstable angina pectoris were higher than patients with stable angina, the levels of serum CysC, hs-CRP and Lp (a) in patients with acute myocardial infarction were higher than patients with unstable angina pectoris, the differences were statistically significant (P < 0.01). There were statistically significant differences in serum levels of CysC, hs-CRP and Lp(a) in patients with different coronary artery lesions (P < 0.05). The levels of serum CysC, hs-CRP and Lp (a) in patients with double vessel disease were higher than those in single vessel disease, and the levels of serum CysC, hs-CRP and Lp (a) were higher in three vessel lesions than double vessel lesions, the differences were statistically significant (P < 0.01). There were statistically significant differences in serum levels of CysC, hs-CRP and Lp (a) in patients with different severity of acute coronary syndrome (P < 0.05). The serum levels of CysC, hs-CRP and Lp (a) in moderate patients were higher than those in mild patients, the levels of serum CysC, hs-CRP and Lp (a) in severe patients were higher than those in moderate patients, the differences were statistically significant (P < 0.05). Pearson test showed that the level of serum CysC, hs-CRP, Lp (a) and the degree of acute coronary syndrome were positively correlated with the degree of acute coronary syndrome (r = 0.663, 0.691, 0.652, P < 0.05). Combined diagnostic sensitivity (95.28%) and accuracy (95.28%) were higher than serum CysC (79.25%, 88.68%), hs-CRP (80.19%, 87.74%), Lp (a) (78.30%, 87.26%) alone, the differences were statistically significant (P < 0.05). There was no significant difference between the combined diagnostic specificity (95.28%) and serum CysC (98.11%), hs-CRP (95.28%), Lp (a) (96.23%) alone (P > 0.05). Conclusion The serum levels of CysC, hs-CRP and Lp (a) in patients with acute coronary syndromes are very high, and there are significant differences in different pathological types. With the increase of the number of diseases and the severity of the disease, the serum levels are increasing. The diagnosis and evaluation of the disease can be effectively identified by the combined detection of the above indexes.

Key words： CysC hs-CRP Lp (a) Degree of disease Acute coronary syndrome Pathological type

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	GUO Qing CHENG Xin YAN Jieting YE Hong

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GUO Qing CHENG Xin YAN Jieting YE Hong. Expression and clinical significance of serum CysC, hs-CRP and Lp (a) in patients with acute coronary syndrome[J]. 中国医药导报, 2019, 16(2): 54-58.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I2/54

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