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| Association of CETP gene I405V and 1696G/A polymorphisms with Simvastatin efficacy |
| LI Juntao1 GUO Zhibin2 CHEN Zhichao1 BAO Zeqing1 WANG Min1 ZHENG Keqin3 |
1.Department of Basic Medicine, Zhaoqing Medical College, Guangdong Province, Zhaoqing 526020, China;
2.Medical Laboratory, Affiliated Hospital of Nantong University, Jiangsu Province, Nantong 226001, China;
3.Department of Medical Genetics, Guangdong Medical University, Guangdong Province, Zhanjiang 524023, China |
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Abstract Objective To explore the association between the lipid-regulating effect of Simvastatin with I405V and 1696G/A polymorphisms in cholesteryl ester transfer protein (CETP) gene. Methods Two hundred and thirty-three cases of patients with dyslipidemia treated in Affiliated Hospital of Guangdong Medical University from February 2008 to June 2010 were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect the genotype frequency distribution of I405V and 1696G/A polymorphisms, and the change of each blood-fat index among different genotypes was compared before and after Simvastatin treatment. Results The distribution of II, IV and VV genotype of I405V polymorphism were 63 cases, 101 cases and 69 cases respectively. The GG, GA and AA genotype distribution of 1696G/A polymorphism were 167 cases, 45 cases and 21 cases respectively. After Simvastatin treatment, the decline of triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) in II genotype patients was the most obvious (P ＜ 0.05 or P ＜ 0.01). There was no statistically significant difference in the change of blood lipid levels among all kinds of 1696G/A genotype patients (P ＞ 0.05). Conclusion The effect of Simvastatin on blood lipid is related to the I405V polymorphism of CETP gene.
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