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| Effect of Xiaoshuan Enteric-dissolution Capsules on nerve injury, cerebral blood perfusion, serum CRP and Hcy in convalescent patients with ischemic stroke |
| DING Huiyan1 ZHANG Shuqin1 DENG Lijun1 HAN Yufu2 |
1.Department of Neurology, the Sixth Hospital of Wuhan City, Hubei Province, Wuhan 430015, China;
2.Department of Neurology, the Second Affiliated Hospital of Army Medical University, Chongqing 400000, China |
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Abstract Objective To observe the effect of Xiaoshuan Enteric-dissolution Capsules on nerve injury, cerebral blood perfusion, serum C-reactive protein (CRP) and serum homocysteine (Hcy) in convalescent patients with ischemic stroke. Methods Ninety-two convalescent patients with ischemic stroke admitted to the Department of Neurology of Wuhan Sixth Hospital from January to October 2017 were selected as the research objects. According to the random number table, they were divided into the observation group and the control group. Forty-six patients in the control group were treated with conventional Western medicine, and forty-six patients in the observation group were treated with Xiaoshuan Enteric-dissolution Capsules on the basis of the treatment in the control group. After 4 weeks of treatment, the cerebral blood flow perfusion [peak systolic velocity (PSV), mean velocity (TMV), resistance index (RI)], nerve injury, [ubiquitin carboxyl terminal hydrolase - 1 (UCH L1), neuron specific enolization enzyme (NSE) and glial fibrillar acidic protein (GFAP), called S100B protein (called S100B)], Hcy and CRP levels, changes of two groups were observed, clinical curative effect was counted, medication safety during treatment was compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, PSV and TMV levels in both groups were significantly higher than those before treatment (all P ＜ 0.05), RI levels were significantly lower than those before treatment (all P ＜ 0.05), and the improvement of the above cerebral blood perfusion indexes in the observation group was significantly better than that in the control group (all P ＜ 0.05). After treatment, UCH-L1, NSE, GFAP and S100B levels in both groups were significantly lower than before treatment (all P ＜ 0.05), and the above nerve injury indexes in the observation group were significantly lower than those in the control group (all P ＜ 0.05). Serum CRP and Hcy levels in both groups after treatment were significantly lower than those before treatment (P ＜ 0.05), and CRP and Hcy levels in the observation group were significantly lower than those in the control group (P ＜ 0.05); blood routine, urine routine, stool routine, liver and kidney function, electrocardiogram, electrolyte were not significantly abnormal during the treatment of the two groups, and no serious adverse reactions occurred. Conclusion Xiaoshuan Enteric-dissolution Capsules can significantly improve cerebral blood perfusion, inhibit the expression of serum Hcy and CRP, reduce inflammatory injury of brain tissue, optimize nerve function, and help improve the degree of nerve function defect in the convalescent period of ischemic stroke, and promote the outcome of the disease.
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[1] 孟文婷，李东翔，佟玲.缺血性脑卒中的治疗研究进展[J].中国新药杂志，2016，25（10）：1114-1120.
[2] 张春朝，唐莉，尹君，等.中医综合疗法在缺血性脑卒中恢复期的研究进展[J].中医临床研究，2016，8（5）：142-144.
[3] 吴波.消栓肠溶胶囊加茴拉西坦治疗对脑梗死康复期患者脑血流灌注、神经功能的影响[J].海南医学院学报，2017，23（24）：3456-3458，3462.
[4] 王新德.各类脑血管疾病诊断要点[J].中华神经科杂志，1996，29（6）：379-380.
[5] 国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准（试行）[J].北京中医药大学学报，1996，19（1）：55-56.
[6] 全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准（1995）[J].中华神经科杂志，1996， 29（6）：62-64.
[7] 徐东勋，伍雪英，何佳，等.消栓肠溶胶囊对脑梗死急性期神经功能及PAF、ET、NO的影响[J].中药药理与临床，2016，32（3）：188-190.
[8] 康云鹏，刘文娴，朱佳佳，等.有缺血性脑卒中史的急性冠状动脉综合征患者临床特点及院内不良事件分析[J].中国医药，2017，12（6）：819-822.
[9] 彭瑞强，牛建平，黄妍妍，等.脉血康胶囊对缺血性脑卒中二级预防的效果[J].中国医药，2017，12（2）：239-242.
[10] 龚秋明，张程立.高同型半胱氨酸血症：研究进展与临床[J].医学信息，2007，20（1）：172-174.
[11] 马玉兰，张凤青，郭丽霞，等.自拟益气活血方联合西药治疗缺血性脑卒中恢复期对患者血清相关因子水平的影响[J].临床合理用药，2015，8（3A）：99-100.
[12] 冒文娟，王姗姗.依达拉奉联合阿托伐他汀钙片治疗急性脑梗死的临床效果[J].中国社区医师，2018，34（15）：91-92.
[13] 汪芳.阿司匹林在心血管疾病一级预防中的研究进展与指南规范分析[J].中国全科医学，2015，18（29）：3519-3523.
[14] 贾世杰，王辉，张新广，等.自拟益气活血方联合西医治疗缺血性脑卒中恢复期疗效观察[J].现代中西医结合杂志，2016，25（10）：1069-1071.
[15] 李雅，尹天雷，蔡光先，等.补阳还五汤复方超微饮片浸泡液与传统汤剂的化学对比研究[J].中药材，2007，30（11）：1459-1461.
[16] 周承.中药黄芪药理作用及临床应用研究[J].亚太传统医药，2014，10（22）：100-101.
[17] 刘如秀，刘宇，汪艳丽，等.当归的药理作用[J].西部中医药，2014，27（11）：153-156.
[18] 陆小华，马骁，王建，等.赤芍的化学成分和药理作用研究进展[J].中草药，2015，46（4）：595-602.
[19] 姜宇懋，王丹巧.川芎嗪药理作用研究进展[J].中国现代中药，2016，18（10）：1364-1370.
[20] 赵永见，牛凯，唐德志，等.桃仁药理作用研究近况[J].辽宁中医杂志，2015，42（4）：888-890.
[21] 江蔚新，侯明阳.红花药材中的化学成分及其药理作用[J].黑龙江医药，2015，28（4）：732-734.
[22] 王春玲.中药地龙的活性成分与药理作用研究[J].亚太传统医药，2015，11（7）：53-54. |
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