肝硬化幽门螺杆菌阳性患者“四联”与“五联”根除幽门螺杆菌的疗效比较

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Abstract Objective To compare the efficacy of “quadruple” and “quintuplicate” in the eradication of Helicobacter pylori (Hp) in patients with liver cirrhosis and positive Hp. Methods A total of 180 Hp positive patients with liver cirrhosis admitted to Baoding Second Central Hospital of Heibei Province from November 2017 to April 2018 were selected as the research objects, and they were divided into the control group (90 cases) and the research group (90 cases) according to the random number table method. The control group was treated with “quadruple” therapy, and the study group was treated with “quintuplicate” therapy. The eradication effect, mucosal repair, incidence of adverse reactions, liver function before and after treatment, and indexes of liver fibrosis in the two groups were observed and studied. Results The eradication rate and mucosal repair of patients in the study group were significantly better than those in the control group (P < 0.05). The incidence of adverse reactions in the study group was significantly lower than that in the control group (P < 0.05). The liver function of the study group was significantly better than that of the control group (P < 0.05). The indexes of liver fibrosis in the study group were significantly better than those in the control group (P < 0.05). Conclusion Both “quadruple” and “quintuplicate” have certain curative effect in the eradication of Hp in the treatment of Hp positive patients with liver cirrhosis. The treatment effect of “quintuplicate” is more obvious and the clinical value is more prominent, which is worthy of further promotion and application in clinical practice.

Key words： Liver cirrhosis Quadruple Quintuplicate Helicobacter pylori Clinical efficacy

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	ZHANG Jicheng

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ZHANG Jicheng. Comparison of the efficacy of “quadruple” and “quintuplicate” in the eradication of Helicobacter pylori in patients with liver cirrhosis and positive Helicobacter pylori[J]. 中国医药导报, 2019, 16(2): 109-112.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I2/109

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