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| Expression of CEACAM-1 in colorectal carcinoma and correlation with tumor angiogenesis and metastasis |
| XIA Longfei1 LIU Yujun1 ZHANG Junmin1 HAN Junyi2 |
1.Department of General Surgery, Maternal and Child Health Hospital of Zhoushan City, Zhejiang Province, Zhoushan 316000, China;
2.Department of Gastrosurgery, Dongfang Hospital, Tongji University, Shanghai 200120, China |
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Abstract Objective To investigate the expression of CEACAM-1 and the correlation with the tumor angiogenesis and metastasis, and explore feasibility as a monitoring indicator for the diagnosis, treatment and prognosis in evaluating colorectal carcinoma. Methods Fifty specimens of colorectal adenomacarcinoma tissues and 50 specimens of normal colorectal tissues from January 2016 to January 2017 in the Department of General Surgery, Maternal and Child Health Hospital of Zhoushan City were collected. The expression of CEACAM-1, VEGF was detected by immunohistochemistry method, and the value of micro-vascular density (MVD) was observed. The correlation between clinicopathologic features of tumors and expression of CEACAM-1, VEGF and MVD value, as well as the correlation among the three indices was analyzed. Results The positive expression of CEACAM-1 and VEGF in colorectal carcinoma tissues were significantly higher than those in normal tissues, and the differences were highly significant (P = 0.000); MVD value in colorectal carcinoma tissues was significantly higher than that of normal tissue, and the difference was highly significant (P = 0.000); the expression of CEACAM-1, VEGF and MVD value were correlated to degree of colorectal tumor differentiation, tumor serous membrane infiltration, TNM staging, vascular infiltration, lymph node metastasis and liver metastasis (P ＜ 0.05); MVD value of CEACAM-1 and VEGF positive expression groups was significantly higher than that of the negative group in colorectal carcinoma tissues (P ＜ 0.01); the expression of CEACAM-1 and VEGF were positively correlated in colorectal carcinoma tissues (r = 0.483, P ＜ 0.001). Conclusion The high expression of CEACAM-1 can induce the formation of tumor microvasculature, and is closely related to the tumor infiltration and metastasis. CEACAM-1 can be used as a potential molecular biological indicator for early diagnosis and prognosis in monitoring colorectal carcinoma.
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