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2018 Vol. 15, No. 30
Published: 2018-10-25
 
 
4 The experimental study on promoting wound healing of keratinocyte growth factor bioactive peptides in diabetic rats
ZONG Xianlei1 CAO Chunyan1 SONG Guodong1 LAI Chenzhi1 YU Panxi1 JIN Xiaolei1 JIANG Duyin2,3
Objective To explore the promoting effect of keratinocyte growth factor (KGF) active peptide on wound healing in diabetic rats. Methods Twenty-four healthy female SD rats were selected, and injected intraperitoneally with streptozotocin to prepare a diabetic rat model. They were randomly divided into 4 groups: negative control group, KGF positive control group, No.1 KGF active short peptide group, and No.2 KGF active short peptide group, with 6 rats in each group. Round wounds of 2 cm in diameter were prepared on the back of the rats, and drugs of each group were injected locally on the wounds. Photographs were taken 14 days after injury, and the unhealed area of the wound was recorded to calculate the wound healing rate. The wound healing was observed by HE staining. Results The chronic wound model of diabetic rats was successfully established. At 14 days after injury, the wound healing rate of KGF positive control group, No.1 KGF active short peptide group and No.2 KGF active short peptide group was significantly higher than that of the negative control group, and the difference was highly statistically significant (P < 0.01). The wound healing rate of No.1 KGF active short peptide group and No.2 KGF active short peptide group was not significantly different from that of KGF positive control group (P > 0.05). In the negative control group, the whole skin of the wound was missing, and the skin attachments such as hair follicles, sweat glands and sebaceous glands were missing. The tissue structure was uniform and dense, no layer, and the inflammatory cell infiltration was obvious. In the other groups, the wounds were well formed, the deep tissue layers were clear, the structure was loose, the infiltrated inflammatory cells was lessen, and the skin attachments such as regenerated hair follicles, sweat glands and sebaceous glands were visible. Conclusion KGF active short peptide can promote wound healing and regeneration of skin attachment in diabetic rats.
2018 Vol. 15 (30): 4-7 [Abstract] ( 199 ) HTML (1 KB)  PDF (676 KB)  ( 86 )
8 Study of PI3K/AKT/mTOR pathway and immunoglobulin in the pathogenesis of granulomatous lobular mastitis
ZHAO Yang1 WANG Xijing2 ZHANG Shuqun2 KANG Huafeng2 GUAN Haitao2 JIN Yaofeng2 SHAN Changyou2 DIAO Yan1
Objective To analyze the pathogenesis of granulomatous lobular mastitis involved in PI3K/AKT/mTOR pathway and immunoglobulin, and provide reference for related treatment. Methods Sixty patients with granulomatous lobular mastitis diagnosed and treated from June 2015 to June 2016 in the Second Affiliated Hospital of Xi′an Jiaotong University (“our hospital” for short) were selected as the observation group. Thirty healthy subjects in our hospital were selected as the control group. The patient′s PI3K/AKT/mTOR pathway protein and immunoglobulin levels were analyzed. Results Compared with the control group, the levels of PI3K, AKT, mTOR and interleukin-2 (IL-2), IL-6, IL-10 were significantly increased in the observation group, and the levels of immunoglobulin IgA, IgM and IgG were significantly decreased, the differences were statistically significant (P < 0.05). Conclusion PI3K/AKT/mTOR pathway proteins and immunoglobulin have a close relationship with the pathogenesis of granulomatous lobular mastitis.
2018 Vol. 15 (30): 8-10 [Abstract] ( 210 ) HTML (1 KB)  PDF (509 KB)  ( 100 )
11 Effects of Yutang Pills on IRS-1 gene expression and protein phosphorylation in pancreatic tissue of diabetic rats
ZHENG Nan1 XIE Ning1 ZHANG Peiqing2 GAO Lijuan3
Objective To study the effects of Yutang Pills on gene expression of insulin receptor substrate-1 (IRS-1) and protein phosphorylation in pancreatic tissue of diabetic rats. Methods In this study, 150 SD rats were randomly divided into two groups according to their weight, with 20 rats in the blank group and 130 rats in the model group. The model group was fed with high fat forage for 10 weeks to prepare type 2 diabetic rat models and then divided into model control group, Tangniaole group, high dosage of Yutang Pills group, low dosage of Yutang Pills group and Glucophage group according to random number table method, with 20 rats in each group. With the equivalent dosage of rats and adults, the high dosage of Yutang Pills group was given 2.70 g/(kg·d) of Yutang Pills, low dosage of Yutang Pills group was given 1.35 g/(kg·d) of Yutang Pills, Tangniaole group was given 2.43 g/(kg·d) of Tangniaole, and Glucophage group was given 0.09 g/(kg·d) of Glucophage, meanwhile, the model control group and the blank group were given 2 mL/d of normal saline. The pancreatic tissues of rats were taken after 8 weeks of continuous intragastric administration, IRS-1 mRNA expression level was detected by Real-time PCR, and IRS-1 protein expression and phosphorylation levels were detected by Western blot. Results Compared with the model control group, the relative expression of IRS-1 mRNA in Glucophage group, Tangniaole group, low dosage of Yutang Pills group and high dosage of Yutang Pills group was increased (P ＜ 0.05 or P ＜ 0.01), and the relative expression of IRS-1 mRNA in high dosage of Yutang Pills group was higher than that in low dosage of Yutang Pills group (P ＜ 0.05). Compared with the model control group, the levels of IRS-1 ser307 protein phosphorylation in Glucophage group, Tangniaole group, low dosage of Yutang Pills group and high dosage of Yutang Pills group were significantly decreased (P ＜ 0.01), and the level of IRS-1 ser307 protein phosphorylation in high dosage of Yutang Pills group was lower than that in low dosage of Yutang Pills group, the difference was highly statistically significant (P ＜ 0.01). Conclusion Yutang Pills can play a therapeutic role in type 2 diabetes mellitus by affecting the relative expression of IRS-1 mRNA and inhibiting the progress of ser307 protein phosphorylation on IRS-1 to reduce insulin resistance.
2018 Vol. 15 (30): 11-14,18 [Abstract] ( 231 ) HTML (1 KB)  PDF (613 KB)  ( 77 )
15 The effect of Major Capillaries Decoction and Bubleurum Decoction on liver ischemia reperfusion injury in rats
ZHANG Beiping1 ZHAI Shuping2 YUAN Wei2 YAN Yong2 ZHANG Xiaobing1 WANG Bailin2▲
Objective To observe the protective effect of Major Capillaries Decoction and Bubleurum Decoction on liver ischemia-reperfusion injury in rats. Methods Liver ischemia-reperfusion model rats were randomly divided into ischemia-reperfusion Chinese medicine group (TCM group, n = 75), ischemia-reperfusion control group (control group, n = 75), and sham operation group (sham group, n = 75). The contents of interleukin-1 (IL-1) in serum, intercellular adhesion molecule-1 (ICAM-1) and nuclear factor-kappa B (NF-κB) in rat liver homogenate tissue were measured by enzyme-linked immunosorbent assay (ELISA) and Western blot. Results After ischemia and reperfusion in three groups, serum IL-1 content gradually increased with the extension of time. In the same time after ischemia-reperfusion, the serum IL-1 content of TCM group was significantly lower than that of the control group, the differences were highly statistically significant (P ＜ 0.01). The expression of NF-κB and ICAM-1 in the liver homogenate tissue of TCM group and control group increased gradually with the extension of time, and the expression of TCM group was higher than that of control group at the same time point（P ＜ 0.05）. Conclusion Major Capillaries Decoction and Bubleurum Decoction can significantly alleviate liver ischemia-reperfusion injury in rats. It may be through inhibiting the activation of NF-κB and reducing the expression of ICAM-1 and IL-1 to play a protective role in ischemia-reperfusion injury.
2018 Vol. 15 (30): 15-18 [Abstract] ( 225 ) HTML (1 KB)  PDF (614 KB)  ( 71 )
19 Research progress on the neuroimaging of mild traumatic brain injury
LUO Hui1* YANG Guangbo2* FU Feng3 SUN Hongtao3 LINGHU Hairui3▲
Mild traumatic brain injury (mTBI) can lead to changes in brain structure or function, manifested as focal neurological, cognitive or behavioral dysfunction. At present, the diagnostic criteria of mTBI is very limited, variable, and mostly based on subjective self-reporting, which limits the clinician's accurate diagnosis, treatment plan formulation, and prognostic evaluation. The development of advanced neuroimaging has made it possible to objectively evaluate mTBI. This article reviews several promising imaging techniques and their applications to understand abnormal brain changes after mTBI. These imaging modalities include understanding of brain structure and tissue structure, monitoring of local blood flow, assessment techniques for microbleeds, measurement of brain function, and metabolic techniques.
2018 Vol. 15 (30): 19-23 [Abstract] ( 241 ) HTML (1 KB)  PDF (623 KB)  ( 113 )
24 Research progress on the prevention and treatment of radiation-induced lung injury
DONG Guangtong1 ZHANG Xieyu2 HOU Wei2
Radiotherapy is one of the main methods for treating malignant tumors of the chest. However, it is unavoidable that normal tissues are involved. The lung is a moderately sensitive organ of ionizing radiation and therefore can easily cause radiation-induced lung injury. It mainly manifests itself as two phases, namely the early stage of radiation pneumonitis periad and the irreversible radiation pulmonary fibrosis period, which seriously reduces the quality of the patient′s life and even causes respiratory failure and endangers the life of the patient. Radiation-induced lung injury greatly limits the radiation dose, affects the therapeutic effect, and even forces it to be interrupted. This article reviews the mechanisms of radiation-induced lung injury, modern research, prediction systems, diagnosis, western medicine prevention and treatment.
2018 Vol. 15 (30): 24-27,35 [Abstract] ( 252 ) HTML (1 KB)  PDF (662 KB)  ( 84 )
28 A comparative study of relaxing qigong and yoga nidra
ZHENG Huili1 Ida Ayu Anom Rastiti1 CHEN Changle2,3
Relaxing qigong and Indian yoga nidra are the splendid treasures of oriental culture. They have a long history, they are different, but also closely linked. This article reviews a large number of related domestic and foreign research and literatures regarding to these topics. Based on the theoretical basis, method, result and modern development, several aspects are compared in order to provide more informations and evidences for scientific research and clinical application. The analysis shows that although relaxing qigong and yoga nidra have different theoretical systems, they have similarities in the methods of breathing, observing and thinking practice. In the medical field, the research focuses on the mental and circulation system. The main diseases are hypertension, anxiety, depression and etc. Nowadays, Yoga nidra is mainly used after yoga postures, practice of yoga is becoming a good trend and showing good market development. The relaxing qigong of its practice gradually develops along with the goverment attention to the development of qigong. Although the development of them are different, they can learn from each other.
2018 Vol. 15 (30): 28-31 [Abstract] ( 241 ) HTML (1 KB)  PDF (607 KB)  ( 253 )
32 Recent research progress on the mechanism of acupuncture in intervention of primary dysmenorrhea
CHEN Pengdian1 YANG Zhuoxin2▲ NING Yan1▲ LIU Fang1 QIU Tingting1 BEI Jianhong1 CHEN Yan1 TANG Meng1
This paper analyzes the mechanism of acupuncture in intervention of primary dysmenorrhea among the experimental study of rats in recent years, argues that the mechanism of acupuncture in intervention of primary dysmenorrhea may be associated with the following aspects: acupuncture can treat primary dysmenorrhea through regulating endocrine function and the body′s immune function, improving the metabolism of nerve and neurotransmitter and uterine microenvironment disorder.
2018 Vol. 15 (30): 32-35 [Abstract] ( 289 ) HTML (1 KB)  PDF (607 KB)  ( 123 )
36 Advances in the conservative treatment of lumbar intervertebral disc herniation
ZHI Xiaocheng1 XU Jing1 QIAN Xiaozhong1,2
Lumbar disc herniation (LDH) is the most common cause of lumbago-leg pain. Conservative treatment is the first choice for the treatment of lumbar disc herniation clinically. Conservative treatment is the preferred method of clinical treatment of LDH. This article reviews bed rest, traction therapy, physical therapy, drug therapy, massage acupuncture and other conservative treatment methods, summarizes the general situation of LDH conservative treatment, and points out that the combination of two or more treatments has good clinical effects, low recurrence rate, in the hope that it can better guides the clinical and provides direction for future clinical research on conservative treatment of LDH.
2018 Vol. 15 (30): 36-39 [Abstract] ( 260 ) HTML (1 KB)  PDF (604 KB)  ( 108 )
40 Research progress on the correlation between thyroid disease and anemia
ZHENG Xiaomin1 YE Fang2▲ LIU Cuiping1
Thyroid disease and anemia are both common clinical diseases, they interact with each other. This paper describes the research progress on the correlation between thyroid disease and anemia, including hyperthyroidism, hypothyroidism, subclinical hypothyroidism and subclinical hypothyroidism in pregnancy, discusses the research progress of clinical prevalence, pathogenesis, clinical outcome, treatment and other aspects of thyroid disease combined with anemia, so as to provide ideas and clues for further study of correlation between thyroid function and anemia.
2018 Vol. 15 (30): 40-43 [Abstract] ( 238 ) HTML (1 KB)  PDF (606 KB)  ( 43 )
44 Analysis of risk factors for hypercholesterolemia in maintenance hemodialysis patients in Guangdong area
XU Yuanzhao QI Airong▲ YANG Jun HAN Xiaowei LUO Denggui
Objective To investigate the risk factors of hypercholesterolemia in maintenance hemodialysis (MHD) patients in Guangdong area. Methods From July to September 2017, a total of 1193 MHD patients admitted to 10 hospitals of the Sixth Affiliated Hospitals, Shenzhen Chinese Traditional Medical Hospital, Shenzhen Chinese Traditional Medical Hospital, Dongguan Donghua Hospital, the People′s Hospital of Dongguan City, the Center People′s Hospital of Huizhou City, the Second People′s Hospital of Futian District in Shenzhen, the First People′s Hospital of Shunde, the First People′s Hospital of Zhaoqing City, the Baoan Center Hospital of Shenzhen City, and Guangzhou Hospital of Integrated Traditional and Western Medicine were selected, the risk factors for high cholesterol in MHD patients were analyzed. Results Among the 1193 patients, there were 795 non-hypercholesterolemia patients and 398 hypercholesterolemia patients. Compared with patients with non-hypercholesterolemia, patients with hypercholesterolemia were older, and the levels of platelets, hemoglobin, white blood cells, blood calcium, blood uric acid, total protein, albumin, triglyceride, hypersensitive C-reactive protein, blood β2 microglobulin were higher, e%, serum uric acid, post transdermal blood urea nitrogen, and pre-protein were lower, and had fewer hemofiltrations, fewer useage of alpha and beta receptor antagonists and calcium agent, and less internal embolization (P < 0.05). Gender, age, use of unfractionated heparin, blood uric acid were the independent risk factor for hypercholesterolemia in patients with MHD（P < 0.05）. Conclusion The occurrence of hypercholesterolemia in MHD patients in Guangdong area is related to gender, age, usage of heparin and blood uric acid.
2018 Vol. 15 (30): 44-47 [Abstract] ( 243 ) HTML (1 KB)  PDF (486 KB)  ( 85 )
48 Investigation on the effect of integrating medical resources between public hospital and community hospital
QIN Shanchun1 TAO Yanxia2 LI Hongtao2
Objective To evaluate the effect of integrating medical resources between tertiary public hospital and community hospital, and to provide reference for the new round of healthcare reform. Methods A self-made community hospital patient satisfaction questionnaire was used as a research tool. A total of 100 patients in the youth apartment community hospital were randomly selected before the integration of medical resources from January to March 2017 and after the integration of medical resources from January to March 2018, and their first consultation hospital, medical service satisfaction and medical experience were investigated. Results Compared with the pre-integration, the patients′ satisfaction with overall medical services, diagnosis and treatment technology, range of available drugs, types of medical treatment, health guidance, doctors′ attitudes and the treatment process all improved. The differences were statistically significant (P < 0.05); there was no significant change in the service attitude, waiting time and satisfaction of the patients in the medical and technical departments, and the difference was not statistically significant (P > 0.05). Comparing the overall probability distribution of community patients′ first hospital choice before and after integration of medical resources, 29.6% of patients chose community hospitals as the first consultation hospital after integration. Before the integration, the difference was statistically significant (P < 0.05). In the aspect of medical experience, 4.5% of patients have increased trust in community doctors, 56.1% of patients thought that medical expenses has been reduced, 68.4% of patients thought that medical treatment has been shortened, and 49.0% of patients thought that "expensive and hard to visit doctors" problem has been solved to a great extent. Conclusion The integration of medical resources in public hospitals and community hospitals has effectively improved the ability and level of primary medical services, guided patients to seek medical care reasonably, and improved the patient′s medical experience.
2018 Vol. 15 (30): 48-51,57 [Abstract] ( 202 ) HTML (1 KB)  PDF (530 KB)  ( 150 )
52 Incidence trend and etiology analysis of upper gastrointestinal bleeding in children
WU Xiaoyu1 FENG Xiaoli1 LI Feng1 CHEN Xiaoyan2
Objective To analyze the clinical data of upper gastrointestinal bleeding (UGIB) in children in different years and ages, and to explore the pathogenesis and etiology of UGIB in children in recent years, and to provide reference for clinical intervention, diagnosis, treatment and prognosis. Methods Clinical data of 512 children with symptoms of UGIB in the Fourth People′s Hospital of Ziyang and the First Affiliated Hospital of Chengdu Medical College from January 2013 to December 2017 were retrospectively analyzed, which within male 315 cases (61.5%), female 197 cases (38.5%), the ratio of male to female was 1.6︰1. Children were divided into five periods: infancy, early childhood, preschool, school age and adolescence according to the age. The incidence, change trend, etiology and onset time of UGIB in children were observed and analyzed, and the differences of different etiologies in gender, age and year were compared. Results The incidence of UGIB in each period was significantly different in different years (P < 0.05), except for school age, showed a downward trend over the years. Septicemia, hemophilia, severe pneumonia, purpura and gastritis were the most common causes of UGIB in children. There was no significant difference between male and female in UGIB etiology (P > 0.05). The differences in etiology of children at different stages were statistically significant (P < 0.05). The proportion of septicemia, hemophilia, severe pneumonia and metabolic acidosis gradually decreased with the age of the children, however, the proportion of inflammation and ulcer-like diseases such as purpura, gastritis, duodenal ulcer, coagulation, leukemia, aplastic anemia and other unknown causes gradually increased. Conclusion In recent years, the incidence of UGIB in children has decreased, but the etiology is still complicated, and the focus of prevention and treatment in different ages and different periods should be paid attention to.
2018 Vol. 15 (30): 52-57 [Abstract] ( 196 ) HTML (1 KB)  PDF (561 KB)  ( 130 )
58 Relationship between serum fasting C-peptide and vascular disease in patients with type 2 diabetes mellitus
QU Xiaoyan1,2 FANG Aijuan3 SUN Lijun2 SHEN Shanmei4▲
Objective To investigate the relationship between serum fasting C-peptide (FCP) and vascular disease in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective analysis of 105 patients with T2DM admitted to School Hospital of Nanjing University of Aeronautics & Astronautics from March 2016 to February 2018 was conducted. According to the results of color doppler examination of the lower limbs, the patients were divided into non vascular lesion group (52 cases) and vascular lesion group (53 cases). The general data of the two groups, biochemical indices including fasting blood glucose (FBG), postprandial 2 h blood sugar (PBG), glycated hemoglobin (HbAlc), FCP, postprandial 2 h C-peptide (CP), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared between the two groups. Multiple Logistic regression analysis was used to analyze the influencing factors of T2DM patients. Results The age, course and hypertension case number in vascular lesion group was higher than those in non vascular lesion group, and the differences between the two groups were statistically significant (P ＜ 0.05). FBG, PBG, HbAlc and LDL-C in vascular lesion group was significantly higher than those in non vascular lesion group, and the differences were statistically significant (P ＜ 0.05). While FCP, CP and HDL-C were significantly lower than those in non vascular lesion group, and the differences between the two groups were statistically significant (P ＜ 0.05). The results of Logistic regression analysis showed that age (≥50 years), diabetes course (≥5 years), PBG (≥17 mmol/L), HbA1c (≥9%), and LDL-C (≥3 mmol/L) was independent risk factors of vascular lesions in T2DM, and FCP (＞0.9 μg/L) and CP (＞ 2.1 μg/L) was protective factors of vascular lesions (P < 0.05). Conclusion FCP may protect the blood vessels, and the decrease of FCP may be one of the reasons for the occurrence and development of vascular disease in T2DM patients.
2018 Vol. 15 (30): 58-61 [Abstract] ( 227 ) HTML (1 KB)  PDF (388 KB)  ( 47 )
62 Effects of continuous renal replacement therapy on clinical effect and IL-6, TNF-α of patients with severe acute kidney injury
LU Jianrong1 CHEN Zhe2 ZHANG Fuquan1
Objective To investigate the effects of continuous renal replacement therapy (CRRT) on clinical effect and IL-6, TNF-α of patients with severe acute kidney injury (AKI). Methods A retrospective analysis was conducted, including 55 cases with severe AKI treated by CRRT in the Department of Severe Medicine, Beijing Haidian Hospital from February 2015 to October 2016 as study group, and another 38 cases with severe AKI treated by intermittent hemodialysis (IHD) in the same period as control group. After 3 months of treatment, clinical efficacy and interlukin-6 (IL-6), umor necrosis factor-alpha (TNF-α) levels of the two groups were analyzed and compared. Results After treatment, the levels of serum creatinine and blood urea nitrogen of the two groups were lower than those before treatment, and the indices in the study group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After treatment, levels of blood biochemical indices improved in the two groups, the improvement of blood biochemical indices in the study group were better than those in the control group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy rate and survival rate in the study group were 74.14%, 87.27% respectively, significantly higher than those in the control group (57.89%, 68.42%), the differences were statistically significant (P ＜ 0.05). After treatment, the levels of IL-6, TNF-α in the two groups were both lower than those before treatment, and the levels of the IL-6 and TNF-α of the study group were significantly lower than those in the control group (P ＜ 0.05). Conclusion CRRT can be effective treatment for severe AKI, which can obviously reduce inflammatory factors and efficiently improve survival rate of the patients, and it is worth of clinical promotion.
2018 Vol. 15 (30): 62-65 [Abstract] ( 271 ) HTML (1 KB)  PDF (378 KB)  ( 141 )
66 Clinical efficacy of total knee arthroplasty in treatment of end-stage Kashin-Beck disease in adults
NIE Zhijun1 YUAN Qiling2 LING Ming1 CHANG Yanhai1 GUO Xiong3
Objective To observe the clinical efficacy after total knee arthroplasty (TKA) for the end-stage Kashin-Beck disease (KBD) in adults. Methods From May 2014 to December 2016, in Shaanxi Provincial People's Hospital, 24 patients (29 knees) with the end-stage KBD and treated with total knee arthrophasty (TKA) at first time were selected. Appropriate prosthesis and surgical approach were selected according to patients′ condition. The changes of Visual analogue scale (VAS) score, Knee society score (KSS), knee range of motion (ROM), femorotibial angle (FTA) and postoperative complications were observed before and after TKA, the patients were followed up for 1-15 months. Results In each period after surgery, the VAS score and FTA decreased significantly compared with that before surgery, KSS and ROM increased significantly compared with those before surgery, the differences were statistically significant (P ＜ 0.05). One case occured muscular venous thrombosis, and was cured by anticoagulation therapy. No serious complications were noted, such as pulmonary embolism, deep vein thrombosis, periprosthetic osteolysis, prosthetic sinking or loosening. Conclusion TKA is an effective treatment for end-stage KBD of the knee joint. It can significantly reduce pain of knee joint, and obtain satisfactory activity range and function of the knee joint.
2018 Vol. 15 (30): 66-70 [Abstract] ( 279 ) HTML (1 KB)  PDF (585 KB)  ( 110 )
71 Applicative effect of different doses of bone cement injection in the unilateral percutaneous vertebroplasty for treatment of osteoporotic vertebral compression fractures
SHEN Yongle WANG Jingxu GONG Shuyi MU Shengkai WU Yan YIN Ximeng LU Zepeng
Objective To investigate the applicative effect of different doses of bone cement injection in the unilateral percutaneous vertebroplasty (PVP) for treatment of osteoporotic vertebral compression fractures (OVCF). Methods One hundred and thirteen patients with OVCF in Shenyang Orthopedics Hospital from February 2015 to December 2016 were selected as research objects. According to random number table method, the patients were divided into control group (n = 57) and study group (n = 56). The control group was given 2.6-3.5 mL of bone cement for PVP, and the study group was given 1.5-2.5 mL of bone cement. The pain state, motor function, Cobb angle, the height ratio of vertebral body front edge and the leakage of bone cement was compared between the two groups before operation and 1 month, 6 months after operation, and the occurrence of other complications was observed. Results The scores of visual analogue scale (VAS) and Oswestry disability index (ODI) in different observation time was lower than those before operation in two groups (P ＜ 0.05), but there was no significant difference between the two groups at 1 month, 6 months after operation (P ＞ 0.05). The Cobb angle of the two groups 1 month and 6 months after the operation was decreased (P ＜ 0.05), but there was no significant difference between the two groups (P ＞ 0.05). The height ratio of vertebral body front edge of two groups was significantly increased 1 month and 6 months after operation, and the control group was higher than that of the study group (P ＜ 0.05). The total leakage rate of the study group was 7.14% (4/56), which was significantly lower than that of the control group (29.82%, 17/57) (P ＜ 0.05). There was no significant difference in the incidence of complications after operation between the two groups (P ＞ 0.05). Conclusion The two different doses of bone cement injection (1.5-2.5 mL and 2.6-3.5 mL) in the PVP for treatment of OVCF can effectively improve the clinical symptoms and reduce the pain in patients, but the low dose of bone cement can reduce the rate of leakage.
2018 Vol. 15 (30): 71-74 [Abstract] ( 764 ) HTML (1 KB)  PDF (444 KB)  ( 43 )
75 Application of new ann mat combined with passive exercise therapy in cerebral palsy children
WANG Chunyu1 WANG Chunnan1▲ LI Jie2 LIN Niannian3
Objective To explore the application effect of new ann mat combined with passive exercise therapy in cerebral palsy children. Methods Clinical data of 113 cerebral palsy children from March 2017 to March 2018 in Rehabilitation Department of Shenyang Children′s Hospital were analyzed, which were divided into two groups according to different intervening measure. In the control group (53 cases), routine systematic observation was applied, and nutrition and disease prevention were given. The observation group (60 cases) were treated with new ann mat combined with passive exercise therapy. The developmental quotient (DQ) score, gross motor function measure (GMFM) score and life quality score of children in the two groups were observed, before intervention and 12 months after birth, and the clinical efficacy of children in the two groups were observed. Results The DQ, GMFM, life quality score before intervention of children in two groups had no statistically significant difference (P > 0.05); 12 months after birth, the DQ, GMFM and life quality score in two groups were higher than those before intervention, and those scores of the observation group were higher than those in control group, the differences had statistical significance (P < 0.05). Conclusion The application of new ann mat combined with passive exercise therapy in cerebral palsy children can improve the development level of children, gross motor function and life quality, and the clinical treatment effect.
2018 Vol. 15 (30): 75-79 [Abstract] ( 1021 ) HTML (1 KB)  PDF (611 KB)  ( 138 )
80 Evaluation of the clinical effect of uterine artery ligation of pernicious placenta previa
XU Hongmei MIN Aiping▲ LUO Xiao
Objective To investigate the clinical value of uterine artery ligation in cesarean section of pernicious placenta previa. Methods A total of 78 cases of cesarean section women admitted to the People′s Hospital of Leshan City from May 2015 to May 2017 were selected as study objects, they were randomly divided into observation group and control group according to the simple number list method. Forty cases in the observation group were treated with uterine artery ligation, 38 cases in the control group were treated with conventional hemostasis. The operation time, the dosage of oxytocin, intraoperative hemorrhage volume, blood transfusion volume, postoperative 24 h hemorrhage volume, postoperative 24 h body temperature, postoperative 24 h neutrophil counts, hysterectomy rate and incidence of complications were compared between the two groups. Results Compared with control group, the operation time, the dosage of oxytocin, intraoperative hemorrhage volume, blood transfusion volume, postoperative 24 h hemorrhage volume, hysterectomy cases and postoperative incidence of complications were lower in observation group, the differences were statistically significant (P < 0.05). There were no significant differences in the postoperative 24 h body temperature and neutrophil counts between two groups (P > 0.05). Conclusion The application of uterine artery ligation in the cesarean section with pernicious placenta previa is effective clinically, safe and reliable, and can be promoted in clinic.
2018 Vol. 15 (30): 80-83 [Abstract] ( 770 ) HTML (1 KB)  PDF (555 KB)  ( 62 )
84 Associations of pre-pregnancy BMI, pregnancy weight gain and newborn weight
ZHAO Jianping1 HUANG Wenbin1 QIN Bingqing2 ZHAO Ruiqing3
Objective To explore the associations of pre-pregnancy body mass index (BMI), pregnancy weight gain and newborn weight. Methods From March 2016 to March 2017, 441 women were selected from Xinxiang Maternal and Child Health Hospital who set birth health card within 12 weeks of pregnancy, had undergone regular childbirth and delivered a single birth. And the data of their pre-pregnancy BMI, pregnancy weight gain and newborn weight were observed and analyzed. Results Among the 441 pregnant women, 73.7%, 14.1%, 10.6% and 1.6% were normal, low weight, overweight and obese before pregnancy, respectively. The pregnancy weight gain was normal, insufficient and excessive, accounting for 40.6%, 38.1% and 21.3%, respectively. The difference in the degree of weight control in pregnancy was highly statistically significant in different pre-pregnancy BMI groups (P < 0.01). Among the 441 newborns, the normal birth weight, low weight and giant children accounted for 89.8%, 6.1 % and 4.1 %, respectively. BMI before pregnancy and pregnancy weight gain had significant effects on newborn weight (P < 0.01), but there was no significant interaction between them (P > 0.05). Conclusion BMI before pregnancy and pregnancy weight gain are closely related to newborn weight. Pregnant women who are thin and overweight before pregnancy and those who gain too much or too little weight should control their weight within an appropriate range to promote maternal and child health.
2018 Vol. 15 (30): 84-86,94 [Abstract] ( 284 ) HTML (1 KB)  PDF (569 KB)  ( 92 )
87 Meta analysis of correlation between repeated abortion and uterine fibroids in Chinese women
LU Danhua1 HONG Li
Objective To evaluate the connection between repeated abortion (≥2 times) and uterine fibroids in Chinese women. Methods CNKI, VIP,  Wanfang and PubMed were searched from the establishment to October 25th, 2016 for collecting eligible studies about the relevance of repeated abortion and uterine fibroids, and other relevant articles were also searched by hand. RevMan5.2 software was used to perform meta-analysis after the study selection, extraction and assessment of its quality. The methodological quality of included study was assessed by Newcastle-Ottawa Scale (NOS) quality evaluation criteria. Results Ten case-control studies involving 1780 cases and 1894 controls were finally included. The results of Meta analysis showed that repeated abortion could raise the risk of uterine fibroids compared with control group. Random effect model: OR = 2.23, 95%CI: 1.72-2.88); fixed effect model: OR = 2.46, 95%CI: 2.14-2.82. Conclusion Repeated abortion could increase the risk of uterine fibroids in Chinese women.
2018 Vol. 15 (30): 87-90 [Abstract] ( 271 ) HTML (1 KB)  PDF (879 KB)  ( 117 )
91 Analysis of the testing results of sex hormone levels in 130 female infertility patients
WANG Chong１ SUN Rui２ WU Zhouya２
Objective To analyze the changes of sex hormones in female infertility patients, provide evidence for etiological diagnosis of female infertility. Methods From March 2015 to May 2017, 130 cases of female infertility in Nanjing Jinling Hospital on Integeration of Chinese and Western Medicine ("our hospital" for short) were selected as study group. According to the menstrual condition, it was divided into normal menstrual group (50 cases) and menstrual disorder group (80 cases). Fifty healthy women carried physical examination in our hospital at the same periods were selected as control group. Levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), pituitary prolactin (PRL), testosterone and progesterone were measured by chemiluminescent Immunoassay. Results In the menstrual disorder group, serum FSH, LH, PRL and testosterone levels were higher than control group and menstrual normal group (P < 0.05 or P < 0.01). Level of serum E2 was significantly lower than that of control group and normal menstrual group (P < 0.01). There was no significant difference between the six hormone levels and the control group in the normal menstrual group (P > 0.05). The levels of sex hormones in patients with different causes of infertility were compared with those in control group and normal menstrual group: LH, testosterone and PRL in 49 patients with polycystic ovary syndrome significantly increased (P < 0.05 or P < 0.01), and LH/FSH≥2. In 21 patients with hyperlactation, PRL significantly increased (P < 0.01), while E2 significantly decreased (P < 0.05). In 5 patients with premature ovarian insufficiency, FSH and LH increased significantly (P < 0.01), while E2 significantly decreased (P < 0.01). In 5 hypothyroidism patients, E2 and testosterone decreased significantly (P < 0.05), while FSH, LH and PRL increased significantly (P < 0.05 or P < 0.01). Conclusion The abnormal level of sex hormones in menstrual disorder group suggested that endocrine factors are the cause of infertility. The abnormal sex hormones in infertility of different etiologies provides an important basis for the analysis of etiology of infertility.
2018 Vol. 15 (30): 91-94 [Abstract] ( 236 ) HTML (1 KB)  PDF (558 KB)  ( 44 )
95 Analysis on biomechanical parameters about low to moderate myopia patients post refractive surgery by Corvis ST
GUAN Wenying ZHAO Haixia
To analyze the changes of biomechanical parameters about patients with low to moderate myopia after refractive surgery and discuss the safety and efficacy of refractive surgery with corneal visualization scheimpflug technology (Corvis ST) from the perspective of corneal biomechanical. Methods A total of 100 eyes from 100 patients with low to moderate myopia treated in Myopia laser center, the Affiliated Hospital of Inner Mongolia Medical University from March 2015 to October 2016 were selected randomly. According to operation method, the patients were divided into two groups, patients performed Sub-Bowman-Keratomileusis enrolled in SBK group and patients performed laser-assisted in situ keratectomy enrolled in LASIK group, with 50 patients in each group. And preoperative examination was performed and corneal biomechanics were tested by Corvis ST. Intraocular pressure (IOP), central corneal thickness (CCT), the first applanation time (A-time1) and deformation amplitude (DA) were observed in the two groups before and after operation and 1 month post-operation. Results Compared with pro-operation, patients in the two groups had significantly lower IOP, CCT and A-time1 after operation (P ＜ 0.05); but no significant difference was detected in DA before and after operation (P ＞ 0.05). Corneal biomechanics in the two groups before treatment have no difference (P > 0.05); there were no significant differences in IOP, CCT and DA between SBK and LASIK group 1 month after operation (P ＞ 0.05); but A-time1 was higher in SBK group than that in LASIK group, and the difference was statistically significant (P ＜ 0.05). Conclusion There are differences in IOP, CCT and A-time1 between pro-operation and post-operation, but DA is not altered. From the perspective biomechanical parameters, SBK has higher A-time1 than LASIK. The changes of biomechanical parameters after refractive surgery should be studied and discussed in further study.
2018 Vol. 15 (30): 95-97,101 [Abstract] ( 243 ) HTML (1 KB)  PDF (408 KB)  ( 67 )
98 Efficacy of krypton yellow laser for polypoidal choroidal vasculopathy outside the macular
SHEN Ran1 WANG Fenghua2▲ GUO Lixia1 YANG Liping1 WANG Yanna1
Objective To observe the effect of krypton yellow laser for polypoidal choroidal vasculopathy (PCV) outside the macular. Methods Eleven cases (11 eyes) with PCV located out of the macular central fovea with 500 μm were selected in Handan City Eye Hospital from June 2015 to June 2017, that were diagnosed by clinical features, medical history, fundus fluorescence angiography (FFA), indocyanine green angiography (ICGA) and optical coherence tomography (OCT). All patients were treated with krypton yellow laser 2-3 times with interval of 15 days to 1 month. The re-treatment indications were according to the color fundus lesions, the reaction of laser, fundus angiography (FFA and ICGA) and OCT examination. All the patients were followed up for 6 to 12 months. Visual acuity, the best corrected visual acuity, FFA, ICGA and OCT results were observed. Results There were 3 eyes that were treated with laser 2 times, while 8 eyes were treated with 3 times. There were 6 patients (6 eyes) replied that the visual acuity improved compared with that before treatment and visual deformation mainly eliminated. There were 2 patients (2 eyes) that had a slightly improvement in the visual acuity and the shadow decreased. Three patients (3 eyes) had significant visual improvement with shadow disappearing. The best corrected vision acuity was 0.1-0.6. FFA and ICG results showed atrophy of PCV lesions. Conclusion Effect of krypton yellow laser treatment for PCV located out of the macular central fovea with 500 μm was reliable, that can stabilize and improve patients′ vision acuity effectively, preventing the further progress of PCV, inexpensive and effective.
2018 Vol. 15 (30): 98-101 [Abstract] ( 226 ) HTML (1 KB)  PDF (396 KB)  ( 97 )
102 Content determination of buddleoside and ginsenoside Rg1 in Zhixue Yangyuan Oral Liquid by HPLC
HU Bei ZHAO Qingchun ZHANG Chaoshen WU Qiong MA Hongda
Objective To establish high-performance liquid chromatography (HPLC) method for the content determination of buddleoside and ginsenoside Rg1 in Zhixue Yangyuan Oral Liquid. Methods HPLC was used to determine the content of buddleoside in Herba Cirsii and ginsenoside Rg1 in Radix Ginseng. The content of buddleoside in Herba Cirsii was determinated with mobile phase consisted of methanol-0.5% acetic acid water (50∶50). The detection wavelength was set at 326 nm. The content of ginsenoside Rg1 in Radix Ginseng was determinated with mobile phase consisted of acetonitrile-water (20∶80). The detection wavelength was set at 203 nm. Results There was a good linear relationship between buddleoside and peak area in the range of 5-160 μg/mL (r = 0.9997) with an average recovery of 97.73%, RSD = 2.01% (n = 6). There was a good linear relationship between ginsenoside Rg1 and peak area in the range of 0.025-0.8 mg/mL (r = 0.9998) with an average recovery of 98.62%, RSD = 2.48% (n = 6). The content determination results of the three batches of samples all met the requirements. Conclusion The method is simple, accurate and reproducible. It is effective in controlling the quality of Zhixue Yangyuan Oral Liquid.
2018 Vol. 15 (30): 102-105,110 [Abstract] ( 232 ) HTML (1 KB)  PDF (812 KB)  ( 106 )
106 Study on the quality standard of Zhideke Granules
HUANG Min1 HUANG Guodong2 WEI Yulong3 XIE Guangyuan3 LU Danping4 WU Bianmei4
Objective To establish a study method for the quality standard of Zhideke Granules. Methods Thin layer chromatography (TLC) was used for the qualitative identification of Cynanchum glaucescens and Belamcanda chinensis. High performance liquid chromatography (HPLC) was used to determine baicalin and irisflorentin by C18 chromatographic column, the mobile phase was methanol-0.2% phosphoric acid solution (49∶51), the flow rate was 1 mL/min, the detection wavelength was set at 266 nm. Results The TLC spots were clear and free from negative interference. In HPLC quantitative determination, baicalin and irisflorentin showed good linear relationships within the ranges of 947.1-7577.2 ng (r = 0.9998) and 18.032-180.32 ng (r = 0.9999), whose average recovery were 100.6% (RSD = 0.4%) and 93.1% (RSD = 0.6%), respectively. Conclusion The method is simple, feasible, sensitive and accurate, which can be used as the quality control method of Zhideke Granules.
2018 Vol. 15 (30): 106-110 [Abstract] ( 263 ) HTML (1 KB)  PDF (539 KB)  ( 105 )
111 Analysis on the quality of loquat leaves from Tangxi
MA Zhelong1 WU Zengyan1 JIANG Fusheng2 DING Zhishan3
Objective To evaluate the quality of different varieties of loquat leaves from Tangxi. Methods Reference to the 2015 edition of Chinese Pharmacopoeia, the water content, total ash content and extract content of different varieties of loquat leaves were measured by oven drying method, ignition method and hot-dip method. The oleanolic acid and ursolic acid were detected useing Kromasil C18 (250 mm×4.6 mm, 5 μm) column, with mobile phase being acetonitrile-methanol-0.5% ammonium acetate (67∶12∶21, v/v/v), column temperature being at 25℃, flow velocity being 1.0 mL/min, and detection wavelength being at 210 nm. The quercetin and kaempferol were detected by Kromasil C18（250 mm×4.6 mm,5 μm）column, with mobile phase being methanol-0.4% phosphoric acid (50∶50, v/v), column temperature being at 30℃, flow velocity being 1.0 mL/min, and detection wavelength being at 360 nm. Results The range of water content, total ash content, and extract content of different varieties of loquat leaves were 7.87%-9.45%, 5.14%-6.22% and 25.41%-29.68%, respectively, the range of total content of oleanolic acid and ursolic acid was 1.04%-1.25%, all in line with the 2015 edition of Chinese Pharmacopoeia. In addition, the range of total content of quercetin and kaempferol in loquat leaves was 0.17%-0.29%. Conclusion The different varieties of loquat leaves in Tangxi all have good quality and deserve further development and utilization.
2018 Vol. 15 (30): 111-114 [Abstract] ( 207 ) HTML (1 KB)  PDF (572 KB)  ( 89 )
115 Effect of Zhizhu Kuanzhong Capsules on Hp eradication rate and recurrence rate in patients with gastric Hp infection
DAI Jinyu1 LIU Qiang2 SU Weixian1 SHI Zenghui1 ZHAO Junjing1
Objective To investigate the effect of Zhizhu Kuanzhong Capsules on Helicobacter pylori (Hp) eradication rate and recurrence rate in patients with gastric Hp infection. Methods From January 2015 to January 2017, in Langfang People′s Hospital, 300 patients with gastric Hp infection were selected, they were divided into the control group and the treatment group by rondom number table method, with 150 cases in each group. The control group was given quadruple therapy, the treatment group was given Zhizhu Kuanzhong Capsules combined with quadruple therapy. The two groups were treated for 2 weeks. The Hp eradication rates of two groups 1 month after discontinuation were compared, the Hp recurrence rates of the two groups 12 months after discontinuation were compared, the serum CRP, PGⅠ, PGⅡ of two groups before treatment and 1 month after discontinuation were compared. The conditions of adverse reactions of the two groups during the treatment were recorded and compared. Results The Hp eradication rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). The Hp recurrence rate of the treatment group 12 months after discontinuation was significantly lower than that of the control group, the difference was statistically significant (P ＜ 0.05). The levels of serum CRP, PGⅡ of the two groups 1 month after discontinuation were significantly lower than those before treatment, the levels of serum PGⅠ of the two groups 1 month after discontinuation were significantly higher than those before treatment, and the improvement of serum CRP, PGⅠ, PGⅡ levels of the treatment group was significantly better than those of the control group, the differences were statistically significant (P ＜ 0.05). During treatment, the rate of adverse reactions between the two groups had no significant difference (P ＞ 0.05). Conclusion Zhizhu Kuanzhong Capsules combined with quadruple therapy in patients with gastric Hp infection has high Hp eradication rate, low recurrence rate, which can improve the inflammation of the gastric mucosa, with good safety, and it is worthy of clinical application.
2018 Vol. 15 (30): 115-118 [Abstract] ( 273 ) HTML (1 KB)  PDF (363 KB)  ( 141 )
119 Effect of grading stratified treatment for obesity with traditional integrated western medicine
WANG Hanlin1 CHEN Jiaxin1 GUO Xinfeng2 GU Caishan1 LI Chuqian1 XIE Changcai2
Obesity is a common, adiposity-based chronic disease. Currently, there is a variety of treatments for obesity, yet no single treatment is adequate. Combined methods are aften used. The Newest Meta analysis in 2017 demonstrates that the integrative medicine is one of the effective treatments. However, in clinical practice, integrative medicine treating obesity still has problems due to the lack of systematically quantitative index, standardized diagnosis and treatments. This article makes a collation on treatment guidelines, combining with clinical practice, and summarizes the known approaches of integrative medicine on obesity treatment with in-depth exploration, to provide some well-developed grading stratified treatment norms, and clearly defines various methods of the integrative medicine in obesity classification and stratified treatment. Meanwhile, the intervention time and characteristics of the three integrative medicine methods are clearly expounded, which may provide some new ideas for the treatment of obesity.
2018 Vol. 15 (30): 119-122,130 [Abstract] ( 224 ) HTML (1 KB)  PDF (889 KB)  ( 106 )
123 Influence of traditional Chinese medicine inheritance processing technology on education development of traditional Chinese medicine
YE Xide1 ZHU Jing1 PENG Qiaozhen2 LE Lixia1 HE Wei1 HE Xiaohui1 ZHONG Lingyun1
This paper summarizes the basic situation of inheritance processing technology of traditional Chinese medicine at home and abroad. On the basis of educational effectiveness by comparing with the achievements of different colleges and universities, both the shortcomings and future development of inheritance processing technology of traditional Chinese medicine at home and abroad in Chinese medical education are clearly analyzed. Meanwhile. This study also indicates that some of problems related to educational ways, contents, qualities and management are pointed out in summing up the influence of Chinese medical education on inheritance processing technology of traditional Chinese medicine. Some of problem-solving measures including creative educational model, rich educational contents, improving educational quality and sound management system are accordingly suggested. The purpose of this paper is to explore the influence of Chinese medical education development on inheritance processing technology of traditional Chinese medicine for its progress, in order to better inherit Chinese medicine processing technology and then promote the development of Chinese medical education.
2018 Vol. 15 (30): 123-126 [Abstract] ( 215 ) HTML (1 KB)  PDF (740 KB)  ( 80 )
127 Summary of XIE Like′s experience in treating Irvine-Gass syndrome
MING Jing XIE Like HAO Xiaofeng QIN Rui QI Yixin LI Xiaoyu
Irvine-Gass syndrome is one of the most common complications after cataract surgery，leading to visual loss and metamorphopsia. At present， its etiology and treatment has not yet reached a unified understanding. Prof. XIE has rich clinical experience in the treatment of eye fundus diseases with traditional Chinese integral western medicine, puts forward that treating this disease mainly by strengthening spleen, removing wind, clearing heat and dredging blood circulation, and this therapy has a good effect. This paper will summarize his experience from the aspects of invasion sites， pathogenesis， clinical manifestation， prevention and care， typical cases, etc.
2018 Vol. 15 (30): 127-130 [Abstract] ( 283 ) HTML (1 KB)  PDF (743 KB)  ( 66 )
131 Meta-analysis of health qigong in the prevention and treatment of primary osteoporosis in the elderly
CAO Qingqing1 ZHU Shihua2 HAO Feng2 WU Liwen2 XU Xie2▲
Objective To assess the effect of health qigong for primary osteoporosis in the elderly by meta-analysis. Methods The databases of CNKI, CBM, VIP, Wanfang, PubMed, Cochrane Library, Elsevier and Web of Science were searched by computer, the retrieval period was set as database until December 31, 2017, and the sample size and type were not limited. The random clinical controlled trials (RCTs) of health qigong in the prevention and treatment of osteoporosis in the elderly were included. The quality of studies was evaluated by Cochrane handbook 5.1.0 and datas were analyzed by RevMan 5.3 and Stata 11.0 software. Results A total of 11 literatures were enrolled, including 1029 objects. The results of meta-analysis indicated that the effects of 3 kinds of health qigong were better than those of control group in the main outcome indicators, such as increasing the lumbar vertebral density [yijinjing group: MD = 0.12, 95%CI (0.06, 0.18), P ＜ 0.0001; wuqinxi group: MD = 0.09, 95%CI (0.04, 0.13), P = 0.0003; baduanjin group: MD = 0.21, 95%CI (0.16, 0.26), P ＜ 0.000 01] and femora BMD [yijinjing group: MD = 0.11, 95%CI (0.06, 0.16), P ＜ 0.000 01; wuqinxi group: MD = 0.21, 95%CI (0.17, 0.26), P ＜ 0.000 01; baduanjin group: MD = 0.23, 95%CI (0.17, 0.28), P ＜ 0.000 01]. In addition, Health qigong had a better effect on relieving pain in secondary outcome than that of control group [yijinjing group: MD = -1.22, 95%CI (-2.05, -0.39), P ＜ 0.004; baduanjin group: MD = -1.39, 95%CI (-1.90, -0.88), P ＜ 0.000 01]. Conclusion Health qigong has some effects on prevention and treatment of primary osteoporosis in the elderly, but we need more high-quality literatures to further support this conclusion due to the small number of studies included and poor quality.
2018 Vol. 15 (30): 131-136 [Abstract] ( 283 ) HTML (1 KB)  PDF (1651 KB)  ( 104 )
137 Experience summary of Professor Xu Rongqian in the diagnosis and treatment of pediatric rhinitis by inspection
CAI Jiang1 WU Lifen2 XU Rongqian3
At present, the incidence of rhinitis in children is increasing gradually, and it may be closely related to environmental factors. However, because children are more difficult to describe symptoms, parents are less likely to find it, and often delay the condition. Professor Xu Rongqian believes that rhinitis, especially allergic rhinitis, is a precursor to the onset of cough variant asthma and asthma in children. Therefore, the treatment of rhinitis is of great significance in preventing the onset of asthma. The nose is the body of the lungs, and there are many diseases in children′s lungs. Therefore, it is very important to look for the nose. The inspection of traditional Chinese medicine in children is often limited to looking at the colors, looking at the form, observing the eyes and looking at the tongue, observing the nasal shape and nasal secretions, etc. In view of the diagnosis of respiratory diseases in children, Professor Xu Rongqian pays special attention to the diagnosis of the internal examination of children′s nasal cavity, and puts forward a special "nasal cavity examination for children". In this paper, Professor Xu Rongqian′s progress in the treatment of rhinitis is summarized by examining the nasal mucosa.
2018 Vol. 15 (30): 137-140,156 [Abstract] ( 282 ) HTML (1 KB)  PDF (809 KB)  ( 164 )
141 Discussion on treatment of Hashimot′s thyroidtis from the perspective of qi deficiency
ZHENG Huaigang WANG Fengying▲ SHAO Yingxin WANG Hong ZHOU Yun
Hashimoto′s thyoiditis (HT) is a clinical autoimmune thyroid disease, which leads to the pathology change of thyroid function and tissue structure, with typical clinical manisfestation of swollen thyroid or thyroid nodules. There is no record of HT in Chinese medicine literature. In traditional Chinese medicine, the disease characterized by the enlargement of the anterior cervical thyroid gland is called gall disease. Gall disease is caused by internal injury of mentality, abnormal diet, water and soil inappropriateness, with the basic pathogenesis of qi stagnation, phlegm, blood stasis accumulating anterior neck. Professor SHAO Yingxin thinks that HT is not exactly the same as gall disease. The disease has a long course, complicated symptoms and qi deficiency is throughout its occurrence and development. The pathogenesis is weak of right qi. Due to deficiency of right qi, the pathologic products such as phlegm dampness, blood stasis accumulate anterior the neck. The key pathogenesis is qi deficiency, phlegm and blood stasis. Further more, clinical trials have proved that treating HT from the perspective of qi deficiency that has satisfied effect. This article hopes that through the discussion of pathogenesis and etiological factors, could reach a consensus, so as to handle complexity by simplicity and improve the curative effect.
2018 Vol. 15 (30): 141-144 [Abstract] ( 249 ) HTML (1 KB)  PDF (738 KB)  ( 71 )
145 The prevention and treatment of health management of Chinese medicine for hyperhomocysteinemia based on regulating biased constitution of Chinese medicine
WU Mengwei YUAN Shanghua
Homocysteine is an independent risk factor for many chronic vascular diseases. The higher the homocysteine content is, the greater the risk of vascular disease is. The constitution of traditional Chinese medicine points out that biased constitution is the intrinsic factor of disease. Through the health management law of traditional Chinese medicine, the patients are given physical examination, health education, drugs, and so on, which can correct biased constitution, reduce the concentration of homocysteine, this method has great significance on prevention of vascular disease.
2018 Vol. 15 (30): 145-148 [Abstract] ( 189 ) HTML (1 KB)  PDF (780 KB)  ( 67 )
149 Effect of acupuncture and medicine on infertility due to polycystic ovary syndrome with kidney deficiency
LUO Ran1 YAN Pengxuan2 ZHU Xiaotong1 ZHENG Weijun3 ZHANG Lu4 SHEN Jianwu5 WEN Shide1 DU Baojun1▲
Objective To evaluate the efficacy of acupuncture plus Bushen Tianjing Formula in the treatment of infertility due to polycystic ovary syndrome (PCOS) with kidney deficiency. Methods Sixty patients with infertility due to PCOS with kidney deficiency met with inclusion criteria were selected from October 2015 to May 2017 in Department of Infertility, Xiyuan Hospital of China Academy of Chinese Medical Sciences. The patients with infertility due to PCOS with kidney deficiency were divided into control group and treatment group, with 30 cases in each group. The patients in both groups were preadjusted for complications for 3 months, after menstruation or withdrawal bleeding for 5 days, the patients in the control group were given Clomiphene Citrate orally and intramuscular injection of chorionic gonadotrophin while ovarian follicle was more than 1.8 cm, and the treatment group was treated with Bushen Tianjing Formula and acupuncture. On the ninth day of menstruation, the ovulation was monitored by vaginal ultrasound, and the rate of ovulation was calculated, the levels of follicle-stimulating hormone (FSH), luteotropichormone (LH) and freetestosterone (FT) were detected. Thirty days after ovulation, the pregnancy was monitored and recorded by B ultrasound, and the pregnancy rate was calculated. Results The ovulation rate of the treatment group was 60.0%, which of the control group was 61.2%, with no significant difference between the two groups (P ＞ 0.05). The pregnancy rate of the treatment group was 60.0%, which was higher than that of the control group (37.5%), the difference was statistically significant (P ＜ 0.05). After treatment, the levels of serum LH in non pregnant patients of the two groups were higher than those before treatment [the treatment group: 8.43 (6.53, 13.26) vs. 6.72 (5.33, 8.74), Z = 2.490, P ＜ 0.05; the control group: 11.26 (8.42, 13.34) vs. 6.47 (4.18, 8.10), Z = 3.621, P ＜ 0.05], and there were no statistically significant differences of the serum FSH and FT levels after treatment compared with those before treatment (P ＞ 0.05). Conclusion Combination of acupuncture and medicine can improve the pregnancy rate of infertility due to PCOS with kidney deficiency.
2018 Vol. 15 (30): 149-152 [Abstract] ( 270 ) HTML (1 KB)  PDF (744 KB)  ( 131 )
153 Professor WU Weiping′s experience in treating chronic obstructive pulmonary disease combined with pulmonary interstitial fibrosis with the method of purging phlegm, activating blood, supplementing qi and nourishing yin
LI Qiannan1 FANG Ying1 CUI Hongsheng2 WU Weiping3 WANG Haiying1▲
Chronic obstructive pulmonary disease (COPD) is a common disease in the elderly. Some of these patients eventually develop pulmonary interstitial fibrosis (PIF). Professor WU Weiping has outstanding curative effect in the treatment of COPD disease complicated with PIF. She thinks that the pathogenesis of the disease is insufficient anti-pathogenic energy, invasion of exogenous pathogens, and symptoms are mainly due to qi and yin deficiency. Phlegm and congestion play an important role in the process of pathogenesis. Professor WU takes the method of purging phlegm, activating blood, supplementing qi and nourishing yin, and her composition of prescription is mild and moderate, simple and effective.
2018 Vol. 15 (30): 153-156 [Abstract] ( 208 ) HTML (1 KB)  PDF (755 KB)  ( 49 )
157 A case report of postoperative metastatic follicular thyroid carcinoma to trachea and mediastina
AI Yongbiao1 LI Meng2 WANG Minghua1
The early stage of follicular thyroid carcinoma is prone to hematogenous metastasis, the common sites of metastasis are lung and bone, the trachea and mediastina metastasis is exceptionally rare. This paper reports a 49-year-old male patient with trachea and mediastina metastasis 4 years after the operation of follicular thyroid carcinoma. The clinical features, diagnosis and differential diagnosis, treatment and prognosis are analyzed with reference to the literature.
2018 Vol. 15 (30): 157-159 [Abstract] ( 205 ) HTML (1 KB)  PDF (311 KB)  ( 86 )
160 Quality control main point on medicine-engineering interaction during design and development of customized bone implant and instrument
GUO Xiaolei LIU Bin
Medicine-engineering interaction runs through the design and development (D&D) of customized bone implant and matching instrument. The procedure, planning, input, output, review, verification, validation, transfer, change and file documentation should be deeply mastered by clinician based on diagnosis, operation and postoperative rehabilitation. So that there should be considerable and systematic control on clinicians′ action to enhance D&D quality of customized implant and instrument. Based on research and development system of manufacturing enterprise, engineers including statisticians transfer clinical need to engineering language, define and calibrate the inter-clinician degree of freedom, so as to ensure stability of product performance. At the same time, the medicine-engineering interaction has deep and further influence on characteristic of long-term clinical study, so that abundant capability of clinical research is necessary for the clinician.
2018 Vol. 15 (30): 160-163,177 [Abstract] ( 273 ) HTML (1 KB)  PDF (647 KB)  ( 146 )
164 Study on optimizing potential of development environment of Yunnan TCM industry
ZHANG Xiaoyan1 YANG Yang2 ZHANG Difan3 GAO Jie3 CAI Yunhai1 MAO Xiangming4
Any industry develops in the surrounding outer environment. In recent years, traditional Chinese medicine (TCM) industry of Yunnan Province develops rapidly, and it has already become the largest and most influential area in the biomedical industry of whole province. However, its development environment is restricted by such factors as weak industrial linkage, insufficient talent support, weak innovation ability and limited comprehensive competitiveness of enterprises. With regards to the high attention of Yunnan provincial Party Committee and provincial government, good industrial foundation, rich resources of Chinese medicinal materials, rich national medical culture, and accelerating standardization construction, Yunnan TCM industry has great potential for optimization of development environment. Thus, it is suggested to strengthen top-level design and guidance, increase talent cultivation and guidance, enhance innovation drive, and let TCM enterprises become large and special, so as to effectively optimize the development environment of Yunnan′s TCM industry, and to promote industrial transformation and upgrading.
2018 Vol. 15 (30): 164-167,181 [Abstract] ( 252 ) HTML (1 KB)  PDF (774 KB)  ( 127 )
168 Reflections on and practice of the development of postgraduate party members in scientific research institutes
HAO Xueqin LI Chen HU Lilei JIA Shuying YU Bin SUN Bo
Taking Institute of Medicinal Biotechnology of Chinese Academy of Medical Sciences as an example, this paper makes an investigation on postgraduate party members development work, also summarizes and analyzes the existing problems in the development work of postgraduate party members in scientific research institutes. Based on the actual situation of the institutes and postgraduate party members, this article attempts to find the root causes of the problem and give the countermeasure on how to do a good job in the development of postgraduate party members in scientific research institutes. It is significant to improve party spirit and ideological and political level of postgraduate party members, vigorously promote the education quality and scientific research innovation ability of postgraduate students, accelerate the construction of first-class universities and first-rate disciplines, and achieve connotation development of higher education.
2018 Vol. 15 (30): 168-171 [Abstract] ( 156 ) HTML (1 KB)  PDF (667 KB)  ( 89 )
172 Application of ImageJ in 3D characterization of the osteocyte lacunae
WANG Bingqian1 LYU Zhengtao2▲
The three-dimensional (3D) morphology of osteocytes is assumed to adapt to physiological mechanical loading, the variation in the morphology of osteocyte lacunae is hypothesized to influence the function of osteocytes as the master mechanosensors of bone. Thus, to reveal the 3D characterization of osteocyte lacunae in cortical bone is essential for a better understanding of its structure in relation to its inferior mechanical properties in a cellular level. In this paper, the authors used a series of 100 consecutive images from laboratory-based instrumentation (3D X-ray microscope, MicroXCT-200) and proposed a computationally efficient image analysis method to quantify the 3D characterization of osteocyte lacunae using ImageJ software. The number of osteocyte lacunae (N.Lc), surface area of osteocyte lacunae (Lc.SA), volume of osteocyte lacunae (Lc.V) and other parameters used to describe 3D characterization of osteocyte lacunae within the region of interest could be accomplished after a series of operations including importing the image stack, thresholding and despeckling, inverting, filling holes and logical calculation.
2018 Vol. 15 (30): 172-177 [Abstract] ( 214 ) HTML (1 KB)  PDF (2017 KB)  ( 94 )
178 Pharmaceutical care of clinical pharmacists participating in critically ill patients
LIU Jianhong PENG Xueqin WANG Fei
To explore the breakthrough point of pharmacy practice of clinical pharmacists participating in the rescue of critically ill patients, by participating in the diagnosis and treatment process of critically ill patients, combining the conditions of kidney function, paying attention to drug interactions, timely adjusting the drug treatment interventions, the clinical pharmacists in drug therapy play their own professional advantages, assist doctors to optimize the treatment plan, play an important role in the clinical treatment team, realize the hospitalized patients through individualized drug treatment.
2018 Vol. 15 (30): 178-181 [Abstract] ( 211 ) HTML (1 KB)  PDF (813 KB)  ( 162 )
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