血清空腹C-肽水平与2型糖尿病患者血管病变的关系

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Abstract Objective To investigate the relationship between serum fasting C-peptide (FCP) and vascular disease in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective analysis of 105 patients with T2DM admitted to School Hospital of Nanjing University of Aeronautics & Astronautics from March 2016 to February 2018 was conducted. According to the results of color doppler examination of the lower limbs, the patients were divided into non vascular lesion group (52 cases) and vascular lesion group (53 cases). The general data of the two groups, biochemical indices including fasting blood glucose (FBG), postprandial 2 h blood sugar (PBG), glycated hemoglobin (HbAlc), FCP, postprandial 2 h C-peptide (CP), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared between the two groups. Multiple Logistic regression analysis was used to analyze the influencing factors of T2DM patients. Results The age, course and hypertension case number in vascular lesion group was higher than those in non vascular lesion group, and the differences between the two groups were statistically significant (P ＜ 0.05). FBG, PBG, HbAlc and LDL-C in vascular lesion group was significantly higher than those in non vascular lesion group, and the differences were statistically significant (P ＜ 0.05). While FCP, CP and HDL-C were significantly lower than those in non vascular lesion group, and the differences between the two groups were statistically significant (P ＜ 0.05). The results of Logistic regression analysis showed that age (≥50 years), diabetes course (≥5 years), PBG (≥17 mmol/L), HbA1c (≥9%), and LDL-C (≥3 mmol/L) was independent risk factors of vascular lesions in T2DM, and FCP (＞0.9 μg/L) and CP (＞ 2.1 μg/L) was protective factors of vascular lesions (P < 0.05). Conclusion FCP may protect the blood vessels, and the decrease of FCP may be one of the reasons for the occurrence and development of vascular disease in T2DM patients.

Key words： C- peptide Type 2 diabetes mellitus Vascular disease Correlation

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	Articles by authors
	QU Xiaoyan1
	2 FANG Aijuan3 SUN Lijun2 SHEN Shanmei4▲

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QU Xiaoyan1,2 FANG Aijuan3 SUN Lijun2 SHEN Shanmei4▲. Relationship between serum fasting C-peptide and vascular disease in patients with type 2 diabetes mellitus[J]. 中国医药导报, 2018, 15(30): 58-61.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I30/58

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