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| Analysis of the testing results of sex hormone levels in 130 female infertility patients |
| WANG Chong１ SUN Rui２ WU Zhouya２ |
1.Department of Nuclear Medicine, Nanjiang Hospital, Nanjing Medical University, Nanjing First Hospital, Jiangsu Province, Nanjing 210019, China;
2.Department of Gynaecology, Nanjing Jinling Hospital on Integeration of Chinese and Western Medicine, Jiangsu Province, Nanjing 210029, China |
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Abstract Objective To analyze the changes of sex hormones in female infertility patients, provide evidence for etiological diagnosis of female infertility. Methods From March 2015 to May 2017, 130 cases of female infertility in Nanjing Jinling Hospital on Integeration of Chinese and Western Medicine ("our hospital" for short) were selected as study group. According to the menstrual condition, it was divided into normal menstrual group (50 cases) and menstrual disorder group (80 cases). Fifty healthy women carried physical examination in our hospital at the same periods were selected as control group. Levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), pituitary prolactin (PRL), testosterone and progesterone were measured by chemiluminescent Immunoassay. Results In the menstrual disorder group, serum FSH, LH, PRL and testosterone levels were higher than control group and menstrual normal group (P < 0.05 or P < 0.01). Level of serum E2 was significantly lower than that of control group and normal menstrual group (P < 0.01). There was no significant difference between the six hormone levels and the control group in the normal menstrual group (P > 0.05). The levels of sex hormones in patients with different causes of infertility were compared with those in control group and normal menstrual group: LH, testosterone and PRL in 49 patients with polycystic ovary syndrome significantly increased (P < 0.05 or P < 0.01), and LH/FSH≥2. In 21 patients with hyperlactation, PRL significantly increased (P < 0.01), while E2 significantly decreased (P < 0.05). In 5 patients with premature ovarian insufficiency, FSH and LH increased significantly (P < 0.01), while E2 significantly decreased (P < 0.01). In 5 hypothyroidism patients, E2 and testosterone decreased significantly (P < 0.05), while FSH, LH and PRL increased significantly (P < 0.05 or P < 0.01). Conclusion The abnormal level of sex hormones in menstrual disorder group suggested that endocrine factors are the cause of infertility. The abnormal sex hormones in infertility of different etiologies provides an important basis for the analysis of etiology of infertility.
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[1] 徐汉.女性不孕症患者性激素水平变化[J].实用临床医药杂志，2013，17（16）：110-112.
[2] 刘卫.性激素检验在不孕症临床诊断中的应用价值研究[J].实用妇科内分泌杂志，2016，3（15）：36-37.
[3] 杨晶，尹凤媛，田威，等.不孕症患者性激素检验结果探讨[J].中国性科学，2016，25（12）：94-95.
[4] 汤美芬.性激素测定对不孕妇女诊断的临床价值[J].医学理论与实践，2014，27（5）：669-670.
[5] 张春燕，潘柏申.激素检测在女性不孕症诊治中的临床应用[J].检验医学，2015，30（7）：761-765.
[6] 谭子强，陈莉莉.多囊卵巢综合征的内分泌变化观察[J].医学信息，2011，24（2）：115.
[7] 吴春凤，刘芸.多囊卵巢综合征卵巢源性高雄激素血症发生机制研究进展[J]临床医学工程，2011，18（1）：147-149.
[8] Adegbola O，Akindde MO. The pattern and challenges of infertility management in Lagos，Nigeria [J]. Afr Health Sci，2013，13（4）：1126-1129.
[9] Cardone A. Imidacloprid induces morphological and molecular damages on testis of lizard（Podarcis sicula） [J]. Ecotoxicology，2015，24（1）：94-105.
[10] Mumm H，Jensen DM，Serensen JA，et al. Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with Differences in obstetric outcomes [J]. Acta Obstet Gynecol Scand，2015，94（2）：204-211.
[11] 王佳宁，阮祥燕.高泌乳素血症的病因及诊疗进展[J].医学综述，2012，18（21）：3629-3632.
[12] 秦辛玲，石峰.高催乳素血症实验室诊断研究进展[J].医学理论与实践，2011，24（14）：1652-1654.
[13] Tsakos E，Tolikas A，Daniilidis A，et al. Predictive value of antimtillerian hormone，follicle-stimulating hormone and antral follicle count on the outcome of ovarian stimulation in women following GnRH-antagonist protocol for IVF/ET [J]. Arch Gynecol Obstet，2014，290（6）：1249-1253.
[14] 中华医学会妇产科分会绝经学组.早发性卵巢功能不全的激素补充治疗专家共识[J].中华妇产科杂志，2016，51（12）：881-886.
[15] 赵倩，叶宸，李文.卵巢早衰的研究现状与进展[J].生殖与避孕，2014，34（1）：59-64.
[16] Affia Tasneem. The incidence of hyperprolactinaemia and associated hypothyroidism：Local experience from Lahore Centre for Nuclear Medicine，Mayo Hospital Lahore，Government College for Boys Gulberg Lahore P [J]. PJNM， 2011，1：49-55.
[17] Dittrich R，Beckmanna MW，Oppelta PG，et al. Thyroid hormone receptors and reproduction [J]. J Reproductive Immunology，2011，90（1）：58-66.
[18] 尹树慧，赵文龙，曹海霞.女性甲状腺功能异常者血清性激素水平的变化分析[J].中国现代医药杂志，2010， 19（3）：61-63.
[19] 张云峰，秦贵军，马笑堃.女性甲状腺功能异常患者性激素水平变化分析[J].实用医药杂志，2013，30（5）：385-387.
[20] 杨菁，倪媛，孙伟.甲状腺功能及其相关疾病与女性生殖关系的研究进展[J].中国性科学，2016，25（4）：141-144. |
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