|
|
|
| Study of PI3K/AKT/mTOR pathway and immunoglobulin in the pathogenesis of granulomatous lobular mastitis |
| ZHAO Yang1 WANG Xijing2 ZHANG Shuqun2 KANG Huafeng2 GUAN Haitao2 JIN Yaofeng2 SHAN Changyou2 DIAO Yan1 |
1.Department of Oncology, the Second Affiliated Hospital of Xi′an Jiaotong University, Shaanxi Province, Xi′an 710004, China;
2.Department of Pathology, the Second Affiliated Hospital of Xi′an Jiaotong University, Shaanxi Province, Xi′an 710004, China |
|
|
|
Abstract Objective To analyze the pathogenesis of granulomatous lobular mastitis involved in PI3K/AKT/mTOR pathway and immunoglobulin, and provide reference for related treatment. Methods Sixty patients with granulomatous lobular mastitis diagnosed and treated from June 2015 to June 2016 in the Second Affiliated Hospital of Xi′an Jiaotong University (“our hospital” for short) were selected as the observation group. Thirty healthy subjects in our hospital were selected as the control group. The patient′s PI3K/AKT/mTOR pathway protein and immunoglobulin levels were analyzed. Results Compared with the control group, the levels of PI3K, AKT, mTOR and interleukin-2 (IL-2), IL-6, IL-10 were significantly increased in the observation group, and the levels of immunoglobulin IgA, IgM and IgG were significantly decreased, the differences were statistically significant (P < 0.05). Conclusion PI3K/AKT/mTOR pathway proteins and immunoglobulin have a close relationship with the pathogenesis of granulomatous lobular mastitis.
|
|
|
|
|
|
[1] Domenech-Ximenos B，Perez E. Idiopathic lobular granulomatous mastitis：Radiological management in two cases [J]. Radiologia，2018，60（4）：359-360.
[2] Wang YS，Li QW，Zhou L，et al. Granulomatous lobular mastitis associated with mycobacterium abscessus in south china：a case report and review of the literature [J]. Case Rep Infect Dis，2017，23（6）：445-449.
[3] Shin YD，Park SS，Song YJ，et al. Is surgical excision necessary for the treatment of granulomatous lobular mastitis? [J]. BMC Womens Health，2017，17（1）：49-55.
[4] Farouk O，Abdelkhalek M，Abdallah A，et al. Rifampicin for idiopathic granulomatous lobular mastitis：a promising alternative for treatment [J]. World J Surg，2017，41（5）：1313-1321.
[5] 张杰，史业辉，赵伟鹏，等.依维莫司治疗PI3K/AKT/mTOR通路突变难治性晚期乳腺癌1例[J].中国肿瘤临床，2017，44（13）：649-650.
[6] Zhang HW，Hu JJ，Fu RQ，et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells [J]. Sci Rep，2018，8（1）：11 255-11 259.
[7] Guerrero-zotano A，Mayer IA，Arteaga CL. PI3K/AKT/mTOR：role in breast cancer progression，drug resistance，and treatment [J]. Cancer Metastasis Rev，2016，35（4）：515-524.
[8] Guo Y，Chang H，Li J，et al. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway [J]. Apoptosis，2015，20（8）：1109-1121.
[9] 陆清，夏亚琳，李琼，等.不同时期浆细胞性乳腺炎患者的免疫功能[J].广西医学，2017，39（12）：1788-1790.
[10] 许锐，郭倩倩，杨乐平，等.非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及其临床意义[J].南方医科大学学报，2016，36（8）：1157-1159.
[11] 李爱辉，李洪，王力斌，等.非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及意义[J].实用临床医学，2018，19（2）：38-39.
[12] 夏亚茹，陈红风，叶媚娜，等.非哺乳期乳腺炎患者外周血T淋巴细胞、免疫球蛋白及补体水平的变化[J].中华乳腺病杂志：电子版，2012，6（5）：504-514.
[13] 王小龙，刘兴，苏依图，等.浆细胞性乳腺炎组织中IL-1β及TNF-α的表达及临床意义[J].现代生物医学进展，2017，17（6）：1110-1112.
[14] 赵慧朵，程旭锋，郭迎树.活血解毒丸对急性乳腺炎患者炎症细胞因子的影响[J].中国实验方剂学杂志，2016， 22（6）：163-166.
[15] 徐金华，李志峰，王甫，等.除癖消溢散对浆细胞性乳腺炎患者TNF-α、IL-6的影响[J].辽宁中医杂志，2016， 43（2）：318-319.
[16] 侯吉学，孙厚启，黄桂林.白细胞介素-2及-4在浆细胞性乳腺炎发病中的作用[J].中华实用诊断与治疗杂志，2015，29（11）：1104-1106.
[17] 马腾飞，曲艺.祛腐生肌方治疗肿块型浆细胞性乳腺炎效果及对白细胞介素的影响[J].中国卫生标准管理，2018， 9（4）：93-95.
[18] 王军，石冬梅，王哲.牛源性大肠杆菌乳腺炎模型大鼠与血清白细胞介素18的相关性[J].江苏农业科学，2016， 44（12）：292-294. |
|
|
|
