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| Effect of acupuncture and medicine on infertility due to polycystic ovary syndrome with kidney deficiency |
| LUO Ran1 YAN Pengxuan2 ZHU Xiaotong1 ZHENG Weijun3 ZHANG Lu4 SHEN Jianwu5 WEN Shide1 DU Baojun1▲ |
1.Department of Infertility, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China;
2.Academy of Chinese Medical Sciences, Beijing 100700, China;
3.College of Basic Medicine, Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310053, China;
4.Department of Acupuncture, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China;
5.Department of Urology Surgery, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China |
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Abstract Objective To evaluate the efficacy of acupuncture plus Bushen Tianjing Formula in the treatment of infertility due to polycystic ovary syndrome (PCOS) with kidney deficiency. Methods Sixty patients with infertility due to PCOS with kidney deficiency met with inclusion criteria were selected from October 2015 to May 2017 in Department of Infertility, Xiyuan Hospital of China Academy of Chinese Medical Sciences. The patients with infertility due to PCOS with kidney deficiency were divided into control group and treatment group, with 30 cases in each group. The patients in both groups were preadjusted for complications for 3 months, after menstruation or withdrawal bleeding for 5 days, the patients in the control group were given Clomiphene Citrate orally and intramuscular injection of chorionic gonadotrophin while ovarian follicle was more than 1.8 cm, and the treatment group was treated with Bushen Tianjing Formula and acupuncture. On the ninth day of menstruation, the ovulation was monitored by vaginal ultrasound, and the rate of ovulation was calculated, the levels of follicle-stimulating hormone (FSH), luteotropichormone (LH) and freetestosterone (FT) were detected. Thirty days after ovulation, the pregnancy was monitored and recorded by B ultrasound, and the pregnancy rate was calculated. Results The ovulation rate of the treatment group was 60.0%, which of the control group was 61.2%, with no significant difference between the two groups (P ＞ 0.05). The pregnancy rate of the treatment group was 60.0%, which was higher than that of the control group (37.5%), the difference was statistically significant (P ＜ 0.05). After treatment, the levels of serum LH in non pregnant patients of the two groups were higher than those before treatment [the treatment group: 8.43 (6.53, 13.26) vs. 6.72 (5.33, 8.74), Z = 2.490, P ＜ 0.05; the control group: 11.26 (8.42, 13.34) vs. 6.47 (4.18, 8.10), Z = 3.621, P ＜ 0.05], and there were no statistically significant differences of the serum FSH and FT levels after treatment compared with those before treatment (P ＞ 0.05). Conclusion Combination of acupuncture and medicine can improve the pregnancy rate of infertility due to PCOS with kidney deficiency.
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