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2018 Vol. 15, No. 19
Published: 2018-07-05
 
 
4 Establishment of SNPs markers of the laboratory red crucian carp C1HD strain
ZHU Feng1 WU Duansheng2
Objective To establish SNP markers of the laboratory red crucian carp C1HD strain. Methods SNPs primers were designed referring to SNPs gene library of the Zebrafish, the SNPs were genotyped by single-tube bi-directional allele-specific amplification (SB-ASA) and were verified by sequencing for the laboratory red crucian carp C1HD strain. Results SNPs-PCR of blood DNA samples of laboratory red crucian carp could be genotyping of three sites Zk261O7 gene zSNP30124211 (G/A type), zC227H20 gene zSNP24678043 (A/T type) and zC39F23 gene zSNP26474328(G/C type). These three SNP markers were able to accurately identify the laboratory red crucian carp C1HD strain and the laboratory red crucian carp closed colony. Conclusion Three SNPs markers of Zk261O7 gene loci zSNP30124211 (G/A type), zC227H20 gene loci zSNP24678043 (A/T type) and zC39F23 gene loci zSNP26474328(G/C type) could be used as SNPs markers in the laboratory red crucian carp.
2018 Vol. 15 (19): 4-7 [Abstract] ( 193 ) HTML (1 KB)  PDF (874 KB)  ( 93 )
8 Clinical effect of ultrasound combined with Felbinac Gel in the treatment of myositis ossificans traumatica
SONG Yixin1,2* LV Xiangwei3* LIU Xifang1 WU Longchang4▲ WANG Hanghui1,2▲
Objective To evaluate the clinical efficacy of combining ultrasound with Felbinac Gel in myositis ossificans traumatica, and to explore the effective rehabilitation approaches of myositis ossificans. Methods Clinical data of 32 patients with myositis ossification (experimental group) and 16 patients with non-myositis ossification during the same period (control group) in Honghui Hospital, Xi′an Jiaotong University from September 2015 to September 2017 were retrospectively analyzed. The X-ray and clinical symptoms, alkaline phosphatase, pain scores, joint activity and patient satisfaction were observed respectively by way of combining ultrasound with Felbinac Gel penetration method. Results After the treatment of ultrasound combined with Felbinac Gel, the clinical symptoms and X-ray of patients were improved, and alkaline phosphatase was reduced significantly 1 month after treatment, as well as the pain scores（P < 0.05）. Meanwhile, the joint activity and joint function scores were superior to those of pre-therapy, and patients′ satisfaction was improved（P < 0.05）. Conclusion The method of ultrasound combined with Felbinac Gel can effectively promote the recovery of joint function and relieve pain of patients with myositis ossificans traumatica. The rehabilitation approach is safe, effective and without side effect. It is worthy of wide application.
2018 Vol. 15 (19): 8-11 [Abstract] ( 252 ) HTML (1 KB)  PDF (609 KB)  ( 70 )
12 Effect and mechanism of overexpression of ATF4 on the apoptosis of HepG2 cells
XIAO Tingyan1 DUAN Wuxia1 XU Ziwei1 ZHOU Shouhong2 ZENG Bin1
Objective To observe the effect of overexpression of activating transcription factor 4 (ATF4) on the apoptosis of HepG2 cells and explore the mechanism. Methods ATF4 expression plasmid was built. Hepatocellular carcinoma line HepG2 cells were transfected with ATF4 expression plasmid through liposome. The plasmids were divided into blank control group, empty plasmid group and ATF4 plasmid group. The apoptosis rate was detected by flow cytometry. The content of lactate in cell culture medium was tested. The expression of Warburg effect protein pyruvate kinase subtype M2 (PKM2) was measured by Western blot. Results Compared with the empty plasmid group, the apoptosis rate of HepG2 cells increased significantly, the content of lactate in cell culture medium decreased significantly and the expression of PKM2 decreased significantly (all P ＜ 0.05). Conclusion Overexpression of ATF4 promotes the apoptosis of hepatocellular carcinoma line HepG2 cells, the mechanism may be related to inhibition of Warburg effect.
2018 Vol. 15 (19): 12-15,29 [Abstract] ( 303 ) HTML (1 KB)  PDF (1217 KB)  ( 112 )
16 Study on the mechanism of the influence of Brusatol for the Nrf2-Notch1 axis of non-small cell lung cancer
WANG Min LIU Qili XU Shuai LI Pinyu LI Juntao▲
Objective To explore the effects of Brusatol in the proliferation of A549 and H460 cells of non-small cell lung cancer. Methods The median inhibitory concentration (IC50) of Brusatol for A549 and H460 cells was assessed by methyl thiazolyl tetrazolium (MTT) assay. Through hoechst33258 staining, the morphological changes of cell apoptosis were observed under the inverted fluorescence microscope. The cell viability was detected by CCK-8. The cell apoptosis was tested by Annexin-V-FITC/PI staining. The expression of Nrf2 and Notch1 protein of A549 and H460 cells was measured by Western blot. Results The IC50 of A549 and H460 cells dealt with Brusatol was (0.70±0.03), (0.47±0.05) μmol/L respectively. The results of flow cytometry showed that the apoptosis rates of A549 and H460 cells dealt with Brusatol were increased obviously, which had highly statistically significant differences compared with those of control group (all P ＜ 0.01). The results of Western blot showed that Brusatol could decrease the expression of Nrf2 and Notch1 protein. Conclusion Brusatol can inhibit the growth of A594 and H460 cells, the mechanism may be related to the inhibition of Nrf2-Notch1 axis.
2018 Vol. 15 (19): 16-19 [Abstract] ( 270 ) HTML (1 KB)  PDF (704 KB)  ( 64 )
20 Study on antioxidant activity of different polar extracts of coix seed
YU Qiaorong1,2 HUANG Suoyi2,3
Objective To study the antioxidant activity of different polar extracts of coicis, and screen for optimum antioxidant active polarity segment. Methods Coix seed was extracted using reflux method by 95% ethanol. Then the concentrated ethanol extract was partitioned between petroleum ether, chloroform, n-butanol and water, respectively, which gave the oil ether part, chloroform part, n-butanol part and water part. The antioxidant activity of different polar regions was studied by determining the scavenging ability of ABTS+ free radicals and DPPH free radicals and the ability of restoring Fe3+, and compared with BHT. Results Different polar extracts had different degrees of clearance ability of DPPH free radicals and ABTS+ free radicals, and had certain reduction capabilities. The order of scavenging capacity of four extracts to ABTS+ free radicals was: water part > n-butanol part > chloroform part > petroleum ether part. The order of scavenging capacity of four extraction sites to DPPH radical was: n-butanol part > water part > chloroform part > petroleum ether part. The order of the capacity of the four extraction sites to the reduction ability of Fe3+ was: water part > n-butanol part > petroleum ether part > chloroform part. The scavenging free radical ability and total reduction ability were lower than the positive control BHT. Conclusion The different polar extracts of Coix seed have free radical scavenging ability and antioxidant effects. The water part has the best ability to scavenge ABTS+ free radical, the n-butanol fraction has the best ability to scavenge DPPH free radical, and the water site has the best ability to restore Fe3+.
2018 Vol. 15 (19): 20-23 [Abstract] ( 235 ) HTML (1 KB)  PDF (680 KB)  ( 74 )
24 Application of Raman spectroscopy on the rapid screening of paclitaxel liposome preparation
ZHAO Yu YIN Lihui HU Changqin
Objective To realize the rapid screening on site, Raman spectroscopy was applied to establish an identification model of paclitaxel liposome preparation. Methods Raman spectra of the whole paclitaxel liposome product with package were first collected, and principal component analysis（PCA） algorithm was then used to extract paclitaxelliposome signals from the identified signals. Classic least squares(CLS) algorithm was used to established the identification model. The threshold was determined by the positive validation and negative challenge tests, and identification results would be get by compare the the correlation coefficients with the threshold. External standard method was utilized to realize the model transfer on three different kinds of Raman spectrometer. Results The correlation coefficient between the extracted spectrum and directly-measured spectrum was 0.9744. The paclitaxelliposome identification model was built with a threshold of 0.85, and results of both positive validation and negative challenge tests were all passed. Model transfer results also indicated that with the use of transfer spectra and peak search, the method established could be used on portable Raman, microscope imaging Raman and FT-Raman spectroscopes. Conclusion The Raman method established in this study could realize expensive anticarcinogen both on-site non-invasively and laboratory use, which can provide a scientific and efficient means for regulation and crackdown on counterfeit expensive medicine. 
2018 Vol. 15 (19): 24-29 [Abstract] ( 270 ) HTML (1 KB)  PDF (1189 KB)  ( 83 )
30 Imaging principle and application of image-guided technology in the precise radiotherapy
LI Hongqi1 WANG Yingjie1 LIU Chengli2 XIA Tingyi1
Stereotactic ablative radiation therapy is one of representative precise radiotherapy technology and has characteristics of precise simulation, accurate delivery, good performance and minimal adverse effect, which has acquired similar results with surgery in the treatment of brain metastasis and early stage non-small cell lung cancer. During the precise delivery management, the image-guided technologies play an important role, which include single imaging system and the combination of imaging system. The former are guided by ultrasound, electron beam, cone beam computer tomography (CT), fan beam CT, nuclear magnetic image and electromagnetic tracking technology; the latter are guided by ExacTrac X-ray six dimensional directional guidance system, etc. This article will review current application of image-guided technology and analyze imaging principle and how to improve the accuracy and shrink surrounding normal tissues irradiated volume, explore the future development.
2018 Vol. 15 (19): 30-33 [Abstract] ( 249 ) HTML (1 KB)  PDF (490 KB)  ( 83 )
34 Research progress on the mechanism of shikonin against cervical cancer
HUANG Guotao HONG Li HU Ming ZHOU Min CHEN Qian
Cervical cancer is a common malignant tumor in women. Studies have shown that shikonin could induce ROS in human cervical cancer cells, regulate the activity of MAPKs, upregulate the expression of p53, change the protein level of B-cell lymphoma-2 family, trigger a cascade of caspase cascades, perturbate the mitochondrial membrane permeability and release the cyt ochrome-C from the mitochondria to the cytoplasm, which induces apoptosis of cells. In addition, it could also inhibit cell proliferation, promote apoptosis and reduce its biological behavior by decreasing the expression level and phosphorylation level of FAK in human cervical cancer cells. In this paper, a summary review is given about the detailed mechanism.
2018 Vol. 15 (19): 34-36,41 [Abstract] ( 261 ) HTML (1 KB)  PDF (502 KB)  ( 55 )
37 Research progress of ubiquitination epithelial sodium channel by the regulation of Nedd4-2
ZHANG Hao1 TIAN Miao2 SUN Xiaohu3 OUYANG Lu4
Neural precursor cell expressed developmentally down-regulated protein 4-2 (Nedd4-2) is a ubiquitin protein ligase of the E3 HECT family, which is known to bind and regulate a number of membrane proteins, and mediate diverse extracellular signals, such as cell differentiation and apoptosis. Epithelial sodium channel (ENaC) is an integral membrane protein, plays a crucial role in Na+ transport and fluid reabsorption in the kidney and lung, whose structural abnormalities or disfunctions may cause some diseases. At present, Nedd4-2 protein participate in the regulation of ENaC and regulate the function of the body. This paper reviewed the structure and function of the Nedd4-2 and ENaC, and summarized the regulation of ENaC trafficking by Nedd4-2.
2018 Vol. 15 (19): 37-41 [Abstract] ( 264 ) HTML (1 KB)  PDF (523 KB)  ( 65 )
42 Research progress of LncRNA in cervical cancer
ZHOU Qing ZHANG Ruijin LIU Shuaimei SHI Hui LIN Ning WU Yulin XU Haoqin
Long non-coding RNAs are a group of RNA molecules considered as transcripts longer than 200 nucleotides without protein coding function. Many studies have indicated that LncRNAs play an important role in the regulation of transcription, epigenetics and transcriptional level and lncRNAs regulate the pathological and physiological process of the body. Some LncRNAs are abnormal expression in cervical cancer tissues and play an important role in the occurrence of cervical cancer, which can be used as a molecular marker for the early diagnosis and prognosis of cervical cancer.
2018 Vol. 15 (19): 42-45 [Abstract] ( 293 ) HTML (1 KB)  PDF (492 KB)  ( 74 )
46 Analysis of nationwide clinical teaching condition and possible strategy in infectious diseases
ZHANG Yulin HUA Wei JIN Ronghua▲
There are some problems in clinical teaching of infectious diseases, such as failure to combine teaching with clinic, unbalanced teaching resources and teaching level lag, which results from the isolated patients with infectious diseases in special hospitals in China, the unbalanced internal teaching resources in special hospitals of infectious disease, the epidemiological characteristics of infectious diseases, and the emergence of new infectious diseases. This article has conducted an analysis of these issues and learned from the latest foreign teaching methods, such as problem-based learning, case-based learning, flipped classroom, internet learning, massive open online courses, microlecture, etc., and put forward some suggestions to raise awareness of infectious diseases teaching, improve teaching conditions, strengthen teaching management, improve the teaching level of infectious diseases, promote teaching method and so on, it hopes it can help to promote the clinical teaching ability of infectious diseases.
2018 Vol. 15 (19): 46-48 [Abstract] ( 707 ) HTML (1 KB)  PDF (613 KB)  ( 70 )
49 The application of experiential teaching in obstetric delivery
WU Hong1 YANG Xiaoying2 YU Mei2▲
Objective To investigate the application effect of experiential teaching in obstetric delivery. Methods Sixty-four obstetric interns in Department of Obstetrics, Chaoyang Maternal and Child Health Hospital of Beijing City from July to December 2016 were selected as the intervention group by convenient sampling method, and 64 obstetric interns from July to December 2015 were selected as the control group. The intervention group accepted experiential teaching, and the control group adopted regular teaching, then critical thinking ability, experiential teaching effect evaluation and assessment results were compared between the two groups. Results The critical thinking ability to find the truth, open mind, analyzing ability, systematical ability, self-confidence of critical thinking, thirst for knowledge, the cognitive maturity and the total score of the intervention group were better than those of the control group, the teaching evaluation of experiential teaching of the intervention group was higher than the control group, and the grade of situational simulation assessment test and theoretical test of the intervention group was higher than that of the control group (P ＜ 0.05). Conclusion Application of experiential teaching in obstetric delivery can improve the critical thinking ability, teaching effect evaluation and assessment results.
2018 Vol. 15 (19): 49-52 [Abstract] ( 225 ) HTML (1 KB)  PDF (681 KB)  ( 48 )
53 Status and measure analysis of traditional Chinese medicine culture integrating into humanity and social science education in traditional Chinese medicine colleges
LI Ang LI Baoqin LI Xiao LIU Bo
Traditional Chinese medicine culture takes on the rich and profound connotation of traditional Chinese culture, which is the important source of enhancing humanistic spirit quality for students in traditional Chinese medicine universities. Traditional Chinese medicine culture is integrated into humanity and social science education, which has great meaning in improving students′ humanistic quality, inheriting traditional Chinese medicine culture, cultivating high-level traditional Chinese medicine talents with creative thinking. The survey contents of students in traditional Chinese medicine universities include students′ cognition of traditional Chinese medicine culture, their satisfaction and requirements of traditional Chinese medicine culture integrated into humanity and social science education. Based on the survey, the current status is analyzed and some measures are proposed, such as setting up elective courses related to traditional Chinese medicine, excavating cultural connotation, adopting modern teaching methods, improving teachers′ knowledge structure etc., to enhance teaching effect.
2018 Vol. 15 (19): 53-56 [Abstract] ( 225 ) HTML (1 KB)  PDF (621 KB)  ( 91 )
57 Discussion on the construction of bedside teaching mode oriented to the position competence
HAN Xu WANG Yue ZHANG Laigen YANG Fan HAO Jiting BAO Anbing
Under the background of “medical education synergy” accelerating reform in the health field, the short board of student training in affiliated hospitals is highlighted. The bedside teaching mode needs a new connotation to support the development. This paper aims to analyze some prominent problems existing in bedside teaching, and expound specific requirements and objectives from five aspects: teaching, learning, management, supervision and evaluation. On the basis above, this paper puts forward the idea of construction bedside teaching methods including teaching, learning, supervision, management and evaluation, so that the bedside teaching will work effectively to improve bedside teaching quality and provide a new path for constructing bedside teaching management mode.
2018 Vol. 15 (19): 57-59,63 [Abstract] ( 224 ) HTML (1 KB)  PDF (690 KB)  ( 231 )
60 Establishment of innovative talents training system for doctor of medicine in eight-year program via “Internet plus”
YI Long RAN Li ZHU Xiaohui ZHOU Xi MI Mantian
 The innovative ability of the eight-year medical doctor cannot be effectively improved in the existing training system through the current training mode, training content and assessment goal. The characteristics of the big data and information technology as well as the embedded and open features of “Internet plus” provide important tool and ways for cultivation of the innovative talents of the eight-year medical doctor. This article provides an introduction to how Army Medical University cultivates and improves the talents quality of the eight-year medical doctorate by use of the advantages of “Internet plus”.
2018 Vol. 15 (19): 60-63 [Abstract] ( 230 ) HTML (1 KB)  PDF (623 KB)  ( 83 )
64 Practice and reflection on diagnostics of traditional Chinese medicine based on theoretical principles of social constructivism
HONG Fang1 TENG Long2 HE Jiancheng1
Diagnostics of traditional Chinese medicine covers diagnostic methods of TCM and syndrome differentiation of TCM. The theory of diagnostic methods of TCM is abstractly and complicated with poor logic. Syndrome differentiation of TCM summarize and analyze sufficient clinical data with the theory of TCM. We establish the scientific educational concept of students centeredness with teachers serving as guides during teaching stages. Based on the analysis of the theoretical principles of social constructivism and the characteristics of diagnostics of TCM, this paper examines the application of different teaching modes in different teaching stages; the construction of the knowledge system should be paid attention at the stage of basic theoretical studying. Training of dialectical thinking ability should be trained at the formation stage of analysis; exercise four skills of TCM, clinical diagnosis and dialectical thinking ability should be trained at the training stage of clinical application skills.
2018 Vol. 15 (19): 64-66,70 [Abstract] ( 226 ) HTML (1 KB)  PDF (634 KB)  ( 165 )
67 Influence of one-to-one teaching mode on job burnout and critical thinking of nursing students from department of ophthalmology
WANG Haiyan YANG Jianying WANG Xiaoxiao
Objective To investigate influence of one-to-one teaching mode on job burnout and critical thinking of nursing students from department of ophthalmology. Methods From July 2013 to March 2017, 150 nursing students from Department of Phthalmology, China Academy of Chinese Medical Sciences were selected, 70 students from July 2013 to March 2017 were selected as control group, they were given conventional teaching method one-to-many mode, 80 students from July 2015 to March 2017 were selected as observation group, they were given one-to-one teaching mode. After their internship in ophthalmology, all students were evaluated in terms of job burnout and critical thinking. Results The job burnout score of observation group was significantly lower than control group, the difference was statistically significant (P ＜ 0.05); the degree of job burnout of observation group was significantly lower than control group, the difference was statistically significant (P ＜ 0.01). The total score and 7 dimensions scores involving critical thinking of observation group were significantly higher than control group, the differences were statistically significant (P ＜ 0.01). Conclusion With the application of one-to-one teaching mode, the job burnout situation of nursing students decrease significantly, and the critical thinking ability improves significantly, it is worthy of promotion.
2018 Vol. 15 (19): 67-70 [Abstract] ( 247 ) HTML (1 KB)  PDF (679 KB)  ( 174 )
71 Evaluation of left ventricular longitudinal myocardial function in patients with polycystic ovary syndrome associated with insulin resistance by cardiac motion quantification
DU Qigen MI Xiangqin XU Hongwei SHANG Weimin ZHOU Liping CHEN Wei▲
Objective To investigate the clinical value of myocardial motion quantification (CMQ) in evaluation of left ventricular longitudinal motion in patients with polycystic ovary combined with insulin resistance (PCOS-IR). Methods From the February 2016 to February 2017, 55 patients with PCOS-IR in Department of Gynecology, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were selected, 55 age matched healthy women were selected as control group. The general data were recorded: waist-to-hipratio (WHR), body mass index (BMI), systolic pressure (SBP), diastolic pressure (DBP), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), fasting plasma insulin (FINS), homeostasis model assessment for IR index (HOMA-IR), and all subjects were given routine echocardiography, the left ventricular end-diastolic dimension (LVDd) and left ventricular end-systolic diameter (LVDs), end-diastolic interventricular septum thickness (IVSTd), end-diastolic left ventricular posterior wall thickness (LVPWTd), and left ventricular ejection fractional (LVEF), early diastolic blood flow peak velocity (E), late diastolic blood flow peak velocity (A), mitral annular early diastolic motion peak velocity (Em) were measured, E/A and E/Em were calculated, E peak deceleration time (DT), isovolumic relaxation time (IVRT) and isovolumic contraction time (IVCT) were measured. CMQ technique was used to trace tracing of myocardial trajectory, and systolic longitudinal peak strain (LS) and systolic global longitudinal peak strain (GLS) of 18 left ventricular segments were obtained. Pearson correlation was used to analyze the correlation between the parameters. Results The WHR, BMI, FINS, HOMA-IR and LDL-C in the PCOS-IR group were higher than those in the control group, the differences were statistically significant (P < 0.05); there was no significant difference in age, SBP, DBP, FPG, HDL-C, TG between the two groups (P > 0.05). Compared with the control group, DT, IVRT, E/Em increased in the PCOS-IR group, and Em decreased, the differences were statistically significant (P < 0.05); there was no significant difference in LVDd, LVDs, IVSTd, LVPWTd, LVEF, E, A, E/A, IVCT between the two groups (P > 0.05). The LS and GLS in each segment of PCOS-IR group were lower than those in the control group, the differences were statistically significant (P < 0.05). There were negative correlations between GLS and FINS, WHR, LDL-C (r = -0.58, -0.46, -0.44, all P < 0.05). There was no correlation between GLS and FPG, HOMA-IR, HDL-C, TG, BMI (P > 0.05). Conclusion Patients with PCOS-IR may show a decline in early longitudinal systolic function under normal LVEF. CMQ technology can detect early left ventricular longitudinal movement abnormalities in patients with PCOS-IR, and provide clinical help for timely intervention.
2018 Vol. 15 (19): 71-74,86 [Abstract] ( 218 ) HTML (1 KB)  PDF (727 KB)  ( 71 )
75 Application value of serum procalcitonin, white blood cell count, C-reactive protein combined with bacterial blood culture detection on infected patients
WANG Xiaofang FENG Wansheng ZHOU Hongcui QIU Yongjia
Objective To analyze the value of serum procalcitonin (PCT), white blood cell count (WBC), C-reactive protein (CRP) combined with bacterial blood culture in the detection on infectious patients. Methods From December 2015 to December 2017, 153 infected patients in People's Hospital of Wuzhou were selected. According to blood culture results, patients were divided into blood culture positive group and blood culture negative group, the blood culture positive group were Gram-positive coccus group, Gram-negative bacillus group and other miscellaneous bacteria group, 100 normal healthy people were selected as control group at the same periord. All objects were given PCT, WBC, and CRP examination, then the results were compared and analyzed. Results Among 153 infected patients, 72 cases were blood culture positive (blood culture positive group), 81 cases were blood culture negative (blood culture negative group). The levels of PCT, WBC, CRP in blood culture positive group were higher than the blood culture negative group, and the levels of PCT, WBC, CRP in the blood culture positive group and blood culture negative group were higher than normal control group, the differences were statistically significant (P < 0.05). There were 48 cases were Gram-negative bacilli in the blood culture positive group, 13 cases were Gram-positive cocci, and 11 cases were other strains. The levels of PCT and WBC in Gram-positive cocci group were compared with Gram-negative bacilli group, other strains group, the differences were not statistically significant (P ＞ 0.05), CRP levels were comapred, the differences were statistically significant (P < 0.05), the levels of PCT, WBC, CRP in Gram-negative bacilli group were compared with other strains group, the differences were not statistically significant (P ＞ 0.05). Conclusion PCT, WBC and CRP are indicators of bacterial infection, but it is not a good way to distinguish which type of bacteria. The combined blood culture test has important clinical application value for diagnosis and treatment of bacterial infection.
2018 Vol. 15 (19): 75-78 [Abstract] ( 597 ) HTML (1 KB)  PDF (657 KB)  ( 125 )
79 Effect of intravascular low frequency and high energy ultrasound ablation on atherosclerotic plaque
ZHAO Hongmei WANG Ying SONG Aixia LI Linru XU Xuexia LIU Xingliang
Objective To study the clinical effect of intravascular low frequency and high energy ultrasound ablation for atherosclerotic plaque patients. Methods From August 2015 to March 2017, the clinical data of 64 patients with atherosclerotic plaque in the First Affiliated Hospital of Hebei North University were retrospectively analyzed, and they were divided into two groups according to the treatment method, the study group was given intravascular low frequency and high energy ultrasound ablation, the control group was given percutaneous transluminal coronary angioplasty. The clinical effect, complication and recurrence of two groups were compared. Results Before the treatment, the stenosis degree in two groups was compared, the difference was not statistically significant (P > 0.05), after the treatment, the stenosis degree in two group reduced significantly, and this in study group was lower than control group, the differences were statistically significant (P < 0.01); the balloon pressure and dilation time in study group were lower than those in control group, the differences were statistically significant (P < 0.01). Before the treatment, experiment sport results in two groups were compared, the difference was not statistically significant (P > 0.05); after treatment, two groups were improved statistically, and the time of angina pectoris and ST segment in study group decreased more significantly than control group, the differences were statistically significant (P < 0.01). The total effective rate in study group was higher than control group, the complication rate and recurrence rate in study group were lower than control group, the differences were statistically significant (P < 0.05). Before the treatment, the heart function classification in two groups were compared, the difference was not statistically significant (P > 0.05); after the treatment, the ratio of cardiac function Ⅰ and Ⅱ in study group was higher than control group, the difference was statistically significant (P < 0.01). Conclusion Patients with atherosclerotic plaque are better treated with intravascular low frequency and high energy ultrasound ablation will have better effects, it can effectively improve the degree of coronary artery stenosis in patients, promote cardiac function to return to normal, avoid complications and recurrence, alleviate the symptoms of angina pectoris, promote the rapid and stable condition, provide protection for the prognosis.
2018 Vol. 15 (19): 79-82,95 [Abstract] ( 303 ) HTML (1 KB)  PDF (681 KB)  ( 111 )
83 Clinical study of white matter fiber bundle anisotropic FA value and gross motor function in spastic cerebral palsy children with magnetic resonance diffusion tensor imaging
LI Sinan TONG Guanglei
Objective To study the white matter fiber bundle anisotropy FA value and gross motor function in spastic cerebral palsy children with magnetic resonance diffusion tensor imaging. Methods From January 2014 to October 2017, in Anhui Provincial Children's Hospital, 60 children with spastic cerebral palsy under 3 years old were selected as the observation group, 30 normal children in the same period were selected as the control group. Magnetic resonance diffusion tensor imaging examination was performed in the two groups. The white matter fibroblasts anisotropy FA values were measured. The GMFM scale was used to evaluate the gross motor function of two groups, and the relationship between gross motor function and FA values was evaluated. Results FA value at the same site in the observation group was lower than the control group, the differences were statistically significant (P < 0.05). In the observation group, FA value of corpus callosum (CC) was the highest, the corticospinal tract and the hindlimb of internal capsule were middle, and the forelimb and knee of internal capsule were the the lowest; the GMFM values at twice in the observation group were lower than the control group, the differences were statistically significant (P < 0.05); the two observations of GMFM change in the observation group were significantly lower than the control group, the differences were statistically significant (P < 0.05); the diffusion tensor imaging FA values at different sites were positively correlated with the GMFM measurements (r = 0.382, 0.401, 0.349, 0.347, P < 0.05), correlation with ICLP was the most significant (r = 0.443, P < 0.05). Conclusion The gross motor function in spastic cerebral palsy children is closely related to white matter fiber bundle injury. The anisotropy FA value of white matter fiber bundle can reflect the motor function status. Magnetic resonance diffusion tensor imaging technology can be widely used in clinical spastic cerebral palsy motor function evaluation.
2018 Vol. 15 (19): 83-86 [Abstract] ( 733 ) HTML (1 KB)  PDF (699 KB)  ( 70 )
87 Study of effect of "accurate cardiopulmonary resuscitation model" on rescue successful rate and survival rate of patients with cardiac arrest
TANG Qi1 LI Shuyan2 ZHANG Yingjian1 WU Zhixin1 LI Kuangyi1▲
Objective To investigate the effect of the "accurate cardiopulmonary resuscitation model" on the rescue successful rate and the survival rate of patients with cardiac arrest. Methods From June 2015 to May 2017, in Department of Emergency, Foshan Chinese Medicine Hospital, the clinical data of 160 patients with cardiac and respiratory arrest were retrospectively analyzed, according to wheather they given "accurate cardiopulmonary resuscitation model" or not, they were divided into the control group and treatment group, with 80 cases in each group. The return of spontaneous circulation (ROSC), 24 h survival rate, discharge survival rate and neurological function score (GCS score) in the two groups were compared. Results The ROSC rate, successful resuscitation rate and 24 h survival rate in the treatment group were higher than the control group, the differences were statistically significant (P < 0.05), but there was no significant difference in the survival rate after hospital discharge in two groups (P > 0.05). In the ROSC cases, ROSC recovery time and duration in the treatment group were better than the control group, the differences were statistically significant (P < 0.05). In patients with successful cardiopulmonary resuscitation, the GCS scores at the moment of resuscitation, 12 h after resuscitation and 24 h after resuscitation in the treatment group were significantly higher than the control group, the differences were statistically significant (P < 0.05). Conclusion "Accurate cardiopulmonary resuscitation mode" can improve the success rate and long-term survival rate of cardiac arrest patients to some extent, and it has a positive effect on patients with cardiac arrest.
2018 Vol. 15 (19): 87-90 [Abstract] ( 232 ) HTML (1 KB)  PDF (700 KB)  ( 57 )
91 The relationship between serum prealbumin, cholinesterase and pulmonary function in patients with chronic obstructive pulmonary disease
WANG Hui XU Xiao▲ YAN Xiaopei RUAN Ting XU Li
Objective To investigate the relationship between serum prealbumin (PA), cholinesterase (CHE) and pulmonary function in patients with chronic obstructive pulmonary disease (COPD). Methods From January 2011 to January 2018, a total of 112 stable COPD patients in Suzhou Municipal Hospital were selected as the study group. A random selection of 112 healthy persons at the same period were served as the control group. The levels of serum PA, CHE and white blood cell (WBC) count were detected in the study group and the control group, as well as the relationship with pulmonary function. The ROC curve was used to evaluate the value of PA and CHE in the assessment of severe COPD patients. Results The levels of serum PA and CHE in the study group were lower than the control group, and the difference was statistically significant (P < 0.05). WBC count between the study group and the control group had no significant difference (P > 0.05). The level of serum PA and CHE decreased with the increase of the degree of pulmonary function in COPD patients (P < 0.05). The serum PA was positively correlated with FEV1% (r = 0.465, P < 0.001) and FVC%(r = 0.449, P < 0.001), and the serum CHE was positively correlated with FEV1% (r = 0.457, P < 0.001) and FVC% (r = 0.475, P < 0.001). The ROC analysis showed that the area under the curve, sensitivity and specificity of PA < 204.55 mg/L were 0.767, 71.4% and 71.4%, and the area under the curve, sensitivity and specificity of CHE < 262.5 U/L for severe COPD patients were 0.720, 82.9%, and 48.6%. Conclusion The decrease of PA and CHE in patients with COPD reflects the severity of COPD disease to some extent. It can become an important reference index for clinicians to determine the condition of COPD.
2018 Vol. 15 (19): 91-95 [Abstract] ( 243 ) HTML (1 KB)  PDF (799 KB)  ( 149 )
96 Effect of low-frequency pulse electric stimulation at the acupoints on autonomic urination in patients after lumbar spine surgery
SUN Yongmei WANG Ling▲ PENG Lijuan BAO Ruizhi SHI Yan
Objective To investigate the effect of low-frequency pulse stimulation at the acupoints on autonomic urination in patients after lumbar spine surgery. Methods From May 2015 to December 2016, a total of 100 patients were recruited in this study after 2-segment lumbar spine surgery was performed. According to the hospitalized order, the patients were divided into the observation group (n = 50) and control group (n = 50). All patients were received routine nursing care before the surgery. In the control group, after pulling out the urine tube, the patients were received routine nursing care for induced urination, while in the observation group, the patients were received the low-frequency pulse acupoint stimulation therapy beyond the nursing care of the control group. The urine tube indwelling time, the number of urethral catheterization, residual urine, psychological status before and after nursing intervention were measured, respectively. Results In the observation group, the urinary tube indwelling time, the number of urethral catheterization, residual urine were (28.8±3.5) h, (0.3±0.1) times,  (52.4±12.4) mL, and respectively, which were lower than those of control group (88.2±24.7) h, (0.5±0.2) times and (86.6±25.0) mL, and the differences were statistically significant (P < 0.01). In the observation group, the SAS and SDS scores after nursing intervention were (23.8±5.1) points and (19.2±3.4) points respectively, which were lower than those of control group with the value of (32.4±6.0) points, (30.4±4.5) points, and the differences were statistically significant (P < 0.01). The patients′ satisfaction in observation group was 92.00%, which was higher than that of the control group 76.00%, and the difference was statistically significant (P < 0.05). The SF-36 scores of physical function, physiological function, physical pain, social function, energy, emotional function, mental health and overall health after nursing intervention of the patients in the observation group were significantly higher than those of the control group, and the differences were statistically significant (P < 0.01). Conclusion The low-frequency pulse stimulation at the acupoints was enhanced the micturition prognosis of the dysuria patients after lumbar spine surgery, and it was helpful to improve the psychological status and the satisfaction and quality of life.
2018 Vol. 15 (19): 96-99 [Abstract] ( 239 ) HTML (1 KB)  PDF (656 KB)  ( 123 )
100 Effects of combined application of different blood purification techniques on soluble transferrin receptor and renal anemia in hemodialysis patients
ZHAO Fangfang LIU Wenhu LIU Hongbo
Objective To evaluate the combined application effect of different blood purification techniques on soluble transferrin receptor (sTfR) and renal anemia in hemodialysis patients. Methods A total of 90 patients who received the maintenance hemodialysis in Beijing Friendship Hospital Affiliated to Capital Medical University from January to July 2016 were selected, and all subjects were divided into hemodialysis group (HD group, n = 30), hemodialysis+hemodiafiltration group (HD+HDF group, n = 30) and hemodialysis+hemoperfusion group (HD+HP group, n = 30) by number table method. Serum sTfR levels and anemia index were detected before hemodialysis, 2, 6 months and 12 months after treatment, and the change value of before and after treatment(Δvalue=after treatment for 12 months-before treatment) were compared among the three groups. Results On different time points after treatment, the serum levels of sTfR were lower in HD+HDF group and HD+HP group than that in HD group; 6 months and 12 months after treatment, the serum level of sTfR was lower in HD+HP group than that in HD+HDF group; the Δ value was higher in HD+HP group and HD+HDF group than that in HD group, and the differences were all statistically significant (P < 0.05 or P < 0.01). 6 months after treatment, the Hb and Ret% were higher in HD+HDF group and HD group, the HTC was higher in HD+HP group than in HD group and HD+HDF group, and the Ret% was higher in HD+HDF group than that in HD group, and the differences were all statistically significant (P < 0.05 or P < 0.01). 12 months after treatment, the Hb, HCT and Ret% were higher in HD+HP group and HD+HDF group than those in HD group, and the Hb and HCT were higher in HD+HP group than those in HD+HDF group, the Δ value of Hb and HTC were higher in HD+HP group than those in HD+HDF group and HD group, and the HD+HDF group were higher than those in HD group, and the differences were all statistically significant (P < 0.01). Conclusion The combination of different methods of blood transfusion has different effects on renal anemia in maintenance hemodialysis patients, and the treatment of hemodialysis combined with hemodiafiltration or hemoperfusion is better than hemodialysis in the treatment of renal anemia. Hemodialysis combined with hemoperfusion has more advantages in the improvement of renal anemia.
2018 Vol. 15 (19): 100-103 [Abstract] ( 745 ) HTML (1 KB)  PDF (658 KB)  ( 58 )
104 Analgesic effect of Levobupivacaine combined with Dexmetidine in intercostal nerve block after NUSS operation in children
QIU Qianqi TIAN Hang SONG Xingrong XU Yingyi
Objective To investigate the effect of ultrasound guided Levobupivacaine combined with Dexmedetomidine on postoperative sedation and postoperative pain score in children undergoing NUSS surgery. Methods From November 1, 2014 to March 1, 2017, 60 children aged 3 to 6 years who received NUSS operation in the Department of Anesthesiology of Guangzhou Women and Children′s Medical Center were selected as the research objects. They were divided into group BD, group B and group C three groups according to the random number table, 20 cases in each group. 0.25% Levobupivacaine and 1 μg/mL Dexmetidine under ultrasound guidance were used to block intercostal nerve after tracheal intubation and general anesthesia in children of group BD, and postoperative analgesia was performed with opioid drugs by self-controlled intravenous administration of PCIA. 0.25% Levobupivacaine under ultrasound guidance were used to block intercostal nerve after tracheal intubation and general anesthesia in children of group B and PCIA was used for the analgesia after operation. The children in group C were operated directly after general anesthesia with tracheal intubation, and PCIA was given for the analgesia after operation. The Riker sedation agitation score of postoperative recovery and extubation, postoperative FLACC pain score, the effective pressing times and actual pressing times of PCIA the cumulative dosage of Sufentanil within 24 h after operation were observed and recorded. The percentage of analgesic failure was calculated. Results The scores of Riker sedation and restlessness in group BD, B and C were (4.0±0.0), (4.0±0.0) and (5.0±0.0) scores respectively. FLACC pain scores at 2, 4, 6, 8, 12, 24 h and 48 h after operation showed that group BD < group B < group C, and the differences between groups were statistically significant (P < 0.01). There were statistically significant differences among the three groups in the number of effective PCIA compressions and actual compressions (P < 0.05). The effective times and actual times of compressions in group C were significantly higher than those in group B and BD, and the differences were statistically significant (P < 0.05). The cumulative dosage of Sufentanil in 24 h was group BD < group B < group C, and the difference was statistically significant (P < 0.05). The percentage of postoperative analgesia failure in the three groups was statistically significant (P < 0.05). Conclusion Ultrasound guided intercostal nerve block combined with PCIA is more effective than PCIA alone in relieving postoperative pain in children with NUSS. Dexmetidine can enhance the effect of Levobupivacaine on intercostal nerve block, and lower the dosage of Sufentanil. It is more suitable for postoperative analgesia after NUSS.
2018 Vol. 15 (19): 104-108 [Abstract] ( 233 ) HTML (1 KB)  PDF (477 KB)  ( 279 )
109 Effects of Sevoflurane on cTnI and GP-BB in patients with coronary heart disease undergoing laparoscopic cholecystectomy and analysis of the prognosis
FU Peng1 MA Ping2 LI Zhenhui1
Objective To investigate the effects of Sevoflurane on cardiac troponin I (cTnI) and glycogen phosphorylase BB (GP-BB) in patients with coronary heart disease undergoing laparoscopic cholecystectomy and analysis of the prognosis. Methods A total of 165 patients with coronary heart disease who received laparoscopic cholecystectomy in Qingdao Fuwai Cardiovascular Disease Hospital From August 2015 to June 2016 were selected, and they were divided by random number table into study group (65 cases) and control group (60 cases). The study group was given Sevoflurane inhalation anesthesia during the operation, and the control group was given Propofol anaesthesia. The changes in the concentration of cTnI and GP-BB in serum of the two groups were compared and the prognosis of patients was analyzed. Results The concentration of cTnI and GP-BB immediately after the operation in the two groups was significantly higher than that before the anesthesia, the concentration of cTnI and GP-BB immediately after the operation in the study group was significantly lower than that in the control group, the differences were statistically significant (P < 0.05). The withdrawal time to the extubation time in the study group was shorter than that in the control group, the awake time in the study group was shorter than that in the control group, the differences were statistically significant (P < 0.05). The incidences of the conventional adverse events and adverse cardiac events in the study group were both significantly lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Sevoflurane has good myocardial protective effect to the patients with coronary heart disease undergoing laparoscopic cholecystectomy, which can reduce the incidences of conventional adverse events and adverse cardiac events, improve patients′ prognosis.
2018 Vol. 15 (19): 109-112 [Abstract] ( 240 ) HTML (1 KB)  PDF (442 KB)  ( 124 )
113 The clinical experience of Yang Huacui Director in treating attack stage of childhood asthma by using classic prescription
LIU Yanmei1 YANG Huacui2
This paper introduces the clinical experience of Yang Huacui Director in treating attack stage of childhood asthma by using Zhang Zhongjing′s classic prescription. Yang Huacui Director believes that the essence of asthma is the deficiency of lung, spleen and kidney, with phlegm and blood stasis lurking inside. The main pathogenesis of attack stage is excessive pathogen. The key pathogenesis is that the lurking phlegm is triggered by the pathogenic factor outside. The pathogenesis is divided into cold and heat in the course of disease. Sustained attack results in vital qi deficiency, and that leads to deficiency and excess complicated symptoms. It needs symptomatic treatment in acute condition according to deficiency and excess, cold and heat. It is important to use Zhang Zhongjing′s classic prescription based on the syndrome differentiation. Yang Huacui is skilled in using Shegan Mahuang Decoction, Daqinglong Decoction, Xiaoqinglong Decoction and Maxing Shigan Decoction, which has achieved good clinical efficacy.
2018 Vol. 15 (19): 113-116 [Abstract] ( 236 ) HTML (1 KB)  PDF (532 KB)  ( 80 )
117 Clinical study of Xuanji acupuncture method on attenuation effects of Platinum chemotherapy regimen in the treatment of malignant tumor
LIAO Guiya1,2 LONG Shunqin1,2 DENG Hong1,2 LI Qiuping1,2 HUANG Jinpeng1,2 GAN Ziyan1,2 BI Jiayi1,2 LIU Yu1
Objective To study the clinical effect of Xuanji acupuncture method on attenuation effects of Platinum chemotherapy regimen in the treatment of malignant tumor. Methods Fifty-nine patients with malignant tumor treated in Guangdong Provincial Hospital of Traditional Chinese Medicine from July to December 2017 were selected and randomly divided into observation group (29 cases) and control group (30 cases) according to the random number table method. Both groups were treated with Platinum chemotherapy regimen routinely for 2 courses, while the observation group was treated with Xuanji acupuncture during chemotherapy for 10 days. The cellular immune function, quality of life, bone marrow suppression conditions and digestive tract reactions before and after treatment between the two groups were compared. Results After treatment, the levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in the observation group were significantly higher than those before treatment; the levels of CD3+ and CD4+ in the control group were significantly higher than those before treatment (all P ＜ 0.05). After treatment, the levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in the observation group were significantly higher than those of the control group (P ＜ 0.05). In European organization for research and treatment of cancer (EORTC) QLQ-C30, the score of total health in the observation group was significantly higher than that of the control group, while the scores of nausea, vomiting, pain and appetite were significantly lower than those of the control group (all P ＜ 0.05). The incidence of bone marrow suppression and digestive tract reaction in the observation group were significantly lower than those in the control group (all P ＜ 0.05). Conclusion Xuanji acupuncture method combined with Platinum chemotherapy regimen can reduce toxicity function of patients with malignant tumor, and it can improve the immune function and quality of life, which may deserve for clinical promotion.
2018 Vol. 15 (19): 117-120 [Abstract] ( 253 ) HTML (1 KB)  PDF (531 KB)  ( 75 )
121 The effect of acupoint catgut embedding combined with Desloratadine Citrate Disodium Tablets in the treatment of allergic rhinitis with syndrome of qi deficiency of lung and spleen
WU Zhigang1 LI Xiubin2 CHEN Xiao2
Objective To observe the clinical effect of acupoint catgut embedding combined with Desloratadine Citrate Disodium Tablets in the treatment of allergic rhinitis with syndrome of qi deficiency of lung and spleen. Methods The clinical data of 214 allergic rhinitis patients with syndrome of qi deficiency of lung and spleen diagnosed in Wenling Hospital of Traditional Chinese Medicine from April 2016 to March 2017 was analyzed retrospectively, and the patients were divided into two groups according to the registration order; 106 cases (from April to September 2016) in the control group were treated with oral administration of Desloratadine Citrate Disodium Tablets, on basis of which, 108 cases (from October 2016 to March 2017) in the treatment group were treated with acupoint catgut embedding. The two groups were treated for 1 month. After treatment, the visual analogue scale (VAS), grading of rhinitis signs and adverse reactions during the treatment period were used to comprehensively evaluate the clinical efficacy of the two groups. Results Before treatment, there were no statistically significant differences of the scores of VAS and the grading of rhinitis signs between the two groups (P ＞ 0.05). After treatment, the scores of VAS and the grading of rhinitis signs in the two groups were significantly lower than those before treatment (P ＜ 0.01). The scores above of the treatment group were significantly lower than those of the control group (P ＜ 0.05). There were no obvious adverse reactions in the two groups during the treatment. Conclusion Acupoint catgut embedding therapy combined with Desloratadine Citrate Disodium Tablets can significantly improve the clinical symptoms and quality of life of patients with allergic rhinitis, which has good clinical efficacy, and it is worthy of clinical promotion.
2018 Vol. 15 (19): 121-124 [Abstract] ( 206 ) HTML (1 KB)  PDF (529 KB)  ( 201 )
125 Clinical diagnostic value of high frequency ultrasound combined with BI - RADS grading in breast tumors
LU Weirong1 HAN Yunsheng1 SHEN Ji1 SHEN Junjun2
Objective To research the clinical diagnostic value of high frequency ultrasound combined with BI-RADS grading in breast tumors. Methods From February 2015 to August 2017, the clinical records of 128 patients with breast tumors (159 lesions) in Huzhou Central Hospital were analyzed, retrospectively. The bilateral breasts were scanned with high frequency ultrasound, and the breast lesions were evaluated according to BI-RADS. The BI-RADS classification and pathological results were compared and analyzed. The clinical value of high frequency ultrasound combined with BI-RADS classification in the diagnosis of breast tumors was evaluated. Results Among 159 breast tumor lesions, 98 benign lesions were confirmed by pathological findings, and 61 malignant lesions were confirmed by pathological findings. The detection rate of malignant lesions in irregular shape, incomplete capsule, marginal burr, internal calcification and axillary lymph node abnormalities were significantly higher than those in benign lesions, the differences were statistically significant (P < 0.01). The internal blood flow of malignant lesions was more abundant than benign lesions. The level of Vmax and RI value of malignant lesions were significantly higher than those of benign lesions, and the differences were statistically significant (P < 0.01). A total of 85 lesions were diagnosed as grade 3 by the BI-RADS classification, which 7 lesions were malignant. There were 35 lesions were diagnosed as grade 4, which 17 lesions were malignant. 39 lesions were diagnosed as grade 5, which 37 lesions were malignant. The sensitivity of BI-RADS classification ultrasound was 88.52% (54/61), the specificity was 79.59% (78/98), and the accuracy was 83.02% (132/159). Conclusion BI-RADS classification has high sensitivity and specificity in the diagnosis of breast tumors. The combination of high frequency ultrasound and BI-RADS classification have great significance for the diagnosis and characterization of breast tumor and the guidance of the treatment scheme.
2018 Vol. 15 (19): 125-128 [Abstract] ( 269 ) HTML (1 KB)  PDF (467 KB)  ( 59 )
129 The CT manifestations of nodular, mass focal organizing pneumonia
WANG Shusheng1 YU Yongmei2
Objective To analyze the CT manifestations of nodular, mass focal organizing pneumonia. Methods The CT manifestations of 21 patients with nodular and mass FOP confirmed by surgery or puncture pathology in Chizhou People's Hospital from January 2013 to February 2018 were retrospectively analyzed. Standardized 64-slice MSCT  and three-phase contrast enhanced spiral CT were performed for all cases, with some of the lesions being displayed using MPR. Results In the 21 cases, 12 cases with nodular type and 9 cases of tumor were found. All lesions were located in the field of the lung or close to the pleura, with the lower lobe of the right lung (8 cases) and the upper lobe of the left lung (9 cases) frequent. There were 20 cases of irregular morphology and 1 case of small circle nodules. The edge was clear in 15 cases, fuzzy in 6 cases. There were 4 cases of arcs, 12 cases of pleural thickening adhesion and 3 cases of pleural depression. There were 19 case heterogeneous enhancement (including 8 cases with smooth inner cavity) and 2 cases of uniform enhancement. There were 12 cases of obvious enhancement, 7 cases of moderate enhancement, 2 cases of mild enhancement, and 2 cases of vascular penetration. Conclusion The FOP CT features of nodules and lumps are very complicated, and there is a certain value in diagnosis according to the location, morphology, strengthening mode and multi-plane reconstruction of the lesion.
2018 Vol. 15 (19): 129-132 [Abstract] ( 191 ) HTML (1 KB)  PDF (679 KB)  ( 91 )
133 Efficacy and safety of Ceftriaxone Sodium and Yan Huning Injection in the treatment of pediatric acute pneumonia: a meta-analysis
LI Haixia1,2 TIAN Fangyuan1,2 XU Ting1
Objective To systematically evaluate the efficacy and safety of Ceftriaxone Sodium and Yan Huning Injection in the treatment of children with acute pneumonia. Methods Two researchers independently searched databases including PubMed, EMbase, the Cochrane Library (Issue 1, 2018), VIP, CBM, CNKI, and WanFang Data by computer and randomized controlled trials (RCTs) on the treatment of acute pneumonia in children with Ceftriaxone Sodium and Yan Huanning Injection from database creating to January 2018 were collected, the experimental group was Ceftriaxone Sodium combined with Yan Huning Injection and the control group was Ceftriaxone Sodium alone. After taking the total effective rate, clinical symptom relief time and adverse reaction as the observation index for data extraction and quality evaluation, Meta-analysis was performed by using RevMan 5.3 software. Results A total of 14 RCTs involving 1937 patients were included. There were 994 cases in the experimental group and 943 cases in the control group. The results of Meta-analysis showed that Ceftriaxone Sodium and Yan Huning Injection in the treatment of children with acute pneumonia in the total effective rate [RR = 1.21, 95%CI (1.17,1.26), P < 0.00001], cooling time [MD = -1.29, 95%CI (-1.43,-1.15), P < 0.00001], cough-disappear time [MD = -2.70, 95%CI (-3.01,-2.39), P < 0.00001], rales disappear time [MD = -2.14, 95%CI (-2.46,-1.81), P < 0.00001], X-ray recovery time [MD = -2.54,95%CI (-2.62,-2.47),P < 0.00001], the incidence of adverse reactions [RR = 0.23,95%CI (0.11,0.46),P < 0.0001] were better than single Ceftriaxone Sodium with statistical significance. Conclusion The efficacy of Ceftriaxone Sodium and Yan Huning Injection in the treatment of acute pneumonia in children is superior to that of single Ceftriaxone Sodium and has a good safe.
2018 Vol. 15 (19): 133-138 [Abstract] ( 250 ) HTML (1 KB)  PDF (1709 KB)  ( 79 )
139 Distribution and drug resistance of deep fungus from AIDS patients with infection in hospital of traditional Chinese medicine
NI Wei YANG Liu LIU Guangzhong
Objective To investigate the differences between the pathogenic bacteria and drug resistance of AIDS patients with deep fungus infection between Hubei Province Hospital of Traditional Chinese Medicine (for short “our hospital”) and west hospitals, in order to discuss the problems in the prevention and control of hospital infection and the effective measures put forward for reference. Methods From January 2008 to December 2017, the specimens of AIDS patients with deep fungal infection in our hospital were isolated and cultured, bacterial identification and drug susceptibility analysis were performed and personal data were collected. Results In our hospital, the sample type of the patient who was diagnosed with HIV infection has been regarded as the main source of sputum (70.89%), while others have been considered to be blood (10.33%), feces (8.45%) and urine (6.57%). In the inspection of 852 specimens, deep fungus detection rate was 5.99%, with Candida albicans (58.83%), while Penicillium marneffei (15.39%), Cryptococcus neoformans (9.80%), Smooth candida (9.80%), Tropical candida (5.88%) were relatively few. The drug resistance rate of Fluconazole was 0.00% for the main Candida. For the main Candida albicans, Amphotericin B resistance rate was over 60.00%. The drug resistance rate of Ketoconazole and Nystatin was lower than 35.00% for the main candida. Conclusion Compared with west hospitals, drug resistance rate for common antibioticsthe of deep fungus isolated from AIDS patients in our hospital is low. However, the hospital should strengthen the monitoring of multidrug resistant bacteria, and emphasize the role of national medical treatment methods and nursing methods in preventing deep fungal infection.
2018 Vol. 15 (19): 139-142 [Abstract] ( 268 ) HTML (1 KB)  PDF (480 KB)  ( 79 )
143 Effect of cold storage time on the stability of biochemical project
LI Ronghai1# YAO Xingwei2# QIU Congying3 YANG Qi2 LU Xin2 ZHANG Ze2 GUO Heng2 WANG Bin2▲
Objective To evaluate the stability and repeatability of every 24 hours biochemical project in the serum samples for 7 days, in order to provide good advice and guidance for clinicians. Methods From January to December in 2017, 30 cases of clinical serum samples from Xiyuan Hospital were collected, and Roche Cobas 8000 automatic analyzer was used for the detection. The samples were stored at 4℃ after being detected with 44 biochemical projects every day in the study, such as glucose (GLU), creatinine (Cr) and C-reactive protein (CRP). Results The detection results of K+, Cl-, Na+, C3, CK-MB, LDH in 24 h were significantly different from those of other time periods, and the differences were statistically significant (P < 0.05). The concentration of K+, Cl-, Na- and complement C3 were significantly increased, while the levels of CK-MB and LDH were significantly decreased. However, the level of other 38 testing projects had not statistically significant (P > 0.05). Conclusion It is important for medical workers to know the changes of some biochemical markers in serum samples during one week, especially the changing concentration of K+, Cl-, Na-, complement C3, CK-MB and LDH.
2018 Vol. 15 (19): 143-146 [Abstract] ( 367 ) HTML (1 KB)  PDF (488 KB)  ( 130 )
147 Value of CT combined with serum CEA and ADAM8 in the diagnosis of lung cancer in elderly patients
HUANG Linhui HUANG Yijiang▲
Objective To evaluate the value of spiral CT combined with serum carcinoembryonic antigen (CEA) and a disintegrin and metalloprotease 8 (ADAM8) in the clinical diagnosis of elderly patients with lung cancer. Methods A total of 72 elderly patients with lung cancer admitted in Hainan Provincial People′s Hospital (for short “our hospital”) from January to December in 2016 were selected as the study group, and 40 patients with benign pulmonary disease and 40 healthy subjects in our hospital were selected as the control in the same period. All the researchers were underwent CT scan and the serum CEA and ADAM8 were measured. The histopathological results were as the gold standard, the value of single and combined detection indexes for the diagnosis of lung cancer were determined. Results The levels of serum CEA and ADAM8 in lung cancer patients were significantly higher than those in benign lung disease group and healthy control group (P < 0.05); and the levels of CEA and ADAM8 in lung cancer patients with stage Ⅲ/Ⅳ were significantly higher than those in patients with stage Ⅰ/Ⅱ (P < 0.05). The sensitivity of CT, CEA and ADAM8 was 68.06%, 48.61% and 70.83% respectively, the specificity was 90.00%, 75.00% and 86.25% respectively, and the accuracy was 79.61%, 62.50% and 78.95% respectively. The sensitivity, specificity and accuracy of three indicators combined detection were 83.33%, 93.75% and 88.82% respectively, which were higher than single detection. Conclusion CEA has a low detection rate of lung cancer patients and is prone to false positive, but it can improve the accuracy of lung cancer detection after combined with CT and ADAM8.
2018 Vol. 15 (19): 147-150 [Abstract] ( 269 ) HTML (1 KB)  PDF (516 KB)  ( 69 )
151 The influence of constructing hospital core value system on medical staffs' practice behavior
XIANG Kelan HE Kechun WANG Qingli ZHOU Wei GONG Lingyun XU Wen
This paper analyzed the medical staffs' misconduct in the practice of medical facilities, proposed that hospital administration should be strengthened by training hospital core values of knowledge connotation, coagulation the core values that conforms to the hospital development, relying on the hospital culture to optimize the medical staffs' implicit system and professional quality in accordance with the core system and job requirements. Thus as the guide of building moral ideas and value orientation, hospital culture as the basis and the unity of knowledge, faith, action, with a third party evaluation for medium hospital core values system, then optimize the medical staffs' implicit system, influence their practice behavior. In the process of cultivating the core values of medical staffs, realize their self-consciousness and self-reflection, standardize their practice behavior, thereby improve the hospital satisfaction.
2018 Vol. 15 (19): 151-154 [Abstract] ( 194 ) HTML (1 KB)  PDF (409 KB)  ( 178 )
155 Effect of preoperative Simvastatin combined with psychological intervention on psychological stress reaction and reperfusion injury in patients with ACS
ZHANG Hongxin LI Guangping LIU Ying ZHAO Ying MA Yi
Objective To explore the effect of preoperative Simvastatin combined with psychological intervention on psychological stress reaction and reperfusion injury in patients with acute coronary syndrome (ACS). Methods A total of 86 patients with ACS treated with percutaneous coronary intervention (PCI) in Tangshan Workers' Hospital from March 2015 to January 2017 were selected as the research objects and divided into the control group and the observation group according to the random lottery method, with 43 cases in each group. The control group was given routine treatment and nursing during the perioperative period, the observation group was given Simvastatin preoperative combined with psychological intervention on the basis of the control group. Both groups were intervined for 6 months. The self-anxiety scale (SAS) and self-depression scale (SDS) were applied to evaluate the degree of anxiety and depression at the admision time and 6 month after operation. The inflammatory mediators of interleukin 6 (IL-6), interleukin 18 (IL-18), high sensitive C reactive protein (hs-CRP), left ventricular ejection fraction (LVEF) and phospholipaseA2 (LP-PLA2) were compared between the two groups. The incidences of blood pressure increasing, drug assisted sleep, thrombosis, reperfusion injury and coronary restenosis were compared between the two groups. Results After operation for 6 months, the scores of SAS and SDS in the observation group were lower than those of control group, with statistically significant differences (P ＜ 0.05); the levels of IL-6, IL-18 and hs-CRP in the two groups were significantly higher than those of at admission time (P ＜ 0.05), and the indicators above in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05); the level of LVEF in the observation group was significantly higher than that of control group, the level of LP-PLA2 was significantly lower than that of control group, with statistically significant differences (P ＜ 0.05); the incidences of blood pressure increasing, drug assisted sleep, thrombosis, reperfusion injury and coronary restenosis in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion Preoperative Simvastatin combined with psychological intervention can effectively reduce the anxiety and depression of patients with  ACS, reduce the psychological stress reaction and optimize the reperfusion injury indexes and improve the prognosis.
2018 Vol. 15 (19): 155-158 [Abstract] ( 228 ) HTML (1 KB)  PDF (570 KB)  ( 102 )
159 The effect of focus resolution mode in patients with sepsis combined with acute renal injury
WANG Hui CAO Yanhui
Objective To explore the effect of focus resolution mode in patients with sepsis combined with acute renal injury. Methods A total of 90 patients with sepsis combined with acute renal injury in Department of Intensive Care Unit, the First Affiliated Hospital of Harbin Medical University from May 2015 to May 2017 were selected as the research objects and divided into the control group and the observation group by random number table, with 45 cases in each group. The control group was given routine nursing intervention, while the observation group was given focus resolution mode on the basis of control group. The clinical indicators in the two groups were compared before and after the intervention. The Pittsburgh sleep quality index (PSQI) was used to evaluate the sleep quality of patients in both groups before and after intervention. The self-designed comfort questionnaire was used to compare the comfort of patients in the two groups after intervention. Results There were no statistically significant differences between the two groups in the incidence of mechanical ventilation during hospitalization and lung injury, body temperature, leukocyte level, prothrombin time (P ＞ 0.05). The incidence of shock, lactic acid level, Charleson's basic disease weight index in the observation group were lower than those of control group; the mean arterial pressure and basal glomerular filtration rate were significantly higher than those of control group, with statistically significant differences (P ＜ 0.05). Before intervention, there were no statistically significant differences in the scores of PSQI of each item and comfort between the two groups (P ＞ 0.05); after intervention, the scores above in the two groups were all significantly lower than those of before intervention and the scores above in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion Focus resolution mode can effectively relieve the clinical discomfort of patients with sepsis combined with acute kidney injury, improve the sleep quality, promote the daily comfort of the patients. It plays an important role in improving the prognosis and life quality of the patients. It is worthy of promotion and application.
2018 Vol. 15 (19): 159-162,176 [Abstract] ( 208 ) HTML (1 KB)  PDF (586 KB)  ( 114 )
163 The application effect of CTC mode-based nursing health education on children with supracondylar fracture of humerus
LU Yingxia CHEN Wanmin WU Wei ZHOU Cailiu
Objective To explore the application effect of child to child (CTC) mode-based nursing health education on children with supracondylar fracture of humerus. Methods A total of 93 children with supracondylar fracture of humerus treated in Foshan Hospital of Traditional Chinese Medicine from January to August 2017 were selected and divided into the control group (46 cases) and the CTC group (47 cases) according to the admission time. The control group was given routine nursing education, while the CTC group was given CTC nursing health education. The treatment compliance, Mayo scores and range of mobility (ROM） in elbow joint in the two groups were compared. Results The treatment compliance in the CTC group was better than that of control group, with statistically significant difference (P ＜ 0.05). Before intervention, there were no statistically significant differences in the scores of pain, swelling, joint ROM and self-care ability between the two groups (P ＞ 0.05). After intervention, the scores above in the two groups were significant lower than those of control group and the scores above in the CTC group were lower than those of control group, with statistically significant differences (P ＜ 0.05). After intervention, flexion, dorsiflexion, pronation and supination of the elbow joint ROM in the CTC group were significantly higher than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion CTC mode-based nursing health education can effectively improve the treatment compliance and elbow joint function in children with supracondylar fracture of humerus, and positively accelerate the rehabilitation.
2018 Vol. 15 (19): 163-167 [Abstract] ( 204 ) HTML (1 KB)  PDF (606 KB)  ( 126 )
168 Application of PDCA cycle management in emotional labor management of nurses of emergency department
LI Xia CHEN Fengyun WANG Qing
Objective To explore the application effect of PDCA cycle management in emotional labor management of emergency department nurses. Methods From July 2014 to August 2014, the nurses from Department of Emergency, Seventh People's Hospital of Shanghai University of TCM were selected as the research objects and divided into the control group (37 cases) and the study group (43 cases) by different management methods and study time. The control group was given routine emotional labor management, while the study group was given PDCA management on the basis of the control group. The scores of emotional labor, general self-efficacy and job satisfaction were compared between the two groups before and after intervention. Results There were no statistically significant differences in the surface performance, deep performance and natural performance before and after intervention in the control group (P ＞ 0.05). After interveniton, the surface performance in study group was lower than that of before intervention, the deep performance and natural performance were higher than those of before intervention, with statistically significant differences (P ＜ 0.05); the surface performance in study group was lower than that of control group, the deep performance and natural performance were higher than those of control group, with statistically significant differences (P ＜ 0.05). There were no statistically significant differences in the scores of general self-efficacy and job satisfaction before and after intervention in the control group (P ＞ 0.05). After interveniton, the scores of general self-efficacy and job satisfaction in the study group were higher than those of before intervention and those of control group at the same period of time, with statistically significant differences (P ＜ 0.05). Conclusion The PDCA cycle can guide emergency nurses to implement high quality emotional labor, increase work enthusiasm and improve the quality of nursing service, which is worthy of popularization and application.
2018 Vol. 15 (19): 168-171 [Abstract] ( 242 ) HTML (1 KB)  PDF (607 KB)  ( 26 )
172 Effects of pathway health education on blood glucose, self-management behavior and emotion in patients with type 2 diabetes mellitus
LIU Xiaoying1 ZHANG Yanling2▲
Objective To explore the effects of pathway health education on blood glucose, self-management behavior and emotion in patients with type 2 diabetes mellitus. Methods A total of 800 clinical data of patients with type 2 diabetes mellitus in Department of Endocrine, Yan′an People′s Hospital from April 2016 to May 2017 were retrospectively analyzed and divided into the control group and the observation group by different health education methods, with 400 cases in each group. The control group was given routine health education and the observation group was given pathway health education. The blood glucose, the scores of self-management behavior and the emotions between the two groups were compared. Results Before intervention, there were no statistically significant differences in the fasting plasma glucose, postprandial 2 h blood glucose and glycosylated hemoglobin between the two groups (P ＞ 0.05); after intervention, the indicators above in the two groups were all lower than those of before intervention, the indicators above in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). Before intervention, there were no statistically significant differences in the scores of anxiety and depression (P ＞ 0.05); after intervention, the scores above in the two groups were all lower than those of before intervention and the scores above in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). Before intervention, there were no statistically significant differences in the scores of diet control, regular exercise, medication following doctor′s advice, blood glucose monitoring, foot care and abnormal blood sugar treatment (P ＞ 0.05); after intervention, the scores above in the two groups were all higher than those of before intervention and the scores above in the observation group were significantly higher than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion The application of pathway health education in patients with type 2 diabetes mellitus can decrease the blood sugar, improve the psychological emotions, increase the self-management behavior. It is worthy of promotion and application.
2018 Vol. 15 (19): 172-176 [Abstract] ( 254 ) HTML (1 KB)  PDF (578 KB)  ( 83 )
177 Study on the correlation between emotional labor and bullying behavior and turnover intention of nurses
LI Yanqiu GUO Chuang▲
Objective To explore the relationship between emotional labor, workplace bullying and turnover intention. Methods A total of 400 nurses working in five tertiary A-level hospitals in Harbin, Heilongjiang Province from October 2016 were selected by convenient sampling method. The survey was conducted by questionnaires including general nurse data, situation questionnaire, workplace bullying questionnaire, nurse emotional labor scales and turnover intention scales and the correlation was analyzed. Results Among the three dimensions of emotional labor, natural movements of the nurses had the highest score (3.67±0.21), followed by the deep movements and the surface movements retrospectively. The scores of nurses′ bullying behavior in the workplace was (1.89±0.43). The scores of turnover intention from the highest to the lowest in three dimensions were finding other jobs, resigning from the current job and obtaining external job retrospectively. The dimension of natural movement in nurses′ emotional work was negatively correlated with the turnover intention, especially with the dimension of resigning from the current job (r = -0.17, P ＜ 0.05), and there was a positive correlation between nurses' workplace bullying behavior and each dimention of turnover intention (r = 0.52, 0.42, 0.18, P ＜ 0.05). Conclusion There is a correlation between nurses′ emotional work and bullying behavior and turnover intention.
2018 Vol. 15 (19): 177-180 [Abstract] ( 194 ) HTML (1 KB)  PDF (603 KB)  ( 139 )
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