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| Research progress of ubiquitination epithelial sodium channel by the regulation of Nedd4-2 |
| ZHANG Hao1 TIAN Miao2 SUN Xiaohu3 OUYANG Lu4 |
1.School of Dentistry, Hubei University of Medicine, Hubei Province, Shiyan 442000, China;
2.School of Nursing, Hubei University of Medicine, Hubei Province, Shiyan 442000, China;
3.Department of Gynecology, Maternal and Child Health Hospital of Shiyan City, Hubei Province, Shiyan 442000, China;
4.Department of Pharmacy, Shiyan Renmin Hospital Affliated to Hubei University of Medicine, Hubei Province, Shiyan 442000, China |
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Abstract Neural precursor cell expressed developmentally down-regulated protein 4-2 (Nedd4-2) is a ubiquitin protein ligase of the E3 HECT family, which is known to bind and regulate a number of membrane proteins, and mediate diverse extracellular signals, such as cell differentiation and apoptosis. Epithelial sodium channel (ENaC) is an integral membrane protein, plays a crucial role in Na+ transport and fluid reabsorption in the kidney and lung, whose structural abnormalities or disfunctions may cause some diseases. At present, Nedd4-2 protein participate in the regulation of ENaC and regulate the function of the body. This paper reviewed the structure and function of the Nedd4-2 and ENaC, and summarized the regulation of ENaC trafficking by Nedd4-2.
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