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| Effects of Sevoflurane on cTnI and GP-BB in patients with coronary heart disease undergoing laparoscopic cholecystectomy and analysis of the prognosis |
| FU Peng1 MA Ping2 LI Zhenhui1 |
1.Department of Anesthesiology, Qingdao Fuwai Cardiovascular Disease Hospital, Shandong Province, Qingdao 266000, China;
2.Department of Anesthesiology, the Third People's Hospital, Shandong Province, Qingdao 266000, China |
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Abstract Objective To investigate the effects of Sevoflurane on cardiac troponin I (cTnI) and glycogen phosphorylase BB (GP-BB) in patients with coronary heart disease undergoing laparoscopic cholecystectomy and analysis of the prognosis. Methods A total of 165 patients with coronary heart disease who received laparoscopic cholecystectomy in Qingdao Fuwai Cardiovascular Disease Hospital From August 2015 to June 2016 were selected, and they were divided by random number table into study group (65 cases) and control group (60 cases). The study group was given Sevoflurane inhalation anesthesia during the operation, and the control group was given Propofol anaesthesia. The changes in the concentration of cTnI and GP-BB in serum of the two groups were compared and the prognosis of patients was analyzed. Results The concentration of cTnI and GP-BB immediately after the operation in the two groups was significantly higher than that before the anesthesia, the concentration of cTnI and GP-BB immediately after the operation in the study group was significantly lower than that in the control group, the differences were statistically significant (P < 0.05). The withdrawal time to the extubation time in the study group was shorter than that in the control group, the awake time in the study group was shorter than that in the control group, the differences were statistically significant (P < 0.05). The incidences of the conventional adverse events and adverse cardiac events in the study group were both significantly lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Sevoflurane has good myocardial protective effect to the patients with coronary heart disease undergoing laparoscopic cholecystectomy, which can reduce the incidences of conventional adverse events and adverse cardiac events, improve patients′ prognosis.
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