联合应用不同血液净化技术对血液透析患者可溶性转铁蛋白受体和肾性贫血的影响

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Abstract Objective To evaluate the combined application effect of different blood purification techniques on soluble transferrin receptor (sTfR) and renal anemia in hemodialysis patients. Methods A total of 90 patients who received the maintenance hemodialysis in Beijing Friendship Hospital Affiliated to Capital Medical University from January to July 2016 were selected, and all subjects were divided into hemodialysis group (HD group, n = 30), hemodialysis+hemodiafiltration group (HD+HDF group, n = 30) and hemodialysis+hemoperfusion group (HD+HP group, n = 30) by number table method. Serum sTfR levels and anemia index were detected before hemodialysis, 2, 6 months and 12 months after treatment, and the change value of before and after treatment(Δvalue=after treatment for 12 months-before treatment) were compared among the three groups. Results On different time points after treatment, the serum levels of sTfR were lower in HD+HDF group and HD+HP group than that in HD group; 6 months and 12 months after treatment, the serum level of sTfR was lower in HD+HP group than that in HD+HDF group; the Δ value was higher in HD+HP group and HD+HDF group than that in HD group, and the differences were all statistically significant (P < 0.05 or P < 0.01). 6 months after treatment, the Hb and Ret% were higher in HD+HDF group and HD group, the HTC was higher in HD+HP group than in HD group and HD+HDF group, and the Ret% was higher in HD+HDF group than that in HD group, and the differences were all statistically significant (P < 0.05 or P < 0.01). 12 months after treatment, the Hb, HCT and Ret% were higher in HD+HP group and HD+HDF group than those in HD group, and the Hb and HCT were higher in HD+HP group than those in HD+HDF group, the Δ value of Hb and HTC were higher in HD+HP group than those in HD+HDF group and HD group, and the HD+HDF group were higher than those in HD group, and the differences were all statistically significant (P < 0.01). Conclusion The combination of different methods of blood transfusion has different effects on renal anemia in maintenance hemodialysis patients, and the treatment of hemodialysis combined with hemodiafiltration or hemoperfusion is better than hemodialysis in the treatment of renal anemia. Hemodialysis combined with hemoperfusion has more advantages in the improvement of renal anemia.

Key words： Hemodialysis Soluble transferrin receptor Renal anemia Continuous renal replacement therapy

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	ZHAO Fangfang LIU Wenhu LIU Hongbo

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ZHAO Fangfang LIU Wenhu LIU Hongbo. Effects of combined application of different blood purification techniques on soluble transferrin receptor and renal anemia in hemodialysis patients[J]. 中国医药导报, 2018, 15(19): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I19/100

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