慢性阻塞性肺疾病患者血清前白蛋白、胆碱酯酶与肺功能的关系

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Abstract Objective To investigate the relationship between serum prealbumin (PA), cholinesterase (CHE) and pulmonary function in patients with chronic obstructive pulmonary disease (COPD). Methods From January 2011 to January 2018, a total of 112 stable COPD patients in Suzhou Municipal Hospital were selected as the study group. A random selection of 112 healthy persons at the same period were served as the control group. The levels of serum PA, CHE and white blood cell (WBC) count were detected in the study group and the control group, as well as the relationship with pulmonary function. The ROC curve was used to evaluate the value of PA and CHE in the assessment of severe COPD patients. Results The levels of serum PA and CHE in the study group were lower than the control group, and the difference was statistically significant (P < 0.05). WBC count between the study group and the control group had no significant difference (P > 0.05). The level of serum PA and CHE decreased with the increase of the degree of pulmonary function in COPD patients (P < 0.05). The serum PA was positively correlated with FEV1% (r = 0.465, P < 0.001) and FVC%(r = 0.449, P < 0.001), and the serum CHE was positively correlated with FEV1% (r = 0.457, P < 0.001) and FVC% (r = 0.475, P < 0.001). The ROC analysis showed that the area under the curve, sensitivity and specificity of PA < 204.55 mg/L were 0.767, 71.4% and 71.4%, and the area under the curve, sensitivity and specificity of CHE < 262.5 U/L for severe COPD patients were 0.720, 82.9%, and 48.6%. Conclusion The decrease of PA and CHE in patients with COPD reflects the severity of COPD disease to some extent. It can become an important reference index for clinicians to determine the condition of COPD.

Key words： PA CHE Pulmonary function Chronic obstructive pulmonary disease

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	WANG Hui XU Xiao▲ YAN Xiaopei RUAN Ting XU Li

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WANG Hui XU Xiao▲ YAN Xiaopei RUAN Ting XU Li. The relationship between serum prealbumin, cholinesterase and pulmonary function in patients with chronic obstructive pulmonary disease[J]. 中国医药导报, 2018, 15(19): 91-95.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I19/91

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