头孢曲松钠联合炎琥宁注射液治疗小儿急性肺炎有效性与安全性的Meta分析

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Abstract Objective To systematically evaluate the efficacy and safety of Ceftriaxone Sodium and Yan Huning Injection in the treatment of children with acute pneumonia. Methods Two researchers independently searched databases including PubMed, EMbase, the Cochrane Library (Issue 1, 2018), VIP, CBM, CNKI, and WanFang Data by computer and randomized controlled trials (RCTs) on the treatment of acute pneumonia in children with Ceftriaxone Sodium and Yan Huanning Injection from database creating to January 2018 were collected, the experimental group was Ceftriaxone Sodium combined with Yan Huning Injection and the control group was Ceftriaxone Sodium alone. After taking the total effective rate, clinical symptom relief time and adverse reaction as the observation index for data extraction and quality evaluation, Meta-analysis was performed by using RevMan 5.3 software. Results A total of 14 RCTs involving 1937 patients were included. There were 994 cases in the experimental group and 943 cases in the control group. The results of Meta-analysis showed that Ceftriaxone Sodium and Yan Huning Injection in the treatment of children with acute pneumonia in the total effective rate [RR = 1.21, 95%CI (1.17,1.26), P < 0.00001], cooling time [MD = -1.29, 95%CI (-1.43,-1.15), P < 0.00001], cough-disappear time [MD = -2.70, 95%CI (-3.01,-2.39), P < 0.00001], rales disappear time [MD = -2.14, 95%CI (-2.46,-1.81), P < 0.00001], X-ray recovery time [MD = -2.54,95%CI (-2.62,-2.47),P < 0.00001], the incidence of adverse reactions [RR = 0.23,95%CI (0.11,0.46),P < 0.0001] were better than single Ceftriaxone Sodium with statistical significance. Conclusion The efficacy of Ceftriaxone Sodium and Yan Huning Injection in the treatment of acute pneumonia in children is superior to that of single Ceftriaxone Sodium and has a good safe.

Key words： Ceftriaxone Sodium Yan Huning Injection Children Acute pneumonia Meta analysis Randomized controlled trials

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	LI Haixia1
	2 TIAN Fangyuan1
	2 XU Ting1

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LI Haixia1,2 TIAN Fangyuan1,2 XU Ting1. Efficacy and safety of Ceftriaxone Sodium and Yan Huning Injection in the treatment of pediatric acute pneumonia: a meta-analysis[J]. 中国医药导报, 2018, 15(19): 133-138.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I19/133

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