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| Effect of preoperative Simvastatin combined with psychological intervention on psychological stress reaction and reperfusion injury in patients with ACS |
| ZHANG Hongxin LI Guangping LIU Ying ZHAO Ying MA Yi |
| The Second Department of Cardiology, Tangshan Workers' Hospital, Hebei Province, Tangshan 063000, China |
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Abstract Objective To explore the effect of preoperative Simvastatin combined with psychological intervention on psychological stress reaction and reperfusion injury in patients with acute coronary syndrome (ACS). Methods A total of 86 patients with ACS treated with percutaneous coronary intervention (PCI) in Tangshan Workers' Hospital from March 2015 to January 2017 were selected as the research objects and divided into the control group and the observation group according to the random lottery method, with 43 cases in each group. The control group was given routine treatment and nursing during the perioperative period, the observation group was given Simvastatin preoperative combined with psychological intervention on the basis of the control group. Both groups were intervined for 6 months. The self-anxiety scale (SAS) and self-depression scale (SDS) were applied to evaluate the degree of anxiety and depression at the admision time and 6 month after operation. The inflammatory mediators of interleukin 6 (IL-6), interleukin 18 (IL-18), high sensitive C reactive protein (hs-CRP), left ventricular ejection fraction (LVEF) and phospholipaseA2 (LP-PLA2) were compared between the two groups. The incidences of blood pressure increasing, drug assisted sleep, thrombosis, reperfusion injury and coronary restenosis were compared between the two groups. Results After operation for 6 months, the scores of SAS and SDS in the observation group were lower than those of control group, with statistically significant differences (P ＜ 0.05); the levels of IL-6, IL-18 and hs-CRP in the two groups were significantly higher than those of at admission time (P ＜ 0.05), and the indicators above in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05); the level of LVEF in the observation group was significantly higher than that of control group, the level of LP-PLA2 was significantly lower than that of control group, with statistically significant differences (P ＜ 0.05); the incidences of blood pressure increasing, drug assisted sleep, thrombosis, reperfusion injury and coronary restenosis in the observation group were significantly lower than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion Preoperative Simvastatin combined with psychological intervention can effectively reduce the anxiety and depression of patients with ACS, reduce the psychological stress reaction and optimize the reperfusion injury indexes and improve the prognosis.
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