中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2018 Vol. 15, No. 8
Published: 2018-03-15
 
 
4 Effects of Naringenin on the proliferation and apoptosis of lung cancer cell NCI-H2170
ZENG Degui1* CHEN Bao′an2* WU Shang3 HUANG Hui3 WU jun1，2
Objective To investigate the effects of Naringenin on the proliferation, apoptosis and cell cycle of human lung squamous cell carcinoma cell line NCI-H2170. Methods The proliferation of NCI-H2170 cells was detected by MTT assay. The morphological changes of NCI-H2170 cells were detected by Hoechst33258/PI staining. Cell cycle changes were measured by flow cytometry (FCM). Western blot was used to detect the expression of PARP, Bid, Bcl-2, procaspase-3 and procaspase-8 in NCI-H2170 cells treated with naringenin. Results The proliferation of human lung squamous cell carcinoma NCI-H2170 cells were inhibited in a dose-dependent manner after treating with Naringenin for 24 h. It was not significant difference between 12.5 μmol/L treatment group and the control group (P > 0.05).However, 25, 50, 100 μmol/L treatment groups were significantly different comparing to the control group (P < 0.05). The results of flow cytometry analysis showed that it was not significant difference between 12.5 μmol/L treatment group and the control group (P > 0.05). However, after NCI-H2170 cells were treated with 25, 50, 100 μmol/L naringenins, the number of cells had significantly increased in G1 phase, desceased in S phase and G2 phase, comparing to the control group (P < 0.05). Naringenin up-regulated Bid expression, promoted the degradation of PARP and the decrease of Bcl-2, proaspase-3 and proaspase-8 in NCI-H2170 cells, comparing to the control group (P < 0.05). Conclusion Naringenin inhibits the proliferation of human lung squamous cell carcinoma cell line NCI-H2170 and induces the G1 phase arrest in NCI-H2170 cells and induces cell apoptosis.
2018 Vol. 15 (8): 4-8 [Abstract] ( 202 ) HTML (1 KB)  PDF (775 KB)  ( 101 )
9 Effect of Isoflurane on anoxia/reoxygenation-induced cardiocyte injury
FU Haiyu QIN Fuen XU Shuai YANG Lin ZHONG Zuling GONG Gu
Objective To investigate the effect of Isoflurane (Iso) on anoxia/reoxygenation (A/R)-induced cardiocyte injury and underlying mechanism. Methods Cultured cardiocytes (H9c2) were pre-treated with Iso (1%, 2%, 3%) and then stimulated with 3 h of anoxia and 3 h of reoxygenation. Cell proliferation was measured by MTT method, and the Iso concentration was selected. The miR-499 overexpression reagent, miR-499 mimic was transfected into cardiocytes pre-treated with 3% Iso and simulated with anoxia/reoxygenation. Cell apoptosis was detected by flow cytometry assay. The expression level of caspase-3, caspase-9, Bax and Bcl-2 were measured by Western blot. The contents of lactic dehydrogenase (LDH), creatine kinase (CK) and alanine aminotransferase (ALT) were detected by corresponding kit, respectively. Results Compared with the control group, cell proliferation was significantly decreased in A/R group (P ＜ 0.05), and increased dose-dependently in Iso pre-treated cells (P ＜ 0.05), thus 3% was selected to be the concentration of Iso pre-treatment. Compared with the control group, the expression of miR-499 was significantly increased in A/R group (P ＜ 0.05), and decreased in 3% Iso treated cells (P ＜ 0.05). Compared with the control group, cell proliferation was significantly decreased (P ＜ 0.05); cell apoptosis was increased (P ＜ 0.05); the expression of pro-apoptotic protein caspase-3, caspase-9 and Bax were increased (P ＜ 0.05), anti-apoptotic protein Bcl-2 was decreased (P ＜ 0.05); the content of LDH, CK and AST were increased in A/R group (P ＜ 0.05). Iso pre-treat inhibited A/R induced H9c2 injury, and the protective effect of Iso was reversed by miR-499 overexpression in damaged cardiocyte. Conclusion Isoflurane attenuates anoxia/reoxygenation-induced cardiocyte injury through inhibiting miR-499 expression.
2018 Vol. 15 (8): 9-14 [Abstract] ( 211 ) HTML (1 KB)  PDF (907 KB)  ( 61 )
15 Effect of polysaccharide of Pholidota chinensis Lindl. on the expression of Th1/Th2 cytokines in mice infected with Mycoplasma pneumoniae
HUANG Meiqing1 ZHU Yanhua2 ZHAO Shiyuan2
Objective To investigate the effects of polysaccharide of Pholidota chinensis Lindl. on the expression of γ- interferon (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-12 and other cytokines in bronchoalveolar lavage fluid (BALF) of model mice of Mycoplasma pneumoniae pneumonia. Methods By matched pair design random method, ninety BALB/c nude mice were randomly divided into three groups: model group, Clarithromycin group and polysaccharide of Pholidota chinensis Lindl. group, with 30 mice in each group. PPLO broth medium was used to cultivate mycoplasma pneumonia, the successfully cultivated Mycoplasma pneumoniae was dropped into the nasal cavity of nude mice 1×107 CCU/mL bacteria solution, each 50 μL (1, 5, 8 d). From the ninth day of modeling, polysaccharide of Pholidota chinensis Lindl. group was started to be use polysaccharide of Pholidota chinensis Lindl., Clarithromycin group was given 15 mg/kg of Clarithromycin by intragastric administration, continued for 6 d, the model group was given same volume of normal saline by gavage. After intervention for 1, 3, 6 d, the mice BALF was collected, SP4 agar plate was used to cultivate BALF Mycoplasma pneumoniae quantificationally, enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-1β, IL-12, IFN-γ, TNF-α. Lung tissue was fixed with neutral formalin to take HE staining. The pathological degree of mice infected by Mycoplasma pneumoniae was observed. Results Compared with model group, the number of bacterial colonies of Mycoplasma pneumoniae cultivated by BALF quantificationally in polysaccharide of Pholidota chinensis Lindl. group was reduced significantly (P ＜ 0.05), the pulmonary inflammation was improved significantly, and the scores of lung pathology and pulmonary parenchyma were decreased significantly (P ＜ 0.05 or P ＜ 0.01). After treatment for 1, 3, 6 d, the levels of IL-1β, IL-12, IFN-γ, TNF-α in polysaccharide of Pholidota chinensis Lindl. group were significantly lower than those of model group, the differences were statistically significant (P ＜ 0.05). Conclusion Polysaccharide of Pholidota chinensis Lindl. can significantly reduce the pulmonary inflammation of mice with Mycoplasma pneumoniae pneumonia, the mechanism may be related to reduce the expression of Th1/Th2 cytokines of IL-1β, IL-12, IFN-γ, TNF-α in model mice with Mycoplasma pneumoniae pneumonia.
[Key words] Pholidota chinensis Lindl.; Polysaccharide; Mycoplasma pneumoniae; Cytokine; Th1/Th2
2018 Vol. 15 (8): 15-19 [Abstract] ( 230 ) HTML (1 KB)  PDF (957 KB)  ( 86 )
20 Autophagy of Cajal mesenchymal cells in the colon Cajal in rats with slow transit constipation and the qualitative analysis of calcium ion level
TIAN Yu MAO Yu′an▲
Objective To investigate the autophagy of Cajal mesenchymal cells in the colon Cajal in rats with slow transit constipation, and qualitatively analyze the calcium ion level. Methods Forty healthy Wistar male rats were divided into control group (n=20, normal rats) and model group (n=20, model rats) by random number table. Compound phenylethylpiperidine was used for preparation on STC rat model, grain number, every grain of waste quality, body quality of rats, the first grain of black were recorded to judge the model successfully established or not. Colon ICCs of rats in two groups were detected bydetection of immunofluorescence assay, and the concentration of calcium ions in ICCs was determined by immunofluorescence assay. Results The control group had good growth during the experiment, and one died in the model group. Daily waste grain number, average body quality after 30 days in model group were less than those in the control group(P < 0.01), the average grain of feces quality was higher than that in the control group (P < 0.05), and the first row of black time was obviously prolonged in the control group (P < 0.05). The rats colon tissue of ICCs in control group were intertwined to form the intensive and precision of the mesh structure, they had obvious cell branch. The number of ICCs in the intestinal tract of the model group was significantly reduced, and the ICCs was thin and the cell shape narrowed. Compared with the control group, the autophagy number of ICCs in the model group increased and showed the apparent autophagy death. In the control group, ICCs were smooth and had multiple directional and irregular cell branches, and intercellular interaction was connected to the network structure. The number of fluorescence spots and fluorescence intensity in the ICCs of STC rats were significantly higher than those in the control group. Conclusion The number of ICCs in STC rats is reduced and autophagy is occurred. In the STC rat model, the free Ca2+ ions in the ICCs cells are elevated, and the increasing of Ca2+ ion may be the cause of the ICCs′ autophagy death.
2018 Vol. 15 (8): 20-23 [Abstract] ( 206 ) HTML (1 KB)  PDF (758 KB)  ( 129 )
24 Research progress of acupuncture and moxibustion in the treatment of pediatric facioplegia
FENG Delin1,2 SUN Zhongren1 FENG Daming1 ZHAO Jingnan1 FEI Shuang1 YIN Hongna1
Acupuncture and moxibustion in the treatment of pediatric facioplegia has definite effect, which has been widely used in clinic. This paper aims to make a brief review of clinical status of acupuncture and moxibustion in the treatment of pediatric facioplegia at present. Through searching related literatures in recent five years on network, and analyzing and comparing the effects of single acupuncture therapy, electroacupuncture, acupuncture combined with moxibustion and Chinese medicine, acupuncture combined with Tuina, and acupuncture combined with electroacupuncture, cupping glasses, acupoint injection and other comprehensive therapies in the treatment of this disease, so as to provide more standardized and effective therapy for acupuncture and moxibustion in the treatment of pediatric facioplegia in clinic.
2018 Vol. 15 (8): 24-27 [Abstract] ( 232 ) HTML (1 KB)  PDF (484 KB)  ( 77 )
28 Effects of PM2.5 on respiratory system and the development of probiotics in respiratory tract
ZHANG Yu XIAO Chunling
When the atmosphere is polluted, the content of various suspended particulates in the atmosphere will increase, especially the fine particulate matter PM2.5. Due to its small particle size and large specific surface area, PM2.5 is easy to adsorb toxic and harmful substances in the air and stays in the air for a long time and has a long transportation distance. Therefore, it occupies an important position in air pollution. PM2.5 easily avoids nasal and bronchial cilia filtration, nasal invasion to the alveoli and deposited in the lung tissue, causing upper respiratory tract infection, and bronchial asthma, pneumonia and other symptoms. Respiratory infections not only affect the healthy development, but also cause a lot of complications, but also serious life-threatening. Classification of respiratory flora, the advantages of bacteria made of probiotics to regulate respiratory microecosystem disorders and other probiotics probiotics research are developing. In recent years, intestinal, vaginal probiotics on human diseases such as microbiological treatment has reached a certain effect, but less application of respiratory probiotics, the finished product treatment needs further research and development.
2018 Vol. 15 (8): 28-31 [Abstract] ( 193 ) HTML (1 KB)  PDF (470 KB)  ( 154 )
32 Research progress of Metformin on metabolic markers in newly diagnosed type 2 diabetic patients
LU Jixuan ZHAN Xiaorong▲
Metformin has been used as a hypoglycemic agent for nearly 60 years. A number of Diabetes Research Institute believes that Metformin can be used as first-line drugs in clinical treatment of type 2 diabetes. Therefore, based on the given lifestyle management, Metformin monotherapy is the most preferred regimen in the treatment of newly diagnosed type 2 diabetes patients. In recent years, Metformin has been paid more and more attention in addition to its hypoglycemic effects. Many studies have shown that Metformin also plays a regulatory role in blood pressure, lipids metabolism, body weight and so on. This article reviews the effects of Metformin on related metabolic parameters in patients with newly diagnosed type 2 diabetes mellitus under the influence of standardized lifestyle（diet and exercise）.
2018 Vol. 15 (8): 32-34,39 [Abstract] ( 195 ) HTML (1 KB)  PDF (740 KB)  ( 70 )
35 Investigation and analysis on the attitude of the elderly in Beijing to the traditional Chinese medicine health care service
YANG Siqiu HOU Shengtian
Objective To investigate and analyze the attitude of the elderly in Beijing towards the health care service of traditional Chinese medicine, in order to provide reference for improving the pension service level. Methods The questionnaire was determined through literature review and expert interviews. From January to March in 2017, 300 elderly people from Huangzhuang Community and Yinghuayuan Community (150 cases in both communities) in Haidian District were surveyed by means of convenience sampling method. SPSS 20.0 was used to describe the survey data and Logistic regression analysis. Results A total of 297 effective questionnaires were collected, and the effective rate was 99.00%. The elderly who had never heard of Beijing traditional Chinese medicine health pension project named “nearby project” accounted for 49.83%, the elderly who heard of but did not quite understand accounted for 41.75%, and only 8.42% of those knew and understood the content. In the survey to discuss whether they were willing to accept the traditional Chinese medicine health care services or not, 45.12% of those said they were willing, 36.36% of those were neutral and 18.52% of those were unwilling. In the survey of whether elderly people would like to spend some time (for one or two months or more) in tourist resorts which were with a pleasant climate and provided Chinese medicine health care services at a reasonable price, 56.57% of those said they were willing, 31.39% of those held neutral opinions and 11.44% of those were unwilling to do so. Logistic regression analysis showed that chronic diseases and different monthly disposable income levels were the main factors affecting the attitude of the elderly towards traditional Chinese medicine(P < 0.05). Conclusion The elderly has a low awareness of the related content of traditional Chinese medicine health pension. Therefore, relevant government departments and social media should step up publicity and interpretation of Chinese medicine health pension policies. Most of the elderly hold a positive attitude towards health care service for traditional Chinese medicine. They should give full play to the advantages of traditional Chinese medicine in the prevention and treatment of chronic disease. Older groups tend to choose home care and nursing home and traditional Chinese medicine travel pension is in the ascendant.
2018 Vol. 15 (8): 35-39 [Abstract] ( 230 ) HTML (1 KB)  PDF (415 KB)  ( 305 )
40 Effect of Amiodarone combined with Yangxin Dingji Capsules on cardiac function and vascular endothelial function in patients with chronic heart failure and ventricular premature beat
TIAN Xiaochao1 HE Weiliang2
Objective To observe the effect of Amiodarone combined with Yangxin Dingji Capsules on cardiac function and vascular endothelial function in patients with chronic heart failure and ventricular premature beat. Methods One hundred and ten cases with chronic heart failure and ventricular premature beat admitted to the Second Hospital of Hebei Medical University from March 2016 to March 2017 were selected and divided into control group and research group by random number table method, with 55 cases in each group. Control group was given conventional Amiodarone treatment. Research group was given Yangxin Dingji Capsules on the basis of control group, the course was eight weeks. The clinical effects, heart function before and after treatment, changes of endothelial function and the conditions of adverse reactions in the two groups were observed. Results The total effective rate of research group was 89.1%, which was significantly higher than that of control group (72.7%) (P ＜ 0.05). After treatment, the levels of left ventricular ejection fraction in the two groups were all significantly increased compared with those before treatment, while the levels of left ventricular end-diastolic diameter, left ventricular end systolic diameter, QT dispersion degree, serum NT-proBNP were significantly lower than those before treatment, and the improvement of cardiac function indices in the research group was obviously better than those in the control group (P ＜ 0.05). After treatment, the levels of NO in the two groups were significantly increased compared with those before treatment, while the levels of ET-1 were significantly lower than those before treatment, and the improvement of vascular endothelial function indices in the research group was significantly better than those in the control group (P ＜ 0.05). Conclusion Amiodarone combined with Yangxin Dingji Capsules in the treatment of patients with chronic heart failure and ventricular premature beat has better clinical effect, which can effectively improve the number of premature beat, ventricular function and vascular endothelial function, and it is worthy of clinical promotion and application.
2018 Vol. 15 (8): 40-43 [Abstract] ( 237 ) HTML (1 KB)  PDF (562 KB)  ( 118 )
44 Value analysis of cardiac failure echocardiography index in evaluation of overall cardiac function of patients with valve disorders
HUANG Lihua1 WANG Yanhua2 GUO Jianqiang3
Objective To analyze the value of cardiac failure echocardiography index to evaluate the overall cardiac function of patients with valve disorders. Methods The clinical data of 90 patients who were diagnosed with valve disorders in Inner Mongolia Maternal And Child Health Care Hospital from April 2014 to June 2017 were retrospectively analyzed, they were selected as the observation group, at the same time, 90 healthy physical examinees were selected as control group, echocardiography indexes were graded, and the scores, grading standard of cardiac function during synchronized, and LgBNP in the two groups were compared, the value of cardiac failure echocardiography index in the evaluation of their overall cardiac function was analyzed. Results The values of HFEI and LgBNP, LAD, LVD in observation group were higher than control group, the differences were statistically significant (P < 0.05). HFEI, LgBNP, LAD and LVD patients with heart function of grade Ⅱ, Ⅲ, Ⅳ were higher than control group, these values increased with the grade of cardiac function, the differences were statistically significant (P < 0.05). Conclusion Cardiac failure echocardiography index is higher value in the evaluation of overall cardiac function of patients, it can clearly show the patients conditions and estimate their overall heart function.
2018 Vol. 15 (8): 44-47 [Abstract] ( 223 ) HTML (1 KB)  PDF (600 KB)  ( 56 )
48 Application of Levosimendan in myocardial ischemia preconditioning in patients with severe valvular heart disease
PENG Xiaopeng1,2 YANG Wencong3,4 SHEN Guogang5 SHAN Fei1 LIN Ming1 KE Lüesen1 Huang Jinsong2▲ ZHOU chengbin2
Objective To study the protective effect of Levosimendan on ischemic preconditioning in patients with severe valvular heart disease, in order to explore the optimal myocardial protection strategy to reduce ischemia-reperfusion injury in cardiac surgery. Methods From January to May in 2017, 40 patients with severe valvular heart disease from Department of Cardiac Surgery in Dongguan Kanghua Hospital were retrospectively andlyzed, and they were divided into two groups according to treatment: Levosimendan ischemic preconditioning group (group A, 20 cases) and untreated Levosimendan group (group B, 20 cases). During the onset of thoracotomy and 10 minutes before the occlusion of the aorta, the total length was about 30 minutes, the peripheral vein of group A was continuously pumped into Levosimendan at a dose of 6-12 μg/kg. the changes of myocardial enzymes (CK-MB), troponin Ⅰ (cTnⅠ) and blood lactic acid （BLA） were measured at 6, 18 h and 48 h after aortic off-clamping in the two groups. LVEF, LVSWI, CI were recorded before and 1, 3, 7 d after operation. The complications of renal injury and arrhythmia and low cardiac output were recorded. Results There were statistically significant differences of CK-MB, cTnⅠ, BLA, LVEF, CI, LVSWI levels between the two groups at different time points after aortic off-clamping (P < 0.05). The incidence of complications in group A was lower than that in group B (P < 0.05). Conclusion Myocardial ischemic preconditioning with Levosimendan in patients with severe valvular heart disease can be used to reduce the degree of myocardial ischemia and reperfusion injury and the complications of perioperative period, which can improve the treatment of patients with cardiac surgery.
2018 Vol. 15 (8): 48-51,59 [Abstract] ( 240 ) HTML (1 KB)  PDF (584 KB)  ( 113 )
52 Effects of adverse emotion on inflammatory reaction and endothelial function in patients with coronary heart disease
ZHANG Xiaolei REN Yanchun ZHAO Yongfeng HU Xitian XU Lei DU Wei
Objective To explore the effect of adverse emotion on inflammatory reaction and endothelial function in patients with coronary heart disease. Methods Ninety-two patients with coronary heart disease combined with adverse emotion in Shijiazhuang First Hospital from April 2016 to April 2017 were collected as case group, in which coronary heart disease with anxiety patients (anxiety group) had 39 cases and coronary heart disease with depression patients (depression group) had 53 cases according to the scores of Zung self-rating anxiety/depression scale (SAS/SDS). At the same time, 50 patients with coronary heart disease without adverse emotion were randomly selected as control group. The serum inflammation factors and endothelium function related factors were detected by the enzyme-linked immunosorbent assay. Results The levels of serum interleukin (IL)-1β, IL-6, IL-6R, IL-18, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) in anxiety group, depression group were higher than those in control group (P ＜ 0.05). The levels of serum endothelin 1 (ET-1), thromboxane B2 (TXB2) in anxiety group, depression group were higher than those in control group, and the levels of NO, 6-keto-prostaglandin F1α (6-keto-PGF1α) in anxiety group, depression group were lower than those in control group, the differences were statistically significant (P ＜ 0.05). The Pearson product moment correlation analysis showed that the scores of SAS, SDS were positively associated with IL-1β, IL-6, IL-6R, IL-18, TNF-α, MMP-9, ET-1, TXB2, which were negatively associated with NO, 6-keto-PGF1α (P ＜ 0.05). Conclusion The patients with coronary heart disease with adverse emotion have inflammatory response activation and endothelial dysfunction with different degrees. Adverse emotion can promote the progress of coronary heart disease by increasing the inflammatory response and endothelial dysfunction.
2018 Vol. 15 (8): 52-55,71 [Abstract] ( 205 ) HTML (1 KB)  PDF (936 KB)  ( 131 )
56 Correlation analysis on the hope level of patients with chronic heart failure and the level of anxiety and depression and coping style
ZHANG Wenshu XIANG Jing HUANG Oujia
Objective To discuss correlation analysis on the hope level of patients with chronic heart failure and the level of anxiety and depression and coping style. Methods From June 2016 to June 2017, 69 patients with chronic heart failure treated in Department of Cardiology， the Sixth People′s Hospital of Chengdu were selected as the research objects. They were investigated by Herth hope scale, anxiety self-assessment scale (SAS), depression self-assessment scale (SDS) and medical coping questionnaire. Results The Hope level score of the chronic heart failure patients was (31.98±0.75), which was at medium level. The level of patient′s hope was negatively correlated with anxiety and depression (P < 0.05), positively correlated with face the coping style（P < 0.05）, and negatively correlated with escape and yield response （P < 0.05）. Conclusion Patients with chronic heart failure have a higher psychological burden. The medical staff should encourage the patients to adopt positive coping style and reasonable intervention according to their specific situation, so as to effectively alleviate the negative emotion and improve the level of hope.
2018 Vol. 15 (8): 56-59 [Abstract] ( 229 ) HTML (1 KB)  PDF (559 KB)  ( 140 )
60 Study of correlation between electrcardiogram QTcd and NIHSS score in early patients with acute cerebrovascular diseases
WANG Xiaoli1 TANG Juan2
Objective To explore the relationship between electrcardiogram QTcd with NIHSS score in patients with acute cerebrovascular diseases. Methods The data of 98 inpatients within 1-12 h after stroke from July 2016 to June 2017 in Department of Neurology of Eastnorth University Affliated Yancheng Hospital were analyzed retrospectively. They were devided into three groups according to NIHSS score: NIHSS score ＜7 scores was mild (32 cases), 7 scores≤NIHSS score ＜15 scores was moderate (39 cases), NIHSS score≥15 scores was severe (27 cases), electrcardiogram QTcd in three groups was compared and analyzed by univariate analysis, χ2 test, multivariate linear regression. Results QTcd parameter of severe patients was compared with mild patients and moderate patients, the differences were statistically significant (P < 0.05), those of mild patients and moderate patients were comared, the differences were not statistically significant (P > 0.05), QTcd was positively correlated with NIHSS score (R = 0.467, P < 0.05). Conclusion Electrocardiogram QTcd is a better indicator to determine the severity in early patients with acute cerebrovascular diseases.
2018 Vol. 15 (8): 60-63 [Abstract] ( 240 ) HTML (1 KB)  PDF (559 KB)  ( 80 )
64 Comparison of the clinical effects of intravascular interventional therapy and simple drug therapy on ischemic cerebrovascular disease
Zuhereayi·yahefu1 DANG Hui1 WANG Chengfeng1 CHEN Wei2
Objective To explore the clinical effect of endovascular treatment and simple drug treatment in the patients with ischemic cerebrovascular disease. Methods One hundred and twenty patients with ICVD in the People′s Hospital of Xinjiang Autonomous Region from January 2013 to January 2016 were randomly drawn, and they were randomly divided into the observation group and the control group, 60 cases in each group. The patients in the observation group were treated with endovascular treatment on the basis of drug treatment, and the control group was only treated with single drugs treatment. One year later, patients of two groups were followed up. The hemodynamic improvement, NIHSS, degree of vascular stenosis and the incidence of adverse reactions were evaluated in two groups, respectively. Results After treatment for one year, the effect of the part of the vertebral artery, basilar artery, internal carotid artery and carotid artery peak systolic velocity in the observation group were better than that in the control group, the differences were statistically significant (P < 0.01). The NIHSS of the observation group was lower than that in the control group, the difference was statistically significant (P < 0.01). The degree of vascular stenosis after treatment was significantly lower than the control group, the difference was statistically significant (P < 0.01). The incidence of adverse reaction in the observation group was also lower than that of the control group, the difference was statistically significant(P < 0.05). Conclusion Endovascular treatment is superior to simple drug therapy in terms of the hemodynamic improvement, NIHSS, vascular stenosis degree and incidence of adverse reactions in the treatment of ICVD, it is worthy of clinical promotion.
2018 Vol. 15 (8): 64-67 [Abstract] ( 193 ) HTML (1 KB)  PDF (502 KB)  ( 42 )
68 Curative efficacy of Nicergoline combined with Shuxuening Injection treating patients with vertigo and influence of TCD parameters
PEI Pei1,2 WEI Mi3▲ CHAO Xiongbing1,2 NAN Maoqiu1,2
Objective To investigate the curative efficacy and changes of transcranial Doppler (TCD) parameters of Nicergoline combinedwith Shuxuening injection in treating patients with vertigo. Methods From January 2016 to June 2017, in Central Hospital of Huangshi City, the data of 116 patients with vertigo were retrospectively analyzed, according to therapeutic schemes, they were divided into control group (52 cases) and observation group (64 cases). On the basis of conventional treatment, the control group was treated with Shuxuening Injection, the observation group was treated with Nicergoline combined with Shuxuening Injection. The curative efficacy, vertigo score and changes of TCD parameters of two groups were compared. Results The total therapeutic efficacy rate of observation group was higher than that in the control group, the difference was statistically significant(P < 0.05). After treatment, vertigo scores in observation group was higher than that in the control group, the difference was statistically significant(P < 0.05). After treatment, the TCD parameters, the observation group had increased blood flow rate of left vertebral artery, right vertebral artery and basilar artery than those in the control group, the differences were statistically significant(P < 0.05). Conclusion Nicergoline combinedn with Shuxuening Injection has well application effect in patients with vertigo. And it can effectively improve clinical symptoms.
2018 Vol. 15 (8): 68-71 [Abstract] ( 226 ) HTML (1 KB)  PDF (529 KB)  ( 87 )
72 Effect of Aspirin and Clopidogrel Bisulfate combined with dietary intervention on cerebral infarction and analysis of clinical influencing factors
GUO Jing
Objective To study the effect of Aspirin and Clopidogrel combined with dietary intervention (diet provided by ANN Montessori nutrition restaurant) factors and clinical effect of the treatment of cerebral infarction effect. Methods A total of 76 patients with cerebral infarction were selected from September 2016 to May 2017 in Tieling Central Hospital of Liaoning Province. The patients were divided into group A and group B according to the digital table method, 36 cases in each group. Group B was treated with Aspirin combined with Clopidogrel Hydrogen Sulfate, group A was treated with dietary intervention on the basis of drug treatment (diet provided by ANN Montessori nutrition restaurant). The treatment effect and adverse reactions (xerostomia, nausea and vomiting, melena, skin ecchymosis, renal damage, etc.), and improve situation of life quality and nutritional status (hemoglobin, albumin) of patients were compared between two groups after treatment. Results The total effective rate, incidence of adverse reaction, nutritional status and quality of life in the group A were significantly better than those in the group B, the difference was statistically significant (P < 0.05 or P < 0.01). Conclusion Aspirin combined with Clopidogrel Hydrogen Sulfate and dietary intervention has more significant effect in the treatment of cerebral infarction, can effectively improve patient outcomes, quality of life and adverse reaction, improve the nutritional status of patients, with clinical application value of this research.

 
2018 Vol. 15 (8): 72-75 [Abstract] ( 216 ) HTML (1 KB)  PDF (500 KB)  ( 82 )
76 Effect of Fasudil Hydrochloride combined with Cinepazide Maleate in the treatment of cerebral vasospasm after aneurismal subarachnoid hemorrhage
LUO Xiaoquan TANG Hui LI Chengke CHEN Bing SHAO Chuan
Objective To evaluate the effect of Fasudil Hydrochloride combined with Cinepazide Maleate in the treatment of cerebral vasospasm(CVS) after aneurismal subarachnoid hemorrhage(aSAH), and to provide evidences for clinical treatment. Methods Seventy-two patients with CVS after aSAH were selected in the Nanchong Central Hospital from January 2016 to March 2017, and divided into control group and observation group by random number table method, with 36 cases in each group. The control group was treated with Fasudil Hydrochloride, and the observation group was treated with Cinepazide Maleate combined with Fasudil Hydrochloride, the levels of IL-6 before and after treatment, CT score, GOS Score, clinical efficacy, adverse events were compared between two groups. Results The levels of IL-6 were decreased significantly after treatment in two groups, and the observation group was significantly lower than the control group, with statistical significance (P ＜ 0.01). The CT score was negatively correlated with GOS score in the control group and observation group(r=-0.635, -0.741, P ＜ 0.05). The total effective rate of observation group(91.67%) was higher than that of control group (72.22%), with statistical significance (P ＜ 0.05). The incidence of adverse events was similar between two groups, with no statistical significance (P > 0.05). Conclusion Fasudil Hydrochloride combined with Cinepazide Maleate has significant therapeutic efficacy on CVS after aSAH, and can effectively inhibit inflammatory factors and reduce adverse events with good safety.
2018 Vol. 15 (8): 76-79 [Abstract] ( 194 ) HTML (1 KB)  PDF (506 KB)  ( 128 )
80 The influence of mother and baby ending in the uterine-incision delivery late broken umbilicus
WU Yan LI Huiying▲ KANG Lan SHI Chun FU Aizhen GUO Renfei ZHANG Hongyu
Objective To study influence of mother and baby ending in the uterine-incision delivery late broken umbilicus. Methods Clinical data of 100 cases of uterine-incision delivery puerpera in Haikou Hospital of the Maternal and Child Health from July to November 2017 were retrospectively analyzed，and they were divided into two groups according to whether delayed cord clamping or not, control group and detection group, 50 cases in each group. The third stage labor, postpartum hemorrhage volume, postpartum 72 h hemoglobin, 24 h capillary hemoglobin after birth, the Apgar score 1 min after birth, the Apgar score 5 min after birth, neonatal bilirubin peak, peak time, complication rate of two groups were detected. Results The third stage labor, postpartum hemorrhage volume of detection group were lower than those of the control group，the postpartum 72 h hemoglobin was higher than that of the control group， the neonatal bilirubin level, neonatal bilirubin peak of detection group were higher than those of the control group, the differences were statistical significance (P < 0.05). The complication rate of two groups had no statistically significant difference (P > 0.05). Conclusion The uterine-incision delivery late broken umbilicus, which can decrease the third stage labor, postpartum hemorrhage volume, improve neonatal mass, acquire good mother and baby ending.
2018 Vol. 15 (8): 80-83 [Abstract] ( 246 ) HTML (1 KB)  PDF (517 KB)  ( 120 )
84 The clinical effect of laparoscopy combined with hysteroscopy plus leuprorel in treatment of endometriosis
FU Xiaowen YAO Liyan WANG Hu XIAO Lizhen
Objective To investigate the clinical effect in patients of endometriosis associated infertility after laparoscopy combined with hysteroscopy plus leuprorel in treatment. Methods From September 2015 to June 2016, 86 cases of endometriosis associated with infertility in the Second Affiliated Hospital of Xinjiang Medical University were selected, according to the different treatments they were divided into two groups: 43 cases in control group were given the treatment of laparoscopy combined with hysteroscopy treatment, 43 cases in the observation group were given the periodic injection of leuprorel on the basis of the control group. Postoperative follow-up of 1 years, the postoperative of pregnancy curative effect, postoperative life quality and estradiol (E2), carbohydrate antigen (CA125) level of patients in the two groups were compared. Results The effective rate of the observation group was higher than that of the control group, and the recurrence rate was lower than that of the control group. the difference was statistically significant (P < 0.05). The pregnancy rate of the observation group was better than that of the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in quality of life score, VAS score, and the level of E2 and CA125 between the two groups before treatment (P > 0.05), and obviously improved after treatment, the differences were statistically significant (P < 0.05). Conclusion Laparoscopy combined with hysteroscopy plus leuprorel treat endometriosis associated with infertility is better than simple surgery, and to a certain extent can reduce the recurrence rate, increase the pregnancy rate, and improve the quality of life of endometriosis.
2018 Vol. 15 (8): 84-87 [Abstract] ( 225 ) HTML (1 KB)  PDF (511 KB)  ( 159 )
88 The effect of adjuvant therapy of Xiaoer Kechuanling Granules combined with Ambroxol Hydrochloride Syrup in the treatment of children with alveobronchiolitis#br#
XIE Jinjin1 XIAO Zhen1 YUAN Hongling2
Objective To approach effect of adjuvant therapy of Xiaoer Kechuanling Granules combined with Ambroxol Hydrochloride Syrup in the treatment of children with alveobronchiolitis. Methods Clinical data of 120 children with alveobronchiolitis in Xiaolan People Hospital in Zhongshan City from January 2015 to January 2017 were analyzed, which was to be divided into two groups by different treatment method, 60 children in the control group were treated only with Ambroxol Hydrochloride Syrup, and 60 children in the observation group were treated with Xiaoer Kechuanling Granules combined with Ambroxol Hydrochloride Syrup. Five days continuous treatment of two group were a treatment course. The clinical symptoms improved time, clinical symptom score before treatment and after treatment, clinical effect of two groups were detected. Results The heat retreat time, coughing stop time, breathing stop time, rale disappearance time of the observation group were shorter than control group, the clinical treatment total effectiveness were higher than control group, the differences were statistical significance (P < 0.05). The cough, expectoration, asthma score of two groups before treatment were no statistically significant difference (P > 0.05). The cough, expectoration, asthma score of the two groups after treatment had no statistically significant difference (P > 0.05). The cough, expectoration, asthma score of control group and observation group after treatment were lower than before treatment, the cough, expectoration, asthma score of observation group after treatment were lower than control group, the differences were statistically significant (P < 0.05). Conclusion The adjuvant therapy clinical symptoms of children with alveobronchiolitis can be improve obviously by the treatment of Xiaoer Kechuanling Granules combined with Ambroxol Hydrochloride Syrup, symptoms disappearance time is short, curative effect is good, it is worthy of clinical application.

 
2018 Vol. 15 (8): 88-91 [Abstract] ( 220 ) HTML (1 KB)  PDF (508 KB)  ( 97 )
92 Expression and clinical significance of p-CHEK2 in invasive breast cancer
HU Xiaohua WANG Ning WANG Yajie▲
Objective To detect protein expression of phosphorylated chekpoint kinase 2 (P-CHEK2Thr68) in invasive breast cancer tissues and reveal the relevant clinical significance. Methods Totally 289 cases of invasive ductal breast cancer tissues were collected from January 2007 to December 2011 in Changhai Hospital Affiliated to Second Military Medical University and Shanghai Huangpu District Central Hospital. The expression of p-CHEK2Thr68 was analyzed by immunohistochemistry, and its relationship with clinicopathological parameters was analyzed. Results The positive expression rate of p-CHEK2Thr68 in breast cancer tissues was 26.0% (75/289), the positive expression rate of the adjacent tissues was 0%, the difference was statistically significant (P ＜ 0.05). P-CHEK2Thr68 expression rate in the non-lymph node metastasis group was higher than the lymph node metastasis group, the ER negative group was higher than the ER positive group, the PR negative group was higher than the PR positive group, the HER2 negative group was higher than the HER2 positive group. P-CHEK2Thr68 expression rate in the tri-negative breast cancer group was higher than non-tri-negative breast cancer group, the difference was statistically significant (P ＜ 0.05). There was no relationships between p-CHEK2Thr68 expression and the age, menstrual status, histological grade, pathological type, tumor size, TNM stage and p53 status. Conclusion Detection of p-CHEK2Thr68 protein expression by immunohistochemistry may help to investigate the biological behavior of invasive breast cancer and to develop individualized treatment strategy．
2018 Vol. 15 (8): 92-95 [Abstract] ( 199 ) HTML (1 KB)  PDF (376 KB)  ( 268 )
96 The effect of complicating deep venous thrombosis on the prognosis of ovarian cancer
HU Yue1 TANG Dong2
Objective To investigate whether the combination of deep venous thrombosis (DVT) in the early diagnosis of ovarian cancer has an effect on its prognosis, and to study whether there was a difference in prognosis between symptomatic DVT and asymptomatic DVT combined with ovarian cancer. Methods Sixty-five patients with ovarian cancer (including primary peritoneal cancer and fallopian tube cancer) hospitalized from January 2008 and December 2015 in Jingzhou Center Hospital were selected and devided into DVT group with 15 cases and no DVT group with 50 cases. The clinical, pathological and survival data of the two groups were compared. Results Median overall-survival of DVT group was significantly shorter than no DVT group (21.7 months vs. 40.0 months) (P = 0.001). There was no statistical significance between DVT group and no DVT group in median progression-free survival (17.2 months vs. 28.7 months) (P = 0.361). Median overall-survival of symptomatic DVT group was significantly shorter than asymptomatic DVT group (21.5 months vs. 37.9 months) (P = 0.010). There were no significant differences between no DVT group and asymptomatic DVT group (P = 0.069), median overall-survival of no DVT group was significantly longer than symptomatic DVT group, the difference was satistically significant (P = 0.008). Conclusion Complicating deep venous thrombosis at time of diagnosis is an adverse prognostic factor in ovarian cancer. It mainly reflected in complicating symptomatic DVT decreasing overall survival of ovarian cancer patients.
2018 Vol. 15 (8): 96-99 [Abstract] ( 195 ) HTML (1 KB)  PDF (445 KB)  ( 84 )
100 Study of plasma non-enzyme antioxidants and thyroid hormone levels in patients with unipolar and bipolar depression
FU Linyan LIU Zhongchun▲ XIANG Dan XIAO Jiawei
Objective To explore the changes of plasma nonenzyme antioxidants and levels of thyroid hormone and their clinical significance in patients with unipolar and bipolar depression. Methods One hundred and one patients with unipolar depression (unipolar depression group), 103 patients with bipolar depression (bipolar depression group) and 85 healthy controls (control group) were enrolled in the Renmin Hospital of Wuhan University from February 2016 to December 2016. According to the questionnaire and Hamilton depression scale, patients of the unipolar depression group and bipolar depression group were divided into negative and non-negative groups respectively. Serum levels of uric acid, albumin, total bilirubin, free triiodothyronine (FT3), free thyroxine (FT4) and hemosiderin (TSH) of each group were measured and compared. Results The levels of uric acid in the bipolar depression group were significantly higher than that in the unipolar depression and control group, the level of uric acid in the unipolar depression group was lower than that of the control group, the levels of albumin and total bilirubin in the unipolar depression group and bipolar depression group were significantly lower than control group, and the both unipolar and bipolar depression group. The level of FT3 in the unipolar depression group was significantly lower than that in the bipolar depression group and the control group, there was no statistically significant difference in FT4, TSH among the three groups (P > 0.05). The level of FT3 in the non-negative groups was significantly lower than that in the negative group, the difference was statistically significant (P < 0.05). Conclusion Serum uric acid, albumin, total bilirubin and thyroid hormone levels are altered in patients with unipolar and bipolar depression, and the level of serum uric acid can be used as an auxiliary reference index for the differential diagnosis between unipolar and bipolar depression.
2018 Vol. 15 (8): 100-103 [Abstract] ( 197 ) HTML (1 KB)  PDF (611 KB)  ( 137 )
104 Study on prognostic predictive value of tumor volume in patients with stage Ⅰ non-small cell lung cancer
WEI Zhenqiang XIE Haojun SU Xiaodong
Objective To investigate the value of tumor volume in predicting the prognosis of patients with stage I non-small cell lung cancer (NSCLC) after radical surgery. Methods Two hundred and Three patients with radical surgery and postoperative pathology was stage Ⅰ NSCLC from January 2007 to December 2010 in Sun Yat-sen University Cancer Center was retrospectively reviewed. The overall survival and disease-free survival in patients were compared between tumor volume ＜8.35 cm3 and tumor volume ≥8.35 cm3 through COX multivariate analysis. Results There were significant differences between the two groups in terms of characteristics of sex, smoking history, histological type, pathological stage, degree of differentiation and bronchial wall invasion (P ＜ 0.05). In multivariate analysis, tumor volume was an independent predictor for the prognosis of stage I NSCLC (HR=2.972, 95% CI：1.566-5.637, P ＜ 0.01). Survival analysis showed that the 5 year overall survival rates (OS) was 88.5% and 74% in tumor volume ＜8.35 cm3 group and tumor volume ≥8.35 cm3 (P ＜ 0.01) respectively. Tumor volume <8.35 cm3 indicated a longer progress-free survival (P ＜ 0.01). Conclusion Tumor volume is an independent predictor of OS and PFS in stage I NSCLC. Preoperative CT measurement of tumor volume helps to assess the prognosis of patients.
2018 Vol. 15 (8): 104-107,123 [Abstract] ( 253 ) HTML (1 KB)  PDF (769 KB)  ( 201 )
108 Risk factors and control measures of multidrug resistance in stroke - related pneumonia
LUO Ya1,2 LI Zhongqiu1 ZENG Meifang2
Objective To understand the risk factors associated with multiple drug-resistant infections in stroke-associated pneumonia and to take relevant control measures based on the relevant risks. Methods A total of 540 acute stroke patients hospitalized from August 2013 to September 2014 in Hunan Normal University Affiliated Xiangnan Hospital were selected. Morning sputum was collected from patients with stroke-associated pneumonia for multi-drug resistance. Univariate and multivariate logistic analyzes were used to analyze the risk factors that led to hospital-acquired nosocomial infections. Results Among the 540 patients with acute stroke, 89 cases were associated with pneu monia and the infection rate was 16.46%. A total of 167 pathogenic bacteria were isolated from 89 stroke-associated pneumonia (SAP) patients, of which 123 were multi-drug resistant bacteria, and the gram-negative bacteria accounting for 68.29% with pseudomonas aeruginosa, klebsiella pneumoniae and acinetobacter baumannii. Gram-positive bacteria accounting for 31.71% with staphylococcus haemolyticus and staphylococcus aureus. The results showed that patients aged≥ 50 years, hospital stay≥ 30 d, with diabetes, disturbance of consciousness, hypoproteinemia, mechanical ventilation and indwelling nasogastric tube and other related invasive procedures were independent risk factors for SAP multidrug resistance (P ＜ 0.05). Conclusion SAP incidence is clinically relatively high, and the incidence of pneumonia associated with the distribution of pathogens are mainly multi-resistant bacteria. Therefore, it is of great significance to use targeted preventive measures to understand the distribution of pathogenic bacteria and the risk factors that cause the multiple drug resistance of SAP.
2018 Vol. 15 (8): 108-111,133 [Abstract] ( 202 ) HTML (1 KB)  PDF (840 KB)  ( 105 )
112 Study of multimodal imaging technology for pathogenesis of plantar fascia inflammatory calcaneodynia
LI Ping WANG Donghai GUO Fangfang WU Danni
Objective To study the correlation between the elasticity of plantar fascia and arch deformation, in order to dicuss pathogenesis of plantar fascia inflammatory calcaneodynia, by high-frequency ultrasound, ultrasonic elastography CT three dimensional reconstruction. Methods From December 2015 to December 2016, in Second Affiliated Hospital of Inner Mongolia Medical University, 88 plantar fasciitis patients (single foot) were selected as observation group, at the same time, 48 healthy volunteers were selected as control group. Two groups were given X-ray lateral and CT three dimensional reconstruction, in order to get the anatomic site and form of plantar fascia, measure thickness and elasticity of plantar fascia, the arch angles while weight-bearing and non-weight-bearing were respectively measured by referring to osseous marks, the thickness, elasticity and regularity of the variation of arch angles of plantar fascia different sites of two groups were compared. Results The thickness of plantar fascia initial segment (PF1) in observation group was more than control group, the difference was statistically significant (P < 0.05). The elasticity of PF1 from the observation group was less than control group, and elasticity of PF1 from was less than plantar fascia contral from (PF2) in observation group, the differences were statistically significant (P < 0.05). The variation of arch angels of observation and control groups from weight-bearing to non-weight-bearing in two groups were compared, the difference was statistically significant (P < 0.05). Conclusion The thickness of plantar fascia can be measured by elastography technique, the elasticity of plantar fascia influences the deformability of arch angel, the recession of the deformability of arch angel is one of the major causes of calcaneodynia due to plantar fasciitis.
2018 Vol. 15 (8): 112-115 [Abstract] ( 196 ) HTML (1 KB)  PDF (793 KB)  ( 58 )
116 Effect comparison between hydrostatic reduction under B-ultrasound and air perfusion under X-ray treating children intussusception
PAN Zhubin GAO Qun HUANG He LU Xianying
Objective To discuss the clinical effect of air perfusion under X-ray and hydrostatic reduction under B-ultrasound scanner treating children intussusception. Methods From January 2015 to May 2017, in Anhui Provincial Children Hospital, the clinical data of 635 children with acute intussusceptions were retrospectively analyzed. According to the therapeutic method, they were divided into two groups, experiment group (262 cases) with air perfusion, control group (373 cases) with hydrostatic enemamonitored by B-ultrasound. The treatment effects, restoration time, CRP, cover time of intestinal function and so on of two groups were compared. Results The successful restoration rate of two groups was compared, the differences were not statistically significant (P > 0.05). The restoration time of experiment group was less than control group, the difference was statistically significant (P < 0.05). The recurernce rate, complications, CRP, cover time of restoration function in control group were better than experiment group, the differences were statistically significant (P < 0.05). Conclusion The clinical efficacy is accurate and the advantages are obvious with hydrostatic reduction of intussusception under B-ultrasound, and it can be used as the preferred method for the intussusception.
2018 Vol. 15 (8): 116-119 [Abstract] ( 212 ) HTML (1 KB)  PDF (653 KB)  ( 123 )
120 Clinical effects of percutaneous transluminal angioplasty guided by B-ultrasound in treatment of stenosis of autogenous arteriovenous fistula
ZHANG Shengze ZHOU Li′na DONG Shaoshao ZHU Yuan WANG Mudan
Objective To observe the clinical efficacy of percutaneous transluminal angioplasty (PTA) in treatment of patients with autogenous arteriovenous fistula (AVF) under the guidance of B-ultrasound. Methods Thirty cases of AVF stenosis patients with maintenance hemodialysis treated in Wenzhou People′s Hospital from January 2016 to December 2017 were enrolled in the study. All patients were given the percutaneous transluminal angioplasty (PTA) under B-ultrasound. The fistula stenosis vascular diameter (D), cross-sectional area (S), stenosis peak velocity (Vmax), brachial artery resistance index (RI), operation success rate, the postoperative diameter stenosis rate and complications were compared before operation, immediately after operation, and at 1, 3 d after operation. Results Compared with before operation, the D and S of the fistula stenosed vessels were significantly increased (P < 0.05), while the Vmax and brachial artery RI were significantly decreased (P < 0.05), and the D and S of the fistula stenosed vessels at 1, 3 d after operation were significantly higher than those immediately after operation (P < 0.05), while the stenosis site Vmax and brachial artery RI were significantly lower than those immediately after operation (P < 0.05), and there was no significant difference in the D, S, Vmax and brachial artery RI between at 1 d after operation and at 3 d after operation (P > 0.05). The operation success rate was 100.00%, and the total incidence of postoperative complications was 6.67%. The complications were completely subsided after treatment. Conclusion PTA under B-ultrasound for AVF has the features of simple operation and high safety, and it can significantly improve the blood flow velocity and lumen diameter of stenosis site, and enhance the success rate of surgery, therefore it is worthy of clinical promotion.
2018 Vol. 15 (8): 120-123 [Abstract] ( 231 ) HTML (1 KB)  PDF (652 KB)  ( 132 )
124 Analysis of the best application time of Tirofiban on patients with acute ST segment elevation myocardial infarction undergoing PCI
ZHANG Nan
Objective To explore the effect of Tirofiban application at different time on the patients with acute ST segment elevation myocardial infarction (STEMI) in PCI. Methods From February 2013 to May 2016, in Department of Emergency, Beijing Shijingshan Hospital, 200 patients with acute STEMI and accepted PCI treatment were selected, according the application time of Tirofiban, they were divided into the group A (95 cases, given Tirofiban after entering the resuscitation room immediately), group B (56 cases, given Tirofiban application at the end of the emergency after coronary angiography,) control group (49 cases, without Tirofiban). The therapeutic effect and safety the three groups were evaluated and compared. Results There were no significant differences in the aspects of TIMI flow grade and myocardial perfusion grade among the three groups before the PCI (P > 0.05). After PCI, there were no significant differences in the aspect of TIMI flow grade among the three groups (P > 0.05), but group A, group B were better than control group in TIMI myocardial perfusion grade， the differences were statistically significant (P < 0.05), there was no significant difference between group A and group B (P > 0.05). Before PCI, CK-MB, cTNT in three groups were copmpared, the differences were not statistically significant (P > 0.05). After PCI, CK-MB, cTNT in group A, group B were lower than control group, the differences were statistically significant (P < 0.05). Before PCI, NT-proBNP and cardiac function in three groups were compared, the differences were not statistically significant (P > 0.05). After PIC, NT-proBNP, LVEDD and LVESD in group A, group B were lower than control group, LVEF was higher than control group, the differences were not statistically significant (P > 0.05). Three patients were followed up for 6 months, occurrence rate of hemorrhage and thrombocytopenia, MACE of three groups were compared, the differences were not statistically significant (P > 0.05). Conclusion Application of tirofiban in STEMI patients with emergency PCI treatment can effectively improve blood flow and myocardial perfusion, decrease myocardial damage, and the earlier application, the effect is more significant, the adverse reactions were tolerable, it is worthy of promotion.
2018 Vol. 15 (8): 124-128 [Abstract] ( 214 ) HTML (1 KB)  PDF (660 KB)  ( 95 )
129 Evaluation for quality of serious adverse intrauterine device event case reports and analysis of related factors
YANG Yuehua1,2 ZHOU Jian1,2 SHI Wenhui1,2 ZHANG Min1,2 XU Haoqin1,2▲ HANG Guifang3▲
Objective To evaluate the quality of the reports of serious adverse intrauterine device event, and seek the influencing factors in order to further improve the quality of reports. Methods According to the quality assessment standards made by Center for Drug Revaluation of CFDA, 263 case reports collected during the period from July 2016 to June 2017 were evaluated, and the scores of each report were input to a database built by Epidata 3.1 and analyzed by SPSS 19.0 software. Results The quality of the reports was generally good. Missing or filling in a mistake of those items such as time limit, impact on the patient, product number or batch number, production date caused subtraction mainly. The monitoring site category, medical data supported, adverse event were all have significant effects on the quality of reports (P ＜ 0.01). Conclusion Governors and rapporteurs should pay more attention to the problems identified in the evaluation and further improve the quality of reports pertinently.
2018 Vol. 15 (8): 129-133 [Abstract] ( 253 ) HTML (1 KB)  PDF (380 KB)  ( 109 )
134 The application effect of carnation care service in patients of cardiological department with temporary pacemaker implantation
WEN Shumin
Objective To explore the application effect of carnation care service in patients of cardiological department with temporary pacemaker implantation. Methods From June 2015 to May 2016, 183 cases of hospitalized patients with surgical implantation of pacemaker in Department of Cardiology, the First People′s Hospital of Neijiang City were selected as the research subjects and divided into the observation group (96 cases) and the control group (87 cases) by random number table. The observation group was given carnation care service and the control group was given traditional surgical nursing. The related complications between the two groups were compared. Results The incidences of catheter displacement, puncture site hemorrhage and venous thrombosis in the observation group were significantly lower than those of control group, with statistically significant differences (all P ＜ 0.05), but there was no statistically significant difference in the incidence of abnormal electrical activity (P ＞ 0.05). The total incidence of complications in the observation group was significantly lower than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion The carnation care service in cardiological department can reduce the incidences of complications in surgical patients with temporary pacemaker implantation. It is worthy of clinical promotion and application.
2018 Vol. 15 (8): 134-137 [Abstract] ( 218 ) HTML (1 KB)  PDF (578 KB)  ( 115 )
138 The effect of experiential teaching in the humanistic training of new nurses
WANG Ruifang1 YANG Xiaoying2 GUO Jia1 SHI Qin1 ZHANG Xiaoqing1 WANG Xueli1 YU Mei2▲
Objective To evaluate the effect of experiential teaching in the humanistic training of new nurses. Methods A total of 90 new nurses recruited in the Army General Hospital from July to August 2015 and July to August 2016 were selected as the research subjects by cluster sampling and divided into the control group and the intervention group by the different training time, with 45 cases in each group. The control group applied the routine humanistic care training and the intervention group applied the experiential training to the new nurses. The care ability and the satisfaction of the medical staffs and the patients were compared between the two groups. Results The scores of understanding, encouragement, patience and the total score in the intervention group were all higher than those of control group, with statistically significant differences (P ＜ 0.05). The satisfaction of the medical staffs and the patients in the intervention group was higher than that of control group, with statistically significant difference (P ＜ 0.05). Conclusion The application of experiential teaching in the humanistic care training of new nurses can improve the ability of humanistic care and the satisfaction of medical staffs and the patients. It is worthy of promotion and application.
2018 Vol. 15 (8): 138-141 [Abstract] ( 243 ) HTML (1 KB)  PDF (627 KB)  ( 108 )
142 The effect of quality control circle on improving the standard rate of safe transformation of newborns
ZHOU Yuan1 NIE Xunmei1 FU Hong1 LI Shurong2 HUANG Changhong3
Objective To investigate the efficacy of quality control circle(QCC) on improving the standard rate of safe transformation of newborns. Methods QCC team was founded, and the theme of "improving the standard rate of safe transrormation of newborns" was determined. The standard rate of safe transformation of newborns from September to October 2016 in Chongqing Jiangjin Central Hospital was observed, and was compared with the standard rate of safe transformation of newborns before the implementation of QCC from November to December 2015. The scores of QCC members′ self-evaluation before and after QCC were compared. Results The standard rate of safe transformation of newborns after the implementation of the QCC was 94.44% and it was higher than that of before implementation (75.31%), with statiscally singificant difference (χ2 = 23.11, P ＜ 0.05). The target achievement rate of quality control circle was 127.19%. After the implementation of QCC, QCC members′ enthusiasm, communication skills and quality management tools application had been greatly improved. Conclusion The standard rate of safe transformation of newborns can be improved by the implementation of QCC, which ensured the safe transformation of newborns effectively. It is worthy of clinical promotion and application.
2018 Vol. 15 (8): 142-145,153 [Abstract] ( 224 ) HTML (1 KB)  PDF (913 KB)  ( 105 )
146 The application effects of individualized nursing intervention based on the infrared spectrophotometry analysis results in the prevention of urinary stones recurrence
LIU Ying1 XU Hui1 WANG Zhiyong1 LIU Xiaowei1 YANG Dehui1 LIU Baoxing2
Objective To explore the effects of individualized nursing intervention on patients with urinary tract stones based on the analysis results of infrared spectrophotometry. Methods From December 2013 to October 2017, 280 patients with urinary stones diagnosed and treated in the Department of Urology, the Affiliated Hospital of Chengde Medical College were selected as the research subjects and divided into the control group and the observation group according to the results of the analysis of the stones components, with 140 cases in each group. The control group was given routine nursing care, while the observation group was given corresponding individualized nursing intervention on the results of the analysis of the composition of infrared spectrum stones on the bases of routine nursing care. The recurrence rate, the recurrence time of urinary tract stones and nursing satisfaction were compared between the two groups. Results The recurrence rate in the control group (32.14%) was higher than that of observation group (11.43%), with statistically significant difference (P ＜ 0.05). The recurrence time of urinary tract stones in the observation group was longer than that of control group, with statistically significant difference (P ＜ 0.05). The nursing satisfaction in the control group (77.14%) was lower than that of observation group (97.86%), with statistically significant difference (P ＜ 0.05). Conclusion According to the results of infrared spectrum analysis, the implementation of individualized nursing intervention targeted for urinary tract stones patients not only can reduce the urinary tract stones recurrence rate, but also can improve the patients' satisfaction with nursing care. It is worthy of clinical application and popularization.
2018 Vol. 15 (8): 146-149 [Abstract] ( 224 ) HTML (1 KB)  PDF (625 KB)  ( 93 )
150 Clinical study of continuous nursing intervention in patients with extensive burn in the neck and its effect on the body immunity
LI Mei1 HU Kaixiu2▲ PENG Jianmei3
Objective To explore the clinical effect of continuous nursing intervention in patients with extensive burn in the neck and its effect on the body immunity. Methods The clinical data of 100 patients with extensive neck burn treated in Ganzi Tibetan Autonomous Prefecture People′s Hospital were selected from March 2015 to April 2017 and divided into the control group and the observation group according to different nursing methods, with 50 cases in each group. The control group was given the routine nursing method and the observation group was given the continuous nursing intervention. The levels of T lymphocyte subsets in peripheral blood were measured by flow cytometry and compared between the two groups. The nursing efficacy and the effect on the body immunity were compared between the two groups. Results After nursing, the incidence of compliance in the observation group (96.00%) was higher than that of control group (84.00%), with statistically significant difference (P ＜ 0.05). Before nursing, there were no significant differences in CD4+,CD8+ and CD4+/CD8+ between the two groups (P ＞ 0.05); after nursing, CD4+, CD8+ and CD4+/CD8+ in the observation group were all higher than those of control group, with statistically significant differences (P ＜ 0.05). Conclusion The effect of continuous nursing intervention on the patients with extensive burn in the neck is ideal, which can improve the patient′s compliance and promote the body immunity. It is worthy of popularization and application.
2018 Vol. 15 (8): 150-153 [Abstract] ( 220 ) HTML (1 KB)  PDF (585 KB)  ( 326 )
154 Effect of PDCA cycle combined with whole-course health education on self-care ability and disease cognition level of elderly patients with hypertension
LIU Xinyan1 CHEN Shasha2 ZHAO Ting3▲
Objecitve To explore the effect of PDCA cycle combined with whole-course health education on self-care ability and disease cognition level of elderly patients with hypertension. Methods From May 2015 to June 2016, 104 hypertensive patients over 65 years in Qingdao Municipal Hospital were selected and divided into the combination group and the conventional group by random number table, with 52 cases in each group. The conventional group received conventional health education and the combination group received PDCA cycle combined with whole-course health education. The two groups were both intervined for 10 months. The blood pressure level, self-care ability and disease cognition level in the two groups before and after intervention were compared. Results There were no statistically significant differences in the blood pressure level, self-care ability and disease cognition level before intervention between the two groups (P ＞ 0.05). After intervention, the systolic and diastolic blood pressure in two groups were all lower than those of before intervention, and the indicators above in the combination group decreased much more remarkably, with statistically significant differences (P ＜ 0.05). The scores of self-care ability and disease cognition level in the two groups were all higher than those of before intervention, and the scores above in the combination group increased much more remarkably, with statistically significant differences (all P ＜ 0.05). Conclusion The PDCA cycle combined with whole-course health education can effectively improve the self-care ability and disease cognition level of elderly patients with hypertension. It is of great significance to control the level of blood pressure. It is worthy of clinical promotion and application.
2018 Vol. 15 (8): 154-157,170 [Abstract] ( 262 ) HTML (1 KB)  PDF (1054 KB)  ( 144 )
158 Research about the development and strategy of assistive products for person with disability in institutional care of the elderly in China which is based on PEST model
BAI Yang OUYANG Zhaolian DU Ranran CHI Hui
This article aimed at describing the current situation of the needs of assistive products for person with disability in institutional care of the elderly, and explaining current situation of the development of it from political, economic, social and technological aspects. Our country should further strengthen the combination of assistive products for person with disability and aging industry. Differentiated management of pension institutions should be promoted and the long-term care insurance system should be improved. Meanwhile, the“medicine-care-rehabilitation-research-application” institutions for mid/high-spending groups should be established on the basis of the need of older citizens. The nursing staff training system should be improved, and the combination of internet +, pension institutions and assistive products for person with disability should be strengthen. This article is expected to provide reference for the further development of assistive products for person with disability in institutional care of the elderly.
2018 Vol. 15 (8): 158-162 [Abstract] ( 266 ) HTML (1 KB)  PDF (669 KB)  ( 173 )
163 Common problems and quality control of immunohistochemical technique in pathological tissue
MAO Yulei CHEN Boqing
Objective To investigate the common problems of immunohistochemistry in skin pathology and the influence of quality control on the quality of immunohistochemical preparation. Methods Twenty male BALB/c rats aged from 6 to 8 weeks old were divided into observation group and the control group by random number table, with 10 rats in each group. The observation group was used by the making slices method after quality control and adopted the complete immunohistochemical procedures and the control group with the traditional production method and the simple immunohistochemical procedures. The making slices quality and immunohistochemistry of two groups were compared. Results The making slices quality in observation group was better than control group, the difference was statistically significant (P < 0.05). The quality of the immunohistochemical pictures in observation group was significantly better than the control group. Conclusion Immunohistochemistry can affect the results of immunohistochemistry in any aspect. Quality control can enhance the comprehensive effect of immunohistochemistry, which is helpful to further improve the clinical diagnosis of the disease and it is worth promoting.
2018 Vol. 15 (8): 163-165,178 [Abstract] ( 210 ) HTML (1 KB)  PDF (623 KB)  ( 208 )
166 The influence of remote management of lifestyle on the college obese girls′ body composition and physical health in the E-era
XU Huaping QIU Hui WANG Dongying
Objective To observe the influence of the remote management of lifestyle on college obese girls′ body composition and physical health, which provide a basis for the college students to develop a healthy lifestyle and improve the physical health of college students. Methods From march to June 2016, 39 obese girls in Shanghai University of Traditional Chinese Medicine were selected randomly. The body composition and physical fitness of all subjects were examined and the Traditional Chinese Medicine constitution type was tested. According to the results, the exercise prescription were made, and lifestyle of 12 weeks were intervened comprehensively (fitness club activities, routine exercise supervision, health education, health preserving). The body composition, physical fitness and Traditional Chinese Medicine constitution type of subjects were compared before and after intervention. Results The weight, body mass index (BMI) and body fat rate of subjects after intervention were lower than those before intervention (P < 0.01). The waistline of subjects after intervention was lower than before intervention (P < 0.01). The close their eyes to stand on one foot time, lung capacity, reaction time of subjects after intervention were all better than those before intervention (P < 0.05). After comprehensive intervention, the biased constitution was decreased, and the proportions of peace constitution were increased. Conclusion Adopt comprehensive intervention of lifestyle to colleges obese girls, such as fitness club, routine exercise supervision, health education and health preserving, can effectively improve obese girls′ body composition and physical quality, adjust the biased constitution to a certain extent, help to prevent the spreading of obesity, improve the physical and mental health of obese college students.
2018 Vol. 15 (8): 166-170 [Abstract] ( 196 ) HTML (1 KB)  PDF (666 KB)  ( 147 )
171 Clinical efficacy and cytology of pulsed high volume blood filtration in patients with septic shock
CAI Rong XU Hongming
Objective To investigate the clinical effect and cytology of pulsed high volume blood filtration in septic shock patients. Methods From June 2015 to November 2016, 88 patients with septic shock in ICU of Yuyao People’s Hospital were selected. According to the different treatment methods, they were divided into control group and observation group, with 44 cases in each group. The control group was treated with continuous blood purification, and the observation group was treated with pulsed high-volume blood filtration 8-16. The levels of lactate, mean arterial pressure (MAP), acute physiology and chronic health evaluation(APACHEⅡ) score, C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor (TNF-α), thrombomodulin (sTM), von Willebrand factor (vWF), endothelin-1 (ET-1), E-selectin (CD62E), soluble cell adhesion factor -1 (sICAM-1) before and after treatment for 3 days between two groups were compared. Results After 3 days of treatment, the levels of lactate, APACHEⅡ score, CRP, IL-6, TNF-α, sTM, vWF, ET-1, CD62E, sICAM-1 were lower than those before treatment (P < 0.01), the MAP higher than before treatment (P < 0.01). The levels of lactate, APACHEⅡ score, IL-6, TNF-α, vWF, ET-1, CD62E, sICAM-1 in the observation group were all lower than those of control group (P < 0.01), the MAP in the observation group was higher than control group (P < 0.01). Conclusion Pulsed high volume blood filtration has a positive clinical effect on patients with septic shock, which can improve the vital signs of patients and reduce the levels of TNF-α, IL-6, CRP, vWF, ET-1, CD62E and sICAM- 1 expression, suggesting that patients with vascular endothelial cells have a regulatory role.
2018 Vol. 15 (8): 171-174 [Abstract] ( 209 ) HTML (1 KB)  PDF (613 KB)  ( 173 )
175 The survey of food contamination status caused by food-borne pathogens from 2010 to 2016 in Daxing, Beijing
JIA Kun YU Huanling
Objective To investigate the occurrence of food-borne pathogenic bacteria in retail foods in Daxing area and provide scientific basis for monitoring, prevention and control of food-borne diseases. Methods Studied on 1272 samples collected in Daxing District area from 2010 to 2016. In accordance with the standard operating procedure from the "national food-borne pathogens monitoring manual", and six food-borne pathogenic bacteria (bacillus cereus, salmonella, staphylococcus aureus, listeria monocytogenes, vibrio parahaemolyticus and vibrio vulnificus) were tested and analyzed. Results From 2010 to 2016, 82 strains of food-borne pathogenic bacteria were detected for 7 years in a row. The detection rate of contaminated samples was 6.45%. In 82 strains of pathogenic bacteria detection, the listeria monocytogenes, salmonella, staphylococcus aureus, vibrio parahaemolyticus, vibrio vulnificus and bacillus cereus, salmonella detection rate than respectively 42.68%, 18.29%, 9.76%, 17.07%, 4.88% and 7.32%. Conclusion In this study sample, the primary contaminant is listeria monocytogenes, mainly contaminated food is raw meat. The food safety supervision department should increase the supervision of food safety and further prevent and control the occurrence of food-borne diseases.
2018 Vol. 15 (8): 175-178 [Abstract] ( 207 ) HTML (1 KB)  PDF (613 KB)  ( 74 )
179 Establishment of management adverse events reporting system
PAN Huixian JIANG Hong LI Zhuoting HU Yajie CAI Zhiling ZHAO Dongyan
In order to improve the management level of modern hospitals, hospitals should encourage clinical and management personnel to pay attention to management problems, find management defects and eliminate adverse consequences caused by management factors or management behaviors in daily work. Combining with the inherent requirements of the modern hospital management system, this paper innovatively proposes the definition and classification of adverse events in management and the organization and responsibilities of the management of adverse events. The working mechanism and process are preliminarily designed. Finally, this paper discusses the attention problems in the management of the reporting of adverse events through actual case analysis.
2018 Vol. 15 (8): 179-180 [Abstract] ( 205 ) HTML (1 KB)  PDF (850 KB)  ( 234 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech