单、双相抑郁患者血浆非酶类抗氧化物和甲状腺激素水平研究

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Abstract Objective To explore the changes of plasma nonenzyme antioxidants and levels of thyroid hormone and their clinical significance in patients with unipolar and bipolar depression. Methods One hundred and one patients with unipolar depression (unipolar depression group), 103 patients with bipolar depression (bipolar depression group) and 85 healthy controls (control group) were enrolled in the Renmin Hospital of Wuhan University from February 2016 to December 2016. According to the questionnaire and Hamilton depression scale, patients of the unipolar depression group and bipolar depression group were divided into negative and non-negative groups respectively. Serum levels of uric acid, albumin, total bilirubin, free triiodothyronine (FT3), free thyroxine (FT4) and hemosiderin (TSH) of each group were measured and compared. Results The levels of uric acid in the bipolar depression group were significantly higher than that in the unipolar depression and control group, the level of uric acid in the unipolar depression group was lower than that of the control group, the levels of albumin and total bilirubin in the unipolar depression group and bipolar depression group were significantly lower than control group, and the both unipolar and bipolar depression group. The level of FT3 in the unipolar depression group was significantly lower than that in the bipolar depression group and the control group, there was no statistically significant difference in FT4, TSH among the three groups (P > 0.05). The level of FT3 in the non-negative groups was significantly lower than that in the negative group, the difference was statistically significant (P < 0.05). Conclusion Serum uric acid, albumin, total bilirubin and thyroid hormone levels are altered in patients with unipolar and bipolar depression, and the level of serum uric acid can be used as an auxiliary reference index for the differential diagnosis between unipolar and bipolar depression.

Key words： Uric acid Thyroid hormone Serum lipids Albumin Depression

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	FU Linyan LIU Zhongchun▲ XIANG Dan XIAO Jiawei

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FU Linyan LIU Zhongchun▲ XIANG Dan XIAO Jiawei. Study of plasma non-enzyme antioxidants and thyroid hormone levels in patients with unipolar and bipolar depression[J]. 中国医药导报, 2018, 15(8): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I8/100

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