肿瘤体积对Ⅰ期非小细胞肺癌术后患者预后预测价值的研究

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Abstract Objective To investigate the value of tumor volume in predicting the prognosis of patients with stage I non-small cell lung cancer (NSCLC) after radical surgery. Methods Two hundred and Three patients with radical surgery and postoperative pathology was stage Ⅰ NSCLC from January 2007 to December 2010 in Sun Yat-sen University Cancer Center was retrospectively reviewed. The overall survival and disease-free survival in patients were compared between tumor volume ＜8.35 cm3 and tumor volume ≥8.35 cm3 through COX multivariate analysis. Results There were significant differences between the two groups in terms of characteristics of sex, smoking history, histological type, pathological stage, degree of differentiation and bronchial wall invasion (P ＜ 0.05). In multivariate analysis, tumor volume was an independent predictor for the prognosis of stage I NSCLC (HR=2.972, 95% CI：1.566-5.637, P ＜ 0.01). Survival analysis showed that the 5 year overall survival rates (OS) was 88.5% and 74% in tumor volume ＜8.35 cm3 group and tumor volume ≥8.35 cm3 (P ＜ 0.01) respectively. Tumor volume <8.35 cm3 indicated a longer progress-free survival (P ＜ 0.01). Conclusion Tumor volume is an independent predictor of OS and PFS in stage I NSCLC. Preoperative CT measurement of tumor volume helps to assess the prognosis of patients.

Key words： Tumor volume StageⅠnon-small cell lung cancer Prognosis

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	WEI Zhenqiang XIE Haojun SU Xiaodong

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WEI Zhenqiang XIE Haojun SU Xiaodong. Study on prognostic predictive value of tumor volume in patients with stage Ⅰ non-small cell lung cancer[J]. 中国医药导报, 2018, 15(8): 104-107,123.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I8/104

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