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| Effect of Fasudil Hydrochloride combined with Cinepazide Maleate in the treatment of cerebral vasospasm after aneurismal subarachnoid hemorrhage |
| LUO Xiaoquan TANG Hui LI Chengke CHEN Bing SHAO Chuan |
| Department of Neurosurgery, Nanchong Central Hospital, Sichuan Province, Nanchong 637000, China |
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Abstract Objective To evaluate the effect of Fasudil Hydrochloride combined with Cinepazide Maleate in the treatment of cerebral vasospasm(CVS) after aneurismal subarachnoid hemorrhage(aSAH), and to provide evidences for clinical treatment. Methods Seventy-two patients with CVS after aSAH were selected in the Nanchong Central Hospital from January 2016 to March 2017, and divided into control group and observation group by random number table method, with 36 cases in each group. The control group was treated with Fasudil Hydrochloride, and the observation group was treated with Cinepazide Maleate combined with Fasudil Hydrochloride, the levels of IL-6 before and after treatment, CT score, GOS Score, clinical efficacy, adverse events were compared between two groups. Results The levels of IL-6 were decreased significantly after treatment in two groups, and the observation group was significantly lower than the control group, with statistical significance (P ＜ 0.01). The CT score was negatively correlated with GOS score in the control group and observation group(r=-0.635, -0.741, P ＜ 0.05). The total effective rate of observation group(91.67%) was higher than that of control group (72.22%), with statistical significance (P ＜ 0.05). The incidence of adverse events was similar between two groups, with no statistical significance (P > 0.05). Conclusion Fasudil Hydrochloride combined with Cinepazide Maleate has significant therapeutic efficacy on CVS after aSAH, and can effectively inhibit inflammatory factors and reduce adverse events with good safety.
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