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| Effect of Amiodarone combined with Yangxin Dingji Capsules on cardiac function and vascular endothelial function in patients with chronic heart failure and ventricular premature beat |
| TIAN Xiaochao1 HE Weiliang2 |
1.Department of Cardiology, the Second Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050000, China;
2.Department of Neurology, Hebei People's Hospital, Hebei Province, Shijiazhuang 050000, China |
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Abstract Objective To observe the effect of Amiodarone combined with Yangxin Dingji Capsules on cardiac function and vascular endothelial function in patients with chronic heart failure and ventricular premature beat. Methods One hundred and ten cases with chronic heart failure and ventricular premature beat admitted to the Second Hospital of Hebei Medical University from March 2016 to March 2017 were selected and divided into control group and research group by random number table method, with 55 cases in each group. Control group was given conventional Amiodarone treatment. Research group was given Yangxin Dingji Capsules on the basis of control group, the course was eight weeks. The clinical effects, heart function before and after treatment, changes of endothelial function and the conditions of adverse reactions in the two groups were observed. Results The total effective rate of research group was 89.1%, which was significantly higher than that of control group (72.7%) (P ＜ 0.05). After treatment, the levels of left ventricular ejection fraction in the two groups were all significantly increased compared with those before treatment, while the levels of left ventricular end-diastolic diameter, left ventricular end systolic diameter, QT dispersion degree, serum NT-proBNP were significantly lower than those before treatment, and the improvement of cardiac function indices in the research group was obviously better than those in the control group (P ＜ 0.05). After treatment, the levels of NO in the two groups were significantly increased compared with those before treatment, while the levels of ET-1 were significantly lower than those before treatment, and the improvement of vascular endothelial function indices in the research group was significantly better than those in the control group (P ＜ 0.05). Conclusion Amiodarone combined with Yangxin Dingji Capsules in the treatment of patients with chronic heart failure and ventricular premature beat has better clinical effect, which can effectively improve the number of premature beat, ventricular function and vascular endothelial function, and it is worthy of clinical promotion and application.
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