|
|
|
| Curative efficacy of Nicergoline combined with Shuxuening Injection treating patients with vertigo and influence of TCD parameters |
| PEI Pei1,2 WEI Mi3▲ CHAO Xiongbing1,2 NAN Maoqiu1,2 |
1.Department of Neurology, Central Hospital of Huangshi City, Hubei Province, Huangshi 435000, China;
2.Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Hubei Province, Huangshi 435000, China;
3. Department Function, Huangshi Maternal and Child Health-Care Hospital, Hubei Province, Huangshi 435000, China |
|
|
|
Abstract Objective To investigate the curative efficacy and changes of transcranial Doppler (TCD) parameters of Nicergoline combinedwith Shuxuening injection in treating patients with vertigo. Methods From January 2016 to June 2017, in Central Hospital of Huangshi City, the data of 116 patients with vertigo were retrospectively analyzed, according to therapeutic schemes, they were divided into control group (52 cases) and observation group (64 cases). On the basis of conventional treatment, the control group was treated with Shuxuening Injection, the observation group was treated with Nicergoline combined with Shuxuening Injection. The curative efficacy, vertigo score and changes of TCD parameters of two groups were compared. Results The total therapeutic efficacy rate of observation group was higher than that in the control group, the difference was statistically significant(P < 0.05). After treatment, vertigo scores in observation group was higher than that in the control group, the difference was statistically significant(P < 0.05). After treatment, the TCD parameters, the observation group had increased blood flow rate of left vertebral artery, right vertebral artery and basilar artery than those in the control group, the differences were statistically significant(P < 0.05). Conclusion Nicergoline combinedn with Shuxuening Injection has well application effect in patients with vertigo. And it can effectively improve clinical symptoms.
|
|
|
|
|
|
[1] Kunel'skaya NL，Baybakova EV，Guseva AL，et al. The importance of vestibular evoked myogenic potentials for the assessment of the otolith function in the patients presenting with benign paroxysmal positional vertigo[J]. Vestn Otorinolaringol，2017，82（4）：5-8.
[2] 廖正寿，姚群英，林建园，等.马来酸桂哌齐特联合盐酸异丙嗪治疗急诊眩晕症疗效观察[J].山东医药，2014，54（21）：68-69.
[3] Beyazal Celiker F，Dursun E，Celiker M，et al. Evaluation of vascular variations at cerebellopontine angle by 3D T2WI magnetic-resonance imaging in patients with vertigo [J]. J Vestib Res，2017，27（2-3）：147-153.
[4] 陈星，欧阳天斌，朱华麟，等.盐酸培他啶联合盐酸异丙嗪注射液治疗眩晕症患者的疗效[J].中国生化药物杂志，2016，36（2）：79-81.
[5] 邵义泽，王会民，赵文莉，等.中西医结合优化治疗眩晕症的临床观察[J].中草药，2014，45（7）：982-984.
[6] Seo T，Shiraishi K，Kobayashi T，et al. Residual dizziness after successful treatment of idiopathic benign paroxysmal positional vertigo originates from persistent utricular dysfunction[J]. Acta Otolaryngol，2017，137（11）：1149-1152.
[7] 刘文娜，张允岭，王乐，等.眩晕的证候诊断与疗效评价初探[J].中药新药与临床药理，2010，21（1）：83-86.
[8] 王凌芬，焦红蕾，苏敬文，等.益心舒胶囊合用脉血康胶囊治疗老年糖尿病眩晕症40例[J].中西医结合心脑血管病杂志，2015，13（15）：1771-1773.
[9] Chang MY，Shin JH，Oh KH，et al. Clinical implication of cervical vestibular evoked myogenic potentials in benign paroxysmal positional vertigo[J]. Clin Neurophysiol，2017， 128（2）：351-356.
[10] 韩振强.天麻素联合舒血宁治疗眩晕症[J].长春中医药大学学报，2014，30（1）：103-104.
[11] Okazaki S，Imai T，Higashi-Shingai K，et al. Office-based differential diagnosis of transient and persistent geotropic positional nystagmus in patients with horizontal canal type of benign paroxysmal positional vertigo[J]. Acta Otolaryngol，2017，137（3）：265-269.
[12] 张广斌，肖小春.天麻葛根汤治疗颈椎病性眩晕症38例[J].中国药业，2014，23（22）：96-97，98.
[13] Califano L. “A safe-repositioning maneuver for the management of benign paroxysmal positional vertigo：Gans vs. Epley maneuver; a randomized comparative clinical trial”：something else about Gans maneuver [J]. Eur Arch Otorhinolaryngol，2017 ，274（8）：3259-3260.
[14] 黄斯倩，颜小均.舒血宁注射液联合前列地尔注射液治疗糖尿病周围血管病变的效果[J].中国医药导报，2016，13（15）：158-161.
[15] 任宏伟，茅利玉，钱华，等.舒血宁注射液联合小牛血去蛋白提取物对脑梗死恢复期患者血清IGF-1、IL-1及ICAM-1水平影响研究[J].中国生化药物杂志，2015，35（11）：133-135.
[16] 申丹丹.舒血宁注射液辅助治疗脑梗死的临床疗效及护理对策[J].中国生化药物杂志，2017，37（9）：84-85，88.
[17] Nishida A，Iwata H，Kudo Y，et al. Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes[J]. Biol Pharm Bull，2004，27（6）：817-820.
[18] 陈国军，张燕柳，张惠莉，等.尼麦角林联合高压氧治疗血管性认知功能障碍疗效观察[J].中华老年医学杂志，2015，34（4）：359-361.
[19] Caraci F，Chisari M，Frasca G，et al. Nicergoline，a drug used for age-dependent cognitive impairment，protects cultured neurons against beta-amyloid toxicity[J]. Brain Res，2005，1047（1）：30-7.
[20] 贾玉娟，侯玉立，侯敬天，等.尼麦角林治疗慢性脑血管功能不全的系统评价[J].中华老年医学杂志，2015，34（10）：1141-1144.
[21] 甘立森，陈北森.眩晕症的病因分析与治疗进展[J].光明中医，2014，29（2）：418-420.
[22] Zalewski P，Konopka W，Pietkiewicz P. Analysis of vascular vertigo due to cervical spondylosis and vertebro-basilar insufficiency based on sex and age in clinical materials[J]. Otolaryngol Pol，2004，58（1）：97-100.
[23] 李同凯，杨光福.中西医结合治疗后循环缺血性眩晕症现状与进展[J].河北医学，2011，17（12）：1687-1689. |
|
|
|
