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2023 Vol. 20, No. 11 Published: 2023-04-15

	4	Expert consensus on the clinical diagnosis and treatment of ductoscopy (2022)

		DOI: 10.20047/j.issn1673-7210.2023.11.01
		Ductoscopy is the top test method for patients with nipple discharge. It has the characteristics of convenient operation, small trauma, direct vision in the duct, real-time imaging recording, and has become the main diagnostic and adjuvant therapy tools for breast intraductal lesions. However, there is no clinical consensus on the application, diagnosis, and treatment of ductoscopy, which limits its clinical popularization. Breast Disease Branch of Chinese Association for Research and Advancement of Chinese Medicine reached consensus on indications, contraindications, equipment and personnel configuration, preparation before examination, operation technique and considerations, manifestations under ductoscopy, endoscopic adjuvant therapy, and complications and management, etc. That is to provide a clinical reference for the optimization and standardization of the technical operation specification of ductoscopy. Looking forward to improving the level of ductoscopy treatment in China.
		2023 Vol. 20 (11): 4-8 [Abstract] ( 22 ) HTML (1 KB) PDF (1079 KB) ( 86 )

	9	Study on traditional Chinese medicine syndrome characteristics and traditional Chinese medicine medication law of primary Sjogren’s syndrome based on data mining
		WEI Naxin SUN Hongyan
		DOI: 10.20047/j.issn1673-7210.2023.11.02
		Objective To excavate and analyze the literature on the treatment of primary Sjogren’s syndrome (pSS) by traditional Chinese medicine, and to summarize the syndrome characteristics and medication rules of pSS. Methods The literature related to traditional Chinese medicine treatment of pSS from January 2011 to December 2021 was retrieved from CNKI and Wanfang data, and the traditional Chinese medicine syndrome elements, tongue and pulse, prescriptions, and so on were counted successively by Excel. SPSS 25.0, SPSS Modeler and Cytoscape were used for cluster analysis, association analysis, and complex network analysis respectively. Results A total of 145 literatures were included, and the syndrome types were mainly Qi and Yin deficiency. The tongue pulse was mainly fine pulse, red tongue, number pulse, and moss stripping. In addition to the self-designed formula, Yiwei decoction was often used; there were 197 kinds of traditional Chinese medicines involved, mainly ophiopogon ophiopogon, licorice and radix rehmanniae. The medicinal tastes were mainly sweet, bitter and pungent, while the medicinal properties were mainly cold and flat, which were mainly attributed to the three classics of lung, liver, and stomach. Seven core drug groups were obtained by systematic cluster analysis. A total of 14 groups of association rules were obtained by association analysis. Complex network analysis showed that the core drug combinations were ophiopogon ophiopogon, Radix rehmanniae, Radix ginseng and licorice. Conclusion pSS syndrome type is based on “Qi and Yin deficiency, stasis, toxicity, phlegm, and dampness as the standard”, and the treatment is based on “tonifying liver and kidney, tonifying lung and tonifying stomach”, supplemented by activating blood circulation and removing blood stasis, clearing heat and cooling blood, regulating qi, and so on.
		2023 Vol. 20 (11): 9-13 [Abstract] ( 22 ) HTML (1 KB) PDF (1611 KB) ( 44 )

	14	Effect of PRL-3 gene on sensitivity of Temozolomide in glioblastoma
		YANG Yuqi1 WANG Yingwen2 JIA Bo3 GUO Qingdong3▲
		DOI: 10.20047/j.issn1673-7210.2023.11.03
		Objective To investigate the expression of PRL-3 gene in glioblastoma and its effect on the sensitivity of Temozolomide in glioblastoma. Methods The expression of PRL-3 gene in glioblastoma and normal tissues was analyzed by the TCGA database, and postoperative tumor tissues of 15 patients with glioblastoma diagnosed and treated by the First Affiliated Hospital of Air Force Military Medical University (ten primary cases, five recurrent cases) were further selected, the expression of PRL-3 positive cells in primary and recurrent glioblastoma tissues was detected by immunohistochemistry. Human glioblastoma LN229 and temozolomid-resistant LN229/TMZ-R cell lines were selected to detect PRL-3 mRNA and protein expression by qRT-PCR and Western blot. LN229, SHG44, and U87 cell lines which was insensitive to Temozolomide were selected, and normal group, control group, no-load liposome group, PRL-3 overexpression group, and PRL-3 downregulation group were set, respectively. The PRL-3 mRNA expression of control group, no-load liposome group, PRL-3 overexpression group, and PRL-3 downregulation group were compared to verify the success of PRL-3 overexpression and downregulation. Then the normal group, PRL-3 overexpression group, and PRL-3 downregulation group were treated with Temozolomide(LN229 and SHG44 cell lines were treated with 100 μmol/L Temozolomide, U87 cell line were treated with 500 μmol/L Temozolomide), while the normal group was not treated, the cell activity was evaluated by CCK-8 method after 72 h. Results Database analysis showed that PRL-3 expression in primary glioblastoma was higher than that in normal tissues and increased with the increase of tumor grade (P＜0.05). The immunohistochemical scores of PRL-3 positive cells in recurrent glioblastoma tissues was higher than that in primary glioblastoma tissues (P＜0.05). The mRNA expression of PRL-3 in LN229/TMZ-R cell line was higher than that in LN229 cell line (P＜0.05), and PRL-3 protein was highly expressed in LN229/TMZ-R cell line. The PRL-3 mRNA in PRL-3 overexpression group was higher than that in normal group, and the PRL-3 downregulation group was lower than that in normal group (P＜0.05). In LN229, SHG44, and U87 cell lines, the cell activity of control group was lower than that of normal group, the cell activity of PRL-3 overexpression group was higher than that of control group, and the cell activity of PRL-3 downregulation group was lower than that of control group (P＜0.05). Conclusion The low expression of PRL-3 gene can enhance the sensitivity of glioblastoma to Temozolomide treatment, which is expected to be a beneficial target for synergistic chemotherapy with Temozolomide.
		2023 Vol. 20 (11): 14-18 [Abstract] ( 23 ) HTML (1 KB) PDF (1998 KB) ( 39 )

	19	Expression and clinical significance of CC chemokine receptor 4 in colorectal cancer
		ZHOU Yuan SHEN Xuning CHEN Zhiheng LI Jin
		DOI: 10.20047/j.issn1673-7210.2023.11.04
		Objective To investigate the expression and clinical significance of CC chemokine receptor 4 (CCR4) in colorectal cancer. Methods Wax samples of cancer tissue and para-cancer tissue were collected from 80 patients with colorectal cancer who were pathologically diagnosed in the First Hospital of Jiaxing, Zhejiang Province from January 2016 to June 2017. The expression level of CCR4 in colorectal cancer tissues and adjacent tissues were determined by immunohistochemistry, and the relationship with the clinicopathological features and prognosis of colorectal cancer were analyzed. Results There was significant difference in the positive rate of CCR4 between colorectal cancer tissues and adjacent tissues (P＜0.05). There was significant difference in the positive rate of CCR4 in colorectal cancer tissues with different depth of invasion, vascular/nerve infiltration, and lymph node metastasis (P＜0.05). The overall survival time and the disease-free survival time of CCR4-positive expression patients were shorter than those of negative expression patients (P＜0.05). Conclusion The increased expression of CCR4 in colorectal cancer tissues is related to its occurrence and development, and may be used as a potential prognostic indicator for colorectal cancer.
		2023 Vol. 20 (11): 19-22,36 [Abstract] ( 16 ) HTML (1 KB) PDF (1450 KB) ( 42 )

	23	Analysis of the acupoint selection rules of acupuncture and moxibustion for tumor treatment in Chinese Medical Code from pre-Qin to late Qing Dynasty based on data mining
		WEI Zheng1 TIAN Hao2 XU Guixing2 LIANG Fanrong2
		DOI: 10.20047/j.issn1673-7210.2023.11.05
		Objective To analyze the acupoint selection rules of acupuncture and moxibustion treatment for tumor diseases from pre-Qin period to late Qing Dynasty in Chinese Medical Code based on data mining technology. Methods Ancient documents on acupuncture and moxibustion treatment of tumor diseases from pre-Qin period to late Qing Dynasty were searched in the 5th edition of Chinese Medical Code. Screening was performed according to inclusion and exclusion criteria, and treatment prescriptions were extracted. IBM SPSS Statistics 26 was used for statistical analysis of acupoints in the prescription and distribution of meridians. IBM SPSS Modeler 18.0 software was used for cluster analysis and association rule analysis. Results A total of 496 acupuncture and moxibustion prescriptions were extracted, including 167 acupoints, and the total frequency of acupoints was 939. The top five acupoints on the frequency of use were qìhǎi, zhōngwǎn, zhōngjí, píshù, and sānjiāoshù. The top five meridians in the ranking frequency were conception vessel, bladder meridian of foot-taiyang, and stomach meridian of foot-yangming. Correlation analysis obtained eight groups of strong correlation acupoints compatibility, among which “zhāngmén-zhōngwǎn” ranked first. Ten effective cluster groups were obtained by using icicle diagram for clustering analysis. Conclusion In the treatment of tumor by acupuncture and moxibustion, it is suggested to take conception vessel point to cultivate and supplement yuan qi as the main, and at the same time to supplement the dialectical point selection.
		2023 Vol. 20 (11): 23-26 [Abstract] ( 15 ) HTML (1 KB) PDF (1015 KB) ( 110 )

	27	Pathological study of gastrointestinal complications in scleroderma model mice induced by different concentrations of Bleomycin
		HUANG Yi1 LI Yongqiang1 ZHANG Yilin1 LYU Junying2
		DOI: 10.20047/j.issn1673-7210.2023.11.06
		Objective To investigate the pathological study of gastrointestinal complications induced by different concentrations of Bleomycin (BLM) in scleroderma model mice. Methods A total of 18 female BALB/c mice were divided into control group, model group 1, and model group 2 by random number table method, with six mice in each group. The control group were injected with 0.1 ml phosphate buffered saline subcutaneously on the back; the model group 1 were injected 0.1 ml 200 μg/ml BLM; the model group 2 were injected 0.1 ml 500 μg/ml BLM. Three groups were continuously injected for 28 days, once per day. On the 28th day, the mice were sacrificed, and the pathological features of the skin in the injected area, the esophagus, and the small intestinal tissue were observed. The serum levels of D-lactic acid (D-LA) and diamine oxidase (DAO) were gavaged. Results The dermis thickness in model group 1 and model group 2 were thicker than those in the control group (P＜0.05), and the dermis thickness of model group 2 was thicker than that in model group 1(P＜0.05). The collagen volume scores of the esophageal and small intestinal in model group 1 and model group 2 were higher than those in the control group (P＜0.05), and the esophageal collagen volume scores in model group 2 were higher than those in model group 1(P＜0.05). The serum levels of D-LA and DAO in model group 1 and model group 2 were higher than those in the control group (P＜0.05), while the serum levels of D-LA and DAO in model group 2 were higher than those in model group 1 (P＜0.05). Conclusion Both modeling methods can show inflammatory infiltration and fibrotic changes in skin and intestine, and the 500 μg/ml BLM-induced scleroderma model has more obvious changes in skin and intestinal pathological.
		2023 Vol. 20 (11): 27-30 [Abstract] ( 26 ) HTML (1 KB) PDF (1714 KB) ( 95 )

	31	Literature visualization analysis of acute lung injury based on CiteSpace and VOSviewer bibliometric method
		HE Yanling1 MAO Xiangzheng1 LI Sha2 WANG Bin1 LIU Jiping1 CHAO Xu3 WANG Guoquan1
		DOI: 10.20047/j.issn1673-7210.2023.11.07
		Objective To analyze the visual atlas of acute lung injury by bibliometric method. Methods Literature on acute lung injury was searched in Chinese National Knowledge Infrastructure and PubMed databases from January 2002 to December 2021. CiteSpace and VOSviewer were used to visualize the authors, research units, countries, and keywords of the included documents. Results A total of 10 376 and 20 335 literatures were included in Chinese National Knowledge Infrastructure and PubMed databases respectively, and there were obvious differences in the published papers between them. Analysis about the authors of the papers indicated that the teams of Qian Guisheng, Qiu Haibo, Duan Yunyu, Michael Matthay, Paolo Pelosi, and Danile Traber published more papers; the major countries were the United States, China, and Germany; key words comparative analysis found that Chinese National Knowledge Infrastructure research were mainly focused on inflammation, oxidative stress, signaling pathway, disease infection source, animal model, pulmonary surfactant, mechanical ventilation, etc.; the PubMed database were mainly focused on the incidence population, animal disease models, disease infection sources, hemodynamics, acute lung injury diagnosis and treatment statistics, inflammatory factors in experimental mechanisms, peroxide research, and immune regulation. Conclusion Acute lung injury has been a hot topic at home and abroad, and there is a significant difference in the comparison between Chinese National Knowledge Infrastructure and PubMed studies. At present, most of its studies are on the experimental basis and clinical application related to blood indicators, inflammatory factors, immune balance and mechanical ventilation, and there are more studies on it in developed countries.
		2023 Vol. 20 (11): 31-36 [Abstract] ( 20 ) HTML (1 KB) PDF (5626 KB) ( 88 )

	37	Research progress in pulmonary sarcoidosis models
		HU Zhuannan ZHANG Shaoyan HUANG Xing LI Cui WU Xianwei ZHOU Wei QIU Lei LU Zhenhui
		DOI: 10.20047/j.issn1673-7210.2023.11.08
		Sarcoidosis is a granulomatous inflammatory disease of unknown etiology that can involve multiple organs throughout the body, with the lungs being the most common. Its pathogenesis is related to excessive immune, microbial infection, environmental, and genetic factors, and there is still no comprehensive or widely accepted disease model. The studies for sarcoidosis have used Propionibacterium acnes, Mycobacterium tuberculosis, and related derivatives, nanoparticles, ApoE and Tsc2 knockout mice to establish animal models. Cellular models use peripheral blood monocytes or macrophages to replicate the immune environment of the disease, while mathematical models based on clinical data provide more options for basic research of sarcoidosis. This paper summarizes the advantages and limitations of pulmonary sarcoidosis models, and then develops appropriate models to explore the pathogenesis of pulmonary sarcoidosis, find new targets for disease treatment and drug evaluation.
		2023 Vol. 20 (11): 37-40,44 [Abstract] ( 14 ) HTML (1 KB) PDF (529 KB) ( 119 )

	41	Research progress of apoptosis in Sjogren’s syndrome
		LI Qiwei TIAN Miaoyuan LIANG Hua LI Ji
		DOI: 10.20047/j.issn1673-7210.2023.11.09
		Sjögren’s syndrome is a connective tissue lesion caused by the activation of the autoimmune system. The etiology is unknown, and the control of this disease remains a major challenge. Apoptosis plays a key role in maintaining immune microenvironment homeostasis and it is an important pathogenesis of Sjögren’s syndrome. This paper summarizes the process of apoptosis in Sjögren’s syndrome, discusses the specific mechanism of apoptosis from the exocrine gland cells and lymphocytes, and introduces the existing intervention methods, which will inspire future research directions.
		2023 Vol. 20 (11): 41-44 [Abstract] ( 22 ) HTML (1 KB) PDF (449 KB) ( 54 )

	45	Research progress of combined application of negative pressure drainage after total knee replacement
		DING Chuan1 TANG Hongjuan2 MA Xianming3 ZHOU Yi3 XIANG Bingyan3 DENG Jiang3▲
		DOI: 10.20047/j.issn1673-7210.2023.11.10
		Total knee arthroplasty (TKA) is currently the gold standard for the treatment of end-stage knee osteoarthritis. And after decades of development and innovation of TKA, the combined application of closed negative pressure drainage（CSD） technology has been widely used as a conventional drainage solution after TKA. It is believed to significantly reduce the formation and relief of hematoma after TKA. Pain, accelerate wound healing, promote the rehabilitation of affected limbs, and promote the implementation of the concept of rapid postoperative recovery plans, but at the same time it may increase the blood loss after TKA, which will lead to an increase in the patient’s blood transfusion rate and longer hospital stays. There is still controversy about the combined application of CSD technology after TKA. This article will review the combined application methods and research progress of CSD technology after TKA. The main methods include CSD technology combined with clamp technology, normal pressure to negative pressure program, negative pressure wound therapy, controller pressure adjustment program, CSD technology combined with autologous blood transfusion and intra-articular tranexamic acid injection, etc., in order to provide reference for clinicians.
		2023 Vol. 20 (11): 45-48 [Abstract] ( 21 ) HTML (1 KB) PDF (440 KB) ( 83 )

	49	Research progress of impulse oscillometry in the diagnosis and treatment of bronchial asthma in children
		JIN Lingling1 YANG Lei2
		DOI: 10.20047/j.issn1673-7210.2023.11.11
		Bronchial asthma is a common chronic inflammatory disease of airway in children’s respiratory system, and its incidence is increasing year by year. Therefore, early diagnosis and control of disease progression are particularly important. At present, the diagnosis of bronchial asthma in children is mainly based on symptoms, signs, and pulmonary function examination. However, the routine pulmonary function examination requires strenuous breathing, and its detection results are not reliable for young children. Therefore, a new detection method is needed for young children. The emergence of impulse oscillometry (IOS) makes up for the deficiencies of conventional lung function detection methods. As a method to evaluate lung function, it is simple to operate and easy to complete, providing effective information for the accurate diagnosis and treatment of bronchial asthma in children. The clinical application of IOS is not only reflected in the diagnosis of bronchial asthma, but also has great value in the assessment of airway reactivity, efficacy monitoring, and prognosis assessment. This paper reviews the basic principles of IOS and its clinical application in children with bronchial asthma, in order to provide new ideas for the diagnosis and treatment of this disease.
		2023 Vol. 20 (11): 49-52,56 [Abstract] ( 25 ) HTML (1 KB) PDF (653 KB) ( 42 )

	53	Research progress in the prevention and treatment of glucocorticoid-induced osteoporosis by traditional Chinese medicine
		ZHANG Xinxin1 YANG Fengwen2 LI Liqiang2
		DOI: 10.20047/j.issn1673-7210.2023.11.12
		Glucocorticoids are commonly used in the treatment of nephrotic syndrome, but long-term and massive use of glucocorticoids will lead to a variety of complications, among which osteoporosis is one of the most common complications. How to take effective prevention and treatment measures to avoid or reduce hormone-induced osteoporosis is very critical. According to traditional Chinese medicine, kidney dominating bone and bone produces bone marrow, the deficiency of kidney essence, and yin-yang disharmony of kidney are the key factors of the disease. Traditional Chinese medicine can treat glucocorticoid-induced osteoporosis based on syndrome differentiation by nourishing yin and clearing heat, warmly invigorating spleen and kidney, and coordinating yin and yang. In recent years, many clinical studies have shown that traditional Chinese medicine has achieved remarkable effects in the prevention and treatment of glucocorticoid-induced osteoporosis, and some progress has been made in the experimental research to explore its related mechanism, but it is still in the stage of exploration. This article reviews the progress in the prevention and treatment of glucocorticoid-induced osteoporosis by traditional Chinese medicine in recent years, in order to provide scientific theoretical basis for clinical treatment.
		2023 Vol. 20 (11): 53-56 [Abstract] ( 18 ) HTML (1 KB) PDF (581 KB) ( 55 )

	57	Research progress on the relationship between trimethylamine-N-oxide and chronic kidney disease and its complications
		YANG Xiangyan1 TIAN Maolu2 ZHA Yan1
		DOI: 10.20047/j.issn1673-7210.2023.11.13
		With the deepening of the research on the “gut-kidney axis”, the relationship between trimethylamine-N-oxide, the metabolic compound of intestinal flora, and chronic kidney disease has become a research hotspot for scholars at home and abroad, providing a new target for the prevention and treatment of chronic kidney disease. This paper reviews the relationship between trimethylamine-N-oxide and chronic kidney disease in recent years, and the promotion of cardiovascular disease, cognitive impairment, peritonitis, cerebrovascular disease, and other complications through inducing oxidative stress and inflammatory response, in order to provide reference ideas for the clinical prevention and treatment of chronic kidney disease and its related complications.
		2023 Vol. 20 (11): 57-60 [Abstract] ( 14 ) HTML (1 KB) PDF (478 KB) ( 26 )

	61	Analysis of situation and influencing factors of health literacy and health education needs in cancer patients undergoing chemotherapy
		SUN Xin1 TENG Fei2 YAN Jincao3 TIAN Gu2 ZHU Yu4 YANG Min5 TIAN Yu3
		DOI: 10.20047/j.issn1673-7210.2023.11.14
		Objective To understand the current situation and factors influencing the health literacy and health education needs of oncology chemotherapy patients. Methods From May to June 2021, 530 patients who were hospitalized for chemotherapy in Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College were selected as the study subjects, and the general information questionnaire, health literacy scale for patients with chronic diseases and health education needs of chemotherapy patients scale were used to investigate the current situation and influencing factors of their health literacy and health education needs. Results Chemotherapy patients had higher health literacy scores and lower health education needs scores. Comparison of health literacy scores of chemotherapy patients by gender, age, marital status, highest education level, disease site, combined other chronic disease, primary family caregiver, smoke, drink alcohol, economic source, medical payment status, and disease burden, with statistically significant differences (P＜0.05); the differences were statistically significant when comparing the health education needs scores of chemotherapy patients by gender, age, highest education level, disease site, combined other chronic disease and number of chemotherapy sessions (P＜0.05). Health literacy and its internal dimensions were negatively correlated with health education needs and its internal dimensions, except for information acquisition ability and self-esteem health education needs, and communication and interaction ability and cognitive, physical, and safety education needs (P＜0.05). Multiple linear regression analysis showed that patient age (X1), highest education level (X2), disease burden (X3), and financial source as family support (X4) were influential factors for health literacy of chemotherapy patients (P＜0.05); combination of three or more other chronic diseases (X1), medical payment status as foreign new cooperative medical system (X2), and number of chemotherapy sessions (X3) were influential factors for health education needs of chemotherapy patients (P＜0.05). The regression equation was as follows: Y1=85.922-2.817 X1+7.239 X2-3.268 X3-3.260 X4; Y2=35.631+11.520 X1- 5.544 X2-4.424 X3. Conclusion Chemotherapy patients have different degrees of health literacy and health education needs. Age, highest education level, disease burden and economic source as family support are the influencing factors of chemotherapy patients’ health literacy, combination of three of more other chronic diseases, medical payment status as new cooperative medical system and chemotherapy for three times are the influencing factors of chemotherapy patients’ health education needs. A targeted, interdisciplinary and all-round health education and health management model should be established to help improve their health literacy and compliance with treatment, thus improving their quality of life.
		2023 Vol. 20 (11): 61-66,75 [Abstract] ( 18 ) HTML (1 KB) PDF (827 KB) ( 186 )

	67	Investigation on family life quality of children with bronchiolitis obliterans and analysis of influencing factors
		ZHONG Lina1 LIU Huayan1▲ CHEN Yanping1 DING Fen1 AN Zhaohui1 YI Shuyu1 WU Bichen1 TAN Xiaoyan2
		DOI: 10.20047/j.issn1673-7210.2023.11.15
		Objective To investigate the family life quality of children with bronchiolitis obliterans (BO), to discuss and analyze its influencing factors. Methods A total of 212 children with BO and their parents who were treated in the Department of Respiratory Hunan Children’s Hospital from January 2018 to December 2021 were selected as research objects by convenience sampling method. General situation questionnaire, family quality of life scale and parents coping style scale were used to investigate. Single factor analysis, Pearson correlation analysis and multiple linear regression analysis were used to explore the influencing factors. Results The score of family life quality of BO children was 171.00 (166.00, 181.00) points, which was generally low. There were statistically significant differences in family life quality scores of BO children with different ages, whether they were the only child, course of disease, parents’ education and occupational status, monthly family income, time of first medication, and family residence (P＜0.05). Multiple linear regression analysis showed that family residence, parents’ education level, disease course, and parents’ coping style were influencing factors of family life quality of BO children (P＜0.05). Conclusion The family life quality of children with BO needs to be further improved. Medical staff should pay attention to families of children with BO in rural areas, parents with low education level and the short course of disease, popularize health knowledge of BO disease and psychological counseling for them, and provide guidance for family cooperation. At the same time, it is suggested that the government actively carry out family mutual assistance services and social welfare assistance services, and provide health education, temporary family care and financial support for BO families, so as to further improve the quality of life of families with BO children.
		2023 Vol. 20 (11): 67-70 [Abstract] ( 24 ) HTML (1 KB) PDF (613 KB) ( 99 )

	71	Meta-analysis of the efficacy and safety of Argatroban combined with Urinary Kallidinogenase in the treatment of acute cerebral infarction
		WANG Qingli LI Zhe MA Zhongliang LIAN Shuai XUE Mengzhou
		DOI: 10.20047/j.issn1673-7210.2023.11.16
		Objective To systematically review the efficacy and safety of Argatroban combination with Urinary Kallidinogenase in the treatment of acute cerebral infarction. Methods SinoMed, CNKI, Wanfang Data, VIP, PubMed, Cochrane Library, Embase, and Web of Science were searched by computer from the inception to March 2022. Randomized controlled trials of Argatroban combined with Urinary Kallidinogenase for acute cerebral infarction were screened, data extraction and systematic review were conducted, and meta-analysis was performed by RevMan 5.4 software. Results Eight studies were included, involving 789 subjects. Meta-analysis showed that the effective rate (RR=1.22, 95%CI: 1.14 to 1.30, P＜0.000 01) and Barthel index (MD=9.77, 95%CI: 7.27 to 12.28, P＜0.05) in the Argatroban combined with Urinary Kallidinogenase group were higher than those in the control group, National Institute of Health stroke scale scores were lower than those in the Argatroban control group (MD=-3.30, 95%CI: -3.87 to -2.74, P＜0.000 01) and the Urinary Kallidinogenase control group (MD=-1.79, 95%CI: -2.16 to -1.42, P＜0.000 01). Conclusion Argatroban combined with Urinary Kallidinogenase is effective in the treatment of acute cerebral infarction, which could effectively improve the degree of neurological deficits and the activities of daily living.
		2023 Vol. 20 (11): 71-74 [Abstract] ( 18 ) HTML (1 KB) PDF (3230 KB) ( 61 )

	76	Correlation analysis of serum interleukin-17, interleukin-23, transforming growth factor-β with cognitive function in patients with Alzheimer’s disease
		YING Xiaoquan1 DAI Bojian2 YE Xinwu3▲
		DOI: 10.20047/j.issn1673-7210.2023.11.17
		Objective To investigate the correlation between serum interleukin (IL)-17, IL-23, transforming growth factor -β (TGF-β) with cognitive function in patients with Alzheimer’s disease (AD). Methods A total of 101 AD patients admitted to the Seventh People’s Hospital of Wenzhou, Zhejiang Province from February 2019 to April 2021 were selected as the research objects, and divided into severe group (22 cases) and mild-moderate group (79 cases) according to the degree of cognitive dysfunction. The clinical data of the two groups were compared, and the factors affecting the degree of cognitive dysfunction in AD patients were analyzed, the value of each index in evaluating the degree of cognitive dysfunction was further discussed. Results Age, proportion of living alone, levels of IL-17, IL-23, TGF-β in severe group were higher than those in mild-moderate group, and time of education was shorter than that in mild-moderate group (P＜0.05). Multivariate analysis showed that after adjusting for age, living alone (OR=4.162, 95%CI: 1.125-15.398), the levels of IL-17 (OR=5.057, 95%CI: 2.774-9.219), IL-23 (OR=4.462, 95%CI: 1.892-10.523), and TGF-β (OR=3.331, 95%CI: 1.174-9.451) were the factors influencing the degree of cognitive dysfunction in AD patients (P＜0.05). The results of receiver operator characteristic curve showed that IL-17, IL-23, TGF-β, and their combination had diagnostic value on the degree of cognitive dysfunction in AD patients (P＜0.05). Conclusion The levels of IL-17, IL-23, and TGF-β in AD patients are related to their cognitive function, which can be used for diagnosis and treatment of AD in clinical work.
		2023 Vol. 20 (11): 76-79 [Abstract] ( 17 ) HTML (1 KB) PDF (822 KB) ( 24 )

	80	Correlation analysis between Alberta stroke program early CT score based on RAPID software and core infarction volume in patients with anterior circulation acute ischemic stroke with large vessel occlusion over time window
		ZHANG Lingwen1 LIU Li2 LIAO Juan3 LIU Shudong1 TANG Ge1 CHEN Yu1 ZHAO Libo1 YANG Deyu1
		DOI: 10.20047/j.issn1673-7210.2023.11.18
		Objective To analyze the correlation between Alberta stroke program early CT score (ASPECTS) based on RAPID software and core infarction volume in patients with anterior circulation acute ischemic stroke with large vessel occlusion (AIS-LVO) over time window. Methods Ninety-eight patients with anterior circulation AIS-LVO over time window admitted to Yongchuan Hospital Affiliated to Chongqing Medical University from January 2019 to December 2021 were selected and further divided into patients with definite onset time (51 cases) and patients with unclear onset time (47 cases) according to the onset time. Clinical and imaging data of these patients were collected. ASPECTS was calculated by RAPID software. Spearman correlation coefficient was used to analyze the correlation between ASPECTS and core infarction volume, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of ASPECTS for core infarction volume ≤70 ml. Results There was a negative correlation between ASPECTS and core infarction volume in patients with anterior circulation AIS-LVO over time window and patients with definite onset time among them (rs＜0, P＜0.05), but no correlation with patients with unclear onset time (P＞0.05). ROC curve results showed that ASPECTS had predictive value for core infarction volume ≤70 ml in patients with anterior circulation AIS-LVO over time window and patients with definite onset time among them (P＜0.05), and cut-off values were seven points. Conclusion The ASPECTS based on RAPID software of patient with anterior circulation AIS-LVO over time window are correlated with their core infarct volume, which can help to determine the further treatment of patients.
		2023 Vol. 20 (11): 80-83 [Abstract] ( 18 ) HTML (1 KB) PDF (838 KB) ( 54 )

	84	Analysis of risk factors for postoperative lower extremity deep venous thrombosis in gynecological malignancy patients
		CUI Xiuping1 LI Xiaojuan1 ZHOU Qin1 SANG Cuiqin2
		DOI: 10.20047/j.issn1673-7210.2023.11.19
		Objective To analyze the risk factors of postoperative lower extremity deep venous thrombosis (DVT) in gynecological malignancy patients. Methods Clinical data of 246 gynecological malignancy patients who treated by operation in Beijing Luhe Hospital, Capital Medical University from January 2018 to October 2020 were retrospectively reviewed. They were divided into DVT group and control group, according to whether they were complicated with lower extremity DVT. The risk factors of postoperative lower extremity DVT in gynecological malignancy patients were analyzed. Results Postoperative DVT of lower extremity occurred in 35 of 246 patients. There were statistically significant differences in age, intraoperative blood loss, postoperative prothrombin time (PT), preoperative, and postoperative D-dimer (D-D) between two groups (P＜0.05). Age (OR=1.051), postoperative PT (OR=0.657), and postoperative D-D (OR=1.419) were independent influencing factors for postoperative DVT in patients with gynecological malignancies (P＜0.05). Conclusion The risk factors of postoperative DVT in patients with gynecological malignant tumor include age, postoperative PT, and postoperative D-D, which should be paid close attention to in clinical work, and active and effective preventive measures should be taken to reduce the occurrence of lower extremity DVT.
		2023 Vol. 20 (11): 84-88 [Abstract] ( 17 ) HTML (1 KB) PDF (594 KB) ( 44 )

	89	Clinical effect of Xiaohe Tongqiao Prescription on adenoid hypertrophy of phlegm-stasis interjunction type in children
		QIAO Shunan1 ZHU Shan2 ZHANG Ya1 LI Xinyang1
		DOI: 10.20047/j.issn1673-7210.2023.11.20
		Objective To explore the clinical effect of Xiaohe Tongqiao Prescription on adenoid hypertrophy of phlegm-stasis interjunction type in children. Methods A total of 77 adenoid hypertrophy with phlegm-stasis interjunction type in Henan Provincial Hospital of Traditional Chinese Medicine from January to December 2021 were selected, they were divided into treatment group (39 cases) and control group (38 cases) according to the random number table method. The treatment group was given Xiaohe Tongqiao Prescription, and the control group was given Mometasone Furoate Nasal Spray and Montelukast Sodium Chewable Tablet. After four weeks, the clinical efficacy, traditional Chinese medicine syndrome score, quality-of-life, adenoid volume A/N score, interleukin (IL)-4, IL-6, eosinophilic percentage (EOS%), and serum total immunoglobulin E (IgE) between two groups were compared, and adverse reactions and recurrence rates between two groups were observed. Results The clinical effect of treatment group was better than that of control group (P＜0.05). After treatment, the scores of night sleep snoring, open mouth breathing, nasal congestion, cough and sputum, sore throat, nausea, head and body sleepiness, breathing and awakening, and face of two groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, the scores of the OSA-18 scale in both groups were lower than those before treatment, and the treatment group was lower than the control group (P＜0.05). After treatment, the scores of A/N of two groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, the levels of IL-4 and IL-6 in both groups were lower than those before treatment, and treatment group was lower than control group (P＜0.05). After treatment, EOS% and serum total IgE in both groups were lower than those before treatment, and EOS% in treatment group was lower than that in control group (P＜0.05). Conclusion Xiaohe Tongqiao Prescription has remarkable effect on adenoid hypertrophy of phlegm-stasis interjunction type in children.
		2023 Vol. 20 (11): 89-93 [Abstract] ( 19 ) HTML (1 KB) PDF (644 KB) ( 21 )

	94	Comparison of the effect of transumbilical two-port laparoscopy and single-port laparoscopic myomectomy
		SHAO Weiwei CHEN Guilin CAO Yushuang LI Zongting▲
		DOI: 10.20047/j.issn1673-7210.2023.11.21
		Objective To investigate the effect of transumbilical two-port laparoscopy and single-port laparoscopic myomectomy. Methods A total of 144 patients with hysteromyoma who underwent myomectomy in Lianyungang Second People’s Hospital, Jiangsu Province from August 2019 to August 2021 were collected as the research objects. According to random number table method, they were divided into two-port group and control group, with 72 cases in each group. The two-port group underwent transumbilical two-port laparoscopic myomectomy, and control group underwent transumbilical single-port laparoscopic myomectomy. The basic conditions of two groups were compared, the visual analogue scale (VAS) scores of two groups were compared at 24, 48 h, and 72 h after operation, the aesthetic satisfaction of the incision at one month after operation of two groups were compared, and the incidence of complications in two groups was counted. Results The operation time, postoperative hospital stay, and anal exhaust time in two-port group were shorter than those in control group, and the intraoperative blood loss and postoperative hemoglobin decline were lower than those in control group, and the differences were statistically significant (P＜0.05). VAS scores of two groups at different time points were statistically significant (P＜0.05); VAS scores at 48 h and 72 h after operation in two-port group were lower than those in control group, and the differences were statistically significant (P＜0.05). There was no significant difference in postoperative incision cosmetic score between two groups (P＞0.05). There was no significant difference in the total incidence of complications between two groups (P＞0.05). Conclusion Transumbilical two-port laparoscopy for the treatment of hysteromyoma can obtain satisfactory therapeutic effects, shorten the operation time, reduce intraoperative blood loss, relieve postoperative pain, and accelerate postoperative rehabilitation of patients.
		2023 Vol. 20 (11): 94-97 [Abstract] ( 23 ) HTML (1 KB) PDF (559 KB) ( 19 )

	98	Clinical study of transcranial direct current stimulation combined with auditory integration training in the treatment of language retardation
		ZHANG Ling LIU Yueyu HUANG Fengwu LIU Chaoyu WANG Qi
		DOI: 10.20047/j.issn1673-7210.2023.11.22
		Objective To investigate the clinical effect of transcranial direct current stimulation combined with auditory integration training in the treatment of language retardation. Methods A total of 148 children with language retardation who were admitted to the Hunan Children’s Hospital from May 2020 to July 2021 were selected as the research object. They were divided into observation group (74 cases) and control group (74 cases) by random number table method. The control group received transcranial direct current stimulation, and observation group received auditory integration training on the basis of control group. Both groups were treated for three months. The mental development, language development quotient (DQ), oral motor function, articulation ability before and after treatment, and clinical efficacy were compared between two groups. Results After treatment, the scores of personal-social behavior, adaptive behavior, language behavior, language DQ, oral motor function, and articulation ability of two groups were higher than those before treatment, and those of observation group were higher than those of control group (P＜0.05). The clinical efficacy of observation group was better than that of control group (P＜0.05). Conclusion Transcranial direct current stimulation combined with auditory integration training in the treatment of children with language retardation has a definite effect, which can improve their intellectual development, language ability, oral motor function, and phonological ability.
		2023 Vol. 20 (11): 98-101 [Abstract] ( 15 ) HTML (1 KB) PDF (534 KB) ( 29 )

	102	Analysis of influencing factors of Mycoplasma combined with influenza B virus infection in children
		YANG Zheng1 QIAN Xueying1 SHEN Zhiying2 YU Yuting1 WAN Rong1▲
		DOI: 10.20047/j.issn1673-7210.2023.11.23
		Objective To study the influencing factors of Mycoplasma combined with influenza B virus (IFVB) infection in children. Methods Two hundred and forty-eight children with bronchopneumonia infected by Mycoplasma pneumoniae (MP) in Jiangsu Shengze Hospital Affiliated to Nanjing Medical University from April 2018 to March 2022 were selected. They were divided into MP group and MP merge IFVB group. The clinical characteristics, cellular immunity, and humoral immunity were compared between two groups, and the prognosis of the disease was analyzed; the influencing factors of MP combined with IFVB were analyzed. Results A total of 121 children with MP combined with IFVB. The proportion of cough, sputum, patchy shadow, lung compunction, wet rale, and neutrophil count, monocyte, CD8+, IgG, IgA, and IgM in MP merge IFVB group was higher than that in MP group; the proportion of normal lung texture, and lymphocyte count, CD3+, and CD4+ was lower than that in MP group, and fever time, cough improvement time, wet rales disappearance time, and hospitalization time were longer than those in MP group (P＜0.05). CD3+, CD4+, CD8+, IgG, IgA, and IgM were the influencing factors of MP combined with IFVB infection (P＜0.05). Conclusion The clinical characteristics of MP combined with IFVB infection in children are obvious, and CD3+, CD4+, CD8+, IgG, IgA, and IgM are all important influencing factors.
		2023 Vol. 20 (11): 102-105 [Abstract] ( 17 ) HTML (1 KB) PDF (527 KB) ( 263 )

	106	Correlation analysis of serum total protein, albumin and hemoglobin with T cell immune balance, regulatory cell and T helper cell 17 in patients with colorectal cancer
		MA Haiyan FENG Haihong GUO Fei WU Xueliang
		DOI: 10.20047/j.issn1673-7210.2023.11.24
		Objective To explore the correlation between serum total protein (TP), albumin (ALB) and hemoglobin (Hb) with T cell immune balance, regulatory cell and T helper cell 17. Methods Nutritional assessment was performed on 500 patients with colorectal cancer admitted to the First Affiliated Hospital of Hebei North University from December 2018 to October 2021 using nutritional status scores in the subjective comprehensive assessment nutrition screening table. According to the nutritional assessment results, 162 patients with good nutritional status, 161 patients with good nutritional status and 177 patients with poor nutritional status were randomly selected. Excellent nutritional status group (40 cases), mild to moderate malnutrition group (40 cases), severe malnutrition group (40 cases) were randomly selected. Nutritional indexes, Th1/Th2, Treg/Th17 immune balance related indexes of patients in different groups were observed and correlation analysis was conducted. Results The expression of TP, ALB, Hb, interleukin (IL)-2, interferon-γ, tumor necrosis factor-α, Th1 cells and Th1/Th2 cells in optimal nutrition group were significantly higher than those in mild-moderate malnutrition group and severe malnutrition group (P＜0.05), and mild-moderate malnutrition group was significantly higher than that in severe malnutrition group (P＜0.05). The expressions of transferrin (TF), L-6, IL-10, IL-5 and Th2 cells in optimal nutrition group were lower than those in mild-moderate malnutrition group and severe malnutrition group (P＜0.05), and mild-moderate malnutrition group was significantly lower than those in severe malnutrition group (P＜0.05). Pearson correlation analysis showed that TP was positively correlated with IL-2, TNF-α levels, Th1 cell expression and Th1/Th2 (r=0.500, 0.471, 0.413, 0.332, P＜0.05), it was negatively correlated with the levels of IL-6, IL-10 and IL-5 and the expression of Th2, Treg and Th17 cells (r=-0.443, -0.442, -0.396, -0.213, -0.422, -0.419, P＜0.05); ALB was positively correlated with the levels of IL-2, IFN-γ, TNF-α, Th1 cell expression and Th1/Th2 (r=0.493, 0.338, 0.393, 0.336, 0.321, P＜0.05), it was negatively correlated with the levels of IL-6, IL-10 and IL-5 and the expression of Th2, Treg and Th17 cells (r=-0.360, -0.313, -0.269, -0.231, -0.369, -0.306, P＜0.05); TF was positively correlated with the levels of IL-6, IL-10 and IL-5 and the expressions of TH2, Treg and Th17 cells (r=0.577, 0.490, 0.345, 0.394, 0.507, 0.490, P＜0.05); it was negatively correlated with the levels of IL-2, IFN-γ, TNF-α, Th1 cell expression and Th1/Th2 (r=-0.665, -0.401, -0.590, -0.540, -0.432, P＜0.05); Hb was positively correlated with IL-2, TNF-α levels and Th1 cell expression (r=0.280, 0.392, 0.194, P＜0.05), it was negatively correlated with the levels of IL-6, IL-10 and IL-5 and the expression of Th2, Treg and Th17 cells (r=-0.284, -0.188, -0.308, -0.210, -0.266, -0.327, P＜0.05). Conclusion The nutritional indexes of patients with colorectal cancer are correlated with Th1/Th2 immune balance and the correlation of Treg and Th17. With the changes of nutritional indexes of patients with colorectal cancer, Th1/Th2 immune balance and the expression levels of Treg and Th17 will be changed, and the Th1/Th2 immune balance of patients with poor nutritional status will shift to TH2. Treg and Th17 increased, and anti-tumor immunity weakened.
		2023 Vol. 20 (11): 106-110,122 [Abstract] ( 18 ) HTML (1 KB) PDF (554 KB) ( 203 )

	111	Clinical effect of chemotherapy combined with Bevacizumab in the targeted treatment of patients with advanced colorectal cancer
		ZHENG Bo1 ZHAO Hongmei2 GUO Pengwei1 WANG Yi1 CUI Haitao1▲
		DOI: 10.20047/j.issn1673-7210.2023.11.25
		Objective To study the clinical effect of chemotherapy combined with Bevacizumab in the targeted treatment of patients with advanced colorectal cancer. Methods A total of 120 patients with advanced colorectal cancer admitted to the First Hospital of Zhangjiakou from June 2020 to June 2021 were divided into observation group (60 cases) and control group (60 cases) by random number table method. The control group was given Oxaliplatin combined with Capecitabine chemotherapy. On the basis of control group, observation group was given Bevacizumab targeted treatment. The clinical efficacy, adverse reactions, quality of life, and the levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199 and CA125 in the two groups were observed. Results The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). After treatment, emotional function and physical function scores of the two groups were increased, and the observation group was higher than the control group, the differences were statistically significant (P＜0.05). After treatment, CEA, CA125 and CA199 levels in two groups were decreased, and observation group was lower than control group, the differences were statistically significant (P＜0.05). Conclusion Chemotherapy combined with Bevacizumab is effective in the treatment of advanced colon cancer patients, with a low incidence of adverse reactions and can reduce the level of tumor markers, which can improve the quality of life of patients.
		2023 Vol. 20 (11): 111-114 [Abstract] ( 21 ) HTML (1 KB) PDF (529 KB) ( 128 )

	115	Application of Zhitong Powder acupoint application combined with auricular point pressing beans in patients with cancer pain
		HE Ying1 LI Xue2 ZHANG Danjing1
		DOI: 10.20047/j.issn1673-7210.2023.11.26
		Objective To explore the clinical effect of Zhitong Powder acupoint application combined with auricular point pressing beans in the treatment of cancer pain. Methods A total of 159 patients with cancer pain in Beijing Hospital from January 2021 to May 2022 were included as the subjects, and they were divided into three groups by random number table method, with 53 cases in each group. All three groups were treated with conventional western medicine. On this basis, auricular point pressing bean group was treated with auricular point pressing beans, acupoint application group was treated with Zhitong Powder acupoint application, and combined group was treated with Zhitong Powder acupoint application combined with auricular point pressing beans for 7 days. The visual analogue scale (VAS), the number of pain outbreaks and Pittsburgh sleep quality index (PSQI) were compared before and after treatment in the three groups; the incidence of adverse reactions in the three group was analyzed. Results After treatment, the VAS scores and the number of pain outbreaks in the three groups were lower than those before treatment, and the VAS scores and the number of pain outbreaks in the combined group were lower than those in the auricular point pressing beans group and acupoint application group (P＜0.05). After treatment, the PSQI scores of the three groups were higher than those before treatment, and the PSQI scores of the combined group were higher than those of the auricular point pressing bean group and the acupoint application group (P＜0.05). There was no statistical significant difference in the incidence of adverse reactions among three groups (P＞0.05). Conclusion The effect of Zhitong Powder acupoint application combined with auricular point pressing bean in the treatment of cancer pain patients is better, which can effectively reduce the degree of pain, reduce the number of pain outbreaks, improve sleep quality, and have better safety.
		2023 Vol. 20 (11): 115-118 [Abstract] ( 17 ) HTML (1 KB) PDF (530 KB) ( 83 )

	119	Methylation of Wnt inhibitory factor-1 gene in childhood acute lymphoblastic leukemia
		HAN Wei WANG Wenpeng YAN Jing LI Xuan GAO Jizhao
		DOI: 10.20047/j.issn1673-7210.2023.11.27
		Objective To investigate the expression of Wnt inhibitory factor-1 (Wif-1) and its methylation status in childhood acute lymphoblastic leukemia (ALL). Methods A total of 43 newly diagnosed children with ALL from June 2017 to February 2022 at the Affiliated Hospital of Xuzhou Medical University were selected as the experimental group, 20 bone marrow transplant donors were selected as the control group. 3-5 ml of bone marrow blood from each of the experimental group and control group were collected, Wif-1 mRNA expression was detected by quantitative real-time fluorescence polymerase chain reaction; Wif-1 protein expression was detected by Western blot; Wif-1 gene methylation status was detected by methylation specific polymerase chain reaction. Results The relative expression of Wif-1 mRNA and protein in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05); the positive rate of Wif-1 gene methylation in the experimental group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Wif-1 gene hypermethylation exists in childhood ALL.
		2023 Vol. 20 (11): 119-122 [Abstract] ( 22 ) HTML (1 KB) PDF (596 KB) ( 61 )

	123	Application of steaming and douche with traditional Chinese medicine in children with anal fistula after therapy of cutting with thread ligation
		WANG Chen1 YANG Wei2 ZHAO Lingling1 LOU Chaosheng1 WU Xian1 QIU Jianming3 YANG Guangen3▲
		DOI: 10.20047/j.issn1673-7210.2023.11.28
		Objective To observe the curative effect of steaming and douche with traditional Chinese medicine after therapy of cutting with thread ligation of anal fistula in children. Methods Sixty children with anal fistula admitted to Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from September 2018 to September 2020 were selected and divided into observation group and control group by random number table method, with 30 cases in each group. The control group was treated with therapy of cutting with thread ligation, and the observation group was treated with steaming and douche with traditional Chinese medicine on the basis of control group. The scores of pain and pruritus, the time to fall asleep, and the scores of edema and exudation degree were compared between the two groups before surgery and 3, 7 d after surgery. The efficacy of the two groups was compared two months after surgery. Results The scores of pain and pruritus, and the scores of edema and exudation degree of two groups at 3 d after surgery were lower than those before surgery, and the time to fall asleep was shorter than that before surgery, the scores of pain and pruritus, and the scores of edema and exudation degree of two groups at 7 d after surgery were lower than those at 3 d after surgery, and the time to fall asleep was shorter than that at 3 d after surgery, the differences were statistically significant (P＜0.05). The scores of pain and pruritus, and the scores of edema and exudation degree of observation group at 7 d after surgery were lower than those of control group at the same time point, and the time to fall asleep was shorter than that of control group at the same time point, the differences were statistically significant (P＜0.05). Two months after surgery, the curative effect of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The steaming and douche with traditional Chinese medicine has positive therapeutic effect on anal fistula in children, which can improve the effective rate of the therapy of cutting with thread ligation, reduce pain, shorten the time to fall asleep, and reduce postoperative edema and seepage degree, which is worthy of further clinical promotion.
		2023 Vol. 20 (11): 123-126 [Abstract] ( 16 ) HTML (1 KB) PDF (582 KB) ( 63 )

	127	Professor Wang Weidong’s experience in treating insomnia based on “unblocking and removing stagnation”
		HE Shiqing1 LI Guixia2 YUAN Guoxing3 CHANG Jingjing2 WANG Weidong2
		DOI: 10.20047/j.issn1673-7210.2023.11.29
		Insomnia is relatively common in clinical practice. Through long-term clinical practice, Professor Wang Weidong put forward the theory of treating insomnia based on “unblocking and removing stagnation” with good effects. Insomnia or new, or lingering for a long time, should be responsible for “stagnation”, affect nutrient qi, defense qi, qi and blood operation, make the body in a state of stagnation, “unblocking and removing” throughout the treatment process of the disease, pay attention to syndrome differentiation, take care of the spleen and stomach, dispersing liver and regulating qi, nourishing blood for tranquillization, promoting blood circulation for removing blood stasis, and other methods to help sleep, make the body in the“unblocking and removing” state, achieve independent sleep, conscious sleep, natural sleep. An experimental case is attached, in order to provide new ideas and methods for the treatment of insomnia in clinic.
		2023 Vol. 20 (11): 127-130,135 [Abstract] ( 20 ) HTML (1 KB) PDF (847 KB) ( 34 )

	131	Discussion on Professor Song Yanli’s experience of Qigui Runzao Prescription in treating atopic dermatitis with type of wind and dryness due to blood deficiency based on “treating blood before treating wind”
		CUI Han ZHANG Tianbo QU Yun LIU Xin WANG Jingjing YAO Chunhai SONG Yanli
		DOI: 10.20047/j.issn1673-7210.2023.11.30
		This article introduces Professor Song Yanli’s experience in treating atopic dermatitis from the perspective of “treating blood before treating wind”. Professor Song believed that the traditional Chinese medicine pathogenesis of atopic dermatitis includes blood deficiency, blood dryness, blood stasis, blood heat generating wind, etc. Clinical method of treatment is based on benefiting qi for promoting production of blood, nourishing yin and moistening dryness, promoting blood circulation for removing blood stasis, and clearing heat and cooling blood, and the empirical prescription Qigui Runzao Prescription is used to treat this disease, and the effect is obvious. Therefore, this paper briefly expounds the theoretical connotation of “treating blood before treating wind”, and based on this, discusses the related etiology and pathogenesis of atopic dermatitis, summarizes the deficiency and excess changes of “blood” in this disease, and then leads to Professor Song’s clinical insights on the application of Qigui Runzao Prescription in the treatment of this disease, focusing on the discussion of prescription ideas and drug characteristics, and gives a trial case for clinical reference.
		2023 Vol. 20 (11): 131-135 [Abstract] ( 22 ) HTML (1 KB) PDF (964 KB) ( 80 )

	136	Visual analysis of acupuncture in the treatment of aphasia after stroke based on CiteSpace
		LIU Jiao MO Xueni MA Wei LIU Na LAN Baixin
		DOI: 10.20047/j.issn1673-7210.2023.11.31
		Objective To visually analyze the literatures related to acupuncture treatment of aphasia after stroke. Methods The literatures on acupuncture treatment of aphasia after stroke was retrieved from China National Knowledge Infrastructure from January 1992 to May 2022 by computer. The number of articles published, authors, institutions, and keywords were analyzed visually by CiteSpace software. Results A total of 834 literatures were included, and the annual publication volume showed a curve rising trend, forming a high-yield team represented by Chang Jingling, Liu Jing, Hou Baoguo, etc. The group cooperation was mainly concentrated in the university of traditional Chinese medicine and its affiliated hospitals. The high-frequency keywords included acupuncture, stroke, aphasia, etc., and the aggregation of keywords was classified into 11 categories. According to the analysis of keyword emergence, the current research focus was language function, quality of life, etc. Conclusion The number of studies on acupuncture treatment of aphasia after stroke is increasing gradually, but the communication and cooperation between different regions need to be further strengthened. Speech function and quality of life are the current research trends.
		2023 Vol. 20 (11): 136-139,144 [Abstract] ( 17 ) HTML (1 KB) PDF (2708 KB) ( 52 )

	140	Wang Guiling’s experience in the differentiation and treatment of refractory insomnia by combination of acupuncture and medicine
		LIU Xiaonan GUO Jing WANG Guiling
		DOI: 10.20047/j.issn1673-7210.2023.11.32
		Refractory insomnia has a long course and is prone to repeated attacks, which seriously affects the physical and mental health of patients. This paper summarizes the experience of Professor Wang Guiling in the treatment of this disease by combination of acupuncture and medicine, and expounds the etiology, pathogenesis and therapeutic principle and method. Professor Wang bases on the theory of “five viscera storing spirit” of Nei Jing, believes the pathogenesis is “five viscera dysfunction, yang doesn’t enter yin, spirit mustn’t store”. About treatment, the pathogenesis should be guarded, focusing on syndrome differentiation of viscera, starting from the five viscera, focusing on regulating the mind and spirit, advocating the combination of acupuncture and medicine, the harmonization of viscera and meridians, and determine treatment on the basis of pattern types. The prescription of traditional Chinese medicine is based on classics. Acupuncture and moxibustion prescription focus on regulating the mind and spirit, flexibly match acupoints according to syndrome differentiation, and cooperate with fire needle or bloodletting to reinforce deficiency and reduce excess to improve the curative effect. And attach the verification case for analysis.
		2023 Vol. 20 (11): 140-144 [Abstract] ( 20 ) HTML (1 KB) PDF (759 KB) ( 74 )

	145	Analysis on Fu Shan’s treatment of restoring coordination between heart and kidney
		DENG Jinpeng1 ZHONG Jiaying2 DU Caifeng1
		DOI: 10.20047/j.issn1673-7210.2023.11.33
		Fu Shan is a famous doctor in the late Ming and early Qing Dynasties. In his works of Fu Qing Zhu Andrology and Fu Qing Zhu Obstetrics and Gynecology, he uses the method of restoring coordination between heart and kidney to treat a variety of diseases, such as insomnia, male spermatorrhea, menstrual diseases, infertility, pregnancy diseases, postpartum diseases of female and so on. Although they are both restoring coordination between heart and kidney, it involves many aspects such as yin, yang, qi, blood, essence and vitality, and the severity and urgency of the disease are different. They either nourish the heart blood and kidney yin, or nourish the heart yin and kidney essence, or nourish the monarch fire to help the ministerial fire, or restore coordination between heart and kidney to regulate the liver, spleen, uterus other viscera disease, or restore coordination between heart and kidney by the liver’s relieving or the rise and fall of the spleen and stomach in the middle energizer, or urgently replenish heart and kidney yin and yang to save the loss of essence and blood. The prescriptions are the same and different. It is flexible, adaptable to clinic, simple and practical, and worthy of in-depth research and mining.
		2023 Vol. 20 (11): 145-148,153 [Abstract] ( 19 ) HTML (1 KB) PDF (703 KB) ( 42 )

	149	Experience of Professor Wang Jinhuan in treating bone marrow suppression after radiotherapy and chemotherapy with the theory of “analysing the source and dredging transportation to promote tonifying”
		HE Dandi1 ZHAO Qi2 WANG Jinhuan2 GU Mengyu1 SHI Wenxuan1 SUN Feng2 SUN Weizheng2
		DOI: 10.20047/j.issn1673-7210.2023.11.34
		After radiotherapy and chemotherapy, bone marrow suppression may manifest as single even multiple lineage cytopenia which may result in treatment interruption in severe cases. Through learning and clinical summary, Professor Wang Jinhuan advocating that the four diagnostic methods should be combined to dissect the reason and emphasizing on recuperating the kidney and correcting the pathological state of toxin, depression, stasis, and knot, so as to generate new niche. It can promote replenishing by making the sanjiao unobstructed, bring the source alive by gastrosplenic invigorating. Chinese and western medicine are integrated to ensure the steady balance of the body. The critically ill patients must rely on modern medical support therapy to maintain the vital signs so as to seize the effective time for Chinese medicine treatment, and next radiotherapy and chemotherapy protocol can be assisted by traditional Chinese medicine intervention. Finally, the harmonious zang-fu ecology and organism environment are restored to achieve the purpose of protecting the yin and yang in a balanced and stable situation. It has been proved to have definite effects.
		2023 Vol. 20 (11): 149-153 [Abstract] ( 13 ) HTML (1 KB) PDF (812 KB) ( 112 )

	154	Professor Yin Kejing’s clinical experience in the treatment of diabetic oculomotor paralysis
		MA Yuyu1 CHEN Lijie1 XU Weiwei1 YIN Kejing2 DU Xu1
		DOI: 10.20047/j.issn1673-7210.2023.11.35
		Diabetic oculomotor paralysis is one of the complications of diabetic neuropathy. Professor Yin Kejing believes that the disease is mainly responsible for the three organs of the liver, spleen, and kidney, emphasizing yin deficiency of the liver and kidney as the root, qi deficiency and blood stasis as the manifestation; Professor Yin Kejing believes that the treatment should strictly observe the pathogenesis, give consideration to both the manifestation and the root cause, and use drugs such as nourishing the liver and kidney and using drugs such as tonifying the liver and kidney, combined with its modern pharmacological research, supplemented by drugs for tonifying qi and activating blood circulation; acupuncture points are mainly used to nourish yin and fill essence, promote blood circulation for removing obstruction in collaterals. Acupuncture combined with medicine to improve the clinical symptoms of diabetic oculomotor paralysis. Combined with Professor Yin’s experience in the diagnosis and treatment of diabetic oculomotor paralysis, this paper summarizes and discusses Professor Yin’s clinical experience in the treatment of diabetic oculomotor paralysis, in order to enlighten the clinical treatment.
		2023 Vol. 20 (11): 154-157 [Abstract] ( 18 ) HTML (1 KB) PDF (593 KB) ( 34 )

	158	Epidemiological research and diagnosis of nonalcoholic fatty liver disease in China
		WU Chemin1 ZHANG Congyu1 XU Huili1 GUO Chenxin1 HUANG Huimin2 JIANG Xueqiang1
		DOI: 10.20047/j.issn1673-7210.2023.11.36
		Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in China and the primary cause of abnormal liver function. There are many risk factors affecting NAFLD, including not only common risk factors such as sex, age, metabolic syndrome, but also rare factors such as sleep disorders, myopathia, etc. With the changes in diet and lifestyle, the prevalence and incidence of NAFLD in China are showing a continuous increase and a trend of younger age. Epidemiological investigation is conducive to the diagnosis, treatment and prevention of NAFLD. In recent years, the epidemiological data of NAFLD in China are constantly improved. This article reviews the prevalence of NAFLD and related risk factors in the past 10 years in China.
		2023 Vol. 20 (11): 158-161 [Abstract] ( 25 ) HTML (1 KB) PDF (589 KB) ( 169 )

	162	Effect of compound insulation strategy in perioperative patients with hepatic cystic echinococcosis
		Gulisumuhan Abulaiti1 Mubalake Yikelamu1 CHEN Han2 JIANG Yu1 ZHAO Ping3 WANG Meixin4
		DOI: 10.20047/j.issn1673-7210.2023.11.37
		Objective To explore the effect of compound insulation strategy in perioperative patients with hepatic cystic echinococcosis. Methods A total of 77 patients with hepatic cystic echinococcosis who underwent surgical treatment in the Department of Hepatobiliary Echinococcosis of the First Affiliated Hospital of Xinjiang Medical University in Xinjiang Uygur Autonomous Region from January to December 2021 were selected, they were divided into control group (38 cases) and experimental group (39 cases) according to random number table method. The control group was treated with conventional insulation nursing, and the experimental group was treated with compound insulation strategy. The body temperature of the two groups were observed at the time of entry, before anesthesia, before incision, 30, 60, 90, 120, 150, 180 min and the end during the surgery. The occurrence of hypothermia, postoperative chills and agitation during recovery were compared between the two groups, the extubation time of tracheal catheter and the retention time of postanesthesia care unit (PACU) were observed in the two groups, the coagulation function of the two groups was compared before and after operation. Results Intraoperative body temperature was compared between the two groups in terms of inter-group, time and interaction, and the differences were statistically significant (P＜0.05); there was no significant difference in body temperature between the two groups at the time of entry, before anesthesia, and before skin resection (P＞0.05), the body temperature of experimental group 30, 60, 90, 120, 150, 180 min and the end was higher than that of control group, and the differences were statistically significant (P＜0.05). The incidence of hypothermia, chills, and agitation in experimental group were lower than that in control group, the differences were statistically significant (P＜0.05). Tracheal catheter extubation time and PACU retention time of experimental group were shorter than those of control group, and the differences were statistically significant (P＜0.05). After surgery, prothrombin time, thrombin time and activated partial thromboplastin time were longer than before surgery, but fibrinogen was less than before surgery the two groups, the four items of postoperative coagulation were compared between the two groups, and the differences were statistically significant (P＜0.05). Conclusion The compound insulation strategy can maintain the relative stability of intraoperative body temperature in patients with hepatic cystic echinococcosis, prevent the occurrence of hypothermia, chills, and agitation, promote anesthesia recovery, and contribute to the stability of coagulation function in patients.
		2023 Vol. 20 (11): 162-166 [Abstract] ( 17 ) HTML (1 KB) PDF (680 KB) ( 22 )

	167	Application effect of shoulder and neck exercises in patients with implantable infusion port via upper arm in breast cancer chemotherapy
		JIANG Qing1 GAO Fangning1 JIANG Jing2 CHEN Jing1 LI Xueyan1 YU Qi1▲
		DOI: 10.20047/j.issn1673-7210.2023.11.38
		Objective To investigate the effect of shoulder and neck exercises in patients with implantable infusion port via upper arm in breast cancer chemotherapy. Methods A total of 96 breast cancer patients receiving upper arm implantable infusion port chemotherapy in the Second Affiliated Hospital of Chinese People’s Liberation Army Air Force Military Medical University from January 2020 to December 2021 were selected as the study objects. The patients were divided into control group and observation group by computer stratification, with 48 cases in each group. The control group received routine nursing intervention, and the observation group received shoulder and neck exercises based on the control group. The intervention time of the two groups was eight weeks. The shoulder joint function score, upper limb function status rating scale, and catheter associated thrombosis (CRT) occurrence were compared between the two groups. Results After eight weeks of intervention, the shoulder joint function scores in both groups were higher than before intervention, and the observation group was higher than the control group (P＜0.05); after eight weeks of intervention, the upper limb dysfunction scores in both groups were lower than before intervention, and the observation group was lower than the control group (P＜0.05); the severity of CRT in the observation group was lower than the control group (P＜0.05). Conclusion Shoulder and neck exercises for breast cancer chemotherapy patients with upper arm implantable infusion port can effectively improve the degree of shoulder joint mobility limitation, improve the upper limb function, and reduce the incidence and severity of CRT.
		2023 Vol. 20 (11): 167-170 [Abstract] ( 17 ) HTML (1 KB) PDF (562 KB) ( 83 )

	171	Application effect of PDCA nursing model on airway function, compliance, and quality of life in patients with bronchial asthma
		LIN Dongmei WANG Fang TANG Danhui
		DOI: 10.20047/j.issn1673-7210.2023.11.39
		Objective To explore the effect of PDCA nursing model on airway function, compliance, and quality of life in patients with bronchial asthma (hereinafter referred to as “our hospital”). Methods A total of 100 patients with asthma admitted to the Western District of Beijing Chaoyang Hospital from May 2019 to June 2022 were selected, and they were divided into PDCA group and control group by random number table method, with 50 cases in each group. PDCA group adopted PDCA nursing mode, the control group received routine care. Both groups were treated for one month. Medication compliance, airway function (tidal volume, respiratory rate, and peak expiratory flow rate [PEF]) and quality of life (assessed by asthma quality of life scale [AQLQ]) were compared between the two groups before and after intervention. Results After intervention, medication compliance in both groups was better than before intervention, and PDCA group was better than control group, the differences were statistically significant (P＜0.05); after intervention, tidal volume of the two groups was higher than before intervention, respiratory rate and PEF were lower than before intervention, and tidal volume of PDCA group was higher than control group, respiratory rate and PEF were lower than control group, the differences were statistically significant (P＜0.05); the mean score of each dimension and total mean score of AQLQ in two groups were higher than before intervention, and PDCA group was higher than control group, the differences were statistically significant (P＜0.05). Conclusion PDCA nursing model for patients with asthma can improve nursing services, improve patients’ medication compliance, and promote the improvement of airway function and quality of life.
		2023 Vol. 20 (11): 171-174 [Abstract] ( 22 ) HTML (1 KB) PDF (568 KB) ( 29 )

	175	Influence of childlike fun communication combined with comic health education on the cooperation degree and recovery effect of pneumonia children treated with atomization
		ZHU Pan YUE Nannan
		DOI: 10.20047/j.issn1673-7210.2023.11.40
		Objective To explore the influence of childlike fun communication combined with comic health education on the cooperation degree and recovery effect of pneumonia children treated with atomization. Methods A total of 90 children with pneumonia diagnosed, and treated in Taihe Hospital of Traditional Chinese Medicine, Anhui University of Chinese Medicine from February 2020 to April 2021 were selected as subjects, and the children were divided into routine group and intervention group by random number method, with 45 cases in each group. The routine group received routine nursing + childlike fun communication, and the intervention group received comic health education intervention based on the routine group nursing. The children’s negative mood improvement, treatment cooperation, and recovery speed were observed. Results After intervention, the scores of children’s emotional disorder screening scale in both groups were lower than before intervention, and the intervention group was lower than those of the conventional group, the differences were statistically significant (P＜0.05); treatment cooperation of the intervention group was better than that of the conventional group, and the difference was statistically significant (P＜0.05); the time for cough, lung rales, and shortness of breath to disappear, the time for body temperature to return to normal and hospitalization of the intervention group were shorter than those of the conventional group, and the differences were statistically significant (P＜0.05). Conclusion In the process of atomization of children with pneumonia, on the basis of routine nursing, children’s fun communication and comic health education can effectively help children alleviate negative emotions, improve the degree of cooperation in treatment, and help children recover faster after treatment.
		2023 Vol. 20 (11): 175-178 [Abstract] ( 20 ) HTML (1 KB) PDF (591 KB) ( 38 )

	179	Orthodontic treatment of scissor bite of adult second molars: a case report and literature analysis
		CHEN Jianming HU Yaozheng GUO Chenlin ZHENG Mengyu LUO Ming
		DOI: 10.20047/j.issn1673-7210.2023.11.41
		A case of adult Class Ⅰ malocclusion with scissor bite of 17/47 from Affiliated Stomatology Hospital of Guangzhou Medical University was reported. The patient in this case has molar scissor bite, which is difficult to correct, and improper vertical control is easy to cause the deterioration of the profile. Mini-screw were implanted in the distal palatine region of the maxillary second molar of the patient, and tension springs were used to produce distal, palatine and vertical compression of the appliance. The scissor bite of the second molar was corrected after three months of treatment, this method not only protects the maxillary molar anchorage, but also helps to control the face height. Therefore, this method is an effective method to correct the scissor bite of the second molar.
		2023 Vol. 20 (11): 179-182 [Abstract] ( 25 ) HTML (1 KB) PDF (3220 KB) ( 39 )

	183	Automatic extraction and information quality evaluation of structured information in clinical randomized controlled trials of traditional Chinese medicine
		ZHANG Yunan LIU Heyuan HUANG Zhe DOU Zhili HAN Dongran▲
		DOI: 10.20047/j.issn1673-7210.2023.11.42
		Objective To improve the utilization rate of data information in the literature of randomized controlled trials of traditional Chinese medicine (RCTs), this subject automatically extracted structured information in the included literature and evaluated the extracted information. Methods From January 1986 to December 2020, the CNKI, Wanfang Data, and VIP were searched and sorted out the clinical RCT literatures, of six diseases including diabetes, rheumatoid arthritis, obesity, knee osteoarthritis, pediatric diarrhea and colorectal cancer. A total of 5 506 articles were randomly included. Optical character recognition technology was used to identify documents in portable document format, convert them into text format, and regular expressions were used to extract information from the documents. From the information extraction rate and accuracy of two aspects were evaluated. Results The study found that the extraction rates of “data”, “method”, “total number of participants”, “age of participants”, “number of participants”, “duration of treatment”, “exclusion criteria”, “inclusion criteria”, and “fund” were 96.60%, 93.30%, 92.60%, 42.23%, 28.29%, 80.20%, 62.60%, 46.00% and 21.10%, respectively, and the accuracy of nine fields were 97.9%, 98.9%, 89.7%, 100.0%, 100.0%, 94.5%, 97.3%, 89.0% and 94.7%, respectively. Conclusion Traditional Chinese medicine clinical RCT literatures can identify and judge the integrity of the structured information of literatures by automatic means, and the extracted structured information can provide data support for the construction of clinical RCTs trial network system of traditional Chinese medicine. On this basis, the author puts forward the idea of structured writing of traditional Chinese medicine clinical RCT literatures.
		2023 Vol. 20 (11): 183-187,192 [Abstract] ( 21 ) HTML (1 KB) PDF (2764 KB) ( 64 )

	188	Research on the protection status quo, existing problems, and countermeasures of living traditional of knowledge Chinese medicine
		ZHANG Fengxia LIU Qian WANG Liuqing ZHU Tingyu AN Hong SHI Xueqin ZHAO Zhupei LIU Jianfeng
		DOI: 10.20047/j.issn1673-7210.2023.11.43
		Living traditional knowledge of Chinese medicine is an important part of traditional Chinese medicine. Starting from the significance of protecting living traditional knowledge of Chinese medicine, this paper introduces the protection content and implementation plan of living traditional knowledge of Chinese medicine at this stage and combines the protection of living traditional knowledge of Chinese medicine. It is found that not only the total number of collected items is quite different, but also the collection of different types of items in the same area is also very different. By analyzing the reasons for the discrepancies, put forward common problems encountered in the collection process, and give corresponding countermeasures and suggestions, to provide a reference for the protection and collection of living traditional knowledge of Chinese medicine in the future.
		2023 Vol. 20 (11): 188-192 [Abstract] ( 17 ) HTML (1 KB) PDF (955 KB) ( 43 )

	193	Value and way of integrating “Luoyang orthopedic traditional Chinese medicine spirit” into medical cultivation of young doctors
		SONG Xin1 LI Zhixuan2 ZHANG Chao3
		DOI: 10.20047/j.issn1673-7210.2023.11.44
		It is particularly important for national and social development to cultivate young traditional Chinese medicine clinical talents with noble medical ethics, because young doctors bear the future of the inheritance and development of traditional Chinese medicine. This paper summarizes and analyzes the current situation of the training of young doctors, and discusses the practical value of integrating the “Luoyang orthopedic traditional Chinese medicine spirit” into the training of young doctors, which is conducive to guiding young doctors to build a modern personality, establish a noble career pursuit, and cultivate a sense of integrity and innovation. At the same time, based on social cognitive theory, this paper proposes specific integration paths such as changing self-efficacy, strengthening behavior practice and shaping cultural environment, which expands new ideas and methods for effectively improving the professional qualities of young doctors.
		2023 Vol. 20 (11): 193-196 [Abstract] ( 19 ) HTML (1 KB) PDF (666 KB) ( 28 )

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