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| Study on traditional Chinese medicine syndrome characteristics and traditional Chinese medicine medication law of primary Sjogren’s syndrome based on data mining |
| WEI Naxin SUN Hongyan |
College of Traditional Chinese Medicine, Xinjiang Medical University Institute of Traditiaonal Chinese Medicine, Xinjiang Uygur Autonomous Region, Urumqi 830017, China
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Abstract Objective To excavate and analyze the literature on the treatment of primary Sjogren’s syndrome (pSS) by traditional Chinese medicine, and to summarize the syndrome characteristics and medication rules of pSS. Methods The literature related to traditional Chinese medicine treatment of pSS from January 2011 to December 2021 was retrieved from CNKI and Wanfang data, and the traditional Chinese medicine syndrome elements, tongue and pulse, prescriptions, and so on were counted successively by Excel. SPSS 25.0, SPSS Modeler and Cytoscape were used for cluster analysis, association analysis, and complex network analysis respectively. Results A total of 145 literatures were included, and the syndrome types were mainly Qi and Yin deficiency. The tongue pulse was mainly fine pulse, red tongue, number pulse, and moss stripping. In addition to the self-designed formula, Yiwei decoction was often used; there were 197 kinds of traditional Chinese medicines involved, mainly ophiopogon ophiopogon, licorice and radix rehmanniae. The medicinal tastes were mainly sweet, bitter and pungent, while the medicinal properties were mainly cold and flat, which were mainly attributed to the three classics of lung, liver, and stomach. Seven core drug groups were obtained by systematic cluster analysis. A total of 14 groups of association rules were obtained by association analysis. Complex network analysis showed that the core drug combinations were ophiopogon ophiopogon, Radix rehmanniae, Radix ginseng and licorice. Conclusion pSS syndrome type is based on “Qi and Yin deficiency, stasis, toxicity, phlegm, and dampness as the standard”, and the treatment is based on “tonifying liver and kidney, tonifying lung and tonifying stomach”, supplemented by activating blood circulation and removing blood stasis, clearing heat and cooling blood, regulating qi, and so on.
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[1] 孙晓泽，焦东方，刘爱华.中西医结合治疗干燥综合征思路探讨[J].中华中医药杂志，2018，33（7）：2956-2959.
[2] 李灿东，方朝义.中医诊断学[M].北京：中国中医药出版社，2021.
[3] GB/T6751.2-1997.中医临床诊疗术语·证侯部分[S].北京：国家标准出版社，1997.
[4] 钟赣生，杨柏灿.中药学[M].北京：中国中医药出版社，2021.
[5] 国家药典委员会.中华人民共和国药典[M].一部.北京：中国医药科技出版社，2020.
[6] 杜梦梦，罗静，周丽，等.基于“内燥”理论探讨原发性干燥综合征的病因病机及治疗[J].中华中医药杂志，2021， 36（1）：250-252.
[7] 李明珠，王坤，罗玳红，等.赖新生通元疗法治疗原发性干燥综合征经验撷英[J].中国中医基础医学杂志，2019， 25（2）：262-264.
[8] 陈剑梅，钱先，金实.基于津血同源理论辨治原发性干燥综合征[J].南京中医药大学学报，2018，34（3）：242-244.
[9] 史佳妮，赵宏利，来韵祺，等.鲁贤昌教授治疗原发性干燥综合征经验撷菁[J].时珍国医国药，2018，29（8）：2005- 2006.
[10] 冯博.基于文献研究探析中医药治疗原发性干燥综合征的用药规律[D].沈阳：辽宁中医药大学，2021：22-23.
[11] 张丽宁，姚传辉，罗静，等.原发性干燥综合征中医治疗经验荟萃[J].中华中医药杂志，2021，36（5）：2588-2592.
[12] 胡永鹏，杜转敏，杨毛吉，等.益气养阴方联合西医疗法治疗原发性干燥综合征临床观察[J].新中医，2017，49（5）：60-62.
[13] 胡琪，罗静，张丽宁，等.114例原发性干燥综合征患者的中医证候特点[J].中日友好医院学报，2021，35（2）：96-98.
[14] 张青.六味地黄丸及其类方治疗原发性干燥综合征62例[J].河南中医，2015，35（1）：196-197.
[15] 宣磊，王景，张昊泽，等.甘露饮合升降散治疗原发性干燥综合征50例分析[J].医学研究杂志，2018，47（5）：126- 130.
[16] 李增变，周全，张国胜，等.基于津液代谢理论观察沙参麦冬汤联合白芍总苷胶囊治疗原发性干燥综合征[J].中国实验方剂学杂志，2020，26（20）：100-104.
[17] 孟庆一，肖瑞崇，李东书.竹叶石膏汤加减方治疗原发性干燥综合征疗效观察[J].光明中医，2017，32（10）：1424- 1426.
[18] 周梦玲.基于TLR4/MyD88/NF-κB/NLRP3信号通路探讨麦冬多糖调节干燥综合征炎性微环境的机制研究[D].南京：南京中医药大学，2020.
[19] 迟宇昊，李暘，申远.麦冬化学成分及药理作用研究进展[J].新乡医学院学报，2021，38（2）：189-192.
[20] 王钧楠，周永峰，崔园园，等.基于抗炎生物效价的甘草传统感官评价科学性研究[J].中国现代中药，2022，24（6）：1018-1025.
[21] 郝飞.甘草酸国外研究进展[J].中国药房，2001（8）：52- 53.
陈金鹏，张克霞，刘毅，等.地黄化学成分和药理作用的研究进展[J].中草药，2021，52（6）：1772-1784.
[22] 邱晓月，景永帅，郑玉光，等.北沙参多糖对免疫系统调节作用研究进展[J].中国药理学与毒理学杂志，2021， 35（10）：794.
[23] 梅寒颖，刘炬，汤曾耀.基于TLR4/MyD88/NF-κB信号通路探讨白芍总苷抑制干燥综合征模型小鼠炎症的作用机制[J].中药新药与临床药理，2021，32（9）：1293- 1299.
[24] 梅寒颖，刘炬，汤曾耀，等.阴虚型原发性干燥综合征患者调节性B淋巴细胞、IL-17水平与血液系统受累情况的相关性分析[J].中国医学创新，2022，19（23）：121- 124.
[25] 孟德钎，李永胜，李鞠，等.咖啡酸片联合传统免疫治疗干燥综合征血液系统损害的临床疗效[J].中国医药科学，2021，11（19）：192-195.
[26] 王慧，李纪高，刘瑞林，等.基于因子分析的原发性干燥综合征中医证型分类研究[J].安徽中医药大学学报，2022， 41（4）：40-45. |
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