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| Research progress on the relationship between trimethylamine-N-oxide and chronic kidney disease and its complications |
| YANG Xiangyan1 TIAN Maolu2 ZHA Yan1 |
1.Graduate School, Zunyi Medical University, Guizhou Province, Zunyi 563000, China;
2.Department of Nephrology, Guizhou Provincial People’s Hospital, Guizhou Province, Guiyang 550002, China
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Abstract With the deepening of the research on the “gut-kidney axis”, the relationship between trimethylamine-N-oxide, the metabolic compound of intestinal flora, and chronic kidney disease has become a research hotspot for scholars at home and abroad, providing a new target for the prevention and treatment of chronic kidney disease. This paper reviews the relationship between trimethylamine-N-oxide and chronic kidney disease in recent years, and the promotion of cardiovascular disease, cognitive impairment, peritonitis, cerebrovascular disease, and other complications through inducing oxidative stress and inflammatory response, in order to provide reference ideas for the clinical prevention and treatment of chronic kidney disease and its related complications.
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