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| Research progress in pulmonary sarcoidosis models |
| HU Zhuannan ZHANG Shaoyan HUANG Xing LI Cui WU Xianwei ZHOU Wei QIU Lei LU Zhenhui |
Institute of Respiratory Diseases, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
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Abstract Sarcoidosis is a granulomatous inflammatory disease of unknown etiology that can involve multiple organs throughout the body, with the lungs being the most common. Its pathogenesis is related to excessive immune, microbial infection, environmental, and genetic factors, and there is still no comprehensive or widely accepted disease model. The studies for sarcoidosis have used Propionibacterium acnes, Mycobacterium tuberculosis, and related derivatives, nanoparticles, ApoE and Tsc2 knockout mice to establish animal models. Cellular models use peripheral blood monocytes or macrophages to replicate the immune environment of the disease, while mathematical models based on clinical data provide more options for basic research of sarcoidosis. This paper summarizes the advantages and limitations of pulmonary sarcoidosis models, and then develops appropriate models to explore the pathogenesis of pulmonary sarcoidosis, find new targets for disease treatment and drug evaluation.
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